Up-regulation of GLI1 in vincristine-resistant rhabdomyosarcoma and Ewing sarcoma

Regulation of GLI1 by cis DNA elements and epigenetic marks

(2019) Robert Taylor et al.   DNA REPAIR

Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas

(2018) Ramon J Whitson et al.   NATURE MEDICINE

From Drosophila segmentation to human cancer therapy

(2018) Philip W. Ingham   DEVELOPMENT

Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells

(2016) F Faião-Flores et al.   ONCOGENE

SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer

(2015) C. M. Della Corte et al.   CLINICAL CANCER RESEARCH

p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9

(2015) Joon Won Yoon et al.   DNA REPAIR

Non-Canonical Hh Signaling in Cancer—Current Understanding and Future Directions

(2015) Dongsheng Gu et al.   Cancers

GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis

(2015) Ritesh K. Srivastava et al.   Oncotarget

Role of erbB3 receptors in cancer therapeutic resistance

(2014) Y. Lee et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance

(2014) Z. Liu et al.   BLOOD

Hedgehog Signaling Drives Radioresistance and Stroma-Driven Tumor Repopulation in Head and Neck Squamous Cancers

(2014) G. N. Gan et al.   CANCER RESEARCH

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

(2014) Hiba Ahmad Zahreddine et al.   NATURE

Hedgehog Signaling Alters Reliance on EGF Receptor Signaling and Mediates Anti-EGFR Therapeutic Resistance in Head and Neck Cancer

(2013) S. B. Keysar et al.   CANCER RESEARCH

Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-targeting Hedgehog Inhibition

(2013) Shamik Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma

(2012) Fergal C. Kelleher et al.   PHARMACOLOGY & THERAPEUTICS

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma

(2011) R R Singh et al.   ONCOGENE

Risk of recurrence and survival after relapse in patients with Ewing sarcoma

(2011) Martin Stahl et al.   PEDIATRIC BLOOD & CANCER

Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: A report from the Children's Oncology Group

(2011) Joseph G. Pressey et al.   PEDIATRIC BLOOD & CANCER

Randomized Phase II Window Trial of Two Schedules of Irinotecan With Vincristine in Patients With First Relapse or Progression of Rhabdomyosarcoma: A Report From the Children's Oncology Group

(2010) Leo Mascarenhas et al.   JOURNAL OF CLINICAL ONCOLOGY

Increased expression of the hedgehog signaling pathway in pediatric solid malignancies

(2010) Takaharu Oue et al.   JOURNAL OF PEDIATRIC SURGERY

Hedgehog signaling maintains chemoresistance in myeloid leukemic cells

(2010) K C S Queiroz et al.   ONCOGENE

Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma

(2010) A Zibat et al.   ONCOGENE

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

(2009) Frédéric Varnat et al.   EMBO Molecular Medicine

Genomic and clinical analyses of 2p24 and 12q13-q14 amplification in alveolar rhabdomyosarcoma: A report from the Children's Oncology Group

(2009) Frederic G. Barr et al.   GENES CHROMOSOMES & CANCER

GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein

(2009) Elspeth Beauchamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gli1 is a potential target for alleviating multidrug resistance of gliomas

(2009) Daming Cui et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

GLI1 Is a Central Mediator of EWS/FLI1 Signaling in Ewing Tumors

(2009) Jay Joo et al.   PLoS One

Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes

(2008) Joon Won Yoon et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor suppressor gene Co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice

(2008) Jessica Svärd et al.   MOLECULAR CARCINOGENESIS

Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence following multi‐modality therapy: A report from the Children's Oncology Group

(2008) Patrick J. Leavey et al.   PEDIATRIC BLOOD & CANCER