Synergistic Effect of the γ-Secretase Inhibitor PF-03084014 and Docetaxel in Breast Cancer Models

Biomarker and Pharmacologic Evaluation of the  -Secretase Inhibitor PF-03084014 in Breast Cancer Models

(2012) C. C. Zhang et al.   CLINICAL CANCER RESEARCH

CD44+CD133+population exhibits cancer stem cell-like characteristics in human gallbladder carcinoma

(2011) Chengjian Shi et al.   CANCER BIOLOGY & THERAPY

Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells

(2011) Yuqing Chen et al.   CANCER BIOLOGY & THERAPY

Notch Signaling Mediates TNF-α-Induced IL-6 Production in Cultured Fibroblast-Like Synoviocytes from Rheumatoid Arthritis

(2011) Zhijun Jiao et al.   Clinical & Developmental Immunology

The clinical and therapeutic implications of cancer stem cell biology

(2011) Liang Cheng et al.   Expert Review of Anticancer Therapy

Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype

(2011) S. Ricardo et al.   JOURNAL OF CLINICAL PATHOLOGY

Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer

(2011) M Kondratyev et al.   ONCOGENE

Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells

(2011) S. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Secretase Inhibitors Enhance Temozolomide Treatment of Human Gliomas by Inhibiting Neurosphere Repopulation and Xenograft Recurrence

(2010) C. A. Gilbert et al.   CANCER RESEARCH

Targeting Notch to Target Cancer Stem Cells

(2010) A. Pannuti et al.   CLINICAL CANCER RESEARCH

BMI1 silencing enhances docetaxel activity and impairs antioxidant response in prostate cancer

(2010) Francesco Crea et al.   INTERNATIONAL JOURNAL OF CANCER

Acetylation Directs Survivin Nuclear Localization to Repress STAT3 Oncogenic Activity

(2010) Haijuan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

(2010) Christophe Ginestier et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluation of Selective  -Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design

(2010) P. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells

(2009) S. S. Rao et al.   CANCER RESEARCH

Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway

(2009) Z. Wang et al.   CANCER RESEARCH

Preclinical Profile of a Potent  -Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties

(2009) L. Luistro et al.   CANCER RESEARCH

 -Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity

(2009) R. D. Meng et al.   CANCER RESEARCH

DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

(2009) Timothy Hoey et al.   Cell Stem Cell

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

(2009) Bin-Bing S. Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim

(2009) J Konishi et al.   ONCOGENE

Multiple Lineages of Human Breast Cancer Stem/Progenitor Cells Identified by Profiling with Stem Cell Markers

(2009) Wendy W. Hwang-Verslues et al.   PLoS One

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advancing Bioluminescence Imaging Technology for the Evaluation of Anticancer Agents in the MDA-MB-435-HAL-Luc Mammary Fat Pad and Subrenal Capsule Tumor Models

(2008) C. Zhang et al.   CLINICAL CANCER RESEARCH

High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability

(2008) Alysha K. Croker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

(2008) X. Li et al.   JNCI-Journal of the National Cancer Institute