CCL2/CCR2 Chemokine Signaling Coordinates Survival and Motility of Breast Cancer Cells through Smad3 Protein- and p42/44 Mitogen-activated Protein Kinase (MAPK)-dependent Mechanisms

CCL2 Is a Negative Regulator of AMP-Activated Protein Kinase to Sustain mTOR Complex-1 Activation, Survivin Expression, and Cell Survival in Human Prostate Cancer PC3 Cells

(2015) Hernan Roca et al.   NEOPLASIA

Loss of Transforming Growth Factor-β Signaling in Mammary Fibroblasts Enhances CCL2 Secretion to Promote Mammary Tumor Progression through Macrophage-Dependent and -Independent Mechanisms

(2015) Stacey L. Hembruff et al.   NEOPLASIA

TGF-β signal transduction spreading to a wider field: a broad variety of mechanisms for context-dependent effects of TGF-β

(2011) Hiroaki Ikushima et al.   CELL AND TISSUE RESEARCH

Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: polyoma middle T transgenic and transplant mouse models of mammary tumor progression

(2011) Wei Bin Fang et al.   CLINICAL & EXPERIMENTAL METASTASIS

Cancer-promoting tumor-associated macrophages: New vistas and open questions

(2011) Alberto Mantovani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Alterations in the Smad pathway in human cancers

(2011) Debangshu Samanta   Frontiers in Bioscience-Landmark

Docetaxel Followed by Fluorouracil/Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy for Patients with Primary Breast Cancer

(2011) H. Iwata et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

TGFBR1 Signaling and Breast Cancer

(2011) Lakisha Moore-Smith et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

TRAPPC4-ERK2 Interaction Activates ERK1/2, Modulates Its Nuclear Localization and Regulates Proliferation and Apoptosis of Colorectal Cancer Cells

(2011) Shu-Liang Zhao et al.   PLoS One

Cancer-related inflammation: Common themes and therapeutic opportunities

(2011) Frances R. Balkwill et al.   SEMINARS IN CANCER BIOLOGY

Immune cell infiltration of primary and metastatic lesions: Mechanisms and clinical impact

(2010) James E. Talmadge   SEMINARS IN CANCER BIOLOGY

Chemokines and chemokine receptors: new insights into cancer-related inflammation

(2010) Gwendal Lazennec et al.   TRENDS IN MOLECULAR MEDICINE

TGF-  Biology in Mammary Development and Breast Cancer

(2010) H. Moses et al.   Cold Spring Harbor Perspectives in Biology

Recent developments in CCR2 antagonists

(2009) Mingde Xia et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression

(2009) Hiroshi Fujimoto et al.   INTERNATIONAL JOURNAL OF CANCER

Chemokine (C-C Motif) Ligand 2 Engages CCR2+Stromal Cells of Monocytic Origin to Promote Breast Cancer Metastasis to Lung and Bone

(2009) Xin Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β1–induced expression of human Mdm2 correlates with late-stage metastatic breast cancer

(2009) Shinako Araki et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune infiltration in human tumors: a prognostic factor that should not be ignored

(2009) F Pagès et al.   ONCOGENE

Monocyte-Mediated Defense Against Microbial Pathogens

(2008) Natalya V. Serbina et al.   Annual Review of Immunology

Treatment of metastatic breast cancer: looking towards the future

(2008) Surabhi Amar et al.   BREAST CANCER RESEARCH AND TREATMENT

The roles of MAPKs in disease

(2008) Michael C Lawrence et al.   CELL RESEARCH

Cyclic GMP/Protein Kinase G Phosphorylation of Smad3 Blocks Transforming Growth Factor-β–Induced Nuclear Smad Translocation

(2008) Iain L.O. Buxton et al.   CIRCULATION RESEARCH

Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone

(2008) Yi Lu et al.   CLINICAL & EXPERIMENTAL METASTASIS

Mutational analysis of caspase 1, 4, and 5 genes in common human cancers

(2008) Young Hwa Soung et al.   HUMAN PATHOLOGY