Structural basis of chemokine and receptor interactions: Key regulators of leukocyte recruitment in inflammatory responses

Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1

(2019) Sanchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7

(2019) Kathrin Jaeger et al.   CELL

The solution structure of monomeric CCL5 in complex with a doubly sulfated N-terminal segment of CCR5

(2018) Meital Abayev et al.   FEBS Journal

The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors

(2018) Lisa Joedicke et al.   Nature Chemical Biology

Illuminating GPCR Signaling by Cryo-EM

(2018) Haaris Ahsan Safdari et al.   TRENDS IN CELL BIOLOGY

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

(2018) Timothy F Miles et al.   eLife

Structure-Based Design of 1-Heteroaryl-1,3-Propanediamine Derivatives as a Novel Series of CC-chemokine Receptor 5 (CCR5) Antagonists

(2018) Panfeng Peng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1

(2018) Julie Sanchez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of coreceptor recognition by HIV-1 envelope spike

(2018) Md Munan Shaik et al.   NATURE

Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists

(2018) Anna-Katharina Apel et al.   STRUCTURE

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV

(2017) Yi Zheng et al.   IMMUNITY

Chemokines from a Structural Perspective

(2017) Michelle Miller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

(2017) Joshua J. Ziarek et al.   Science Signaling

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

(2017) Zil E. Huma et al.   Science Signaling

Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

(2017) Joshua J. Ziarek et al.   Science Signaling

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

(2017) Zil E. Huma et al.   Science Signaling

New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model

(2016) Andrew B. Kleist et al.   BIOCHEMICAL PHARMACOLOGY

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists

(2016) Yi Zheng et al.   NATURE

Intracellular allosteric antagonism of the CCR9 receptor

(2016) Christine Oswald et al.   NATURE

Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices

(2016) Melanie P. Wescott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homogeneous Sulfopeptides and Sulfoproteins: Synthetic Approaches and Applications To Characterize the Effects of Tyrosine Sulfation on Biochemical Function

(2015) Martin J. Stone et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biased Signaling at Chemokine Receptors

(2015) Jenny Corbisier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

(2015) J. S. Burg et al.   SCIENCE

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

(2015) L. Qin et al.   SCIENCE

Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists

(2014) Laura Ajram et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1).

(2014) Joshua H. Y. Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: The N-Terminal Region of CCR3 Bound to CCL11/Eotaxin-1

(2014) Christopher J. Millard et al.   STRUCTURE

Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

(2013) Prem Raj B. Joseph et al.   BIOCHEMICAL JOURNAL

The structural role of receptor tyrosine sulfation in chemokine recognition

(2013) Justin P Ludeman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chemokine CXCL1 Dimer Is a Potent Agonist for the CXCR2 Receptor

(2013) Aishwarya Ravindran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

(2013) Sudarshan Rajagopal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solid-state NMR spectroscopy structure determination of a lipid-embedded heptahelical membrane protein

(2013) Shenlin Wang et al.   NATURE METHODS

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

(2013) Q. Tan et al.   SCIENCE

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

Design and Receptor Interactions of Obligate Dimeric Mutant of Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)

(2012) Joshua H. Y. Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis E vaccine debuts

(2012) Soo Bin Park   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

(2011) L. J. Drury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Structural Basis for Differential Binding of the Interleukin-8 Monomer and Dimer to the CXCR1 N-Domain: Role of Coupled Interactions and Dynamics

(2009) Aishwarya Ravindran et al.   BIOCHEMISTRY

Regulation of Chemokine Recognition by Site-Specific Tyrosine Sulfation of Receptor Peptides

(2009) Levi S. Simpson et al.   CHEMISTRY & BIOLOGY

Chemokines and chemokine receptors: an overview

(2009) Raffaella Bonecchi   Frontiers in Bioscience-Landmark

Differential Activation and Regulation of CXCR1 and CXCR2 by CXCL8 Monomer and Dimer

(2009) M. W. Nasser et al.   JOURNAL OF IMMUNOLOGY

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

(2009) D. A. Zidar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Putative Intracellular Allosteric Antagonist Binding-Site in the CXC Chemokine Receptors 1 and 2

(2008) D. J. Nicholls et al.   MOLECULAR PHARMACOLOGY

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

(2008) C. T. Veldkamp et al.   Science Signaling