Syk and Src Family Kinases Regulate C-type Lectin Receptor 2 (CLEC-2)-mediated Clustering of Podoplanin and Platelet Adhesion to Lymphatic Endothelial Cells

The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets

(2014) Craig E. Hughes et al.   BLOOD

CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP

(2014) A. Borgognone et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy

(2013) René Hägerling et al.   EMBO JOURNAL

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life

(2013) Paul R. Hess et al.   JOURNAL OF CLINICAL INVESTIGATION

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

(2013) Brett H. Herzog et al.   NATURE

Test Samples for Optimizing STORM Super-Resolution Microscopy

(2013) Daniel J. Metcalf et al.   Jove-Journal of Visualized Experiments

Improved platelet survival after cold storage by prevention of glycoprotein Ib  clustering in lipid rafts

(2012) E. Gitz et al.   HAEMATOLOGICA

Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

(2012) Sophie E. Acton et al.   IMMUNITY

Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells

(2012) Makoto Osada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin Receptor-2)

(2012) Craig E. Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Podoplanin: emerging functions in development, the immune system, and cancer

(2012) Jillian L. Astarita et al.   Frontiers in Immunology

Podoplanin Is Regulated by AP-1 and Promotes Platelet Aggregation and Cell Migration in Osteosarcoma

(2011) Akiko Kunita et al.   AMERICAN JOURNAL OF PATHOLOGY

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

(2011) B. A. Finney et al.   BLOOD

CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses

(2011) Diego Mourão-Sá et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2

(2011) A. M. KERRIGAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Tumor Lymphangiogenesis and Metastasis to Lymph Nodes Induced by Cancer Cell Expression of Podoplanin

(2010) Leah N. Cueni et al.   AMERICAN JOURNAL OF PATHOLOGY

Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42

(2010) Angels Navarro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model

(2010) M. P. Reilly et al.   BLOOD

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac

(2010) A. Y. Pollitt et al.   BLOOD

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

(2010) C. C. Bertozzi et al.   BLOOD

Regulation of Developmental Lymphangiogenesis by Syk+ Leukocytes

(2010) Ruben Böhmer et al.   DEVELOPMENTAL CELL

A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis

(2010) Tie Zheng Hou et al.   FEBS LETTERS

Essentialin VivoRoles of the C-type Lectin Receptor CLEC-2

(2010) Katsue Suzuki-Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syk-dependent Phosphorylation of CLEC-2

(2010) Sonia Séverin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PALM imaging and cluster analysis of protein heterogeneity at the cell surface

(2010) Dylan M. Owen et al.   Journal of Biophotonics

CLEC-2 is not required for platelet aggregation at arteriolar shear

(2010) C. E. HUGHES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A mouse knockout library for secreted and transmembrane proteins

(2010) Tracy Tang et al.   NATURE BIOTECHNOLOGY

A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

(2010) Byron B Au-Yeung et al.   NATURE IMMUNOLOGY

Lifeact mice for studying F-actin dynamics

(2010) Julia Riedl et al.   NATURE METHODS

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

(2010) K. Salaita et al.   SCIENCE

Lck and the nature of the T cell receptor trigger

(2010) Simon J. Davis et al.   TRENDS IN IMMUNOLOGY

Functional Anatomy of T Cell Activation and Synapse Formation

(2009) David R. Fooksman et al.   Annual Review of Immunology

The Platelet Receptor CLEC-2 Is Active as a Dimer

(2009) Aleksandra A. Watson et al.   BIOCHEMISTRY

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

(2009) F. May et al.   BLOOD

The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets

(2009) J. C. SPALTON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

T1α/podoplanin is essential for capillary morphogenesis in lymphatic endothelial cells

(2008) Angels Navarro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Renal cells activate the platelet receptor CLEC-2 through podoplanin

(2008) Charita M. Christou et al.   BIOCHEMICAL JOURNAL

Phospholipase C 2 is necessary for separation of blood and lymphatic vasculature in mice

(2008) H. Ichise et al.   DEVELOPMENT

Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

(2008) Tadashi Yokosuka et al.   IMMUNITY

Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

(2008) Michele Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE