The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?

Mutant KRAS promotes malignant pleural effusion formation

(2017) Theodora Αgalioti et al.   Nature Communications

Ccl2/Ccr2 signalling recruits a distinct fetal microchimeric population that rescues delayed maternal wound healing

(2017) Mathieu Castela et al.   Nature Communications

Induction of Monocyte Chemoattractant Proteins in Macrophages via the Production of Granulocyte/Macrophage Colony-Stimulating Factor by Breast Cancer Cells

(2016) Teizo Yoshimura et al.   Frontiers in Immunology

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis

(2015) Elvin Wagenblast et al.   NATURE

A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis

(2014) Shicheng Su et al.   CANCER CELL

Acetylation of Snail Modulates the Cytokinome of Cancer Cells to Enhance the Recruitment of Macrophages

(2014) Dennis Shin-Shian Hsu et al.   CANCER CELL

CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile

(2014) E. Sierra-Filardi et al.   JOURNAL OF IMMUNOLOGY

Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

(2014) Laura Bonapace et al.   NATURE

Twist1 Induces CCL2 and Recruits Macrophages to Promote Angiogenesis

(2013) J. M. Low-Marchelli et al.   CANCER RESEARCH

Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages

(2013) O. Bloch et al.   CLINICAL CANCER RESEARCH

Monocyte Chemoattractant Protein-1/CCL2 Produced by Stromal Cells Promotes Lung Metastasis of 4T1 Murine Breast Cancer Cells

(2013) Teizo Yoshimura et al.   PLoS One

Cell Surface Receptor FPR2 Promotes Antitumor Host Defense by Limiting M2 Polarization of Macrophages

(2012) Y. Liu et al.   CANCER RESEARCH

CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem Cells

(2012) A. Tsuyada et al.   CANCER RESEARCH

Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer

(2012) Kenneth J. Pienta et al.   INVESTIGATIONAL NEW DRUGS

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models

(2012) D. C. Lacey et al.   JOURNAL OF IMMUNOLOGY

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Monocyte Chemoattractant Protein–1 Blockade Inhibits Lung Cancer Tumor Growth by Altering Macrophage Phenotype and Activating CD8+Cells

(2010) Zvi G. Fridlender et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Oncogenic Ras Diverts a Host TNF Tumor Suppressor Activity into Tumor Promoter

(2010) Julia B. Cordero et al.   DEVELOPMENTAL CELL

CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice

(2010) Yue Si et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple Roles of Chemokine (C-C Motif) Ligand 2 in Promoting Prostate Cancer Growth

(2010) J. Zhang et al.   JNCI-Journal of the National Cancer Institute

Tumors induce complex DNA damage in distant proliferative tissues in vivo

(2010) C. E. Redon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Destructive Cascade Mediated by CCL2 Facilitates Prostate Cancer Growth in Bone

(2009) Xin Li et al.   CANCER RESEARCH

Blockade of a Chemokine, CCL2, Reduces Chronic Colitis-Associated Carcinogenesis in Mice

(2009) B. K. Popivanova et al.   CANCER RESEARCH

Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression

(2009) Hiroshi Fujimoto et al.   INTERNATIONAL JOURNAL OF CANCER

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Monocyte Chemoattractant Protein-1 (MCP-1), Not MCP-3, Is the Primary Chemokine Required for Monocyte Recruitment in Mouse Peritonitis Induced with Thioglycollate or Zymosan A

(2009) M. Takahashi et al.   JOURNAL OF IMMUNOLOGY

First Results for Agents Targeting Cancer-Related Inflammation

(2009) Ken Garber   JNCI-Journal of the National Cancer Institute

NF-κB and cancer: how intimate is this relationship

(2009) Sahdeo Prasad et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Sp1: Emerging roles—Beyond constitutive activation of TATA-less housekeeping genes

(2008) Inken Wierstra   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The inflammatory chemokines CCL2 and CCL5 in breast cancer

(2008) Gali Soria et al.   CANCER LETTERS

A Central Role for Tumor-derived Monocyte Chemoattractant Protein-1 in Malignant Pleural Effusion

(2008) G. T. Stathopoulos et al.   JNCI-Journal of the National Cancer Institute

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY