Klotho‐mediated targeting of CCL 2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments

The Involvement of NF-κB/Klotho Signaling in Colorectal Cancer Cell Survival and Invasion

(2019) Biao Xie et al.   PATHOLOGY & ONCOLOGY RESEARCH

Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo

(2018) Yue Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Klotho suppresses colorectal cancer through modulation of the unfolded protein response

(2018) Tammi Arbel Rubinstein et al.   ONCOGENE

Tumor stroma with senescence-associated secretory phenotype in steatohepatitic hepatocellular carcinoma

(2017) Jee San Lee et al.   PLoS One

Ectopic expression of the chemokine CXCL17 in colon cancer cells

(2016) Lina Ohlsson et al.   BRITISH JOURNAL OF CANCER

Senescent Carcinoma-Associated Fibroblasts Upregulate IL8 to Enhance Prometastatic Phenotypes

(2016) Tao Wang et al.   MOLECULAR CANCER RESEARCH

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

(2016) Megan K. Ruhland et al.   Nature Communications

Heterotypic paracrine signaling drives fibroblast senescence and tumor progression of large cell carcinoma of the lung

(2016) Roberto Lugo et al.   Oncotarget

Reduced expression and growth inhibitory activity of the aging suppressor klotho in epithelial ovarian cancer

(2015) Irina Lojkin et al.   CANCER LETTERS

Nucleotide metabolism, oncogene-induced senescence and cancer

(2015) Katherine M. Aird et al.   CANCER LETTERS

Tumor Suppressor Activity of Klotho in Breast Cancer Is Revealed by Structure-Function Analysis

(2015) H. Ligumsky et al.   MOLECULAR CANCER RESEARCH

Senescence-associated inflammatory responses: aging and cancer perspectives

(2015) Audrey Lasry et al.   TRENDS IN IMMUNOLOGY

CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function

(2015) Eunyoung Chun et al.   Cell Reports

Klotho: a novel biomarker for cancer

(2014) Xiangxiang Zhou et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Senescent stroma promotes prostate cancer progression: The role of miR-210

(2014) Maria Letizia Taddei et al.   Molecular Oncology

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Cellular senescence and cancer chemotherapy resistance

(2012) Ryan R. Gordon et al.   DRUG RESISTANCE UPDATES

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer

(2011) Jie Pan et al.   TUMOR BIOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

Klotho and aging

(2009) Makoto Kuro-o   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Many roads lead to oncogene-induced senescence

(2008) S Courtois-Cox et al.   ONCOGENE

Critical pathways in cellular senescence and immortalization revealed by gene expression profiling

(2008) A L Fridman et al.   ONCOGENE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY