Functional characterization of recombinant snake venom rhodocytin: rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis

C-type lectin-like receptor 2 promotes hematogenous tumor metastasis and prothrombotic state in tumor-bearing mice

(2017) T. Shirai et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Aggretin Venom Polypeptide as a Novel Anti-angiogenesis Agent by Targeting Integrin alpha2beta1

(2017) Ching Hu Chung et al.   Scientific Reports

Metastasis: new functional implications of platelets and megakaryocytes

(2016) Raphael Leblanc et al.   BLOOD

Platelets in cancer metastasis: To help the “villain” to do evil

(2015) Nailin Li   INTERNATIONAL JOURNAL OF CANCER

Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis

(2015) Yao-Wen Chang et al.   Oncotarget

CLEC-2 expression is maintained on activated platelets and on platelet microparticles

(2014) E. Gitz et al.   BLOOD

Inhibitory effects of polypeptides derived from a snake venom C-type lectin, aggretin, on tumor cell-induced platelet aggregation

(2014) C.-H. Chang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Copy Number Analysis of the Murine Platelet Proteome Spanning the Complete Abundance Range

(2014) Marlis Zeiler et al.   MOLECULAR & CELLULAR PROTEOMICS

A Platform of C-type Lectin-like Receptor CLEC-2 for Binding O -Glycosylated Podoplanin and Nonglycosylated Rhodocytin

(2014) Masamichi Nagae et al.   STRUCTURE

Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells

(2012) Makoto Osada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simple Cloning via Direct Transformation of PCR Product (DNA Multimer) to Escherichia coli and Bacillus subtilis

(2011) Chun You et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Essentialin VivoRoles of the C-type Lectin Receptor CLEC-2

(2010) Katsue Suzuki-Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Snaclecs (snake C-type lectins) that inhibit or activate platelets by binding to receptors

(2010) Kenneth J. Clemetson   TOXICON

Renal cells activate the platelet receptor CLEC-2 through podoplanin

(2008) Charita M. Christou et al.   BIOCHEMICAL JOURNAL

The Crystal Structure of the Platelet Activator Aggretin Reveals a Novel (αβ)2Dimeric Structure†‡

(2008) Elizabeth Hooley et al.   BIOCHEMISTRY

Platelet aggregation in the formation of tumor metastasis

(2008) Takashi TSURUO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2

(2008) Aleksandra A. Watson et al.   PROTEIN SCIENCE