Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy
Authors
Keywords
-
Journal
Communications Biology
Volume 3, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-11-27
DOI
10.1038/s42003-020-01441-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
- (2020) Jean-Christophe Beltra et al. IMMUNITY
- Delivery technologies for cancer immunotherapy
- (2019) Rachel S. Riley et al. NATURE REVIEWS DRUG DISCOVERY
- Targeting DDR2 enhances tumor response to anti–PD-1 immunotherapy
- (2019) Megan M. Tu et al. Science Advances
- Blockade of CCL2/CCR2 signaling pathway prevents inflammatory monocyte recruitment and attenuates OVA-Induced allergic asthma in mice
- (2019) Shaohong Jiang et al. IMMUNOLOGY LETTERS
- Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers
- (2019) Chia-Hsueh Lin et al. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
- Monocyte-derived Alveolar Macrophages: The Dark Side of Lung Repair?
- (2018) Alexandra C. McQuattie-Pimentel et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non–Small Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab
- (2018) Brandon W. Higgs et al. CLINICAL CANCER RESEARCH
- Overall survival in a trial of orally administered CCR2 inhibitor CCX872 in locally advanced/metastatic pancreatic cancer: Correlation with blood monocyte counts.
- (2018) David Linehan et al. JOURNAL OF CLINICAL ONCOLOGY
- Safety and efficacy of axitinib (axi) in combination with pembrolizumab (pembro) in patients (pts) with advanced renal cell cancer (aRCC).
- (2018) Michael B. Atkins et al. JOURNAL OF CLINICAL ONCOLOGY
- Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer
- (2018) Leena Gandhi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Macrophages orchestrate breast cancer early dissemination and metastasis
- (2018) Nina Linde et al. Nature Communications
- High levels of CCL2 or CCL4 in the tumor microenvironment predict unfavorable survival in lung adenocarcinoma
- (2018) Lei Li et al. Thoracic Cancer
- Lenvatinib + pembrolizumab in patients with renal cell carcinoma: Updated results.
- (2018) Chung-Han Lee et al. JOURNAL OF CLINICAL ONCOLOGY
- Macrophages of distinct origins contribute to tumor development in the lung
- (2018) Pierre-Louis Loyher et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
- (2018) Spencer C. Wei et al. Cancer Discovery
- Dietary Lipids Differentially Shape NASH Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages
- (2018) Brett McGettigan et al. HEPATOLOGY
- Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells
- (2018) Naofumi Mukaida et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Viewing Siglecs through the lens of tumor immunology
- (2017) Isabella Fraschilla et al. IMMUNOLOGICAL REVIEWS
- LAG3 (CD223) as a cancer immunotherapy target
- (2017) Lawrence P. Andrews et al. IMMUNOLOGICAL REVIEWS
- PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity
- (2017) Vikram R. Juneja et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The benefits of immunotherapy combinations
- (2017) Charles Schmidt NATURE
- Identification of essential genes for cancer immunotherapy
- (2017) Shashank J. Patel et al. NATURE
- In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
- (2017) Robert T. Manguso et al. NATURE
- Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade
- (2017) Pornpimol Charoentong et al. Cell Reports
- Combination immunotherapy: a road map
- (2017) Patrick A. Ott et al. Journal for ImmunoTherapy of Cancer
- Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues
- (2016) Yen-Rei A. Yu et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- CXCR4 signaling in health and disease
- (2016) Tommaso Pozzobon et al. IMMUNOLOGY LETTERS
- Nivolumab in Combination With Platinum‐Based Doublet Chemotherapy for First-Line Treatment of Advanced Non–Small-Cell Lung Cancer
- (2016) Naiyer A. Rizvi et al. JOURNAL OF CLINICAL ONCOLOGY
- Expression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer
- (2016) Joanna M. Poczobutt et al. JOURNAL OF IMMUNOLOGY
- Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial
- (2016) Timothy M Nywening et al. LANCET ONCOLOGY
- Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): an open-label, randomised, phase 2 trial
- (2016) Jeffrey S Weber et al. LANCET ONCOLOGY
- Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study
- (2016) Corey J Langer et al. LANCET ONCOLOGY
- Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth
- (2015) Sonja Kleffel et al. CELL
- Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma
- (2015) Xiaoguang Li et al. GUT
- Macrophage Migration Inhibitory Factor–CXCR4 Is the Dominant Chemotactic Axis in Human Mesenchymal Stem Cell Recruitment to Tumors
- (2015) Sofia Lourenco et al. JOURNAL OF IMMUNOLOGY
- Mechanisms of action of therapeutic antibodies for cancer
- (2015) J.M. Redman et al. MOLECULAR IMMUNOLOGY
- Robust enumeration of cell subsets from tissue expression profiles
- (2015) Aaron M Newman et al. NATURE METHODS
- Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
- (2015) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
- (2015) Ruea-Yea Huang et al. Oncotarget
- An online tool for evaluating diagnostic and prognostic gene expression biomarkers in bladder cancer
- (2015) Garrett M. Dancik BMC Urology
- Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy
- (2014) Woonyoung Choi et al. CANCER CELL
- IL-33–Induced Hematopoietic Stem and Progenitor Cell Mobilization Depends upon CCR2
- (2014) Juyang Kim et al. JOURNAL OF IMMUNOLOGY
- Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis
- (2014) Laura Bonapace et al. NATURE
- ArrayExpress update—simplifying data submissions
- (2014) Nikolay Kolesnikov et al. NUCLEIC ACIDS RESEARCH
- Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer
- (2014) Heinz Läubli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- voom: precision weights unlock linear model analysis tools for RNA-seq read counts
- (2014) Charity W Law et al. GENOME BIOLOGY
- Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model
- (2014) S. Chen et al. Cancer Immunology Research
- A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors
- (2013) Shahneen K. Sandhu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Obesity Promotes Breast Cancer by CCL2-Mediated Macrophage Recruitment and Angiogenesis
- (2013) L. M. Arendt et al. CANCER RESEARCH
- Nivolumab plus Ipilimumab in Advanced Melanoma
- (2013) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
- Transcriptional Signatures of Ral GTPase Are Associated with Aggressive Clinicopathologic Characteristics in Human Cancer
- (2012) S. C. Smith et al. CANCER RESEARCH
- Combination of a Novel Gene Expression Signature with a Clinical Nomogram Improves the Prediction of Survival in High-Risk Bladder Cancer
- (2012) Markus Riester et al. CLINICAL CANCER RESEARCH
- Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer
- (2012) Kenneth J. Pienta et al. INVESTIGATIONAL NEW DRUGS
- RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration
- (2012) Neveen Said et al. JOURNAL OF CLINICAL INVESTIGATION
- Distinct Macrophage Subpopulations Characterize Acute Infection and Chronic Inflammatory Lung Disease
- (2012) M. Duan et al. JOURNAL OF IMMUNOLOGY
- Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
- (2012) Emmanuel L Gautier et al. NATURE IMMUNOLOGY
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- NCBI GEO: archive for functional genomics data sets—update
- (2012) Tanya Barrett et al. NUCLEIC ACIDS RESEARCH
- Integrated Genomic and Gene Expression Profiling Identifies Two Major Genomic Circuits in Urothelial Carcinoma
- (2012) David Lindgren et al. PLoS One
- CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis
- (2012) R. E. Miller et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fas Determines Differential Fates of Resident and Recruited Macrophages during Resolution of Acute Lung Injury
- (2011) William J Janssen et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Strategies for aggregating gene expression data: The collapseRows R function
- (2011) Jeremy A Miller et al. BMC BIOINFORMATICS
- RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
- (2011) Bo Li et al. BMC BIOINFORMATICS
- Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape
- (2011) S.-R. Woo et al. CANCER RESEARCH
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
- (2011) Bin-Zhi Qian et al. NATURE
- Combined Gene Expression and Genomic Profiling Define Two Intrinsic Molecular Subtypes of Urothelial Carcinoma and Gene Signatures for Molecular Grading and Outcome
- (2010) David Lindgren et al. CANCER RESEARCH
- Predictive value of progression-related gene classifier in primary non-muscle invasive bladder cancer
- (2010) Wun-Jae Kim et al. Molecular Cancer
- CCL2 Blockade Augments Cancer Immunotherapy
- (2009) Z. G. Fridlender et al. CANCER RESEARCH
- Chemokines in the vascular inflammatory response of atherosclerosis
- (2009) A. Zernecke et al. CARDIOVASCULAR RESEARCH
- Inhibition of the chemokine (C–C motif) ligand 2/chemokine (C–C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy
- (2009) S. J. Yang et al. DIABETOLOGIA
- Monocyte Chemoattractant Protein-1 (MCP-1): An Overview
- (2009) Satish L. Deshmane et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started