The complex world of WNT receptor signalling

The many roles of PTK7: A versatile regulator of cell–cell communication

(2012) Hanna Peradziryi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

(2012) Atsuhiko T. Naito et al.   CELL

Nuclear Envelope Budding Enables Large Ribonucleoprotein Particle Export during Synaptic Wnt Signaling

(2012) Sean D. Speese et al.   CELL

A zebrafish Notum homolog specifically blocks the Wnt/ -catenin signaling pathway

(2012) G. P. Flowers et al.   DEVELOPMENT

Initiation of synapse formation by Wnt-induced MuSK endocytosis

(2012) L. R. Gordon et al.   DEVELOPMENT

Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin

(2012) Yong Jiang et al.   EMBO JOURNAL

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

(2012) Jurian Schuijers et al.   EMBO JOURNAL

Mitotic and mitogenic Wnt signalling

(2012) Christof Niehrs et al.   EMBO JOURNAL

The Wnt Receptor Ryk Plays a Role in Mammalian Planar Cell Polarity Signaling

(2012) Maria L. Macheda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling

(2012) H. Sakane et al.   JOURNAL OF CELL SCIENCE

Biglycan Is an Extracellular MuSK Binding Protein Important for Synapse Stability

(2012) A. R. Amenta et al.   JOURNAL OF NEUROSCIENCE

LGR5 Interacts and Cointernalizes with Wnt Receptors To Modulate Wnt/ -Catenin Signaling

(2012) K. S. Carmon et al.   MOLECULAR AND CELLULAR BIOLOGY

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

The Tangled Web of Non-Canonical Wnt Signalling in Neural Migration

(2012) Charlotte E.J. Clark et al.   NEUROSIGNALS

Wnt4 Participates in the Formation of Vertebrate Neuromuscular Junction

(2012) Laure Strochlic et al.   PLoS One

Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis

(2012) H.-Y. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Wnt Signaling in Mammalian Development: Lessons from Mouse Genetics

(2012) J. Wang et al.   Cold Spring Harbor Perspectives in Biology

 -Catenin-Dependent Wnt Signaling in C. elegans: Teaching an Old Dog a New Trick

(2012) B. M. Jackson et al.   Cold Spring Harbor Perspectives in Biology

Wnt/Wingless Signaling in Drosophila

(2012) S. Swarup et al.   Cold Spring Harbor Perspectives in Biology

Wnt Signaling in Cancer

(2012) P. Polakis   Cold Spring Harbor Perspectives in Biology

Wnt proteins regulate acetylcholine receptor clustering in muscle cells

(2012) Bin Zhang et al.   Molecular Brain

Wnt/Ca2+ signaling pathway: a brief overview

(2011) Antara De   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Yellow submarine of the Wnt/Frizzled signaling: Submerging from the G protein harbor to the targets

(2011) Alexey Koval et al.   BIOCHEMICAL PHARMACOLOGY

Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling

(2011) Sabine Fischer et al.   BMC DEVELOPMENTAL BIOLOGY

Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis

(2011) Bisei Ohkawara et al.   DEVELOPMENTAL CELL

PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling

(2011) Hanna Peradziryi et al.   EMBO JOURNAL

Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2to LRP6 phosphorylation

(2011) Kristina Tanneberger et al.   EMBO JOURNAL

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

(2011) Andrei Glinka et al.   EMBO REPORTS

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling

(2011) Jason D. Berndt et al.   JOURNAL OF CELL BIOLOGY

Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation

(2011) J. Liang et al.   MOLECULAR AND CELLULAR BIOLOGY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRP6 Mediates cAMP Generation by G Protein-Coupled Receptors Through Regulating the Membrane Targeting of G s

(2011) M. Wan et al.   Science Signaling

WNTing embryonic stem cells

(2011) Jason Wray et al.   TRENDS IN CELL BIOLOGY

Wnt Signaling: Multivesicular Bodies Hold GSK3 Captive

(2010) Christof Niehrs et al.   CELL

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

Wnt/Frizzled Signaling Requires dPRR, the Drosophila Homolog of the Prorenin Receptor

(2010) Tina Buechling et al.   CURRENT BIOLOGY

On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes

(2010) C. Niehrs   DEVELOPMENT

Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

(2010) Akiko Mukai et al.   EMBO JOURNAL

Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling

(2010) Francesca Puppo et al.   EMBO REPORTS

Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2

(2010) Florian Witte et al.   FASEB JOURNAL

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors

(2010) L. Grumolato et al.   GENES & DEVELOPMENT

Non-canonical Wnt Signaling Induces Ubiquitination and Degradation of Syndecan4

(2010) Loreto Carvallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

(2010) Eric Bourhis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse

(2010) H. Sakane et al.   JOURNAL OF CELL SCIENCE

Ror2/Frizzled Complex Mediates Wnt5a-Induced AP-1 Activation by Regulating Dishevelled Polymerization

(2010) M. Nishita et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitogen-Activated Protein Kinases Promote WNT/ -Catenin Signaling via Phosphorylation of LRP6

(2010) I. Cervenka et al.   MOLECULAR AND CELLULAR BIOLOGY

Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning

(2010) Hai Song et al.   NATURE

Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling

(2010) C.-M. Cruciat et al.   SCIENCE

G   Activates GSK3 to Promote LRP6-Mediated  -Catenin Transcriptional Activity

(2010) K. K. Jernigan et al.   Science Signaling

Wnt Trafficking: New Insights into Wnt Maturation, Secretion and Spreading

(2010) Fillip Port et al.   TRAFFIC

TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling

(2009) Harald J. Junge et al.   CELL

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

Cell Cycle Control of Wnt Receptor Activation

(2009) Gary Davidson et al.   DEVELOPMENTAL CELL

Wnt5a regulates distinct signalling pathways by binding to Frizzled2

(2009) Akira Sato et al.   EMBO JOURNAL

G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway

(2009) Minyong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ror2 Receptor Requires Tyrosine Kinase Activity to Mediate Wnt5A Signaling

(2009) Amanda Mikels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt Signals Organize Synaptic Prepattern and Axon Guidance through the Zebrafish unplugged/MuSK Receptor

(2009) Lili Jing et al.   NEURON

Identification of targets of the Wnt pathway destruction complex in addition to  -catenin

(2009) N.-G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes

(2009) E. Cadieu et al.   SCIENCE

Mammalian Wnt3a is Released on Lipoprotein Particles

(2009) Sylvia Neumann et al.   TRAFFIC

Ryks: new partners for Wnts in the developing and regenerating nervous system

(2009) Lee G. Fradkin et al.   TRENDS IN NEUROSCIENCES

Planar Cell Polarity Signaling: From Fly Development to Human Disease

(2008) Matias Simons et al.   Annual Review of Genetics

Wnt-ligand-dependent interaction of TAK1 (TGF-β-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling

(2008) Andreas Winkel et al.   CELLULAR SIGNALLING

PTK7 recruits dsh to regulate neural crest migration

(2008) I. Shnitsar et al.   DEVELOPMENT

The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development

(2008) O. Kazanskaya et al.   DEVELOPMENT

Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system

(2008) R. R. Wouda et al.   DEVELOPMENT

R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

(2008) S. M. Bell et al.   DEVELOPMENT

Wnt3a and Dkk1 Regulate Distinct Internalization Pathways of LRP6 to Tune the Activation of β-Catenin Signaling

(2008) Hideki Yamamoto et al.   DEVELOPMENTAL CELL

Cleavage of the Wnt Receptor Ryk Regulates Neuronal Differentiation during Cortical Neurogenesis

(2008) Jungmook Lyu et al.   DEVELOPMENTAL CELL

Parathyroid hormone signaling through low-density lipoprotein-related protein 6

(2008) M. Wan et al.   GENES & DEVELOPMENT

Chondroitin 4-O-Sulfotransferase-1 Modulates Wnt-3a Signaling through Control of E Disaccharide Expression of Chondroitin Sulfate

(2008) Satomi Nadanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor Tyrosine Kinase Ror2 Mediates Wnt5a-induced Polarized Cell Migration by Activating c-Jun N-terminal Kinase via Actin-binding Protein Filamin A

(2008) Akira Nomachi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential forXenopus laevisconvergent extension movements

(2008) Gun-Hwa Kim et al.   JOURNAL OF CELL BIOLOGY

Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase

(2008) Yan Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density

(2008) K. Ellwanger et al.   MOLECULAR AND CELLULAR BIOLOGY

R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism

(2008) Kyung-Ah Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

(2008) Shunfu Piao et al.   PLoS One

Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation

(2008) W. Pan et al.   SCIENCE

Alternative Wnt Signaling Is Initiated by Distinct Receptors

(2008) R. van Amerongen et al.   Science Signaling

Ror receptor tyrosine kinases: orphans no more

(2008) Jennifer L. Green et al.   TRENDS IN CELL BIOLOGY