Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model

(2020) Gernot Riedel et al.   Current Alzheimer Research

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

(2019) Peter T Nelson et al.   BRAIN

Use of Cholinesterase Inhibitors in Non-Alzheimer’s Dementias

(2019) Paul Noufi et al.   DRUGS & AGING

Targeting Autophagy for the Treatment of Alzheimer’s Disease: Challenges and Opportunities

(2019) Jie Liu et al.   Frontiers in Molecular Neuroscience

New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures

(2019) Adam L. Boxer et al.   Alzheimers & Dementia

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

(2019) Bjoern O. Schelter et al.   JOURNAL OF ALZHEIMERS DISEASE

Methylene blue protects dopaminergic neurons against MPTP-induced neurotoxicity by upregulating brain-derived neurotrophic factor

(2018) Sunil Bhurtel et al.   Annals of the New York Academy of Sciences

The behavioural variant frontotemporal dementia phenocopy syndrome is a distinct entity - evidence from a longitudinal study

(2018) E. Devenney et al.   BMC Neurology

Memantine in Behavioral Variant Frontotemporal Dementia: Negative Results

(2018) Martine Vercelletto et al.   JOURNAL OF ALZHEIMERS DISEASE

Cysteine-Independent Inhibition of Alzheimer's Disease-like Paired Helical Filament Assembly by Leuco-Methylthioninium (LMT)

(2018) Youssra K. Al-Hilaly et al.   JOURNAL OF MOLECULAR BIOLOGY

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Cortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia

(2018) Vesna Vuksanović et al.   International Journal of Neural Systems

Therapeutic trial design for frontotemporal dementia and related disorders

(2018) Philippe Desmarais et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer’s Disease

(2018) Mikael Marttinen et al.   Frontiers in Neuroscience

Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials

(2018) Adam M Staffaroni et al.   BRAIN

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

(2017) Gordon K. Wilcock et al.   JOURNAL OF ALZHEIMERS DISEASE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Frontotemporal Dementia

(2017) Nicholas T. Olney et al.   NEUROLOGIC CLINICS

The social and economic burden of frontotemporal degeneration

(2017) James E. Galvin et al.   NEUROLOGY

Tau: From research to clinical development

(2016) David M. Holtzman et al.   Alzheimers & Dementia

The Prevalence and Incidence of Dementia Due to Alzheimer’s Disease: a Systematic Review and Meta-Analysis

(2016) Kirsten M. Fiest et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

The Prevalence and Incidence of Frontotemporal Dementia: a Systematic Review

(2016) David B. Hogan et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysis

(2016) Kalyani Kansal et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

(2016) Serge Gauthier et al.   LANCET

Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes

(2016) Ian T.S. Coyle-Gilchrist et al.   NEUROLOGY

Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models

(2015) Valeria Melis et al.   BEHAVIOURAL PHARMACOLOGY

Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease

(2015) Charles R. Harrington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylene blue exerts a neuroprotective effect against traumatic brain injury by promoting autophagy and inhibiting microglial activation

(2015) MINGFEI ZHAO et al.   Molecular Medicine Reports

Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity

(2014) Cliona Stack et al.   HUMAN MOLECULAR GENETICS

Validation of the Addenbrooke's Cognitive Examination III in Frontotemporal Dementia and Alzheimer's Disease

(2013) Sharpley Hsieh et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Pilot study of pharmacological treatment for frontotemporal dementia: Risk of donepezil treatment for behavioral and psychological symptoms

(2013) Takemi Kimura et al.   Geriatrics & Gerontology International

Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial

(2013) Adam L Boxer et al.   LANCET NEUROLOGY

Dissociable executive functions in behavioral variant frontotemporal and Alzheimer dementias

(2013) K. L. Possin et al.   NEUROLOGY

The Impact of Dementia Severity on Caregiver Burden in Frontotemporal Dementia and Alzheimer Disease

(2012) Eneida Mioshi et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

(2012) Erin E. Congdon et al.   Autophagy

Mitochondrial pharmacology: Electron transport chain bypass as strategies to treat mitochondrial dysfunction

(2012) Hani Atamna et al.   BIOFACTORS

Methylene blue administration fails to confer neuroprotection in two amyotrophic lateral sclerosis mouse models

(2012) J.-N. Audet et al.   NEUROSCIENCE

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

(2011) Katya Rascovsky et al.   BRAIN

Methylene blue inhibits function of the 5-HT transporter

(2011) Murat Oz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Frontotemporal Dementia

(2011) William W. Seeley et al.   NEUROSCIENTIST

Nonprogressive behavioural frontotemporal dementia: recent developments and clinical implications of the ‘bvFTD phenocopy syndrome’

(2010) Christopher M Kipps et al.   CURRENT OPINION IN NEUROLOGY

Gray matter atrophy rate as a marker of disease progression in AD

(2010) Valerie M. Anderson et al.   NEUROBIOLOGY OF AGING

Clinical staging and disease progression in frontotemporal dementia

(2010) E. Mioshi et al.   NEUROLOGY

Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models

(2009) Makiko Yamashita et al.   FEBS LETTERS

Can progressive and non-progressive behavioural variant frontotemporal dementia be distinguished at presentation?

(2009) M Hornberger et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year

(2009) D. S. Knopman et al.   NEUROLOGY

Development of methodology for conducting clinical trials in frontotemporal lobar degeneration

(2008) D. S. Knopman et al.   BRAIN

Galantamine in Frontotemporal Dementia and Primary Progressive Aphasia

(2008) A. Kertesz et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Quantification of cationic anti-malaria agent methylene blue in different human biological matrices using cation exchange chromatography coupled to tandem mass spectrometry

(2008) Jürgen Burhenne et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Measuring progression in frontotemporal dementia

(2008) C. M. Kipps et al.   NEUROLOGY

Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways

(2007) Hani Atamna et al.   FASEB JOURNAL