A biophysical view on von Willebrand factor activation

pH-Dependent Interactions in Dimers Govern the Mechanics and Structure of von Willebrand Factor

(2016) Jochen P. Müller et al.   BIOPHYSICAL JOURNAL

von Willebrand factor multimerization and the polarity of secretory pathways in endothelial cells

(2016) M. Lopes da Silva et al.   BLOOD

Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction

(2016) Jochen P. Müller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

(2016) Wei Deng et al.   Nature Communications

Force-Sensitive Autoinhibition of the von Willebrand Factor Is Mediated by Interdomain Interactions

(2015) Camilo Aponte-Santamaría et al.   BIOPHYSICAL JOURNAL

Structural Origins of Misfolding Propensity in the Platelet Adhesive Von Willebrand Factor A1 Domain

(2015) Michael T. Zimmermann et al.   BIOPHYSICAL JOURNAL

Mutational Constraints on Local Unfolding Inhibit the Rheological Adaptation of von Willebrand Factor

(2015) Alexander Tischer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases

(2015) Jongseong Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Misfolding of vWF to Pathologically Disordered Conformations Impacts the Severity of von Willebrand Disease

(2014) Alexander Tischer et al.   BIOPHYSICAL JOURNAL

Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex

(2014) W. Zhang et al.   BLOOD

von Willebrand factor, Jedi knight of the bloodstream

(2014) T. A. Springer   BLOOD

Structural Basis of Regulation of von Willebrand Factor Binding to Glycoprotein Ib

(2014) Mark A. Blenner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet GpIbα Binding to von Willebrand Factor Under Fluid Shear: Contributions of the D'D3‐Domain, A1‐Domain Flanking Peptide and O‐Linked Glycans

(2014) Sri R. Madabhushi et al.   Journal of the American Heart Association

Circulating but not immobilized N-deglycosylated von Willebrand factor increases platelet adhesion under flow conditions

(2013) M. A. Fallah et al.   Biomicrofluidics

The N-terminal Flanking Region of the A1 Domain Regulates the Force-dependent Binding of von Willebrand Factor to Platelet Glycoprotein Ibα

(2013) Lining Ju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mechanism for Localized Dynamics-driven Affinity Regulation of the Binding of von Willebrand Factor to Platelet Glycoprotein Ibα

(2013) Guangjian Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

von Willebrand factor remodeling during exocytosis from vascular endothelial cells

(2013) M. J. Mourik et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mechanical Activation of a Multimeric Adhesive Protein Through Domain Conformational Change

(2013) Sithara S. Wijeratne et al.   PHYSICAL REVIEW LETTERS

A molten globule intermediate of the Von Willebrand factor A1 domain firmly tethers platelets under shear flow

(2013) Alexander Tischer et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Sequence and structure relationships within von Willebrand factor

(2012) Y.-F. Zhou et al.   BLOOD

N-terminal Flanking Region of A1 Domain in von Willebrand Factor Stabilizes Structure of A1A2A3 Complex and Modulates Platelet Activation under Shear Stress

(2012) Matthew Auton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of platelet-binding von Willebrand factor strings on non-endothelial cells

(2012) J. W. WANG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

von Willebrand factor: the old, the new and the unknown

(2012) P. J. LENTING et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A thermodynamic definition of protein domains

(2012) L. L. Porter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPIbα-vWF Rolling under Shear Stress Shows Differences between Type 2B and 2M von Willebrand Disease

(2011) L.A. Coburn et al.   BIOPHYSICAL JOURNAL

Unfolding the A2 Domain of Von Willebrand Factor with the Optical Trap

(2010) Junyi Ying et al.   BIOPHYSICAL JOURNAL

Elongational Flow Induces the Unfolding of von Willebrand Factor at Physiological Flow Rates

(2010) Charles E. Sing et al.   BIOPHYSICAL JOURNAL

Specific N-linked glycosylation sites modulate synthesis and secretion of von Willebrand factor

(2010) T. A. J. McKinnon et al.   BLOOD

A mechanically stabilized receptor–ligand flex-bond important in the vasculature

(2010) Jongseong Kim et al.   NATURE

Changes in Thermodynamic Stability of von Willebrand Factor Differentially Affect the Force-Dependent Binding to Platelet GPIbα

(2009) Matthew Auton et al.   BIOPHYSICAL JOURNAL

Glycoprotein Ib  inhibitor complex structure reveals a combined steric and allosteric mechanism of von Willebrand factor antagonism

(2009) P. A. McEwan et al.   BLOOD

Mechanoenzymatic Cleavage of the Ultralarge Vascular Protein von Willebrand Factor

(2009) X. Zhang et al.   SCIENCE