Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2020) Tamta Arakhamia et al.   CELL

Dysregulation of histone acetylation pathways in hippocampus and frontal cortex of Alzheimer's disease patients

(2020) Estelle Schueller et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy

(2020) Xu Chen et al.   Molecular Neurodegeneration

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

Glycogen Synthase Kinase 3 (GSK3): Its Role and Inhibitors

(2020) Pankaj Wadhwa et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Semisynthetic Modification of Tau Protein with Di-Ubiquitin Chains for Aggregation Studies

(2020) Francesca Munari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cryo-EM structures of tau filaments

(2020) Sjors HW Scheres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

(2019) Israel Hernandez et al.   Science Translational Medicine

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes

(2019) Changyi Ji et al.   Autophagy

Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH

(2019) Rabab A. Charafeddine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspases in Cell Death, Inflammation, and Disease

(2019) Nina Van Opdenbosch et al.   IMMUNITY

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

(2019) Philipp Kirchner et al.   PLOS BIOLOGY

Cryo-EM of amyloid fibrils and cellular aggregates

(2019) Anthony WP Fitzpatrick et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Quantification of Tau Protein Lysine Methylation in Aging and Alzheimer’s Disease

(2019) Carol J. Huseby et al.   JOURNAL OF ALZHEIMERS DISEASE

Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics

(2018) Ibraheem Ali et al.   CHEMICAL REVIEWS

Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers

(2018) James P. Quinn et al.   JOURNAL OF ALZHEIMERS DISEASE

An outlook on lysine methylation of non-histone proteins in plants

(2018) Nelson B C Serre et al.   JOURNAL OF EXPERIMENTAL BOTANY

SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy

(2018) Sang-Won Min et al.   JOURNAL OF NEUROSCIENCE

Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States

(2018) Mahmood Haj-Yahya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The ABCs of PTMs

(2018) Karl W Barber et al.   Nature Chemical Biology

Sirtuin 1 and Alzheimer's disease: An up-to-date review

(2018) Liara Rizzi et al.   NEUROPEPTIDES

Extranuclear SUMOylation in Neurons

(2018) Jeremy M. Henley et al.   TRENDS IN NEUROSCIENCES

Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy

(2018) Taeko Kimura et al.   Frontiers in Neuroscience

Intrinsic Disorder and Posttranslational Modifications: The Darker Side of the Biological Dark Matter

(2018) April L. Darling et al.   Frontiers in Genetics

The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality

(2018) Jyotiska Chaudhuri et al.   Cell Metabolism

Endolysosomal degradation of Tau and its role in glucocorticoid‐driven hippocampal malfunction

(2018) João Vaz‐Silva et al.   EMBO JOURNAL

N-terminal Truncation of Microtubule Associated Protein Tau Dysregulates its Cellular Localization

(2018) Kristina Paholikova et al.   JOURNAL OF ALZHEIMERS DISEASE

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator

(2018) Snehajyoti Chatterjee et al.   EMBO Molecular Medicine

Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport

(2018) Victoria J Butler et al.   HUMAN MOLECULAR GENETICS

Functions and mechanisms of non-histone protein acetylation

(2018) Takeo Narita et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Calpain-mediated tau fragmentation is altered in Alzheimer’s disease progression

(2018) Hsu-Hsin Chen et al.   Scientific Reports

The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)

(2017) Fatima Ardito et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

An acetylation–phosphorylation switch that regulates tau aggregation propensity and function

(2017) Yari Carlomagno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

The winding path of protein methylation research: milestones and new frontiers

(2017) Jernej Murn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein O-GlcNAcylation: emerging mechanisms and functions

(2017) Xiaoyong Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapeutic Strategies for Restoring Tau Homeostasis

(2017) Zapporah T. Young et al.   Cold Spring Harbor Perspectives in Medicine

Propagation of Tau aggregates

(2017) Michel Goedert et al.   Molecular Brain

A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy

(2017) Hanna Trzeciakiewicz et al.   Scientific Reports

O-GlcNAcylation: A regulator of tau pathology and neurodegeneration

(2016) Cheng-Xin Gong et al.   Alzheimers & Dementia

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease

(2016) Waltraud Mair et al.   ANALYTICAL CHEMISTRY

Protein lysine methylation by seven- -strand methyltransferases

(2016) P. O. Falnes et al.   BIOCHEMICAL JOURNAL

Glycation alter the process of Tau phosphorylation to change Tau isoforms aggregation property

(2016) Kefu Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The world of protein acetylation

(2016) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

CSF N-glycoproteomics for early diagnosis in Alzheimer's disease

(2016) Angelo Palmigiano et al.   Journal of Proteomics

Overexpression of Tau Rescues Nogo-66-Induced Neurite Outgrowth Inhibition In Vitro

(2016) Yu-Chao Zuo et al.   Neuroscience Bulletin

Glycation and cardiovascular disease in diabetes: A perspective on the concept of metabolic memory

(2016) Sho-ichi Yamagishi et al.   Journal of Diabetes

Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy

(2016) Antonio Piras et al.   Acta Neuropathologica Communications

Protein Oxidation in Aging: Does It Play a Role in Aging Progression?

(2015) Sandra Reeg et al.   ANTIOXIDANTS & REDOX SIGNALING

Cellular factors modulating the mechanism of tau protein aggregation

(2015) Sarah N. Fontaine et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

(2015) Y. Kizuka et al.   EMBO Molecular Medicine

Protein glycation — Between tissue aging and protection

(2015) Andreas Simm et al.   EXPERIMENTAL GERONTOLOGY

NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease

(2015) V. Corsetti et al.   HUMAN MOLECULAR GENETICS

Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity

(2015) Malte Butzlaff et al.   HUMAN MOLECULAR GENETICS

Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT

(2015) Teresa Sposito et al.   HUMAN MOLECULAR GENETICS

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

(2015) Meaghan Morris et al.   NATURE NEUROSCIENCE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation

(2015) Sean J. Humphrey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders

(2015) Vladimir N. Uversky   Frontiers in Aging Neuroscience

Mass Spectrometry-Based Detection and Assignment of Protein Posttranslational Modifications

(2014) Sophia Doll et al.   ACS Chemical Biology

Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

(2014) Kristen E. Funk et al.   BIOCHEMICAL JOURNAL

Nuclear Magnetic Resonance Analysis of the Acetylation Pattern of the Neuronal Tau Protein

(2014) Amina Kamah et al.   BIOCHEMISTRY

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding

(2014) Katharina Flach et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

O-GlcNAc Modification of tau Directly Inhibits Its Aggregation without Perturbing the Conformational Properties of tau Monomers

(2014) Scott A. Yuzwa et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Insight into Tau Protein’s Paradox of Intrinsically Disordered Behavior, Self-Acetylation Activity, and Aggregation

(2014) Yin Luo et al.   Journal of Physical Chemistry Letters

OGlcNAcylation and Phosphorylation Have Opposing Structural Effects in tau: Phosphothreonine Induces Particular Conformational Order

(2014) Michael A. Brister et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The functional diversity of protein lysine methylation

(2014) S. Lanouette et al.   Molecular Systems Biology

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

(2014) Hong-Bin Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins

(2014) Eric B. Dammer et al.   PROTEOMICS

Acetylation: a new key to unlock tau’s role in neurodegeneration

(2014) Casey Cook et al.   Alzheimers Research & Therapy

In vivo axonal transport deficits in a mouse model of fronto-temporal dementia

(2014) Tabassum Majid et al.   NeuroImage-Clinical

Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation

(2013) Lea Tenenholz Grinberg et al.   ACTA NEUROPATHOLOGICA

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

Acetylated Tau Neuropathology in Sporadic and Hereditary Tauopathies

(2013) David J. Irwin et al.   AMERICAN JOURNAL OF PATHOLOGY

Considering Protonation as a Posttranslational Modification Regulating Protein Structure and Function

(2013) André Schönichen et al.   Annual Review of Biophysics

N-linked protein glycosylation in the ER

(2013) Markus Aebi   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease

(2013) Paula Merino-Serrais et al.   BRAIN

Cysteine Oxidative Posttranslational Modifications

(2013) Heaseung S. Chung et al.   CIRCULATION RESEARCH

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

(2013) James A Nathan et al.   EMBO JOURNAL

The role of protein glycosylation in Alzheimer disease

(2013) Sophia Schedin-Weiss et al.   FEBS Journal

Deciphering post-translational modification codes

(2013) Adam P. Lothrop et al.   FEBS LETTERS

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

Proteoform: a single term describing protein complexity

(2013) Lloyd M Smith et al.   NATURE METHODS

The microtubule-associated tau protein has intrinsic acetyltransferase activity

(2013) Todd J Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

The Importance of Tau Phosphorylation for Neurodegenerative Diseases

(2013) Wendy Noble et al.   Frontiers in Neurology

Tau Clearance Mechanisms and Their Possible Role in the Pathogenesis of Alzheimer Disease

(2013) Adrianne S. Chesser et al.   Frontiers in Neurology

Protein Tyrosine Nitration: Biochemical Mechanisms and Structural Basis of Functional Effects

(2012) Rafael Radi   ACCOUNTS OF CHEMICAL RESEARCH

Degradation of tau protein by autophagy and proteasomal pathways: Figure 1

(2012) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

(2012) David J. Irwin et al.   BRAIN

Regulatory modules: Coupling protein stability to phopshoregulation during cell division

(2012) Liam J. Holt   FEBS LETTERS

The human phosphatase interactome: An intricate family portrait

(2012) Francesca Sacco et al.   FEBS LETTERS

Cell signaling, post-translational protein modifications and NMR spectroscopy

(2012) Francois-Xavier Theillet et al.   JOURNAL OF BIOMOLECULAR NMR

Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis

(2012) Mary Katherine Tarrant et al.   Nature Chemical Biology

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

Function and regulation of SUMO proteases

(2012) Christopher M. Hickey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

SUMO-1 is Associated with a Subset of Lysosomes in Glial Protein Aggregate Diseases

(2012) Mathew B. Wong et al.   NEUROTOXICITY RESEARCH

Selective tau tyrosine nitration in non-AD tauopathies

(2011) Juan F. Reyes et al.   ACTA NEUROPATHOLOGICA

Abnormalities of NBR1, a novel autophagy-associated protein, in muscle fibers of sporadic inclusion-body myositis

(2011) Carla D’Agostino et al.   ACTA NEUROPATHOLOGICA

Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach

(2011) Stefani N. Thomas et al.   ACTA NEUROPATHOLOGICA

Tyrosine Nitration within the Proline-Rich Region of Tau in Alzheimer's Disease

(2011) Juan F. Reyes et al.   AMERICAN JOURNAL OF PATHOLOGY

Ubiquitin is Associated with Early Truncation of Tau Protein at Aspartic Acid421 during the Maturation of Neurofibrillary Tangles in Alzheimer's Disease

(2011) Francisco García-Sierra et al.   BRAIN PATHOLOGY

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

(2011) Sharmistha Sinha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau

(2011) Song-In Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation

(2011) Caroline Smet-Nocca et al.   Molecular BioSystems

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

Constructing and decoding unconventional ubiquitin chains

(2011) Christian Behrends et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Implicating Calpain in Tau-Mediated Toxicity In Vivo

(2011) James B. Reinecke et al.   PLoS One

Expanding the proteome: disordered and alternatively folded proteins

(2011) H. Jane Dyson   QUARTERLY REVIEWS OF BIOPHYSICS

Regulation of p53 function by lysine methylation

(2011) Lisandra E West et al.   Epigenomics

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody

(2010) Scott A. Yuzwa et al.   AMINO ACIDS

Dual Vulnerability of Tau to Calpains and Caspase-3 Proteolysis Under Neurotoxic and Neurodegenerative Conditions

(2010) Ming Cheng Liu et al.   ASN Neuro

Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation

(2010) Yipeng Wang et al.   Autophagy

Influence of glycosidic linkage on the nature of carbohydrate binding in β-prism I fold lectins: An X-ray and molecular dynamics investigation on banana lectin–carbohydrate complexes

(2010) Alok Sharma et al.   GLYCOBIOLOGY

A Caspase Cleaved Form of Tau Is Preferentially Degraded through the Autophagy Pathway

(2010) Philip J. Dolan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Tau, a Key Player in Neuronal DNA Protection

(2010) Audrey Sultan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

(2010) Troy T. Rohn et al.   NEUROBIOLOGY OF DISEASE

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

The role of nucleotide sugar transporters in development of eukaryotes

(2010) Li Liu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Ubiquitination and cysteine nitrosylation during aging and Alzheimer's disease

(2009) Irène M. Riederer et al.   BRAIN RESEARCH BULLETIN

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Phosphorylated Tau Interacts with c-Jun N-terminal Kinase-interacting Protein 1 (JIP1) in Alzheimer Disease

(2009) Lars M. Ittner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons

(2009) Rodrigo A. Quintanilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

(2009) Leslie Michels Thompson et al.   JOURNAL OF CELL BIOLOGY

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases

(2009) Yang Yu et al.   JOURNAL OF NEUROCHEMISTRY

FLEXIQuant: A Novel Tool for the Absolute Quantification of Proteins, and the Simultaneous Identification and Quantification of Potentially Modified Peptides

(2009) Sasha Singh et al.   JOURNAL OF PROTEOME RESEARCH

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

Molecular mechanisms of proteasome assembly

(2009) Shigeo Murata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sumoylation and human disease pathogenesis

(2009) Kevin D. Sarge et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

Crosstalk between Cdk5 and GSK3β: Implications for Alzheimer's Disease

(2009) Olivia Engmann   Frontiers in Molecular Neuroscience

O -GlcNAcylation modulates the self-aggregation ability of the fourth microtubule-binding repeat of tau

(2008) Chun-Hui Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Natively Unfolded Character of Tau and Its Aggregation to Alzheimer-like Paired Helical Filaments†

(2008) Sadasivam Jeganathan et al.   BIOCHEMISTRY

Ubiquitin-independent degradation of proteins by the proteasome

(2008) Isabelle Jariel-Encontre et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death

(2008) Tori A. Matthews-Roberson et al.   BRAIN RESEARCH

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

(2008) Tadanori Hamano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Carboxyl terminus of heat-shock cognate 70-interacting protein degrades tau regardless its phosphorylation status without affecting the spatial memory of the rats

(2008) Y.-J. Zhang et al.   JOURNAL OF NEURAL TRANSMISSION

Histone deacetylase 6 interacts with the microtubule-associated protein tau

(2008) Huiping Ding et al.   JOURNAL OF NEUROCHEMISTRY

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

(2008) Carl Julien et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications

(2008) Xiang-Jiao Yang et al.   MOLECULAR CELL

Diversity of degradation signals in the ubiquitin–proteasome system

(2008) Tommer Ravid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A possible link between astrocyte activation and tau nitration in Alzheimer's disease

(2008) Juan F. Reyes et al.   NEUROBIOLOGY OF DISEASE

Effect of glycosylation on protein folding: A close look at thermodynamic stabilization

(2008) D. Shental-Bechor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE