Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture

Death-associated protein kinase 3 controls the tumor progression of A549 cells through ERK MAPK/c-Myc signaling

(2017) Satoru Kake et al.   ONCOLOGY REPORTS

The role of GLI1 for 5-Fu resistance in colorectal cancer

(2017) Lining Zhang et al.   Cell and Bioscience

Self-renewal molecular mechanisms of colorectal cancer stem cells

(2016) Tianhui Pan et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3)

(2016) Nobuyuki Fujiwara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma

(2016) Zhaoting Yang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cancer Stem Cells – Are Surface Markers Alone Sufficient?

(2016) Rohit Nagare et al.   Current Stem Cell Research & Therapy

Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment

(2016) Tatsuya Usui et al.   Stem Cells International

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Stromal Indian Hedgehog Signaling Is Required for Intestinal Adenoma Formation in Mice

(2015) Nikè V.J.A. Büller et al.   GASTROENTEROLOGY

Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity

(2015) Mai F. Tolba et al.   Scientific Reports

Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance

(2015) Komaraiah Palle et al.   Cancers

Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation

(2015) Ryotaro Yabe et al.   PLoS One

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer

(2015) Akwasi Agyeman et al.   Oncotarget

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

(2014) Xingnan Li et al.   NATURE MEDICINE

Intestinal stem cells and the colorectal cancer microenvironment

(2014) Bryan A Ong   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular Pathways: The Hedgehog Signaling Pathway in Cancer

(2012) R. McMillan et al.   CLINICAL CANCER RESEARCH

Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations

(2012) FABRIZIO GALIMBERTI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer

(2012) R. F. Hwang et al.   MOLECULAR CANCER RESEARCH

Identification of CD44+CD24+ gastric cancer stem cells

(2011) Chaojun Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Colon Cancer Stem Cells: Promise of Targeted Therapy

(2010) Matilde Todaro et al.   GASTROENTEROLOGY

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Clinical Experience With Hedgehog Pathway Inhibitors

(2010) Jennifer A. Low et al.   JOURNAL OF CLINICAL ONCOLOGY

DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

(2009) Timothy Hoey et al.   Cell Stem Cell

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

(2009) Frédéric Varnat et al.   EMBO Molecular Medicine

Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer

(2009) Maria–Theresa Mueller et al.   GASTROENTEROLOGY

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

(2009) H. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

First-line combination treatment of colorectal cancer with hepatic metastases: Choosing a targeted agent

(2008) Heinz-Josef Lenz   CANCER TREATMENT REVIEWS

Cancer stem cells: implications for the progression and treatment of metastatic disease

(2008) A.K Croker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Colon cancer stem cells: implications for prevention and therapy

(2008) Emina H. Huang et al.   TRENDS IN MOLECULAR MEDICINE