Nature of Tau-Associated Neurodegeneration and the Molecular Mechanisms

Activation of GSK-3 disrupts cholinergic homoeostasis in nucleus basalis of Meynert and frontal cortex of rats

(2017) Yue Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer’s Disease

(2017) Zhi-Hao Wang et al.   MOLECULAR CELL

Correcting miR92a-vGAT-Mediated GABAergic Dysfunctions Rescues Human Tau-Induced Anxiety in Mice

(2017) Xiaoguang Li et al.   MOLECULAR THERAPY

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

(2017) Zhentao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease

(2017) Zhentao Zhang et al.   Nature Communications

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease

(2017) Zhentao Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tau-Induced Ca2+/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation

(2017) Yu-Ping Wei et al.   Neuroscience Bulletin

Knockdown of pp32 Increases Histone Acetylation and Ameliorates Cognitive Deficits

(2017) Qiong Feng et al.   Frontiers in Aging Neuroscience

Overexpression of Tau Proteins Antagonizes Amyloid-β-Potentiated Apoptosis Through Mitochondria-Caspase-3 Pathway in N2a Cells

(2017) Ze-Fen Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Dephosphorylation Potentiates Apoptosis by Mechanisms Involving a Failed Dephosphorylation/Activation of Bcl-2

(2017) Xin-An Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Paternal spatial training enhances offspring’s cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer’s mice

(2017) Shujuan Zhang et al.   Scientific Reports

GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory

(2017) Enjie Liu et al.   Scientific Reports

Hyperphosphorylation determines both the spread and the morphology of tau pathology

(2016) Wen Hu et al.   Alzheimers & Dementia

Long-term Ameliorative Effects of the Antidepressant Fluoxetine Exposure on Cognitive Deficits in 3 × TgAD Mice

(2016) Li Jin et al.   MOLECULAR NEUROBIOLOGY

Spatial training promotes short-term survival and neuron-like differentiation of newborn cells in Aβ 1-42 -injected rats

(2016) Juan Zeng et al.   NEUROBIOLOGY OF AGING

Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling

(2016) Yaling Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposite monosynaptic scaling of BLP–vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory

(2016) Ying Yang et al.   Nature Communications

Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

(2016) Xia-Chun Li et al.   Scientific Reports

Altered Intranetwork and Internetwork Functional Connectivity in Type 2 Diabetes Mellitus With and Without Cognitive Impairment

(2016) Shi-Qi Yang et al.   Scientific Reports

Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2

(2016) Yaling Yin et al.   Scientific Reports

CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease

(2015) Xia Jiang et al.   NEUROBIOLOGY OF AGING

Intraperitoneal Administration of a Novel TAT-BDNF Peptide Ameliorates Cognitive Impairments via Modulating Multiple Pathways in Two Alzheimer’s Rodent Models

(2015) Yuanyuan Wu et al.   Scientific Reports

Spatial training preserves associative memory capacity with augmentation of dendrite ramification and spine generation in Tg2576 mice

(2015) Xia Jiang et al.   Scientific Reports

Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3β

(2015) Jun Jiang et al.   Scientific Reports

Expression of 1N3R-Tau Isoform Inhibits Cell Proliferation by Inducing S Phase Arrest in N2a Cells

(2015) Li Li et al.   PLoS One

The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling

(2014) D Liu et al.   CELL DEATH AND DIFFERENTIATION

Knockdown of phosphotyrosyl phosphatase activator induces apoptosis via mitochondrial pathway and the attenuation by simultaneous tau hyperphosphorylation

(2014) Dan-Ju Luo et al.   JOURNAL OF NEUROCHEMISTRY

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Magnesium Protects Cognitive Functions and Synaptic Plasticity in Streptozotocin-Induced Sporadic Alzheimer’s Model

(2014) Zhi-Peng Xu et al.   PLoS One

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

(2014) Hong-Bin Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease

(2013) Gustavo Basurto-Islas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing PP2A Inhibitor by Lenti-shRNA Interference Ameliorates Neuropathologies and Memory Deficits in tg2576 Mice

(2013) Gong-Ping Liu et al.   MOLECULAR THERAPY

Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model

(2013) Cai-Xia Peng et al.   NEUROBIOLOGY OF AGING

Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase

(2013) Qian Jiang et al.   NEUROBIOLOGY OF AGING

Expression of Tau40 Induces Activation of Cultured Rat Microglial Cells

(2013) Lu Wang et al.   PLoS One

Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response

(2012) Xin-An Liu et al.   APOPTOSIS

Upregulation of astrocytes protein phosphatase-2A stimulates astrocytes migration via inhibiting p38 MAPK in tg2576 mice

(2012) Xiu-Ping Liu et al.   GLIA

Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine

(2012) Gao-Shang Chai et al.   JOURNAL OF NEUROCHEMISTRY

Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation

(2012) Yan Xiong et al.   NEUROBIOLOGY OF AGING

AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation

(2011) Xiao-Hong Li et al.   NEUROBIOLOGY OF AGING

GSK-3  Inhibits Presynaptic Vesicle Exocytosis by Phosphorylating P/Q-Type Calcium Channel and Interrupting SNARE Complex Formation

(2010) L.-Q. Zhu et al.   JOURNAL OF NEUROSCIENCE

Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2

(2010) L.-Q. Zhu et al.   JOURNAL OF NEUROSCIENCE

I2PP2A regulates p53 and Akt correlatively and leads the neurons to abort apoptosis

(2010) Gong-Ping Liu et al.   NEUROBIOLOGY OF AGING

Hyperhomocysteinemia Increases β-Amyloid by Enhancing Expression of γ-Secretase and Phosphorylation of Amyloid Precursor Protein in Rat Brain

(2009) Chang-E Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Essential role of tau phosphorylation in adult hippocampal neurogenesis

(2009) Xiao-Ping Hong et al.   HIPPOCAMPUS

Proteasome inhibition increases tau accumulation independent of phosphorylation

(2008) Ying-Hua Liu et al.   NEUROBIOLOGY OF AGING

Microtubule-associated protein tau in development, degeneration and protection of neurons

(2008) Jian-Zhi Wang et al.   PROGRESS IN NEUROBIOLOGY

Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus

(2007) Chang-E. Zhang et al.   NEUROBIOLOGY OF AGING