Extracellular matrix: the gatekeeper of tumor angiogenesis

Deciphering the complex role of thrombospondin-1 in glioblastoma development

(2019) Thomas Daubon et al.   Nature Communications

Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29

(2019) N.E. Calabro et al.   MATRIX BIOLOGY

Dissecting the role of hyaluronan synthases in the tumor microenvironment

(2019) Alberto Passi et al.   FEBS Journal

Tumour-Derived Laminin α5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition

(2019) Alex Gordon-Weeks et al.   Cancers

N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization

(2019) Federico Corti et al.   Nature Communications

Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature

(2018) Thomas Neill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human expression patterns: qualitative and quantitative analysis of thrombospondin-1 under physiological and pathological conditions

(2018) Chen Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis

(2018) Philip L.S.M. Gordts et al.   MATRIX BIOLOGY

HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2

(2018) Susan C. MacLauchlan et al.   MATRIX BIOLOGY

The α4β1/EMILIN1 interaction discloses a novel and unique integrin-ligand type of engagement

(2018) Alessandra Capuano et al.   MATRIX BIOLOGY

Pro-inflammatory roles of chondroitin sulfate proteoglycans in disorders of the central nervous system

(2018) Erin L. Stephenson et al.   MATRIX BIOLOGY

N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration

(2018) Chia-yi Chen et al.   MATRIX BIOLOGY

Extracellular matrix: The driving force of mammalian diseases

(2018) Renato V. Iozzo et al.   MATRIX BIOLOGY

CCN4/WISP1 controls cutaneous wound healing by modulating proliferation, migration and ECM expression in dermal fibroblasts via α5β1 and TNFα

(2018) Mitsuaki Ono et al.   MATRIX BIOLOGY

Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease

(2018) Joanne E. Murphy-Ullrich et al.   MATRIX BIOLOGY

The multifaceted roles of perlecan in fibrosis

(2018) Megan S. Lord et al.   MATRIX BIOLOGY

Decoding fibrosis: Mechanisms and translational aspects

(2018) Liliana Schaefer   MATRIX BIOLOGY

Connective tissue growth factor (CTGF) from basics to clinics

(2018) Yasaman Ramazani et al.   MATRIX BIOLOGY

The ablation of the matricellular protein EMILIN2 causes defective vascularization due to impaired EGFR-dependent IL-8 production affecting tumor growth

(2018) Alice Paulitti et al.   ONCOGENE

Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics

(2018) Nikos K. Karamanos et al.   CHEMICAL REVIEWS

Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor, decorin

(2018) Maria A Gubbiotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases

(2018) Nikos K. Karamanos et al.   MATRIX BIOLOGY

Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis

(2018) Eva Andreuzzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrin binding site within the gC1q domain orchestrates EMILIN-1-induced lymphangiogenesis

(2018) Alessandra Capuano et al.   MATRIX BIOLOGY

The function of heparan sulfate during branching morphogenesis

(2017) Vaishali N. Patel et al.   MATRIX BIOLOGY

Thrombospondin-4 in tissue remodeling

(2017) Olga Stenina-Adognravi et al.   MATRIX BIOLOGY

Cell therapy for basement membrane-linked diseases

(2017) Alexander Nyström et al.   MATRIX BIOLOGY

Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling

(2017) R.S. Ghadiali et al.   MATRIX BIOLOGY

The perlecan-interacting growth factor progranulin regulates ubiquitination, sorting, and lysosomal degradation of sortilin

(2017) Ryuta Tanimoto et al.   MATRIX BIOLOGY

Fragments generated upon extracellular matrix remodeling: Biological regulators and potential drugs

(2017) Sylvie Ricard-Blum et al.   MATRIX BIOLOGY

Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy

(2017) Simone Buraschi et al.   MATRIX BIOLOGY

Proteomic definitions of basement membrane composition in health and disease

(2017) Michael J. Randles et al.   MATRIX BIOLOGY

Proteoglycans remodeling in cancer: Underlying molecular mechanisms

(2017) Achilleas D. Theocharis et al.   MATRIX BIOLOGY

Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium

(2017) Federico Galvagni et al.   MATRIX BIOLOGY

Provisional matrix: A role for versican and hyaluronan

(2017) Thomas N. Wight   MATRIX BIOLOGY

A current view of perlecan in physiology and pathology: A mosaic of functions

(2017) Maria A. Gubbiotti et al.   MATRIX BIOLOGY

Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons

(2017) Kelsey A. Robinson et al.   MATRIX BIOLOGY

The nature and biology of basement membranes

(2017) Ambra Pozzi et al.   MATRIX BIOLOGY

Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2)

(2017) Georgina S. Butler et al.   MATRIX BIOLOGY

WISP-1 positively regulates angiogenesis by controlling VEGF-A expression in human osteosarcoma

(2017) Hsiao-Chi Tsai et al.   Cell Death & Disease

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression

(2017) Alexandra Naba et al.   Scientific Reports

Integration of pro- and anti-angiogenic signals by endothelial cells

(2017) Shideh Kazerounian et al.   Journal of Cell Communication and Signaling

Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers

(2016) Chiara Poluzzi et al.   ADVANCED DRUG DELIVERY REVIEWS

Decorin as a multivalent therapeutic agent against cancer

(2016) Thomas Neill et al.   ADVANCED DRUG DELIVERY REVIEWS

Sprouting angiogenesis is regulated by shedding of the C-type lectin family 14, member A (CLEC14A) ectodomain, catalyzed by rhomboid-like 2 protein (RHBDL2)

(2016) Peter J. Noy et al.   FASEB JOURNAL

Endorepellin-evoked Autophagy Contributes to Angiostasis

(2016) Atul Goyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombospondin-1 promotes mesenchymal stromal cell functions via TGFβ and in cooperation with PDGF

(2016) Dorina Belotti et al.   MATRIX BIOLOGY

Biglycan potentially regulates angiogenesis during fracture repair by altering expression and function of endostatin

(2016) Maja Myren et al.   MATRIX BIOLOGY

Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions

(2016) Maria A. Gubbiotti et al.   MATRIX BIOLOGY

Single molecule force measurements of perlecan/HSPG2: A key component of the osteocyte pericellular matrix

(2016) Sithara S. Wijeratne et al.   MATRIX BIOLOGY

The extracellular matrix: Tools and insights for the “omics” era

(2016) Alexandra Naba et al.   MATRIX BIOLOGY

Dietary fat overcomes the protective activity of thrombospondin-1 signaling in the Apc Min/+ model of colon cancer

(2016) D R Soto-Pantoja et al.   Oncogenesis

Decoding the Matrix: Instructive Roles of Proteoglycan Receptors

(2015) Thomas Neill et al.   BIOCHEMISTRY

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

(2015) Achilleas D. Theocharis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy

(2015) Stephen Douglass et al.   CONNECTIVE TISSUE RESEARCH

Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin

(2015) Cristina Colombelli et al.   JOURNAL OF CELL BIOLOGY

Multiple-interactions among EMILIN1 and EMILIN2 N- and C-terminal domains

(2015) Simonetta Bot et al.   MATRIX BIOLOGY

Pivotal role for decorin in angiogenesis

(2015) Hannu Järveläinen et al.   MATRIX BIOLOGY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Genetic compensation induced by deleterious mutations but not gene knockdowns

(2015) Andrea Rossi et al.   NATURE

Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth

(2015) P J Noy et al.   ONCOGENE

MULTIMERIN2 binds VEGF-A primarily via the carbohydrate chains exerting an angiostatic function and impairing tumor growth

(2015) Roberta Colladel et al.   Oncotarget

Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors

(2015)   Oncotarget

Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment

(2015) Po-Chun Chen et al.   Oncotarget

The Extracellular Matrix Glycoprotein Elastin Microfibril Interface Located Protein 2: A Dual Role in the Tumor Microenvironment

(2015) Maurizio Mongiat et al.   NEOPLASIA

Instructive Roles of Extracellular Matrix on Autophagy

(2014) Thomas Neill et al.   AMERICAN JOURNAL OF PATHOLOGY

Perlecan Heparan Sulfate Proteoglycan Is a Critical Determinant of Angiogenesis in Response to Mouse Hind-Limb Ischemia

(2014) Beiping Qiang et al.   CANADIAN JOURNAL OF CARDIOLOGY

Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer

(2014) Achilleas D. Theocharis et al.   FEBS Journal

Decorin Induces Mitophagy in Breast Carcinoma Cells via Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and Mitostatin

(2014) Thomas Neill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endorepellin Evokes Autophagy in Endothelial Cells

(2014) Chiara Poluzzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shed syndecan-2 inhibits angiogenesis

(2014) G. De Rossi et al.   JOURNAL OF CELL SCIENCE

Current understanding of the thrombospondin-1 interactome

(2014) Andrea Resovi et al.   MATRIX BIOLOGY

Biomarkers and proteomic analysis of osteoarthritis

(2014) Ming-Feng Hsueh et al.   MATRIX BIOLOGY

Revisiting the matricellular concept

(2014) Joanne E. Murphy-Ullrich et al.   MATRIX BIOLOGY

The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling

(2014) Megan S. Lord et al.   MATRIX BIOLOGY

Biglycan up-regulated vascular endothelial growth factor (VEGF) expression and promoted angiogenesis in colon cancer

(2014) Xiaojing Xing et al.   TUMOR BIOLOGY

CTGF increases vascular endothelial growth factor-dependent angiogenesis in human synovial fibroblasts by increasing miR-210 expression

(2014) S-C Liu et al.   Cell Death & Disease

Fibromodulin promoted in vitro and in vivo angiogenesis

(2013) Jia Jian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells

(2013) Chris D. Willis et al.   FEBS Journal

EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration

(2013) Stefano Marastoni et al.   JOURNAL OF PATHOLOGY

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

(2013) Helena C. Christianson et al.   MATRIX BIOLOGY

Heparan sulfate as a regulator of endochondral ossification and osteochondroma development

(2013) Katja Jochmann et al.   MATRIX BIOLOGY

Decorin causes autophagy in endothelial cells via Peg3

(2013) S. Buraschi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation

(2012) Kristin Moreth et al.   CELL CYCLE

Endorepellin Affects Angiogenesis by Antagonizing Diverse Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-evoked Signaling Pathways

(2012) Atul Goyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mast Cells Produce Novel Shorter Forms of Perlecan That Contain Functional Endorepellin

(2012) MoonSun Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombospondins in physiology and disease: New tricks for old dogs

(2012) Joanne E. Murphy-Ullrich et al.   MATRIX BIOLOGY

A biomechanical role for perlecan in the pericellular matrix of articular cartilage

(2012) Rebecca E. Wilusz et al.   MATRIX BIOLOGY

A Fragment of the LG3 Peptide of Endorepellin Is Present in the Urine of Physically Active Mining Workers: A Potential Marker of Physical Activity

(2012) Tony J. Parker et al.   PLoS One

LG3 fragment of endorepellin is a possible biomarker of severity in IgA nephropathy

(2012) Brigitte Surin et al.   PROTEOMICS

Targeting angiogenesis with compounds from the extracellular matrix

(2011) Dorina Belotti et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Endorepellin, the Angiostatic Module of Perlecan, Interacts with Both the α2β1 Integrin and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)

(2011) Atul Goyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decorin Antagonizes the Angiogenic Network

(2011) Thomas Neill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the LG3 Domain of Endorepellin, an Angiogenesis Inhibitor

(2011) Binh V. Le et al.   JOURNAL OF MOLECULAR BIOLOGY

MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway

(2011) E Lorenzon et al.   ONCOGENE

Mitostatin Is Down-Regulated in Human Prostate Cancer and Suppresses the Invasive Phenotype of Prostate Cancer Cells

(2011) Matteo Fassan et al.   PLoS One

Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner

(2011) L. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Thrombospondins

(2011) J. C. Adams et al.   Cold Spring Harbor Perspectives in Biology

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Decorin Antagonizes Met Receptor Activity and Down-regulates β-Catenin and Myc Levels

(2010) Simone Buraschi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity

(2009) A. Nystrom et al.   BLOOD

Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis

(2009) Jason J. Zoeller et al.   MATRIX BIOLOGY

Basement membrane proteoglycans: Modulators Par Excellence of cancer growth and angiogenesis

(2009) Renato V. Iozzo et al.   MOLECULES AND CELLS

An Antimetastatic Role for Decorin in Breast Cancer

(2008) Silvia Goldoni et al.   AMERICAN JOURNAL OF PATHOLOGY

Caspase-3 Activation Triggers Extracellular Cathepsin L Release and Endorepellin Proteolysis

(2008) Jean-François Cailhier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A central function for perlecan in skeletal muscle and cardiovascular development

(2008) Jason J. Zoeller et al.   JOURNAL OF CELL BIOLOGY

MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer

(2008) A Vecchione et al.   ONCOGENE

Urinary proteomic analysis of chronic allograft nephropathy

(2008) Edmond O'Riordan et al.   Proteomics Clinical Applications

Identification of circulating endorepellin LG3 fragment: Potential use as a serological biomarker for breast cancer

(2007) Jong Wook Chang et al.   Proteomics Clinical Applications