Overcoming Wnt–β-catenin dependent anticancer therapy resistance in leukaemia stem cells

Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells

(2019) Yuxuan Miao et al.   CELL

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

(2018) Tathiane M. Malta et al.   CELL

STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

(2018) Jung-Mao Hsu et al.   Nature Communications

Combined inhibition of β-catenin and Bcr–Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo

(2017) H Zhou et al.   LEUKEMIA

Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation

(2017) Abdullah Al-Dhfyan et al.   Molecular Cancer

The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

(2017) Hamid Bolouri et al.   NATURE MEDICINE

Surface PD-L1, E-cadherin, CD24, and VEGFR2 as markers of epithelial cancer stem cells associated with rapid tumorigenesis

(2017) Goodwin G. Jinesh et al.   Scientific Reports

Distinct signaling programs control human hematopoietic stem cell survival and proliferation

(2016) David J. H. F. Knapp et al.   BLOOD

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

(2015) Lorenzo Galluzzi et al.   CANCER CELL

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy

(2015) W. Peng et al.   Cancer Discovery

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Long Circulating Self-Assembled Nanoparticles from Cholesterol-Containing Brush-Like Block Copolymers for Improved Drug Delivery to Tumors

(2014) Thanh-Huyen Tran et al.   BIOMACROMOLECULES

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

(2014) J. E. Roderick et al.   BLOOD

Wnt inhibition leads to improved chemosensitivity in paediatric acute lymphoblastic leukaemia

(2014) Smita Dandekar et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia

(2014) S. Schubbert et al.   CANCER RESEARCH

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

 -Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL

(2013) D. Kaveri et al.   BLOOD

 -Catenin/POU5F1/SOX2 Transcription Factor Complex Mediates IGF-I Receptor Signaling and Predicts Poor Prognosis in Lung Adenocarcinoma

(2013) C. Xu et al.   CANCER RESEARCH

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia

(2012) T. Bhatla et al.   BLOOD

Attenuation of miR-126 Activity Expands HSC In Vivo without Exhaustion

(2012) Eric R. Lechman et al.   Cell Stem Cell

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

(2012) Li Ding et al.   NATURE

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

(2012) Stephan P Tenbaum et al.   NATURE MEDICINE

Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways

(2012) Jian Huang et al.   NATURE MEDICINE

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

(2012) S. J. Conley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies

(2011) L. E. Hogan et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Present and Future of PI3K Pathway Inhibition in Cancer: Perspectives and Limitations

(2011) E. Ciraolo et al.   CURRENT MEDICINAL CHEMISTRY

Cooperation between both Wnt/ -catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion

(2011) J. M. Perry et al.   GENES & DEVELOPMENT

Cancer stem cells renew their impact

(2011) Mel Greaves   NATURE MEDICINE

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker

(2011) M. Jan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TIM-3 Is a Promising Target to Selectively Kill Acute Myeloid Leukemia Stem Cells

(2010) Yoshikane Kikushige et al.   Cell Stem Cell

Phosphoinositide 3-Kinase Signaling Mediates β-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis

(2010) Goo Lee et al.   GASTROENTEROLOGY

Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation

(2010) Elizabeth A. Griffiths et al.   LEUKEMIA & LYMPHOMA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

(2009) A. Gutierrez et al.   BLOOD

Flow minimal residual disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34+CD38lowCD19+ in B-lineage childhood acute lymphoblastic leukemia

(2009) K. Wilson et al.   HAEMATOLOGICA

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling

(2009) Hasan Korkaya et al.   PLOS BIOLOGY

Stem cell concepts renew cancer research

(2008) J. E. Dick   BLOOD

CD34+CD38+CD19+ as well as CD34+CD38−CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL

(2008) Y Kong et al.   LEUKEMIA

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

(2008) Wei Guo et al.   NATURE

Initiating and Cancer-Propagating Cells in TEL-AML1-Associated Childhood Leukemia

(2008) D. Hong et al.   SCIENCE