ADAP interactions with talin and kindlin promote platelet integrin  IIb 3 activation and stable fibrinogen binding

The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3

(2013) Feng Ye et al.   CURRENT BIOLOGY

A directional switch of integrin signalling and a new anti-thrombotic strategy

(2013) Bo Shen et al.   NATURE

Agonist stimulation, talin-1, and kindlin-3 are crucial for αIIbβ3 activation in a human megakaryoblastic cell line, CMK

(2012) Tsuyoshi Nakazawa et al.   EXPERIMENTAL HEMATOLOGY

Kindlins, Integrin Activation and the Regulation of Talin Recruitment to αIIbβ3

(2012) Bryan N. Kahner et al.   PLoS One

CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules

(2011) S. Kliche et al.   BLOOD

Reconstruction of integrin activation

(2011) F. Ye et al.   BLOOD

Visualizing protein partnerships in living cells and organisms

(2011) Melissa A Lowder et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Talin-1 and Kindlin-3 Regulate α 4 β 1 Integrin-Mediated Adhesion Stabilization, but Not G Protein-Coupled Receptor-Induced Affinity Upregulation

(2011) Sharon J. Hyduk et al.   JOURNAL OF IMMUNOLOGY

A Novel Leukocyte Adhesion Deficiency III Variant: Kindlin-3 Deficiency Results in Integrin- and Nonintegrin-Related Defects in Different Steps of Leukocyte Adhesion

(2011) P. Robert et al.   JOURNAL OF IMMUNOLOGY

Kindlins in FERM adhesion

(2010) N. L. Malinin et al.   BLOOD

T Cell Receptor “Inside-Out” Pathway via Signaling Module SKAP1-RapL Regulates T Cell Motility and Interactions in Lymph Nodes

(2010) Monika Raab et al.   IMMUNITY

Recreation of the terminal events in physiological integrin activation

(2010) Feng Ye et al.   JOURNAL OF CELL BIOLOGY

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adhesion and Degranulation Promoting Adapter Protein (ADAP) Is a Central Hub for Phosphotyrosine-Mediated Interactions in T Cells

(2010) Marc Sylvester et al.   PLoS One

Coordination of Receptor Signaling in Multiple Hematopoietic Cell Lineages by the Adaptor Protein SLP-76

(2010) M. S. Jordan et al.   Cold Spring Harbor Perspectives in Biology

Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin

(2009) David R. Critchley   Annual Review of Biophysics

Role for ADAP in shear flow-induced platelet mechanotransduction

(2009) A. Kasirer-Friede et al.   BLOOD

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets

(2009) Katherine L. Tucker et al.   PROTEOMICS

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3

(2008) Naohide Watanabe et al.   JOURNAL OF CELL BIOLOGY

Analysis of Fyn function in hemostasis and  IIb 3-integrin signaling

(2008) K. B. Reddy et al.   JOURNAL OF CELL SCIENCE

Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo

(2008) Natalie A. Bezman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE