First-In-Class CD13-Targeted Tissue Factor tTF-NGR in Patients with Recurrent or Refractory Malignant Tumors: Results of a Phase I Dose-Escalation Study

The beginning of the end for conventional RECIST — novel therapies require novel imaging approaches

(2019) Mirjam Gerwing et al.   Nature Reviews Clinical Oncology

R-CHOP preceded by blood-brain barrier permeabilization with engineered tumor necrosis factor-α in primary CNS lymphoma

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Role of Tissue Factor in Tumor Progression and Cancer-Associated Thrombosis

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Myeloid cell–synthesized coagulation factor X dampens antitumor immunity

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Serial Troponin for Early Detection of Nivolumab Cardiotoxicity in Advanced Non‐Small Cell Lung Cancer Patients

(2018) Matteo Sarocchi et al.   ONCOLOGIST

Aminopeptidase N (CD13): Expression, Prognostic Impact, and Use as Therapeutic Target for Tissue Factor Induced Tumor Vascular Infarction in Soft Tissue Sarcoma

(2018) Torsten Kessler et al.   Translational Oncology

Tissue Factor As a Predictor of Recurrent Venous Thromboembolism in Malignancy: Biomarker Analyses of the CATCH Trial

(2017) Alok A. Khorana et al.   JOURNAL OF CLINICAL ONCOLOGY

CD13 as target for tissue factor induced tumor vascular infarction in small cell lung cancer

(2017) Lars Henning Schmidt et al.   LUNG CANCER

Potential therapeutic impact of CD13 expression in non-small cell lung cancer

(2017) Lars Henning Schmidt et al.   PLoS One

Application of Cardiac Troponin in Cardiovascular Diseases Other Than Acute Coronary Syndrome

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Combinatorial effects of doxorubicin and retargeted tissue factor by intratumoral entrapment of doxorubicin and proapoptotic increase of tumor vascular infarction

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In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR)

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Synthesis and evaluation of novel Tc-99 m labeled NGR-containing hexapeptides as tumor imaging agents

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Tumor Growth Inhibition via Occlusion of Tumor Vasculature Induced by N-Terminally PEGylated Retargeted Tissue Factor tTF-NGR

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Radiolabeled NGR phage display peptide sequence for tumor targeting

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Possible contribution of aminopeptidase N (APN/CD13) to migration and invasion of human osteosarcoma cell lines

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MicroPET Imaging of CD13 Expression Using a 64Cu-Labeled Dimeric NGR Peptide Based on Sarcophagine Cage

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Non-invasive monitoring of tumor-vessel infarction by retargeted truncated tissue factor tTF–NGR using multi-modal imaging

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Peptide-Mediated Targeting of Cytokines to Tumor Vasculature: The NGR-hTNF Example

(2013) Angelo Corti et al.   BIODRUGS

Anticancer Therapy by Tumor Vessel Infarction with Polyethylene Glycol Conjugated Retargeted Tissue Factor

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Early Increases in Multiple Biomarkers Predict Subsequent Cardiotoxicity in Patients With Breast Cancer Treated With Doxorubicin, Taxanes, and Trastuzumab

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Cardiac troponin level elevations not related to acute coronary syndromes

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Non-invasive imaging for studying anti-angiogenic therapy effects

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Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment

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Hallmarks of Cancer: The Next Generation

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How to Interpret Elevated Cardiac Troponin Levels

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The 10 commandments of troponin, with special reference to high sensitivity assays

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Aminopeptidase N (CD13) as a target for cancer chemotherapy

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Phase II Study of Asparagine-Glycine-Arginine–Human Tumor Necrosis Factor α, a Selective Vascular Targeting Agent, in Previously Treated Patients With Malignant Pleural Mesothelioma

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Tissue-factor fusion proteins induce occlusion of tumor vessels

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Infarction of tumor vessels by NGR-peptide-directed targeting of tissue factor: experimental results and first-in-man experience

(2009) R. Bieker et al.   BLOOD

Assessing Risk of Venous Thromboembolism in the Patient With Cancer

(2009) Alok A. Khorana et al.   JOURNAL OF CLINICAL ONCOLOGY

Cardiac Toxicity of Sunitinib and Sorafenib in Patients With Metastatic Renal Cell Carcinoma

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