MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease

(2019) Paul M. Levine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

(2019) Harold G. Selnick et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological Inhibition of O-GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway

(2018) Yanping Zhu et al.   ACS Chemical Neuroscience

Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy

(2018) Xiaohai Wang et al.   PLoS One

Tau Transgenic Mice as Models for Cerebrospinal Fluid Tau Biomarkers

(2018) Donna M. Barten et al.   JOURNAL OF ALZHEIMERS DISEASE

Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies

(2018) Tiffany S. Pinho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

(2017) Nicholas B. Hastings et al.   Molecular Neurodegeneration

O-GlcNAcylation: A regulator of tau pathology and neurodegeneration

(2016) Cheng-Xin Gong et al.   Alzheimers & Dementia

Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

(2015) Lixin Song et al.   Molecular Neurodegeneration

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease

(2015) Nicholas P. Marotta et al.   Nature Chemistry

O-GlcNAcylation Prevents Aggregation of the Polycomb Group Repressor Polyhomeotic

(2014) Maria Cristina Gambetta et al.   DEVELOPMENTAL CELL

O-GlcNAc Modification of tau Directly Inhibits Its Aggregation without Perturbing the Conformational Properties of tau Monomers

(2014) Scott A. Yuzwa et al.   JOURNAL OF MOLECULAR BIOLOGY

Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy

(2013) Danielle L. Graham et al.   NEUROPHARMACOLOGY

Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice

(2013) Peter Borghgraef et al.   PLoS One

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation

(2012) Yang Yu et al.   PLoS One

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

The clinical use of structural MRI in Alzheimer disease

(2010) Giovanni B. Frisoni et al.   Nature Reviews Neurology

Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510)

(2010) Dewen Yang et al.   NEUROIMAGE

Dysregulation of the nutrient/stress sensor O-GlcNAcylation is involved in the etiology of cardiovascular disorders, type-2 diabetes and Alzheimer's disease

(2009) Tony Lefebvre et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

(2008) Scott A Yuzwa et al.   Nature Chemical Biology

Whole-brain atrophy rate and CSF biomarker levels in MCI and AD: A longitudinal study

(2008) Jasper D. Sluimer et al.   NEUROBIOLOGY OF AGING

Neuropsychological correlates of whole brain atrophy in Alzheimer's disease

(2008) J.M. Schott et al.   NEUROPSYCHOLOGIA