The Hedgehog pathway as targetable vulnerability with 5-azacytidine in myelodysplastic syndrome and acute myeloid leukemia

Targeting hedgehog signaling in myelofibrosis and other hematologic malignancies

(2014) Raoul Tibes et al.   Journal of Hematology & Oncology

Synergistic Targeting of AML Stem/Progenitor Cells With IAP Antagonist Birinapant and Demethylating Agents

(2014) Bing Z. Carter et al.   JNCI-Journal of the National Cancer Institute

BCL-2 family proteins as 5-Azacytidine-sensitizing targets and determinants of response in myeloid malignancies

(2014) J M Bogenberger et al.   LEUKEMIA

Ex vivoactivity of BCL-2 family inhibitors ABT-199 and ABT-737 combined with 5-azacytidine in myeloid malignancies

(2014) James M. Bogenberger et al.   LEUKEMIA & LYMPHOMA

Characterization of the TGF- 1 signaling abnormalities in the Gata1low mouse model of myelofibrosis

(2013) M. Zingariello et al.   BLOOD

Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors

(2013) A. Jimeno et al.   CLINICAL CANCER RESEARCH

CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo

(2013) L. Chaudhuri et al.   HAEMATOLOGICA

Azacitidine in patients with WHO-defined AML – Results of 155 patients from the Austrian Azacitidine Registry of the AGMT-Study Group

(2013) Lisa Pleyer et al.   Journal of Hematology & Oncology

Azacitidine might be beneficial in a subgroup of older AML patients compared to intensive chemotherapy: a single centre retrospective study of 227 consecutive patients

(2013) Lieke H van der Helm et al.   Journal of Hematology & Oncology

Epigenetic changes: a common theme in acute myelogenous leukemogenesis

(2013) Soraya E Gutierrez et al.   Journal of Hematology & Oncology

RNAi screening of the kinome with cytarabine in leukemias

(2012) R. Tibes et al.   BLOOD

Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors

(2011) P. M. LoRusso et al.   CLINICAL CANCER RESEARCH

Activation of the hedgehog pathway in chronic myelogeneous leukemia patients

(2011) Bing Long et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

(2009) Chen Zhao et al.   NATURE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

5q– myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing actin dynamics

(2009) K M Eisenmann et al.   ONCOGENE