The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies

Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis

(2021) Min Lu et al.   Cell Death & Disease

Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway

(2021) Sushil Kumar et al.   Nature Communications

The miR-181a-SFRP4 axis regulates Wnt activation to drive stemness and platinum resistance in ovarian cancer

(2021) Anil Belur Nagaraj et al.   CANCER RESEARCH

Fam83D promotes tumorigenesis and gemcitabine resistance of pancreatic adenocarcinoma through the Wnt/β-catenin pathway

(2021) Yong-Qiang Hua et al.   LIFE SCIENCES

Hedgehog Pathway Activation Might Mediate Pemetrexed Resistance in NSCLC Cells

(2020) YICHAO LIU et al.   ANTICANCER RESEARCH

Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance

(2020) Ramesh Pothuraju et al.   Molecular Cancer

Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species

(2020) Sahba Kasiri et al.   ONCOGENE

Inhibition of Wnt/β-Catenin Signaling in Neuroendocrine Tumors In Vitro: Antitumoral Effects

(2020) Xi-Feng Jin et al.   Cancers

Inhibition of NOTCH signaling pathway chemosensitizes HCC CD133+ cells to vincristine and 5-fluorouracil through upregulation of BBC3

(2020) Hamed Hemati et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of deleterious NOTCH mutation as novel predictor to efficacious immunotherapy in NSCLC

(2020) Kai Zhang et al.   CLINICAL CANCER RESEARCH

Co-targeting of CXCR4 and hedgehog pathways disrupts tumor-stromal crosstalk and improves chemotherapeutic efficacy in pancreatic cancer

(2020) Mohammad Aslam Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overcoming Wnt–β-catenin dependent anticancer therapy resistance in leukaemia stem cells

(2020) John M. Perry et al.   NATURE CELL BIOLOGY

Up-regulation of GLI1 in vincristine-resistant rhabdomyosarcoma and Ewing sarcoma

(2020) Joon Won Yoon et al.   BMC CANCER

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

Hedgehog signaling promotes multidrug resistance by regulation of ABC transporters in oral squamous cell carcinoma

(2020) Xiangwan Lu et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes

(2020) Cefan Zhou et al.   Molecular Cancer

TET1 downregulates epithelial-mesenchymal transition and chemoresistance in PDAC by demethylating CHL1 to inhibit the Hedgehog signaling pathway

(2020) Hao Li et al.   ONCOGENE

Inhibition of Notch pathway enhances the anti-tumor effect of docetaxel in prostate cancer stem-like cells

(2020) Lei Wang et al.   Stem Cell Research & Therapy

Efficacy of immunotherapy in lung cancer with co-occurring mutations in NOTCH and homologous repair genes

(2020) Marco Mazzotta et al.   Journal for ImmunoTherapy of Cancer

ST8SIA1 inhibition sensitizes triple negative breast cancer to chemotherapy via suppressing Wnt/β-catenin and FAK/Akt/mTOR

(2020) H. Wan et al.   Clinical & Translational Oncology

RPN2 is targeted by miR-181c and mediates glioma progression and temozolomide sensitivity via the wnt/β-catenin signaling pathway

(2020) Jikui Sun et al.   Cell Death & Disease

Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells

(2020) Agnese Po et al.   Scientific Reports

Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation

(2020) Junke Long et al.   Science Advances

Impact of Wnt/β-Catenin Inhibition on Cell Proliferation through CDC25A Downregulation in Soft Tissue Sarcomas

(2020) Esther Martinez-Font et al.   Cancers

Targeting the Wnt/β-catenin signaling pathway in cancer

(2020) Ya Zhang et al.   Journal of Hematology & Oncology

Role of Notch Receptors in Hematologic Malignancies

(2020) Laura Gragnani et al.   Cells

WNT Signaling in Hematological Malignancies

(2020) Michela Frenquelli et al.   Frontiers in Oncology

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1

(2020) Vivien Kohlhaas et al.   BLOOD

Integrative genomic analysis of pediatric T-cell lymphoblastic lymphoma reveals candidates of clinical significance

(2020) Tasneem Khanam et al.   BLOOD

WNT/β-catenin pathway activation correlates with immune exclusion across human cancers

(2019) Jason J. Luke et al.   CLINICAL CANCER RESEARCH

Delta-like 1 homologue promotes tumorigenesis and epithelial-mesenchymal transition of ovarian high-grade serous carcinoma through activation of Notch signaling

(2019) Chao-Cheng Huang et al.   ONCOGENE

Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1

(2019) Mercedes Tomé et al.   Stem Cell Research

Leptin-elicited miRNA-342-3p potentiates gemcitabine resistance in pancreatic ductal adenocarcinoma

(2019) Longyang Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck

(2019) Qiancheng Jing et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PRMT1 regulates the tumour-initiating properties of esophageal squamous cell carcinoma through histone H4 arginine methylation coupled with transcriptional activation

(2019) Yue Zhao et al.   Cell Death & Disease

Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer

(2019) Hao Xie et al.   Cells

Targeting cancer stem cells in drug discovery: Current state and future perspectives

(2019) Fang-Yu Du et al.   World Journal of Stem Cells

Proteasome inhibitor induced SIRT1 deacetylates GLI2 to enhance hedgehog signaling activity and drug resistance in multiple myeloma

(2019) Ying Xie et al.   ONCOGENE

Suppressing Hedgehog signaling reverses drug resistance of refractory acute myeloid leukemia

(2019) Kaikai Huang et al.   OncoTargets and Therapy

Belinostat suppresses cell proliferation by inactivating Wnt/β-catenin pathway and promotes apoptosis through regulating PKC pathway in breast cancer

(2019) Pengwei Lu et al.   Artificial Cells Nanomedicine and Biotechnology

ErbB3 Phosphorylation as Central Event in Adaptive Resistance to Targeted Therapy in Metastatic Melanoma: Early Detection in CTCs during Therapy and Insights into Regulation by Autocrine Neuregulin

(2019) Ciro Francesco Ruggiero et al.   Cancers

Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance

(2019) Michela Colombo et al.   HAEMATOLOGICA

Role of Sonic hedgehog signaling in cell cycle, oxidative stress, and autophagy of temozolomide resistant glioblastoma

(2019) Jessica R. Honorato et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment

(2019) Amy J. Petty et al.   JOURNAL OF CLINICAL INVESTIGATION

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

Notch inhibition overcomes resistance to tyrosine kinase inhibitors in EGFR-driven lung adenocarcinoma

(2019) Emilie Bousquet Mur et al.   JOURNAL OF CLINICAL INVESTIGATION

Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia

(2019) Yoon-A Kang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Patched 1-interacting Peptide Represses Fibrosis in Pancreatic Cancer to Augment the Effectiveness of Immunotherapy

(2019) Yasuhiro Oyama et al.   JOURNAL OF IMMUNOTHERAPY

Targeting signalling pathways and the immune microenvironment of cancer stem cells — a clinical update

(2019) Joseph A. Clara et al.   Nature Reviews Clinical Oncology

PRKD2 Promotes Progression and Chemoresistance of AML via Regulating Notch1 Pathway

(2019) Qian Liu et al.   OncoTargets and Therapy

Wnt Signaling and Its Significance Within the Tumor Microenvironment: Novel Therapeutic Insights

(2019) Sonal Patel et al.   Frontiers in Immunology

WNT Signaling in Tumors: The Way to Evade Drugs and Immunity

(2019) Elena Martin-Orozco et al.   Frontiers in Immunology

Nanoparticle-Mediated Trapping of Wnt Family Member 5A in Tumor Microenvironments Enhances Immunotherapy for B-Raf Proto-Oncogene Mutant Melanoma

(2018) Qi Liu et al.   ACS Nano

Reversal of docetaxel resistance in prostate cancer by Notch signaling inhibition

(2018) Shi Qiu et al.   ANTI-CANCER DRUGS

Lanatoside C inhibits cell proliferation and induces apoptosis through attenuating Wnt/β-catenin/c-Myc signaling pathway in human gastric cancer cell

(2018) Yudong Hu et al.   BIOCHEMICAL PHARMACOLOGY

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma

(2018) Natalie Cook et al.   BRITISH JOURNAL OF CANCER

Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors

(2018) Nithya Krishnamurthy et al.   CANCER TREATMENT REVIEWS

Inhibition of HER2 Enriches for Jagged1-dependent Breast Cancer Stem Cells: Role for Membrane Jagged1

(2018) Deep Shah et al.   CLINICAL CANCER RESEARCH

Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture

(2018) Tatsuya Usui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long-Term Outcomes in Patients With BRAF V600–Mutant Metastatic Melanoma Who Received Dabrafenib Combined With Trametinib

(2018) Georgina V. Long et al.   JOURNAL OF CLINICAL ONCOLOGY

Wnt signaling in multiple myeloma: a central player in disease with therapeutic potential

(2018) Ingrid Spaan et al.   Journal of Hematology & Oncology

Notch Pathway Inhibition Using DAPT, a γ-secretase inhibitor (GSI), Enhances the Antitumor Effect of Cisplatin in Resistant Osteosarcoma

(2018) Guo Dai et al.   MOLECULAR CARCINOGENESIS

Notch-1-PTEN-ERK1/2 signaling axis promotes HER2+ breast cancer cell proliferation and stem cell survival

(2018) Andrew Baker et al.   ONCOGENE

Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma

(2018) Jennifer Teichman et al.   PLoS One

Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer

(2018) Yen-An Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt signaling induces radioresistance through upregulating HMGB1 in esophageal squamous cell carcinoma

(2018) Yuanyuan Zhao et al.   Cell Death & Disease

Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

(2018) Aurélie S. Cazet et al.   Nature Communications

Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide

(2018) Jilian R. Melamed et al.   Oncotarget

CBP modulates sensitivity to dasatinib in pre-BCR+ acute lymphoblastic leukemia

(2018) Jesus Duque-Afonso et al.   CANCER RESEARCH

A novel inhibitor of ADAM17 sensitizes colorectal cancer cells to 5-Fluorouracil by reversing Notch and epithelial-mesenchymal transition in vitro and in vivo

(2018) Dan-Dan Li et al.   CELL PROLIFERATION

T Cell–Inflamed versus Non-T Cell–Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection

(2018) Jonathan A. Trujillo et al.   Cancer Immunology Research

Regulation of periostin expression by Notch signaling in hepatocytes and liver cancer cell lines

(2018) Pornrat Kongkavitoon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Major vault protein is a direct target of Notch1 signaling and contributes to chemoresistance in triple-negative breast cancer cells

(2018) Ying-Sheng Xiao et al.   CANCER LETTERS

Modulating ROS to overcome multidrug resistance in cancer

(2018) Qingbin Cui et al.   DRUG RESISTANCE UPDATES

HIF-2α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways

(2018) Yuanyuan Yan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway

(2018) Binghua Li et al.   EBioMedicine

The Wnt inhibitor LGK-974 enhances radiosensitivity of HepG2 cells by modulating Nrf2 signaling

(2017) Dan Tian et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Hedgehog signaling pathway affects the sensitivity of hepatoma cells to drug therapy through the ABCC1 transporter

(2017) Jia Ding et al.   LABORATORY INVESTIGATION

Increased SHISA3 expression characterizes chronic lymphocytic leukemia patients sensitive to lenalidomide

(2017) Rossana Maffei et al.   LEUKEMIA & LYMPHOMA

Wnt/β-Catenin Pathway Activation Mediates Adaptive Resistance to BRAF Inhibition in Colorectal Cancer

(2017) Guangming Chen et al.   MOLECULAR CANCER THERAPEUTICS

Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

(2017) Jing Shan Lim et al.   NATURE

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway

(2017) Roberta Quaranta et al.   Cell Death & Disease

GLI1-mediated regulation of side population is responsible for drug resistance in gastric cancer

(2017) Beiqin Yu et al.   Oncotarget

A Cell-Cycle “Safe Space” for Surviving Chemotherapy

(2017) Mansi Arora et al.   Cell Systems

Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells

(2016) Nobuaki Fukushima et al.   CANCER SCIENCE

AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non–Small Cell Lung Cancer Cells Following EGFR Inhibition

(2016) Hannah A. Scarborough et al.   CLINICAL CANCER RESEARCH

Sonic Hedgehog Pathway Activation Is Associated With Resistance to Platinum-Based Chemotherapy in Advanced Non–Small-Cell Lung Carcinoma

(2016) Etienne Giroux Leprieur et al.   Clinical Lung Cancer

Wnt signaling inhibitor FH535 selectively inhibits cell proliferation and potentiates imatinib-induced apoptosis in myeloid leukemia cell lines

(2016) Kran Suknuntha et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Hedgehog and retinoid signaling alters multiple myeloma microenvironment and generates bortezomib resistance

(2016) Salvador Alonso et al.   JOURNAL OF CLINICAL INVESTIGATION

β-catenin signaling pathway regulates cisplatin resistance in lung adenocarcinoma cells by upregulating Bcl-xl

(2016) JIN ZHANG et al.   Molecular Medicine Reports

Inhibiting Notch Activity in Breast Cancer Stem Cells by Glucose Functionalized Nanoparticles Carrying γ-secretase Inhibitors

(2016) Veronika Mamaeva et al.   MOLECULAR THERAPY

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

(2016) Ximena Bonilla et al.   NATURE GENETICS

Pygo2 activates MDR1 expression and mediates chemoresistance in breast cancer via the Wnt/β-catenin pathway

(2016) Z-M Zhang et al.   ONCOGENE

Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells

(2016) F Faião-Flores et al.   ONCOGENE

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Curcumin inhibits hypoxia-induced epithelial-mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway

(2016) LEI CAO et al.   ONCOLOGY REPORTS

Eliminating Cancer Stem Cells by Targeting Embryonic Signaling Pathways

(2016) Ohad Oren et al.   Stem Cell Reviews and Reports

Potential role of Shh-Gli1-BMI1 signaling pathway nexus in glioma chemoresistance

(2016) M. H. Shahi et al.   TUMOR BIOLOGY

LIG4 mediates Wnt signalling-induced radioresistance

(2016) Sohee Jun et al.   Nature Communications

Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia

(2016) David A. Irvine et al.   Scientific Reports

NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex

(2016) Marek Adamowicz et al.   Cell Reports

Eliminating Cancer Stem Cells by Targeting Embryonic Signaling Pathways

(2016) Ohad Oren et al.   Stem Cell Reviews and Reports

Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells

(2015) Z. Kabiri et al.   BLOOD

RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells

(2015) M. Ilmer et al.   CANCER RESEARCH

SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer

(2015) C. M. Della Corte et al.   CLINICAL CANCER RESEARCH

A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo

(2015) M. Stasiulewicz et al.   DEVELOPMENT

The Hedgehog pathway as targetable vulnerability with 5-azacytidine in myelodysplastic syndrome and acute myeloid leukemia

(2015) Raoul Tibes et al.   Journal of Hematology & Oncology

β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma

(2015) Jenny Zinke et al.   Molecular Cancer

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

(2015) Philipp Rathert et al.   NATURE

BET inhibitor resistance emerges from leukaemia stem cells

(2015) Chun Yew Fong et al.   NATURE

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Notch is a direct negative regulator of the DNA-damage response

(2015) Jelena Vermezovic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Resveratrol inhibits hypoxia-driven ROS-induced invasive and migratory ability of pancreatic cancer cells via suppression of the Hedgehog signaling pathway

(2015) WEI LI et al.   ONCOLOGY REPORTS

Twist1 and Snail Link Hedgehog Signaling to Tumor-Initiating Cell-Like Properties and Acquired Chemoresistance Independently of ABC Transporters

(2015) Ying Kong et al.   STEM CELLS

Notch is a direct negative regulator of the DNA-damage response

(2015) Jelena Vermezovic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting Notch to overcome radiation resistance

(2015) Sanaz Yahyanejad et al.   Oncotarget

Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy

(2015) A. Holtzhausen et al.   Cancer Immunology Research

Targeting Wnt Canonical Signaling by Recombinant sFRP1 Bound Luminescent Au-Nanocluster Embedded Nanoparticles in Cancer Theranostics

(2015) Archita Ghoshal et al.   ACS Biomaterials-Science & Engineering

Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non–Small Cell Lung Cancer

(2015) Namrata Bora-Singhal et al.   NEOPLASIA

Targeting Wnt Canonical Signaling by Recombinant sFRP1 Bound Luminescent Au-Nanocluster Embedded Nanoparticles in Cancer Theranostics

(2015) Archita Ghoshal et al.   ACS Biomaterials Science & Engineering

The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer

(2015) Erhong Meng et al.   Cancers

Proteasome inhibition reverses hedgehog inhibitor and taxane resistance in ovarian cancer

(2015) Adam D. Steg et al.   Oncotarget

PDGFRα up-regulation mediated by Sonic Hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation

(2015) Francesco Sabbatino et al.   Oncotarget

Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933

(2014) Sylvia M. Lee et al.   CANCER

Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance

(2014) Zhongwei Cao et al.   CANCER CELL

Hedgehog Signaling Drives Radioresistance and Stroma-Driven Tumor Repopulation in Head and Neck Squamous Cancers

(2014) G. N. Gan et al.   CANCER RESEARCH

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

Wnt–Notch signalling crosstalk in development and disease

(2014) Giovanna M. Collu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Therapeutic modulation of Notch signalling — are we there yet?

(2014) Emma R. Andersson et al.   NATURE REVIEWS DRUG DISCOVERY

Notch-1 Signaling Promotes the Malignant Features of Human Breast Cancer through NF-κB Activation

(2014) Li Li et al.   PLoS One

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

ROS, Notch, and Wnt Signaling Pathways: Crosstalk between Three Major Regulators of Cardiovascular Biology

(2014) C. Caliceti et al.   Biomed Research International

Non-Canonical Notch Signaling in Cancer and Immunity

(2014) Furkan Ayaz et al.   Frontiers in Oncology

Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy

(2013) Yimin Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lgr5 promotes cancer stemness and confers chemoresistance through ABCB1 in colorectal cancer

(2013) Yi-Shiuan Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Notch controls generation and function of human effector CD8+ T cells

(2013) L. M. Kuijk et al.   BLOOD

Direct Reversal of Glucocorticoid Resistance by AKT Inhibition in Acute Lymphoblastic Leukemia

(2013) Erich Piovan et al.   CANCER CELL

Hedgehog Signaling Alters Reliance on EGF Receptor Signaling and Mediates Anti-EGFR Therapeutic Resistance in Head and Neck Cancer

(2013) S. B. Keysar et al.   CANCER RESEARCH

Notch signaling at a glance

(2013) K. Hori et al.   JOURNAL OF CELL SCIENCE

Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling

(2013) N. Wakabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting Notch signaling pathway in cancer: Clinical development advances and challenges

(2013) Naoko Takebe et al.   PHARMACOLOGY & THERAPEUTICS

Synergistic Effect of the γ-Secretase Inhibitor PF-03084014 and Docetaxel in Breast Cancer Models

(2013) Cathy C. Zhang et al.   Stem Cells Translational Medicine

Notch3 Overexpression as Potential Therapeutic Target in Advanced Stage Chemoresistant Ovarian Cancer

(2012) Mohammed Tanjimur Rahman et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

A phase II study of RO4929097 in metastatic colorectal cancer

(2012) Jonathan R. Strosberg et al.   EUROPEAN JOURNAL OF CANCER

Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer

(2012) Hyun-A Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

(2012) S. M. McAuliffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Analysis of N1ICD/RBPJ Targets In Vivo Reveals Direct Transcriptional Regulation of Wnt, SHH, and Hippo Pathway Effectors by Notch1

(2012) Yaochen Li et al.   STEM CELLS

Non-canonical Notch signaling: emerging role and mechanism

(2012) Peter Andersen et al.   TRENDS IN CELL BIOLOGY

Notch Signaling

(2012) R. Kopan   Cold Spring Harbor Perspectives in Biology

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

(2011) L Qiang et al.   CELL DEATH AND DIFFERENTIATION

Targeting the Notch Ligand Jagged1 in Both Tumor Cells and Stroma in Ovarian Cancer

(2011) A. D. Steg et al.   CLINICAL CANCER RESEARCH

Interaction of Wnt/β-catenin and notch signaling in the early stage of cardiac differentiation of P19CL6 cells

(2011) Binhong Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer

(2011) Veronika Mamaeva et al.   MOLECULAR THERAPY

Notch post-translationally regulates β-catenin protein in stem and progenitor cells

(2011) Chulan Kwon et al.   NATURE CELL BIOLOGY

The Notch-2 Gene Is Regulated by Wnt Signaling in Cultured Colorectal Cancer Cells

(2011) Jonas Ungerbäck et al.   PLoS One

Epithelial-Mesenchymal Transition in tumor microenvironment

(2011) Yingying Jing et al.   Cell and Bioscience

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

The Notch Target Hes1 Directly Modulates Gli1 Expression and Hedgehog Signaling: A Potential Mechanism of Therapeutic Resistance

(2010) K. C. Schreck et al.   CLINICAL CANCER RESEARCH

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951

(2010) E Clappier et al.   LEUKEMIA

Wnt Signaling Stimulates Transcriptional Outcome of the Hedgehog Pathway by Stabilizing GLI1 mRNA

(2009) F. K. Noubissi et al.   CANCER RESEARCH

Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway

(2009) Z. Wang et al.   CANCER RESEARCH

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity

(2009) Dana S. Wall et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Notch3 enhances sensitivity to gemcitabine in pancreatic cancer through an inactivation of PI3K/Akt-dependent pathway

(2009) Jun Yao et al.   MEDICAL ONCOLOGY

Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression

(2009) W D Thomas et al.   ONCOGENE

The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/β-catenin pathway

(2009) M Flahaut et al.   ONCOGENE

Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases

(2008) I. Joshi et al.   BLOOD

Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

(2008) E. Rosati et al.   BLOOD

Crosstalk between the Androgen Receptor and  -Catenin in Castrate-Resistant Prostate Cancer

(2008) G. Wang et al.   CANCER RESEARCH

The many facets of Notch ligands

(2008) B D'Souza et al.   ONCOGENE