Platelets, Constant and Cooperative Companions of Sessile and Disseminating Tumor Cells, Crucially Contribute to the Tumor Microenvironment

Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

(2021) Xiaoxu Wei et al.   Molecular Cancer

Blocking podoplanin inhibits platelet activation and decreases cancer-associated venous thrombosis

(2021) Xia Wang et al.   THROMBOSIS RESEARCH

The CC and CXC chemokines: major regulators of tumor progression and the tumor microenvironment

(2020) Andreas Bikfalvi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Insights into Protein–Ligand Interactions in Integrin Complexes: Advances in Structure Determinations

(2020) Yajun Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction

(2020) Gaofeng Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade

(2020) Irene Izquierdo et al.   THROMBOSIS AND HAEMOSTASIS

Targeting hemostasis-related moieties for tumor treatment

(2020) Bo Zhang et al.   THROMBOSIS RESEARCH

An Overview of Vasculogenic Mimicry in Breast Cancer

(2020) Marco A. Andonegui-Elguera et al.   Frontiers in Oncology

Collagen biology making inroads into prognosis and treatment of cancer progression and metastasis

(2020) Ana C. Martins Cavaco et al.   CANCER AND METASTASIS REVIEWS

The Emerging Role of Platelets in the Formation of the Micrometastatic Niche: Current Evidence and Future Perspectives

(2020) Stavros Gkolfinopoulos et al.   Frontiers in Oncology

Temporal TGF-β Supergene Family Signalling Cues Modulating Tissue Morphogenesis: Chondrogenesis within a Muscle Tissue Model?

(2020) Fei Xiong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The myofibroblast at a glance

(2020) Pardis Pakshir et al.   JOURNAL OF CELL SCIENCE

Beyond thrombosis: the impact of tissue factor signaling in cancer

(2020) Dusten Unruh et al.   Journal of Hematology & Oncology

Structure‐function of platelet glycoprotein Ib‐IX

(2020) M. Edward Quach et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

First-In-Class CD13-Targeted Tissue Factor tTF-NGR in Patients with Recurrent or Refractory Malignant Tumors: Results of a Phase I Dose-Escalation Study

(2020) Christoph Schliemann et al.   Cancers

Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy

(2020) Yanfei Yang et al.   Frontiers in Cell and Developmental Biology

Immune microenvironment in different molecular subtypes of ductal breast carcinoma

(2020) Mona Sadeghalvad et al.   BREAST CANCER RESEARCH AND TREATMENT

Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression

(2020) Jinfen Wei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Immune Microenvironment in Pancreatic Cancer

(2020) Magdalena Huber et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

(2020) Maria Teresa Masucci et al.   Frontiers in Immunology

Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment

(2020) Stephan Niland et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multifaceted Functions of Platelets in Cancer: From Tumorigenesis to Liquid Biopsy Tool and Drug Delivery System

(2020) Melania Dovizio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases

(2020) Maan H. Harbi et al.   PLATELETS

Thrombin Generation and Cancer: Contributors and Consequences

(2019) Caroline Reddel et al.   Cancers

Structurally Robust and Functionally Highly Versatile—C-Type Lectin (-Related) Proteins in Snake Venoms

(2019) Johannes Eble   Toxins

Vessel co-option in cancer

(2019) Elizabeth A. Kuczynski et al.   Nature Reviews Clinical Oncology

Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting

(2019) Jiansong Huang et al.   Journal of Hematology & Oncology

Podoplanin in Inflammation and Cancer

(2019) Miguel Quintanilla et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuropilins in the Context of Tumor Vasculature

(2019) Stephan Niland et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

VEGF in Signaling and Disease: Beyond Discovery and Development

(2019) Rajendra S. Apte et al.   CELL

The extracellular matrix in tumor progression and metastasis

(2019) Johannes A. Eble et al.   CLINICAL & EXPERIMENTAL METASTASIS

Fibrin and Fibrinolysis in Cancer

(2019) Hau Kwaan et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Role of Tissue Factor in Tumor Progression and Cancer-Associated Thrombosis

(2019) Araci Rondon et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Tumor-Associated Neutrophils in Cancer: Going Pro

(2019) Wu et al.   Cancers

Platelets, Thrombo-Inflammation, and Cancer: Collaborating With the Enemy

(2019) Ana Luisa Palacios-Acedo et al.   Frontiers in Immunology

Involvement of Platelets in Cancers

(2019) Diane Mege et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

From Patients to Platelets and Back Again: Pharmacological Approaches to Glycoprotein VI, a Thrilling Antithrombotic Target with Minor Bleeding Risks

(2019) Augusto Martins Lima et al.   THROMBOSIS AND HAEMOSTASIS

Extracellular matrix: the gatekeeper of tumor angiogenesis

(2019) Maurizio Mongiat et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin

(2019) Katsue Suzuki-Inoue   BLOOD

TGF-β1 – A truly transforming growth factor in fibrosis and immunity

(2019) Monika Lodyga et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Platelet Mechanotransduction

(2018) Caroline E. Hansen et al.   Annual Review of Biomedical Engineering

Epithelial Mesenchymal Transition in Tumor Metastasis

(2018) Vivek Mittal   Annual Review of Pathology-Mechanisms of Disease

Tissue Factor

(2018) Steven P. Grover et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The spatial molecular pattern of integrin recognition sites and their immobilization to colloidal nanobeads determine α2β1 integrin-dependent platelet activation

(2018) Augusto Martins Lima et al.   BIOMATERIALS

14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling

(2018) Yunfeng Chen et al.   BLOOD

The coagulome and the oncomir: impact of cancer-associated haemostatic dysregulation on the risk of metastasis

(2018) Kate Burbury et al.   CLINICAL & EXPERIMENTAL METASTASIS

Functional characterization of recombinant snake venom rhodocytin: rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis

(2018) T. Sasaki et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mechanisms and impact of altered tumour mechanics

(2018) Hamid Mohammadi et al.   NATURE CELL BIOLOGY

Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases

(2018) Jennifer Yeung et al.   PHARMACOLOGICAL REVIEWS

Contact System Activation and Cancer: New Insights in the Pathophysiology of Cancer-Associated Thrombosis

(2018) E. Campello et al.   THROMBOSIS AND HAEMOSTASIS

Platelets, NETs and cancer

(2018) Jessica Cedervall et al.   THROMBOSIS RESEARCH

Platelets Promote Metastasis via Binding Tumor CD97 Leading to Bidirectional Signaling that Coordinates Transendothelial Migration

(2018) Yvona Ward et al.   Cell Reports

Snake venom components in medicine: From the symbolic rod of Asclepius to tangible medical research and application

(2018) Maria-Inacia Estevão-Costa et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Tumor Vascular Endothelium as Decision Maker in Cancer Therapy

(2018) Diana Klein   Frontiers in Oncology

Platelet Signaling in Primary Haemostasis and Arterial Thrombus Formation: Part 1

(2018) Rüdiger Scharf   Hamostaseologie

Platelet Signaling in Primary Haemostasis and Arterial Thrombus Formation: Part 2

(2018) Rüdiger Scharf   Hamostaseologie

Anti-tissue factor pathway inhibitor (TFPI) therapy: a novel approach to the treatment of haemophilia

(2018) Pratima Chowdary   INTERNATIONAL JOURNAL OF HEMATOLOGY

Role of platelets and platelet receptors in cancer metastasis

(2018) Martin Schlesinger   Journal of Hematology & Oncology

Signal transduction via integrin adhesion complexes

(2018) Jonathan D Humphries et al.   CURRENT OPINION IN CELL BIOLOGY

Tumor vascular infarction: prospects and challenges

(2017) Rana Jahanban-Esfahlan et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

A biophysical view on von Willebrand factor activation

(2017) Achim Löf et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins

(2017) Lisa M. Miller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics

(2017) Alexandra Naba et al.   JOURNAL OF PROTEOME RESEARCH

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

(2017) N. S. Poulter et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Novel insights into the regulation of coagulation by factor V isoforms, tissue factor pathway inhibitorα, and protein S

(2017) B. Dahlbäck   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural basis of kindlin-mediated integrin recognition and activation

(2017) Huadong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Platelet receptors as therapeutic targets: Past, present and future

(2017) Janina Jamasbi et al.   THROMBOSIS AND HAEMOSTASIS

Reciprocal links between venous thromboembolism, coagulation factors and ovarian cancer progression

(2017) Nathalie Swier et al.   THROMBOSIS RESEARCH

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

(2017) Julie Rayes et al.   Nature Communications

Role of tumor microenvironment in tumorigenesis

(2017) Maonan Wang et al.   Journal of Cancer

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

Thrombin—unique coagulation system protein with multifaceted impacts on cancer and metastasis

(2016) Marek Z. Wojtukiewicz et al.   CANCER AND METASTASIS REVIEWS

Extracellular matrix proteins in the regulation of thrombus formation

(2016) Yiming Wang et al.   CURRENT OPINION IN HEMATOLOGY

Rethinking events in the haemostatic process: role of factor V and TFPI

(2016) R. M. Camire   HAEMOPHILIA

The extracellular matrix: Tools and insights for the “omics” era

(2016) Alexandra Naba et al.   MATRIX BIOLOGY

Mechanisms of ephrin–Eph signalling in development, physiology and disease

(2016) Artur Kania et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neutrophil extracellular traps: protagonists of cancer progression?

(2016) L Erpenbeck et al.   ONCOGENE

Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-angiogenic Signaling

(2016) Tristan Rupp et al.   Cell Reports

Protease-activated receptors (PARs)—biology and role in cancer invasion and metastasis

(2015) Marek Z. Wojtukiewicz et al.   CANCER AND METASTASIS REVIEWS

Regulation of hematogenous tumor metastasis by acid sphingomyelinase

(2015) A. Carpinteiro et al.   EMBO Molecular Medicine

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

αIIbβ3: structure and function

(2015) B. S. Coller   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

(2015) Stefanie K. Wculek et al.   NATURE

Tissue Factor: Old and New Links with Cancer Biology

(2015) Henri Versteeg   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Microvesicles from platelets: novel drivers of vascular inflammation

(2015) Tanja Vajen et al.   THROMBOSIS AND HAEMOSTASIS

Platelet microparticles and cancer: An intimate cross-talk

(2015) Hadi Goubran et al.   TRANSFUSION AND APHERESIS SCIENCE

Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis

(2015) Yao-Wen Chang et al.   Oncotarget

von Willebrand Factor Directly Interacts With DNA From Neutrophil Extracellular Traps

(2014) S. Grassle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CLEC-2 expression is maintained on activated platelets and on platelet microparticles

(2014) E. Gitz et al.   BLOOD

ADAP interactions with talin and kindlin promote platelet integrin  IIb 3 activation and stable fibrinogen binding

(2014) A. Kasirer-Friede et al.   BLOOD

Living in shear: platelets protect cancer cells from shear induced damage

(2014) Karl Egan et al.   CLINICAL & EXPERIMENTAL METASTASIS

Primary haemostasis: newer insights

(2014) M. C. Berndt et al.   HAEMOPHILIA

Syk and Src Family Kinases Regulate C-type Lectin Receptor 2 (CLEC-2)-mediated Clustering of Podoplanin and Platelet Adhesion to Lymphatic Endothelial Cells

(2014) Alice Y. Pollitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue factor in tumor microenvironment: a systematic review

(2014) Xiao Han et al.   Journal of Hematology & Oncology

α2β1 Integrin, GPVI Receptor, and Common FcRγ Chain on Mouse Platelets Mediate Distinct Responses to Collagen in Models of Thrombosis

(2014) Robin J. Marjoram et al.   PLoS One

Platelets guide the formation of early metastatic niches

(2014) M. Labelle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Platelets, Selectins, and the Control of Tumor Metastasis

(2014) Lucy A. Coupland et al.   SEMINARS IN ONCOLOGY

A Platform of C-type Lectin-like Receptor CLEC-2 for Binding O -Glycosylated Podoplanin and Nonglycosylated Rhodocytin

(2014) Masamichi Nagae et al.   STRUCTURE

Angiogenesis in Spontaneous Tumors and Implications for Comparative Tumor Biology

(2014) C. Benazzi et al.   TheScientificWorldJOURNAL

The various states of von Willebrand factor and their function in physiology and pathophysiology

(2014) Volker Huck et al.   THROMBOSIS AND HAEMOSTASIS

Insights into platelet-based control of coagulation

(2014) Susanne M. de Witt et al.   THROMBOSIS RESEARCH

Platelets: bridging hemostasis, inflammation, and immunity

(2013) C. N. Jenne et al.   International Journal of Laboratory Hematology

Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb-IX-V, and CLEC-2

(2013) Y. Ozaki et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Nanotechnological strategies for therapeutic targeting of tumor vasculature

(2013) Yanping Ding et al.   Nanomedicine

Platelet biology: the role of shear

(2013) Angus Ka Tsun Wong   Expert Review of Hematology

Vascular Hyperpermeability, Angiogenesis, and Stroma Generation

(2013) J. A. Nagy et al.   Cold Spring Harbor Perspectives in Medicine

Cancer-associated thrombosis

(2013) G. C. Connolly et al.   Hematology-American Society of Hematology Education Program

Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway

(2012) Monika Julia Wolf et al.   CANCER CELL

Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin Receptor-2)

(2012) Craig E. Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GITR Ligand Provided by Thrombopoietic Cells Inhibits NK Cell Antitumor Activity

(2012) T. Placke et al.   JOURNAL OF IMMUNOLOGY

The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination

(2012) M. Labelle et al.   Cancer Discovery

The relationship between tissue factor and cancer progression: insights from bench and bedside

(2011) Y. W. van den Berg et al.   BLOOD

Platelets Alter Tumor Cell Attributes to Propel Metastasis: Programming in Transit

(2011) Laurie J. Gay et al.   CANCER CELL

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

Tissue Factor-Activated Coagulation Cascade in the Tumor Microenvironment Is Critical for Tumor Progression and an Effective Target for Therapy

(2011) Y. Liu et al.   CANCER RESEARCH

Platelet-Derived MHC Class I Confers a Pseudonormal Phenotype to Cancer Cells That Subverts the Antitumor Reactivity of Natural Killer Immune Cells

(2011) T. Placke et al.   CANCER RESEARCH

Microparticles in Hemostasis and Thrombosis

(2011) A. Phillip Owens et al.   CIRCULATION RESEARCH

Biofunctionalization of a generic collagenous triple helix with the α2β1 integrin binding site allows molecular force measurements

(2011) Stephan Niland et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

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(2011) Carla Jennewein et al.   MOLECULAR MEDICINE

Blood platelet biochemistry

(2011) Katleen Broos et al.   THROMBOSIS RESEARCH

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac

(2010) A. Y. Pollitt et al.   BLOOD

Talin-dependent integrin activation is required for fibrin clot retraction by platelets

(2010) J. R. Haling et al.   BLOOD

Deadly allies: the fatal interplay between platelets and metastasizing cancer cells

(2010) L. Erpenbeck et al.   BLOOD

Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood

(2010) N. Pugh et al.   BLOOD

Plasma Fibronectin Promotes Lung Metastasis by Contributions to Fibrin Clots and Tumor Cell Invasion

(2010) Gunjan Malik et al.   CANCER RESEARCH

Transiently Entrapped Circulating Tumor Cells Interact with Neutrophils to Facilitate Lung Metastasis Development

(2010) S. J. Huh et al.   CANCER RESEARCH

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Hallmarks of cancer: Interactions with the tumor stroma

(2010) Kristian Pietras et al.   EXPERIMENTAL CELL RESEARCH

Syk-dependent Phosphorylation of CLEC-2

(2010) Sonia Séverin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

(2010) Renato V. Iozzo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Revitalizing membrane rafts: new tools and insights

(2010) Kai Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tissue-factor fusion proteins induce occlusion of tumor vessels

(2010) Christian Schwöppe et al.   THROMBOSIS RESEARCH

Platelet adhesion to collagen

(2010) Benedicte P. Nuyttens et al.   THROMBOSIS RESEARCH

Continuing Education Course #2: Current Understanding of Hemostasis

(2010) Andrew J. Gale   TOXICOLOGIC PATHOLOGY

The Platelet Receptor CLEC-2 Is Active as a Dimer

(2009) Aleksandra A. Watson et al.   BIOCHEMISTRY

Adhesion-Induced Unclasping of Cytoplasmic Tails of Integrin αIIbβ3†,‡

(2009) Nataly P. Podolnikova et al.   BIOCHEMISTRY

Control of Integrin αIIbβ3Outside-In Signaling and Platelet Adhesion by Sensing the Physical Properties of Fibrin(ogen) Substrates

(2009) Nataly P. Podolnikova et al.   BIOCHEMISTRY

Platelet-Derived Transforming Growth Factor-  Down-Regulates NKG2D Thereby Inhibiting Natural Killer Cell Antitumor Reactivity

(2009) H.-G. Kopp et al.   CANCER RESEARCH

Ixolaris, a tissue factor inhibitor, blocks primary tumor growth and angiogenesis in a glioblastoma model

(2009) T. C. CARNEIRO-LOBO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Microparticle-associated tissue factor activity in cancer patients with and without thrombosis

(2009) M. E. T. TESSELAAR et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets

(2009) J. C. SPALTON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin αIIbβ3

(2008) Timothy A. Springer et al.   JOURNAL OF CELL BIOLOGY

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE

Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2

(2008) Aleksandra A. Watson et al.   PROTEIN SCIENCE