A critical appraisal of tau‐targeting therapies for primary and secondary tauopathies

Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol

(2021) Juan Carlos Polanco et al.   ACTA NEUROPATHOLOGICA

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

(2021) Carolina Alquezar et al.   Frontiers in Neurology

Similarities and Differences in the Pattern of Tau Hyperphosphorylation in Physiological and Pathological Conditions: Impacts on the Elaboration of Therapies to Prevent Tau Pathology

(2021) Antoine Duquette et al.   Frontiers in Neurology

Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial

(2021) Günter U Höglinger et al.   LANCET NEUROLOGY

Tau strains shape disease

(2021) Jaime Vaquer-Alicea et al.   ACTA NEUROPATHOLOGICA

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

(2021) Kevin Clayton et al.   Molecular Neurodegeneration

Role of the endolysosomal pathway and exosome release in tau propagation

(2021) Minli Yan et al.   NEUROCHEMISTRY INTERNATIONAL

Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer’s disease

(2021) Gai Ayalon et al.   Science Translational Medicine

Exosomal and vesicle‐free tau seeds—propagation and convergence in endolysosomal permeabilization

(2021) Juan Carlos Polanco et al.   FEBS Journal

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease

(2021) Stephen Salloway et al.   NATURE MEDICINE

Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model

(2020) Gernot Riedel et al.   Current Alzheimer Research

Variants in saposin D domain of prosaposin gene linked to Parkinson’s disease

(2020) Yutaka Oji et al.   BRAIN

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

(2020) Helen Shiells et al.   JOURNAL OF ALZHEIMERS DISEASE

Progressive supranuclear palsy: Advances in diagnosis and management

(2020) David G. Coughlin et al.   PARKINSONISM & RELATED DISORDERS

Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

(2020) Jacob W. Vogel et al.   Nature Communications

Astroglia and Tau: New Perspectives

(2020) Gabor G. Kovacs   Frontiers in Aging Neuroscience

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

(2020) Sarah A. Kent et al.   ACTA NEUROPATHOLOGICA

Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ

(2020) Arne Ittner et al.   ACTA NEUROPATHOLOGICA

Should drug discovery scientists still embrace the amyloid hypothesis for Alzheimer’s disease or should they be looking elsewhere?

(2020) Bruno Pietro Imbimbo et al.   Expert Opinion on Drug Discovery

MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy

(2020) Xiaohai Wang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Passive immunotherapies targeting Aβ and tau in Alzheimer's disease

(2020) Steven S. Plotkin et al.   NEUROBIOLOGY OF DISEASE

Advances and Challenges in Understanding MicroRNA Function in Tauopathies: A Case Study of miR-132/212

(2020) Emmanuelle Boscher et al.   Frontiers in Neurology

A single ascending dose study in healthy volunteers to assess the safety and PK of LY3372689, an inhibitor of O‐GlcNAcase (OGA) enzyme

(2020) William Kielbasa et al.   Alzheimers & Dementia

Brain target occupancy of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme: Translation from rat to human

(2020) Sergey Shcherbinin et al.   Alzheimers & Dementia

CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer’s disease

(2020) Kanta Horie et al.   BRAIN

Characterization of tau binding by gosuranemab

(2020) Richelle Sopko et al.   NEUROBIOLOGY OF DISEASE

High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

(2020) Kenji Tagai et al.   NEURON

The Significance of Tau Aggregates in the Human Brain

(2020) Rudy J. Castellani   Brain Sciences

A walk through tau therapeutic strategies

(2019) Santosh Jadhav et al.   Acta Neuropathologica Communications

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

(2019) Israel Hernandez et al.   Science Translational Medicine

Rapamycin and Alzheimer’s disease: Time for a clinical trial?

(2019) Matt Kaeberlein et al.   Science Translational Medicine

New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease

(2019) Nicolas Sergeant et al.   NEUROBIOLOGY OF DISEASE

Rapamycin and Alzheimer disease: a double-edged sword?

(2019) Julian M Carosi et al.   Autophagy

Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody

(2019) Marie Albert et al.   BRAIN

Tau immunotherapies for Alzheimer’s disease

(2019) Justin L. Hoskin et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Disease-modifying therapies for tauopathies: agents in the pipeline

(2019) Francesco Panza et al.   Expert Review of Neurotherapeutics

Elucidating Tau function and dysfunction in the era of cryo-EM

(2019) Guy Lippens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest

(2019) Martha S Foiani et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised, placebo-controlled, multiple ascending dose phase 1b trial

(2019) Adam L Boxer et al.   LANCET NEUROLOGY

Four-repeat tauopathies

(2019) Thomas W. Rösler et al.   PROGRESS IN NEUROBIOLOGY

Traumatic Brain Injury-related voiding dysfunction in mice is caused by damage to rostral pathways, altering inputs to the reflex pathways

(2019) Onder Albayram et al.   Scientific Reports

Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

(2019) Harold G. Selnick et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microtubules gate tau condensation to spatially regulate microtubule functions

(2019) Ruensern Tan et al.   NATURE CELL BIOLOGY

Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

(2019) Valerie Siahaan et al.   NATURE CELL BIOLOGY

Propagation of Tau via Extracellular Vesicles

(2019) Mar Pérez et al.   Frontiers in Neuroscience

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

(2019) Morvane Colin et al.   ACTA NEUROPATHOLOGICA

Mechanisms of secretion and spreading of pathological tau protein

(2019) Cecilia A. Brunello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Progranulin mutations result in impaired processing of prosaposin and reduced glucocerebrosidase activity

(2019) Clarissa Valdez et al.   HUMAN MOLECULAR GENETICS

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

(2019) Bjoern O. Schelter et al.   JOURNAL OF ALZHEIMERS DISEASE

Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome

(2019) Richard M. Tsai et al.   JAMA Neurology

Extracellular tau induces microglial phagocytosis of living neurons in cell cultures

(2019) Katryna Pampuscenko et al.   JOURNAL OF NEUROCHEMISTRY

Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects

(2019) Nicole Matejka et al.   Radiation Oncology

Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer’s disease and aged brains: increased levels correlate with neuropathology

(2019) Anarmaa Mendsaikhan et al.   Acta Neuropathologica Communications

Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains

(2018) Liang Qiang et al.   CURRENT BIOLOGY

An Overview on the Clinical Development of Tau-Based Therapeutics

(2018) Miguel Medina   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tau Immunotherapies for Alzheimer’s Disease and Related Tauopathies: Progress and Potential Pitfalls

(2018) Einar M. Sigurdsson   JOURNAL OF ALZHEIMERS DISEASE

Nature of Tau-Associated Neurodegeneration and the Molecular Mechanisms

(2018) Ying Yang et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau can switch microtubule network organizations: from random networks to dynamic and stable bundles

(2018) Elea Prezel et al.   MOLECULAR BIOLOGY OF THE CELL

Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies

(2018) Wenyan Sun et al.   NATURE NEUROSCIENCE

What triggers tauopathy in chronic traumatic encephalopathy?

(2018) Liam Chen   Neural Regeneration Research

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

(2018) Lewis D. Evans et al.   Cell Reports

Tau Activates Transposable Elements in Alzheimer’s Disease

(2018) Caiwei Guo et al.   Cell Reports

MicroRNA-455-3p as a Potential Biomarker for Alzheimer's Disease: An Update

(2018) Subodh Kumar et al.   Frontiers in Aging Neuroscience

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

(2018) Eduard Willms et al.   Frontiers in Immunology

Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau

(2018) Jean-Philippe Courade et al.   ACTA NEUROPATHOLOGICA

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

N-terminal Truncation of Microtubule Associated Protein Tau Dysregulates its Cellular Localization

(2018) Kristina Paholikova et al.   JOURNAL OF ALZHEIMERS DISEASE

MicroRNAs in Plasma and Cerebrospinal Fluid as Potential Markers for Alzheimer's Disease

(2018) Takehiro Kiko et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease

(2018) Sarah C. Hopp et al.   Journal of Neuroinflammation

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

(2018) Benjamin Falcon et al.   ACTA NEUROPATHOLOGICA

Biomarkers for tau pathology

(2018) Michael Schöll et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer’s disease

(2018) Petr Novak et al.   Alzheimers Research & Therapy

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

(2017) Gordon K. Wilcock et al.   JOURNAL OF ALZHEIMERS DISEASE

Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope

(2017) Clara Theunis et al.   JOURNAL OF ALZHEIMERS DISEASE

Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases

(2017) Gabor G. Kovacs et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Microtubule-Associated Protein Tau Mediates the Organization of Microtubules and Their Dynamic Exploration of Actin-Rich Lamellipodia and Filopodia of Cortical Growth Cones

(2017) Sayantanee Biswas et al.   JOURNAL OF NEUROSCIENCE

Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial

(2017) Petr Novak et al.   LANCET NEUROLOGY

Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches

(2017) Adam L Boxer et al.   LANCET NEUROLOGY

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

(2017) Nicholas B. Hastings et al.   Molecular Neurodegeneration

Tau PET imaging: present and future directions

(2017) Laure Saint-Aubert et al.   Molecular Neurodegeneration

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease

(2017) Hongjun Fu et al.   NEURON

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae

(2017) Onder Albayram et al.   Nature Communications

Research Gaps and Controversies in Chronic Traumatic Encephalopathy

(2017) Breton M. Asken et al.   JAMA Neurology

What is the evidence that tau pathology spreads through prion-like propagation?

(2017) Amrit Mudher et al.   Acta Neuropathologica Communications

Overexpression of Tau Proteins Antagonizes Amyloid-β-Potentiated Apoptosis Through Mitochondria-Caspase-3 Pathway in N2a Cells

(2017) Ze-Fen Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Therapeutic strategies for the treatment of tauopathies: Hopes and challenges

(2016) Mansi R. Khanna et al.   Alzheimers & Dementia

PHARMACOKINETICS AND PHARMACODYNAMICS TO SUPPORT CLINICAL STUDIES OF MK-8719: AN O-GLCNACASE INHIBITOR FOR PROGRESSIVE SUPRANUCLEAR PALSY

(2016) Punam Sandhu et al.   Alzheimers & Dementia

Tideglusib, a chemical inhibitor of GSK3β, attenuates hypoxic-ischemic brain injury in neonatal mice

(2016) Haitao Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology

(2016) Helen Ling et al.   BRAIN

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Randomized placebo-controlled trial of sodium valproate in progressive supranuclear palsy

(2016) Laurène Leclair-Visonneau et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain

(2016) Evgenia Salta et al.   EMBO Molecular Medicine

Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice

(2016) Siân Baker et al.   JOURNAL OF ALZHEIMERS DISEASE

Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological Features From a Large Autopsy Study

(2016) Roberta Diehl Rodriguez et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

(2016) Serge Gauthier et al.   LANCET

Tau antagonizes end-binding protein tracking at microtubule ends through a phosphorylation-dependent mechanism

(2016) Sacnicte Ramirez-Rios et al.   MOLECULAR BIOLOGY OF THE CELL

Presence of a carboxy-terminal pseudorepeat and disease-like pseudohyperphosphorylation critically influence tau’s interaction with microtubules in axon-like processes

(2016) Benedikt Niewidok et al.   MOLECULAR BIOLOGY OF THE CELL

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Suspected non-Alzheimer disease pathophysiology — concept and controversy

(2016) Clifford R. Jack et al.   Nature Reviews Neurology

Exosomes in Alzheimer's disease

(2016) Tarja Malm et al.   NEUROCHEMISTRY INTERNATIONAL

Tauopathies as clinicopathological entities

(2016) David J. Irwin   PARKINSONISM & RELATED DISORDERS

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases

(2016) Saida Abounit et al.   Prion

Prosaposin is a regulator of progranulin levels and oligomerization

(2016) Alexandra M. Nicholson et al.   Nature Communications

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

(2016) Seung-Hye Lee et al.   Cell Reports

Potential of the Antibody Against cis–Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury

(2016) Kun Ping Lu et al.   JAMA Neurology

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

(2016) Meryem Tardivel et al.   Acta Neuropathologica Communications

Chloroquine and Chloroquinoline Derivatives as Models for the Design of Modulators of Amyloid Peptide Precursor Metabolism

(2015) Patricia Melnyk et al.   ACS Chemical Neuroscience

PART is part of Alzheimer disease

(2015) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

(2015) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy

(2015) Ann C. McKee et al.   ACTA NEUROPATHOLOGICA

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase-3β Signaling Pathway in an Alzheimer's Disease Model

(2015) Zhi-Min Long et al.   CNS Neuroscience & Therapeutics

Treatment of Primary Progressive Aphasia

(2015) Donna C. Tippett et al.   Current Treatment Options in Neurology

miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregationin vivo

(2015) Pascal Y. Smith et al.   HUMAN MOLECULAR GENETICS

Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes

(2015) Nataliya Golovyashkina et al.   Molecular Neurodegeneration

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

(2015) Asami Kondo et al.   NATURE

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Spreading of pathology in neurodegenerative diseases: a focus on human studies

(2015) Johannes Brettschneider et al.   NATURE REVIEWS NEUROSCIENCE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Invited review: Neuropathology of tauopathies: principles and practice

(2015) G. G. Kovacs   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

(2015) Sarah L. Shammas et al.   Nature Communications

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

(2015) Shuko Takeda et al.   Nature Communications

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

(2015) Wenjie Luo et al.   Scientific Reports

The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy

(2015) Robert Siman et al.   PLoS One

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease

(2014) Ludovic Collin et al.   BRAIN

Prion-like Properties of Tau Protein: The Importance of Extracellular Tau as a Therapeutic Target

(2014) Brandon B. Holmes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain-Penetrant, Orally Bioavailable Microtubule-Stabilizing Small Molecules Are Potential Candidate Therapeutics for Alzheimer’s Disease and Related Tauopathies

(2014) Kevin Lou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of Tau-Promoted Microtubule Assembly As Probed by NMR Spectroscopy

(2014) Benoît Gigant et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial

(2014) Adam L Boxer et al.   LANCET NEUROLOGY

Single-molecule tracking of tau reveals fast kiss-and-hop interaction with microtubules in living neurons

(2014) Dennis Janning et al.   MOLECULAR BIOLOGY OF THE CELL

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

(2014) Eduardo Tolosa et al.   MOVEMENT DISORDERS

Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial

(2014) Günter U. Höglinger et al.   MOVEMENT DISORDERS

Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel

(2014) Thor D Stein et al.   Alzheimers Research & Therapy

First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

(2014) Eva Kontsekova et al.   Alzheimers Research & Therapy

Antisense-mediated Exon Skipping Decreases Tau Protein Expression: A Potential Therapy For Tauopathies

(2014) Reeteka Sud et al.   Molecular Therapy-Nucleic Acids

Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice

(2013) Florence Clavaguera et al.   ACTA NEUROPATHOLOGICA

Globular glial tauopathies (GGT): consensus recommendations

(2013) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Mental and Physical Activities Delay Cognitive Decline in Older Persons with Dementia

(2013) Sheung-Tak Cheng et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Valproic Acid Attenuates Neuronal Loss in the Brain of APP/PS1 Double Transgenic Alzheimer’s Disease Mice Model

(2013) Zhimin Long et al.   Current Alzheimer Research

A Double-Blind, Placebo-Controlled, Ascending-Dose, Randomized Study to Evaluate the Safety, Tolerability and Effects on Cognition of AL-108 after 12 Weeks of Intranasal Administration in Subjects with Mild Cognitive Impairment

(2013) Bruce H. Morimoto et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Glial and Neuronal Tau Pathology in Tauopathies

(2013) Isidre Ferrer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Antisense Reduction of Tau in Adult Mice Protects against Seizures

(2013) S. L. DeVos et al.   JOURNAL OF NEUROSCIENCE

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy

(2013) S Quraishe et al.   MOLECULAR PSYCHIATRY

NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: Protection against impairments in axonal transport

(2013) Yan Jouroukhin et al.   NEUROBIOLOGY OF DISEASE

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

(2013) Kiran Yanamandra et al.   NEURON

Microtubule-stabilizing peptides and small molecules protecting axonal transport and brain function: Focus on davunetide (NAP)

(2013) Iddo Magen et al.   NEUROPEPTIDES

Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy

(2013) Danielle L. Graham et al.   NEUROPHARMACOLOGY

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

(2013) Sefika Ozcelik et al.   PLoS One

Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy

(2013) Clara Theunis et al.   PLoS One

Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice

(2013) Peter Borghgraef et al.   PLoS One

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycogen Synthase Kinase 3 Inhibition Promotes Adult Hippocampal Neurogenesis in Vitro and in Vivo

(2012) Jose A. Morales-Garcia et al.   ACS Chemical Neuroscience

Degradation of tau protein by autophagy and proteasomal pathways: Figure 1

(2012) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

(2012) Kazuhiro Nakamura et al.   CELL

Targeting Phospho-Ser422 by Active Tau Immunotherapy in the THYTau22 Mouse Model: A Suitable Therapeutic Approach

(2012) Nadege Zommer et al.   Current Alzheimer Research

Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027

(2012) D. M. Barten et al.   JOURNAL OF NEUROSCIENCE

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

(2012) B. Zhang et al.   JOURNAL OF NEUROSCIENCE

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

(2011) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Ectosomes

(2011) Emanuele Cocucci et al.   CURRENT BIOLOGY

Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models

(2011) Xiyun Chai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration

(2011) Smita Saxena et al.   NEURON

Microtubule destruction induces tau liberation and its subsequent phosphorylation

(2010) Tomohiro Miyasaka et al.   FEBS LETTERS

Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases

(2010) H. Sudo et al.   HUMAN MOLECULAR GENETICS

Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

(2010) K. R. Brunden et al.   JOURNAL OF NEUROSCIENCE

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Hippocampal sclerosis with four-repeat tau-positive round inclusions in the dentate gyrus: a new type of four-repeat tauopathy

(2009) Yasuo Miki et al.   ACTA NEUROPATHOLOGICA

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

Essential role of tau phosphorylation in adult hippocampal neurogenesis

(2009) Xiao-Ping Hong et al.   HIPPOCAMPUS

Partial deletion of theMAPTgene: A novel mechanism of FTDP-17

(2009) Anne Rovelet-Lecrux et al.   HUMAN MUTATION

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases

(2009) Yang Yu et al.   JOURNAL OF NEUROCHEMISTRY

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

The Natively Unfolded Character of Tau and Its Aggregation to Alzheimer-like Paired Helical Filaments†

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Argyrophilic grain disease

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(2008) Y. Matsuoka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Microtubule-severing Proteins Spastin and Katanin Participate Differently in the Formation of Axonal Branches

(2008) Wenqian Yu et al.   MOLECULAR BIOLOGY OF THE CELL

Tau-Induced Traffic Jams Reflect Organelles Accumulation at Points of Microtubule Polar Mismatching

(2008) Or A. Shemesh et al.   TRAFFIC