An Overview of Nanocarrier-Based Adjuvants for Vaccine Delivery

Chitosan and chitosan nanoparticles as adjuvant in local Rift Valley Fever inactivated vaccine

(2020) Ashgan F. El-Sissi et al.   3 Biotech

A single dose polyanhydride-based nanovaccine against paratuberculosis infection

(2020) Akanksha Thukral et al.   npj Vaccines

Gold nanoparticles for preparation of antibodies and vaccines against infectious diseases

(2020) Lev A. Dykman   Expert Review of Vaccines

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

(2020) Feng-Cai Zhu et al.   LANCET

Antibody response of a particle-inducing, liposome vaccine adjuvant admixed with a Pfs230 fragment

(2020) Wei-Chiao Huang et al.   npj Vaccines

Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized with DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins

(2020) Juan García-Arriaza et al.   Vaccines

Recent Progress on the Versatility of Virus-Like Particles

(2020) Ciying Qian et al.   Vaccines

Better Adjuvants for Better Vaccines: Progress in Adjuvant Delivery Systems, Modifications, and Adjuvant–Antigen Codelivery

(2020) Zhi-Biao Wang et al.   Vaccines

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

(2020) Yuan Huang et al.   ACTA PHARMACOLOGICA SINICA

Polyanhydride nanoparticles stabilize pancreatic cancer antigen MUC4β

(2020) Luman Liu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

(2020) Pedro M Folegatti et al.   LANCET

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polyethylenimine: An Intranasal Adjuvant for Liposomal Peptide-Based Subunit Vaccine against Group A Streptococcus

(2020) Charles Chuankai Dai et al.   ACS Infectious Diseases

Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia

(2020) Denis Y Logunov et al.   LANCET

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances

(2019) Hatem A.F.M. Hassan et al.   JOURNAL OF CONTROLLED RELEASE

The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function

(2019) Dennis Awuah et al.   JOURNAL OF IMMUNOLOGY

MF59 adjuvant enhances the immunogenicity and protective immunity of the OmpK/Omp22 fusion protein from Acineterbacter baumannii through intratracheal inoculation in mice

(2019) Ai‐qiong Yang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Oxidized carbon nanoparticles as an effective protein antigen delivery system targeting the cell-mediated immune response

(2019) Pritsana Sawutdeechaikul et al.   International Journal of Nanomedicine

CpG ODN G9.1 as a novel nasal ODN adjuvant elicits complete protection from influenza virus infection without causing inflammatory immune responses

(2019) Koichiro Tateishi et al.   VACCINE

Substitution of Human Papillomavirus Type 16 L2 Neutralizing Epitopes Into L1 Surface Loops: The Effect on Virus-Like Particle Assembly and Immunogenicity

(2019) Aleyo Chabeda et al.   Frontiers in Plant Science

Polyethylenimine-coated PLGA nanoparticles-encapsulated Angelica sinensis polysaccharide as an adjuvant to enhance immune responses

(2019) Pengfei Gu et al.   CARBOHYDRATE POLYMERS

A fucoidan-quaternary chitosan nanoparticle adjuvant for anthrax vaccine as an alternative to CpG oligodeoxynucleotides

(2019) Chuan-Chang Chuang et al.   CARBOHYDRATE POLYMERS

Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector

(2019) M. Giel-Moloney et al.   Scientific Reports

Induction of strong immune response against a multicomponent antigen of Mycobacterium tuberculosis in BALB/c mice using PLGA and DOTAP adjuvant

(2018) Farzad Khademi et al.   APMIS

Gold nanoparticles conjugating recombinant influenza hemagglutinin trimers and flagellin enhanced mucosal cellular immunity

(2018) Chao Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Squalane-based emulsion vaccine delivery system: composition with murabutide activate Th1 response

(2018) Ravi Kantipakala et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Mucosal immunization with PspA (Pneumococcal surface protein A)-adsorbed nanoparticles targeting the lungs for protection against pneumococcal infection

(2018) Tasson C. Rodrigues et al.   PLoS One

Evaluation of G2 Citric Acid-Based Dendrimer as an Adjuvant in Veterinary Rabies Vaccine

(2018) Vahid Asgary et al.   VIRAL IMMUNOLOGY

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

(2018) Adam Vandergriff et al.   Theranostics

Development of novel vaccine vectors: Chimpanzee adenoviral vectors

(2018) Jingao Guo et al.   Human Vaccines & Immunotherapeutics

C-Type Lectin Receptors in Antiviral Immunity and Viral Escape

(2018) Marta Bermejo-Jambrina et al.   Frontiers in Immunology

Formulation in DDA-MPLA-TDB Liposome Enhances the Immunogenicity and Protective Efficacy of a DNA Vaccine against Mycobacterium tuberculosis Infection

(2018) Maopeng Tian et al.   Frontiers in Immunology

Integrase Defective Lentiviral Vector as a Vaccine Platform for Delivering Influenza Antigens

(2018) Alessandra Gallinaro et al.   Frontiers in Immunology

Activation of B-1 cells promotes tumor cell killing in the peritoneal cavity

(2018) Marcela A Haro et al.   CANCER RESEARCH

Virus-like particle vaccines: immunology and formulation for clinical translation

(2018) Braeden Donaldson et al.   Expert Review of Vaccines

OUP accepted manuscript

(2018)   JOURNAL OF INFECTIOUS DISEASES

TLR4-based immunotherapeutics in cancer: a review of the achievements and shortcomings

(2018) Maryam A. Shetab Boushehri et al.   MOLECULAR PHARMACEUTICS

Polysaccharides as vaccine adjuvants

(2018) Beini Sun et al.   VACCINE

New Vaccine Technologies to Combat Outbreak Situations

(2018) Susanne Rauch et al.   Frontiers in Immunology

Recent clinical trends in Toll-like receptor targeting therapeutics

(2018) Muhammad Ayaz Anwar et al.   MEDICINAL RESEARCH REVIEWS

The protective effects of nasal PcrV-CpG oligonucleotide vaccination against Pseudomonas aeruginosa pneumonia

(2018) Yoshifumi Naito et al.   MICROBIOLOGY AND IMMUNOLOGY

Induction of herpes simplex virus type 1 cell-to-cell spread inhibiting antibodies by a calcium phosphate nanoparticle-based vaccine

(2018) Mathis Kopp et al.   Nanomedicine-Nanotechnology Biology and Medicine

Combined adjuvant-delivery system for new generation vaccine antigens: alliance has its own advantage

(2018) Monika Kaurav et al.   Artificial Cells Nanomedicine and Biotechnology

Efficient Induction of T Cells against Conserved HIV-1 Regions by Mosaic Vaccines Delivered as Self-Amplifying mRNA

(2018) Nathifa Moyo et al.   Molecular Therapy-Methods & Clinical Development

Graphene quantum dots inhibit T cell-mediated neuroinflammation in rats

(2018) Jelena Tosic et al.   NEUROPHARMACOLOGY

Calcium phosphate nanoparticles as a new generation vaccine adjuvant

(2017) Yahua Lin et al.   Expert Review of Vaccines

CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies

(2017) Nobutaka Hanagata   International Journal of Nanomedicine

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses

(2017) David J. Dowling et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Single immunization with MF59-adjuvanted inactivated whole-virion H7N9 influenza vaccine provides early protection against H7N9 virus challenge in mice

(2017) Haiyan Chang et al.   MICROBES AND INFECTION

Poly-ϵ-caprolactone/chitosan nanoparticles provide strong adjuvant effect for hepatitis B antigen

(2017) Sandra Jesus et al.   Nanomedicine

C-Type lectin receptor(s)-targeted nanoliposomes: an intelligent approach for effective cancer immunotherapy

(2017) Rajeev Sharma et al.   Nanomedicine

Engineering biodegradable guanidyl-decorated PEG-PCL nanoparticles as robust exogenous activators of DCs and antigen cross-presentation

(2017) Pan Li et al.   Nanoscale

Calcium phosphate nanoparticle (CaPNP) for dose-sparing of inactivated whole virus pandemic influenza A (H1N1) 2009 vaccine in mice

(2017) Tülin Morçӧl et al.   VACCINE

Targeting Pattern Recognition Receptors (PRR) for Vaccine Adjuvantation: From Synthetic PRR Agonists to the Potential of Defective Interfering Particles of Viruses

(2017) Andri Vasou et al.   Viruses-Basel

Advances in Non-Viral DNA Vectors for Gene Therapy

(2017) Cinnamon Hardee et al.   Genes

Liposomal Formulations in Clinical Use: An Updated Review

(2017) Upendra Bulbake et al.   Pharmaceutics

Incorporation of tetanus-epitope into virus-like particles achieves vaccine responses even in older recipients in models of psoriasis, Alzheimer’s and cat allergy

(2017) Andris Zeltins et al.   npj Vaccines

An Intranasal Proteosome-Adjuvanted Trivalent Influenza Vaccine Is Safe, Immunogenic & Efficacious in the Human Viral Influenza Challenge Model. Serum IgG & Mucosal IgA Are Important Correlates of Protection against Illness Associated with Infection

(2017) Rob Lambkin-Williams et al.   PLoS One

Multivalent and Multipathogen Viral Vector Vaccines

(2016) Katharina B. Lauer et al.   Clinical and Vaccine Immunology

Functional crosstalk between membrane lipids and TLR biology

(2016) Marielle S Köberlin et al.   CURRENT OPINION IN CELL BIOLOGY

Cytomegalovirus Vaccines: Current Status and Future Prospects

(2016) K. M. Anderholm et al.   DRUGS

Liposomal adjuvants for human vaccines

(2016) Carl R. Alving et al.   Expert Opinion on Drug Delivery

An overview on the role of silica-based materials in vaccine development

(2016) Gabriela Navarro-Tovar et al.   Expert Review of Vaccines

Calcium phosphate: a substitute for aluminum adjuvants?

(2016) Jean-Daniel Masson et al.   Expert Review of Vaccines

Safety and Immunogenicity of Novel Adenovirus Type 26– and Modified Vaccinia Ankara–Vectored Ebola Vaccines

(2016) Iain D. Milligan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, andToxoplasma gondiichallenges with a single dose

(2016) Jasdave S. Chahal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel ISCOMs from Quillaja brasiliensis saponins induce mucosal and systemic antibody production, T-cell responses and improved antigen uptake

(2016) Samuel Paulo Cibulski et al.   VACCINE

Maturation of dendritic cells by pullulan promotes anti-cancer effect

(2016) Wei Zhang et al.   Oncotarget

A two-dose heterologous prime-boost vaccine regimen eliciting sustained immune responses to Ebola Zaire could support a preventive strategy for future outbreaks

(2016) Georgi Shukarev et al.   Human Vaccines & Immunotherapeutics

Liposome-Based Adjuvants for Subunit Vaccines: Formulation Strategies for Subunit Antigens and Immunostimulators

(2016) Signe Tandrup Schmidt et al.   Pharmaceutics

Novel adjuvant Alum-TLR7 significantly potentiates immune response to glycoconjugate vaccines

(2016) Cecilia Buonsanti et al.   Scientific Reports

Role of lipid microdomains in TLR-mediated signalling

(2015) Jean-Marie Ruysschaert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Toll-Like Receptor Pathways in Autoimmune Diseases

(2015) Ji-Qing Chen et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Pulmonary dry powder vaccine of pneumococcal antigen loaded nanoparticles

(2015) Nitesh K. Kunda et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The Development of Self-Emulsifying Oil-in-Water Emulsion Adjuvant and an Evaluation of the Impact of Droplet Size on Performance

(2015) Ruchi R. Shah et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial

(2015) Katrin Ramsauer et al.   LANCET INFECTIOUS DISEASES

Progress with viral vectored malaria vaccines: A multi-stage approach involving “unnatural immunity”

(2015) Katie J. Ewer et al.   VACCINE

Safety and tolerability evaluation of the use of Montanide ISA™51 as vaccine adjuvant: A systematic review

(2015) Eva van Doorn et al.   Human Vaccines & Immunotherapeutics

Advances in aluminum hydroxide-based adjuvant research and its mechanism

(2015) Peng He et al.   Human Vaccines & Immunotherapeutics

Cholesteryl Pullulan Encapsulated TNF-αNanoparticles Are an Effective Mucosal Vaccine Adjuvant against Influenza Virus

(2015) Daiki Nagatomo et al.   Biomed Research International

Virus-Based Nanoparticles as Versatile Nanomachines

(2015) Kristopher J. Koudelka et al.   Annual Review of Virology

Safety data of Montanide ISA 51 VG and Montanide ISA 720 VG, two adjuvants dedicated to human therapeutic vaccines

(2015) Stephane Ascarateil et al.   Journal for ImmunoTherapy of Cancer

Cationic Liposomes Loaded with a Synthetic Long Peptide and Poly(I:C): a Defined Adjuvanted Vaccine for Induction of Antigen-Specific T Cell Cytotoxicity

(2014) Eleni Maria Varypataki et al.   AAPS Journal

Nanomedicines: addressing the scientific and regulatory gap

(2014) Sally Tinkle et al.   Annals of the New York Academy of Sciences

Advax-Adjuvanted Recombinant Protective Antigen Provides Protection against Inhalational Anthrax That Is Further Enhanced by Addition of Murabutide Adjuvant

(2014) Brandon Feinen et al.   Clinical and Vaccine Immunology

Hemagglutinin-based polyanhydride nanovaccines against H5N1 influenza elicit protective virus neutralizing titers and cell-mediated immunity

(2014) Balaji Narasimhan et al.   International Journal of Nanomedicine

Comparison of the safety and immunogenicity of an MF59®-adjuvanted with a non-adjuvanted seasonal influenza vaccine in elderly subjects

(2014) Sharon E. Frey et al.   VACCINE

A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration

(2014) Giovanni Della Cioppa et al.   Human Vaccines & Immunotherapeutics

Applications of nanomaterials as vaccine adjuvants

(2014) Motao Zhu et al.   Human Vaccines & Immunotherapeutics

Mucosal vaccination against tuberculosis using Ag85A-loaded immunostimulating complexes

(2014) Swati Pabreja et al.   Artificial Cells Nanomedicine and Biotechnology

An overview of adjuvant formulations and delivery systems

(2013) Alexis García et al.   APMIS

Murabutide Revisited: A Review of its Pleiotropic Biological Effects

(2013) Ziga Jakopin   CURRENT MEDICINAL CHEMISTRY

Poxvirus DNA Replication

(2013) B. Moss   Cold Spring Harbor Perspectives in Biology

Biodegradable particles as vaccine antigen delivery systems for stimulating cellular immune responses

(2013) Vijaya B Joshi et al.   Human Vaccines & Immunotherapeutics

Vaccine Adjuvants: Mode of Action

(2013) Ennio De Gregorio et al.   Frontiers in Immunology

Mechanisms of Action of Adjuvants

(2013) Sunita Awate et al.   Frontiers in Immunology

Nanostructured Materials in Drug and Gene Delivery: A Review of the State of the Art

(2012) Kailash C. Petkar et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8+T-cell responses in melanoma patients

(2012) Simone M. Goldinger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Aflunov®: a prepandemic influenza vaccine

(2012) Roberto Gasparini et al.   Expert Review of Vaccines

The history of MF59®adjuvant: a phoenix that arose from the ashes

(2012) Derek T O’Hagan et al.   Expert Review of Vaccines

ISCOMATRIX: a novel adjuvant for use in prophylactic and therapeutic vaccines against infectious diseases

(2012) A. Baz Morelli et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Comparative Analysis of Simian Immunodeficiency Virus Gag-Specific Effector and Memory CD8+T Cells Induced by Different Adenovirus Vectors

(2012) Wendy G. Tan et al.   JOURNAL OF VIROLOGY

Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment

(2012) Ligeng Xu et al.   NANO LETTERS

A prospective observational safety study on MF59® adjuvanted cell culture-derived vaccine, Celtura® during the A/H1N1 (2009) influenza pandemic

(2012) Humberto Reynales et al.   VACCINE

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

(2011) Jean-Laurent Casanova et al.   Annual Review of Immunology

Influenza virosomes as a vaccine adjuvant and carrier system

(2011) Christian Moser et al.   Expert Review of Vaccines

Proteosome-adjuvanted intranasal influenza vaccines: advantages, progress and future considerations

(2011) David Burt et al.   Expert Review of Vaccines

Cationic liposomes as vaccine adjuvants

(2011) Dennis Christensen et al.   Expert Review of Vaccines

CpG DNA as a vaccine adjuvant

(2011) Christian Bode et al.   Expert Review of Vaccines

Type 2 innate immune responses and the natural helper cell

(2011) Shigeo Koyasu et al.   IMMUNOLOGY

Vaccine adjuvants – Current status and prospects on controlled release adjuvancity

(2011) S.M. Sivakumar et al.   SAUDI PHARMACEUTICAL JOURNAL

The use of calcium phosphate nanoparticles encapsulating Toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell activation

(2010) Viktoriya Sokolova et al.   BIOMATERIALS

Carbon Nanotubes Enhance CpG Uptake and Potentiate Antiglioma Immunity

(2010) D. Zhao et al.   CLINICAL CANCER RESEARCH

Vaccination with a modified vaccinia virus Ankara (MVA)-vectored HIV-1 immunogen induces modest vector-specific T cell responses in human subjects

(2010) Sarah Howles et al.   VACCINE

Viral nanoparticles and virus-like particles: platforms for contemporary vaccine design

(2010) Emily M. Plummer et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

ACAM2000™: The new smallpox vaccine for United States Strategic National Stockpile

(2010) Aysegul Nalca et al.   Drug Design Development and Therapy

Dendrimers for Vaccine and Immunostimulatory Uses. A Review

(2009) Peter M. H. Heegaard et al.   BIOCONJUGATE CHEMISTRY

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Mechanism of action of licensed vaccine adjuvants

(2009) Elaine Tritto et al.   VACCINE

Bioconjugated quantum dots for in vivo molecular and cellular imaging☆

(2008) A SMITH et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanotechnology in vaccine delivery

(2008) Laura J. Peek et al.   ADVANCED DRUG DELIVERY REVIEWS

Epaxal®: a virosomal vaccine to prevent hepatitis A infection

(2008) Patrick A Bovier   Expert Review of Vaccines

Quantum Dots for Tracking Dendritic Cells and Priming an Immune Response In Vitro and In Vivo

(2008) Debasish Sen et al.   PLoS One

Particle-based vaccines for transcutaneous vaccination

(2007) Behazine Combadière et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES