Spreading of pathology in neurodegenerative diseases: a focus on human studies
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Spreading of pathology in neurodegenerative diseases: a focus on human studies
Authors
Keywords
-
Journal
NATURE REVIEWS NEUROSCIENCE
Volume 16, Issue 2, Pages 109-120
Publisher
Springer Nature
Online
2015-01-15
DOI
10.1038/nrn3887
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD)
- (2014) Johannes Brettschneider et al. ACTA NEUROPATHOLOGICA
- Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
- (2014) Staffan Holmqvist et al. ACTA NEUROPATHOLOGICA
- Predicting Alzheimer disease with β-amyloid imaging: Results from the Australian imaging, biomarkers, and lifestyle study of ageing
- (2014) Christopher C. Rowe et al. ANNALS OF NEUROLOGY
- Diffusion tensor imaging analysis of sequential spreading of disease in amyotrophic lateral sclerosis confirms patterns of TDP-43 pathology
- (2014) J. Kassubek et al. BRAIN
- Non-invasive assessment of Alzheimer’s disease neurofibrillary pathology using 18F-THK5105 PET
- (2014) Nobuyuki Okamura et al. BRAIN
- Transport and diffusion of Tau protein in neurons
- (2014) Tim Scholz et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Glial cells in amyotrophic lateral sclerosis
- (2014) T. Philips et al. EXPERIMENTAL NEUROLOGY
- Alzheimer's disease under strain
- (2014) Adriano Aguzzi NATURE
- Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases
- (2014) Jing L Guo et al. NATURE MEDICINE
- Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
- (2014) David W. Sanders et al. NEURON
- Diffusion tensor imaging of white matter degeneration in Alzheimer’s disease and mild cognitive impairment
- (2014) I.K. Amlien et al. NEUROSCIENCE
- Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms
- (2014) Leslie I. Grad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intramuscular injection of -synuclein induces CNS -synuclein pathology and a rapid-onset motor phenotype in transgenic mice
- (2014) A. N. Sacino et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
- (2014) Hien T. Tran et al. Cell Reports
- Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies
- (2014) Simon Dujardin et al. Acta Neuropathologica Communications
- Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice
- (2013) Florence Clavaguera et al. ACTA NEUROPATHOLOGICA
- Staging TDP-43 pathology in Alzheimer’s disease
- (2013) Keith A. Josephs et al. ACTA NEUROPATHOLOGICA
- Stages of pTDP-43 pathology in amyotrophic lateral sclerosis
- (2013) Johannes Brettschneider et al. ANNALS OF NEUROLOGY
- Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
- (2013) Ariadna Recasens et al. ANNALS OF NEUROLOGY
- Prion-like spreading of pathological α-synuclein in brain
- (2013) Masami Masuda-Suzukake et al. BRAIN
- Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons
- (2013) Jing L. Guo et al. CELL
- Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
- (2013) Scott D. Ryan et al. CELL
- Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice
- (2013) Götz Heilbronner et al. EMBO REPORTS
- Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau
- (2013) Jing L. Guo et al. FEBS LETTERS
- The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease
- (2013) Li Zuo et al. GENE
- Alpha-synuclein transfers from neurons to oligodendrocytes
- (2013) Juan F. Reyes et al. GLIA
- Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy
- (2013) M. Iba et al. JOURNAL OF NEUROSCIENCE
- Novel 18F-Labeled Arylquinoline Derivatives for Noninvasive Imaging of Tau Pathology in Alzheimer Disease
- (2013) N. Okamura et al. JOURNAL OF NUCLEAR MEDICINE
- Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
- (2013) Mathias Jucker et al. NATURE
- Aβ-independent processes—rethinking preclinical AD
- (2013) Gaël Chételat Nature Reviews Neurology
- Amyotrophic lateral sclerosis—a model of corticofugal axonal spread
- (2013) Heiko Braak et al. Nature Reviews Neurology
- Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls
- (2013) Masahiro Maruyama et al. NEURON
- Astrocyte signaling and neurodegeneration
- (2013) Liliana Brambilla et al. Prion
- Transmission of multiple system atrophy prions to transgenic mice
- (2013) J. C. Watts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Brain homogenates from human tauopathies induce tau inclusions in mouse brain
- (2013) Florence Clavaguera et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease
- (2013) T. L. S. Benzinger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
- (2013) B. B. Holmes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neurodegenerative lesions: Seeding and spreading
- (2013) C. Duyckaerts REVUE NEUROLOGIQUE
- Identification and Rescue of -Synuclein Toxicity in Parkinson Patient-Derived Neurons
- (2013) C. Y. Chung et al. SCIENCE
- Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains
- (2013) Takashi Nonaka et al. Cell Reports
- Evaluation of Potential Infectivity of Alzheimer and Parkinson Disease Proteins in Recipients of Cadaver-Derived Human Growth Hormone
- (2013) David J. Irwin et al. JAMA Neurology
- Incidence of Dementia With Lewy Bodies and Parkinson Disease Dementia
- (2013) Rodolfo Savica et al. JAMA Neurology
- Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study
- (2012) Milos D. Ikonomovic et al. ACTA NEUROPATHOLOGICA
- Spinal cord lesions in sporadic Parkinson’s disease
- (2012) Kelly Del Tredici et al. ACTA NEUROPATHOLOGICA
- TDP-43 skeins show properties of amyloid in a subset of ALS cases
- (2012) John L. Robinson et al. ACTA NEUROPATHOLOGICA
- Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport
- (2012) Eric C. Freundt et al. ANNALS OF NEUROLOGY
- The spectrum of disease in chronic traumatic encephalopathy
- (2012) Ann C. McKee et al. BRAIN
- Cellular mechanisms of protein aggregate propagation
- (2012) Brandon B. Holmes et al. CURRENT OPINION IN NEUROLOGY
- The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth
- (2012) Claudia Fallini et al. HUMAN MOLECULAR GENETICS
- Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons
- (2012) Jessica W. Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Trans-cellular Propagation of Tau Aggregation by Fibrillar Species
- (2012) Najla Kfoury et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Prion-like spread of protein aggregates in neurodegeneration: Figure 1.
- (2012) Magdalini Polymenidou et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug
- (2012) Steven M. Johnson et al. JOURNAL OF MOLECULAR BIOLOGY
- Spreading of Neurodegenerative Pathology via Neuron-to-Neuron Transmission of -Amyloid
- (2012) S. Nath et al. JOURNAL OF NEUROSCIENCE
- Antibody-Aided Clearance of Extracellular -Synuclein Prevents Cell-to-Cell Aggregate Transmission
- (2012) E.-J. Bae et al. JOURNAL OF NEUROSCIENCE
- Exosomal cell-to-cell transmission of alpha synuclein oligomers
- (2012) Karin M Danzer et al. Molecular Neurodegeneration
- Lewy pathology and neurodegeneration in premotor Parkinson's disease
- (2012) Kelly Del Tredici et al. MOVEMENT DISORDERS
- 100 years of Lewy pathology
- (2012) Michel Goedert et al. Nature Reviews Neurology
- Norepinephrine: A Neuromodulator That Boosts the Function of Multiple Cell Types to Optimize CNS Performance
- (2012) John O’Donnell et al. NEUROCHEMICAL RESEARCH
- A Network Diffusion Model of Disease Progression in Dementia
- (2012) Ashish Raj et al. NEURON
- Predicting Regional Neurodegeneration from the Healthy Brain Functional Connectome
- (2012) Juan Zhou et al. NEURON
- Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
- (2012) Alix de Calignon et al. NEURON
- Trans-Synaptic Spread of Tau Pathology In Vivo
- (2012) Li Liu et al. PLoS One
- Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo
- (2012) Elodie Angot et al. PLoS One
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts
- (2011) Lisa Fellner et al. ACTA NEUROPATHOLOGICA
- TDP-43 pathological changes in early onset familial and sporadic Alzheimer’s disease, late onset Alzheimer’s disease and Down’s Syndrome: association with age, hippocampal sclerosis and clinical phenotype
- (2011) Yvonne S. Davidson et al. ACTA NEUROPATHOLOGICA
- 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease
- (2011) M. T. Fodero-Tavoletti et al. BRAIN
- Use of Florbetapir-PET for Imaging β-Amyloid Pathology
- (2011) Christopher M. Clark JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- A Seeding Reaction Recapitulates Intracellular Formation of Sarkosyl-insoluble Transactivation Response Element (TAR) DNA-binding Protein-43 Inclusions
- (2011) Yoshiaki Furukawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease
- (2011) Sudad Saman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interaction between pathogenic proteins in neurodegenerative disorders
- (2011) Kurt A. Jellinger JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
- (2011) Christian Hansen et al. JOURNAL OF CLINICAL INVESTIGATION
- Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats
- (2011) Rebecca F. Rosen et al. JOURNAL OF NEUROCHEMISTRY
- Population based epidemiology of amyotrophic lateral sclerosis using capture-recapture methodology
- (2011) M. H. B. Huisman et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Soluble A Seeds Are Potent Inducers of Cerebral -Amyloid Deposition
- (2011) F. Langer et al. JOURNAL OF NEUROSCIENCE
- Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study
- (2011) Henryk Barthel et al. LANCET NEUROLOGY
- Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease
- (2011) Kathleen M. Shannon et al. MOVEMENT DISORDERS
- Prion-like acceleration of a synucleinopathy in a transgenic mouse model
- (2011) Anne-Laure Mougenot et al. NEUROBIOLOGY OF AGING
- Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat
- (2011) Jeffrey H. Kordower et al. NEUROBIOLOGY OF DISEASE
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Unmyelinated axons are more vulnerable to degeneration than myelinated axons of the cardiac nerve in Parkinson's disease
- (2011) S. Orimo et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Animal models of multiple system atrophy
- (2011) P.-O. Fernagut et al. NEUROSCIENCE
- Patterns of alpha-synuclein pathology in incidental cases and clinical subtypes of Parkinson's disease
- (2011) Wilma D.J. van de Berg et al. PARKINSONISM & RELATED DISORDERS
- Intermolecular transmission of superoxide dismutase 1 misfolding in living cells
- (2011) L. I. Grad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells
- (2011) Christian Münch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
- (2010) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s disease
- (2010) Kelly Del Tredici et al. ACTA NEUROPATHOLOGICA
- TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease
- (2010) Eileen H. Bigio et al. ACTA NEUROPATHOLOGICA
- The pathological process underlying Alzheimer’s disease in individuals under thirty
- (2010) Heiko Braak et al. ACTA NEUROPATHOLOGICA
- 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial
- (2010) Rik Vandenberghe et al. ANNALS OF NEUROLOGY
- Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
- (2010) Lars M. Ittner et al. CELL
- Seeded Aggregation and Toxicity of α-Synuclein and Tau
- (2010) Takashi Nonaka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies
- (2010) He-Jin Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell-Produced -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
- (2010) E. Emmanouilidou et al. JOURNAL OF NEUROSCIENCE
- Induction of Amyloid Fibrils by the C-Terminal Fragments of TDP-43 in Amyotrophic Lateral Sclerosis
- (2010) Allan K.-H. Chen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
- (2010) Jia-Yi Li et al. MOVEMENT DISORDERS
- Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network
- (2010) Julie A. Harris et al. NEURON
- Identifying the amylome, proteins capable of forming amyloid-like fibrils
- (2010) Lukasz Goldschmidt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Peripherally Applied A -Containing Inoculates Induce Cerebral -Amyloidosis
- (2010) Y. S. Eisele et al. SCIENCE
- Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice
- (2010) Xing-Long Gu et al. Molecular Brain
- Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
- (2009) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- Phosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies
- (2009) Tetsuaki Arai et al. ACTA NEUROPATHOLOGICA
- Lewy body pathology in fetal grafts
- (2009) Yaping Chu et al. Annals of the New York Academy of Sciences
- Parkinson's Disease
- (2009) Christopher H. Hawkes et al. Annals of the New York Academy of Sciences
- Propagation of Tau Misfolding from the Outside to the Inside of a Cell
- (2009) Bess Frost et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Beyond the prion principle
- (2009) Adriano Aguzzi NATURE
- Transmission and spreading of tauopathy in transgenic mouse brain
- (2009) Florence Clavaguera et al. NATURE CELL BIOLOGY
- Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates
- (2009) Pei-Hsien Ren et al. NATURE CELL BIOLOGY
- The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids
- (2009) Adriano Aguzzi et al. NEURON
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyloid- and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
- (2009) V. Rhein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Temporal lobar predominance of TDP-43 neuronal cytoplasmic inclusions in Alzheimer disease
- (2008) William T. Hu et al. ACTA NEUROPATHOLOGICA
- Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia
- (2008) Fumiaki Mori et al. ACTA NEUROPATHOLOGICA
- The olfactory vector hypothesis of neurodegenerative disease: Is it viable?
- (2008) Richard L. Doty ANNALS OF NEUROLOGY
- Molecular Mechanisms of Prion Pathogenesis
- (2008) Adriano Aguzzi et al. Annual Review of Pathology-Mechanisms of Disease
- Assembly-dependent endocytosis and clearance of extracellular a-synuclein
- (2008) He-Jin Lee et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease
- (2008) D. Farfara et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Transplanted dopaminergic neurons develop PD pathologic changes: A second case report
- (2008) Jeffrey H. Kordower et al. MOVEMENT DISORDERS
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype
- (2008) K. A. Josephs et al. NEUROLOGY
- AA-Amyloidosis Can Be Transferred by Peripheral Blood Monocytes
- (2008) Jana Sponarova et al. PLoS One
- Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
- (2007) Fernanda G. De Felice et al. NEUROBIOLOGY OF AGING
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search