Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

Overall survival in a trial of orally administered CCR2 inhibitor CCX872 in locally advanced/metastatic pancreatic cancer: Correlation with blood monocyte counts.

(2018) David Linehan et al.   JOURNAL OF CLINICAL ONCOLOGY

Selective targeting of tumor associated macrophages in different tumor models

(2018) Bianca Kakoschky et al.   PLoS One

Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity

(2018) Hui-Ming Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

CD47 Blockade Inhibits Tumor Progression through Promoting Phagocytosis of Tumor Cells by M2 Polarized Macrophages in Endometrial Cancer

(2018) Shenglan Gu et al.   Journal of Immunology Research

Cancer immunotherapy targeting the CD47/SIRPα axis

(2017) Kipp Weiskopf   EUROPEAN JOURNAL OF CANCER

Orally administered CCR2 selective inhibitor CCX872-b clinical trial in pancreatic cancer.

(2017) Marcus Smith Noel et al.   JOURNAL OF CLINICAL ONCOLOGY

Is CD47 an innate immune checkpoint for tumor evasion?

(2017) Xiaojuan Liu et al.   Journal of Hematology & Oncology

Tumor-associated macrophages: from basic research to clinical application

(2017) Li Yang et al.   Journal of Hematology & Oncology

Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein

(2017) Yulei Chen et al.   Journal of Hematology & Oncology

Leukocyte immunoglobulin-like receptors in human diseases: an overview of their distribution, function, and potential application for immunotherapies

(2017) Jilu Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Engineering macrophages to eat cancer: from “marker of self” CD47 and phagocytosis to differentiation

(2017) Cory Alvey et al.   JOURNAL OF LEUKOCYTE BIOLOGY

EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis

(2017) D M Hardbower et al.   ONCOGENE

Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

(2017) Peiwen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

(2017) Michael A. Cannarile et al.   Journal for ImmunoTherapy of Cancer

Epigenetic Regulation of Monocyte and Macrophage Function

(2016) Marten A. Hoeksema et al.   ANTIOXIDANTS & REDOX SIGNALING

CCL5 secreted by tumor associated macrophages may be a new target in treatment of gastric cancer

(2016) Haixia Ding et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming

(2016) Young Chan Chae et al.   CANCER CELL

Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of itsin vivosynergism with gemcitabine, in pancreatic adenocarcinoma mouse models

(2016) María Virtudes Céspedes et al.   Disease Models & Mechanisms

Phase I clinical and pharmacokinetic study of PM01183 (a tetrahydroisoquinoline, Lurbinectedin) in combination with gemcitabine in patients with advanced solid tumors

(2016) Luis Paz-Ares et al.   INVESTIGATIONAL NEW DRUGS

The impact of hypoxia on tumor-associated macrophages

(2016) Anne-Theres Henze et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthesis and evaluation of multivalent M2pep peptides for targeting alternatively activated M2 macrophages

(2016) Chayanon Ngambenjawong et al.   JOURNAL OF CONTROLLED RELEASE

Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice

(2016) Lingxiang Kong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation

(2016) Theodore S. Kapellos et al.   MEDIATORS OF INFLAMMATION

Macrophage Susceptibility to Emactuzumab (RG7155) Treatment

(2016) Leon P. Pradel et al.   MOLECULAR CANCER THERAPEUTICS

Cannabinoid receptor-2 agonist inhibits macrophage induced EMT in non-small cell lung cancer by downregulation of EGFR pathway

(2016) Janani Ravi et al.   MOLECULAR CARCINOGENESIS

Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages

(2016) Xiang Ying et al.   Oncotarget

Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3

(2016) Dror Alishekevitz et al.   Cell Reports

miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer

(2016) Zhigang Wang et al.   Scientific Reports

The challenge of targeting metastasis

(2015) Isaiah J. Fidler et al.   CANCER AND METASTASIS REVIEWS

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in Late-Stage Epithelial Ovarian Cancer

(2015) D. L. Moughon et al.   CANCER RESEARCH

Prostaglandin E2 transactivates the colony-stimulating factor-1 receptor and synergizes with colony-stimulating factor-1 in the induction of macrophage migration via the mitogen-activated protein kinase ERK1/2

(2015) Graziana Digiacomo et al.   FASEB JOURNAL

Pulmonary Alveolar Macrophages Contribute to the Premetastatic Niche by Suppressing Antitumor T Cell Responses in the Lungs

(2015) Sharad K. Sharma et al.   JOURNAL OF IMMUNOLOGY

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway

(2015) XIUYING MA et al.   ONCOLOGY REPORTS

Dequalinium blocks macrophage-induced metastasis following local radiation

(2015) Michael Timaner et al.   Oncotarget

Collaborative effects between the TNFα-TNFR1-macrophage axis and the VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis

(2015) Renhai Cao et al.   OncoImmunology

Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment

(2015) Po-Chun Chen et al.   Oncotarget

The Chemokine CCL2 Increases Prostate Tumor Growth and Bone Metastasis through Macrophage and Osteoclast Recruitment

(2015) Kosuke Mizutani et al.   NEOPLASIA

A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis

(2014) Shicheng Su et al.   CANCER CELL

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

(2014) Carola H. Ries et al.   CANCER CELL

Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor Development

(2014) J. Wang et al.   CANCER RESEARCH

The origin and function of tumor-associated macrophages

(2014) Yang Liu et al.   Cellular & Molecular Immunology

First-In-Human Phase I Study of Lurbinectedin (PM01183) in Patients with Advanced Solid Tumors

(2014) M. E. Elez et al.   CLINICAL CANCER RESEARCH

Effects of the MCP-1 synthesis inhibitor bindarit on tumorigenesis and inflammatory markers in the C3(1)/SV40Tag mouse model of breast cancer

(2014) J.L. Steiner et al.   CYTOKINE

312: Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts

(2014) G. Comito et al.   EUROPEAN JOURNAL OF CANCER

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis

(2014) Ole Helm et al.   INTERNATIONAL JOURNAL OF CANCER

Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway

(2014) XIU-TAO FU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile

(2014) E. Sierra-Filardi et al.   JOURNAL OF IMMUNOLOGY

Metastasis risk after anti-macrophage therapy

(2014) Ioanna Keklikoglou et al.   NATURE

Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

(2014) Laura Bonapace et al.   NATURE

EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation

(2014) Hanane Lanaya et al.   NATURE CELL BIOLOGY

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

(2014) Sandra S. McAllister et al.   NATURE CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes

(2014) F. H. W. Shand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients

(2014) Meiying Zhang et al.   Journal of Ovarian Research

The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor

(2014) A. Swierczak et al.   Cancer Immunology Research

Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis

(2014) Vladimir Riabov et al.   Frontiers in Physiology

Hypoxia and Metabolic Properties of Hematopoietic Stem Cells

(2013) Cheng Cheng Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

The pre-metastatic niche: finding common ground

(2013) Jaclyn Sceneay et al.   CANCER AND METASTASIS REVIEWS

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

(2013) Giovanni Germano et al.   CANCER CELL

CD40 immunotherapy for pancreatic cancer

(2013) Robert H. Vonderheide et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer

(2013) J. Xu et al.   CANCER RESEARCH

Clinical significance of macrophage heterogeneity in human malignant tumors

(2013) Yoshihiro Komohara et al.   CANCER SCIENCE

A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma

(2013) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Trabectedin mechanism of action: what’s new?

(2013) Maurizio D’Incalci   Future Oncology

Combining phenotypic and proteomic approaches to identify membrane targets in a ‘triple negative’ breast cancer cell type

(2013) Steven Rust et al.   Molecular Cancer

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival

(2013) M. Cieslewicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-mediated control of macrophages and its implications for cancer

(2013) Mario Leonardo Squadrito et al.   TRENDS IN IMMUNOLOGY

Macrophages as potential targets for zoledronic acid outside the skeleton—evidence from in vitro and in vivo models

(2013) T. L. Rogers et al.   CELLULAR ONCOLOGY

Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice

(2012) A. M. Gil-Bernabe et al.   BLOOD

TIE2-expressing monocytes as a diagnostic marker for hepatocellular carcinoma correlates with angiogenesis

(2012) Tokuhiro Matsubara et al.   HEPATOLOGY

Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages

(2012) Nina Linde et al.   JOURNAL OF PATHOLOGY

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

(2012) Sergei I. Grivennikov et al.   NATURE

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

(2011) D. A. Hume et al.   BLOOD

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

(2011) Xin Lu et al.   CANCER CELL

Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs

(2011) Qing Chen et al.   CANCER CELL

Hypoxia Induces Escape from Innate Immunity in Cancer Cells via Increased Expression of ADAM10: Role of Nitric Oxide

(2011) I. B. Barsoum et al.   CANCER RESEARCH

Antiangiogenic effects of zoledronate on cancer neovasculature

(2011) Stephen Metcalf et al.   Future Oncology

Paired Immunoglobin-like Receptor-B Regulates the Suppressive Function and Fate of Myeloid-Derived Suppressor Cells

(2011) Ge Ma et al.   IMMUNITY

IL-6 and leukemia-inhibitory factor are involved in the generation of tumor-associated macrophage: regulation by IFN-γ

(2011) Pascale Jeannin et al.   Immunotherapy

Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions

(2011) Damya Laoui et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells

(2011) Mikiko Kawata et al.   JOURNAL OF BIOCHEMISTRY

Obstacles and opportunities for understanding macrophage polarization

(2011) P. J. Murray et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification and manipulation of tumor associated macrophages in human cancers

(2011) Moniek Heusinkveld et al.   Journal of Translational Medicine

Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial

(2011) Michael Gnant et al.   LANCET ONCOLOGY

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Extracellular matrix: A gatekeeper in the transition from dormancy to metastatic growth

(2010) Dalit Barkan et al.   EUROPEAN JOURNAL OF CANCER

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

(2010) V. Gocheva et al.   GENES & DEVELOPMENT

Stromal Macrophage Expressing CD204 is Associated with Tumor Aggressiveness in Lung Adenocarcinoma

(2010) Yoichi Ohtaki et al.   Journal of Thoracic Oncology

A Review of Trabectedin (ET-743): A Unique Mechanism of Action

(2010) Maurizio D'Incalci et al.   MOLECULAR CANCER THERAPEUTICS

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy

(2009) S. J. Priceman et al.   BLOOD

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

(2009) Yadi Wu et al.   CANCER CELL

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination

(2009) B. D. Robinson et al.   CLINICAL CANCER RESEARCH

Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway

(2009) Marta Coscia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth

(2009) Binzhi Qian et al.   PLoS One

Macrophage CD40 signaling: A pivotal regulator of disease protection and pathogenesis

(2009) Jill Suttles et al.   SEMINARS IN IMMUNOLOGY

Epigenetics: Definition, Mechanisms and Clinical Perspective

(2009) Cathérine Dupont et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Macrophage-Derived SPARC Bridges Tumor Cell-Extracellular Matrix Interactions toward Metastasis

(2008) Sabina Sangaletti et al.   CANCER RESEARCH

Macrophages define the invasive microenvironment in breast cancer

(2008) Jeffrey W. Pollard   JOURNAL OF LEUKOCYTE BIOLOGY