Recent Progress on the Versatility of Virus-Like Particles

Venezuelan equine encephalitis vaccine with rearranged genome resists reversion and protects non-human primates from viremia after aerosol challenge

(2020) Irina Tretyakova et al.   VACCINE

Influenza Hemagglutinin Nanoparticle Vaccine Elicits Broadly Neutralizing Antibodies against Structurally Distinct Domains of H3N2 HA

(2020) Alyse D. Portnoff et al.   Vaccines

Efficient expression of enterovirus 71 based on virus-like particles vaccine

(2019) Hye-Jin Kim et al.   PLoS One

A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice

(2019) Tian-Ying Zhang et al.   GUT

Efficacy, safety, and immunogenicity of an Escherichia coli-produced bivalent human papillomavirus vaccine: An interim analysis of a randomized clinical trial

(2019) You-Lin Qiao et al.   JNCI-Journal of the National Cancer Institute

Current and new rotavirus vaccines

(2019) Rachel M. Burke et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Combining antimalarial drugs and vaccine for malaria elimination campaigns: a randomised safety and immunogenicity trial of RTS,S/AS01 administered with dihydroartemisinin, piperaquine and primaquine in healthy Thai adult volunteers

(2019) Lorenz von Seidlein et al.   Human Vaccines & Immunotherapeutics

Substitution of Human Papillomavirus Type 16 L2 Neutralizing Epitopes Into L1 Surface Loops: The Effect on Virus-Like Particle Assembly and Immunogenicity

(2019) Aleyo Chabeda et al.   Frontiers in Plant Science

Human COBRA 2 vaccine contains two major epitopes that are responsible for eliciting neutralizing antibody responses against heterologous clades of viruses

(2019) Ivette A. Nuñez et al.   VACCINE

A Two-Dose Hepatitis B Vaccine for Adults (Heplisav-B)

(2018)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Improved Titers against Influenza Drift Variants with a Nanoparticle Vaccine

(2018) Vivek Shinde et al.   NEW ENGLAND JOURNAL OF MEDICINE

A virus-like particle vaccine candidate for influenza A virus based on multiple conserved antigens presented on hepatitis B tandem core particles

(2018) Alejandro Ramirez et al.   VACCINE

Dengue virus-like particles mimic the antigenic properties of the infectious dengue virus envelope

(2018) Stefan W. Metz et al.   Virology Journal

A virus-like particle-based tetravalent vaccine for hand, foot, and mouth disease elicits broad and balanced protective immunity

(2018) Wei Zhang et al.   Emerging Microbes & Infections

Humoral and cell-mediated immune responses to H5N1 plant-made virus-like particle vaccine are differentially impacted by alum and GLA-SE adjuvants in a Phase 2 clinical trial

(2018) Stéphane Pillet et al.   npj Vaccines

Progress on norovirus vaccine research: public health considerations and future directions

(2018) Claire P. Mattison et al.   Expert Review of Vaccines

N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro

(2018) Minxi Wei et al.   Emerging Microbes & Infections

B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen

(2018) Sheng Hong et al.   IMMUNITY

Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

(2018) Zhihai Li et al.   Nature Communications

Hepatitis B virus: virology, molecular biology, life cycle and intrahepatic spread

(2017) P. Karayiannis   Hepatology International

Safety and Immunogenicity of Different Formulations of Norovirus Vaccine Candidate in Healthy Adults: A Randomized, Controlled, Double-Blind Clinical Trial

(2017) Geert Leroux-Roels et al.   JOURNAL OF INFECTIOUS DISEASES

Safety and immunogenicity of a parenteral P2-VP8-P[8] subunit rotavirus vaccine in toddlers and infants in South Africa: a randomised, double-blind, placebo-controlled trial

(2017) Michelle J Groome et al.   LANCET INFECTIOUS DISEASES

Major findings and recent advances in virus–like particle (VLP)-based vaccines

(2017) Mona O. Mohsen et al.   SEMINARS IN IMMUNOLOGY

Characterization of an Escherichia coli -derived human papillomavirus type 16 and 18 bivalent vaccine

(2017) Ying Gu et al.   VACCINE

HBcAg produced in transgenic tobacco triggers Th1 and Th2 response when intramuscularly delivered

(2017) Marcin Pyrski et al.   VACCINE

A phase 1 randomized open-label clinical study to evaluate the safety and tolerability of a novel recombinant hepatitis E vaccine

(2017) Yu-Feng Cao et al.   VACCINE

Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus

(2017) Zhihai Li et al.   mBio

Characterization of T-cell immune responses in clinical trials of the candidate RTS,S malaria vaccine

(2017) Philippe Moris et al.   Human Vaccines & Immunotherapeutics

Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults

(2017) Louis Fries et al.   Immunity & Ageing

Enhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine

(2017) Katharine A. Collins et al.   Scientific Reports

Immunogenicity of the 9-Valent HPV Vaccine Using 2-Dose Regimens in Girls and Boys vs a 3-Dose Regimen in Women

(2016) Ole-Erik Iversen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Rapid Responses to 2 Virus-Like Particle Norovirus Vaccine Candidate Formulations in Healthy Adults: A Randomized Controlled Trial

(2016) Robert L. Atmar et al.   JOURNAL OF INFECTIOUS DISEASES

pH-responsive Virus-like Nanoparticles with Enhanced Tumour-targeting Ligands for Cancer Drug Delivery

(2016) Roya Biabanikhankahdani et al.   Scientific Reports

Engineering virus-like particles as vaccine platforms

(2016) Kathryn M Frietze et al.   Current Opinion in Virology

A high-throughput neutralizing assay for antibodies and sera against hepatitis E virus

(2016) Wei Cai et al.   Scientific Reports

Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma

(2015) Monika Zochowska et al.   Nanomedicine-Nanotechnology Biology and Medicine

Age-dependent decrease of anti-HBs titers and effect of booster doses using 2 different vaccines in Palestinian children vaccinated in early childhood

(2015) Mohammad Qawasmi et al.   Human Vaccines & Immunotherapeutics

The development of a recombinant hepatitis E vaccine HEV 239

(2015) Shao-Wei Li et al.   Human Vaccines & Immunotherapeutics

Induction of Humoral and Cell-Mediated Immune Responses by Hepatitis B Virus Epitope Displayed on the Virus-Like Particles of Prawn Nodavirus

(2014) Chean Yeah Yong et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Adenovirus Vectors for Gene Therapy, Vaccination and Cancer Gene Therapy

(2014) William Wold et al.   CURRENT GENE THERAPY

Viral Particles Drive Rapid Differentiation of Memory B Cells into Secondary Plasma Cells Producing Increased Levels of Antibodies

(2014) F. Zabel et al.   JOURNAL OF IMMUNOLOGY

Norovirus Vaccine Against Experimental Human GII.4 Virus Illness: A Challenge Study in Healthy Adults

(2014) D. I. Bernstein et al.   JOURNAL OF INFECTIOUS DISEASES

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: Results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers

(2014) Jenny G.H. Low et al.   VACCINE

Virus-like particle-based human vaccines: quality assessment based on structural and functional properties

(2013) Qinjian Zhao et al.   TRENDS IN BIOTECHNOLOGY

Virus-induced humoral immunity: on how B cell responses are initiated

(2013) Franziska Zabel et al.   Current Opinion in Virology

Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8+T-cell responses in melanoma patients

(2012) Simone M. Goldinger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of safety and immunogenicity of two doses of investigational hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide and three doses of a licensed hepatitis B vaccine in healthy adults 18–55 years of age

(2012) Scott A. Halperin et al.   VACCINE

Immunogenicity and specificity of norovirus Consensus GII.4 virus-like particles in monovalent and bivalent vaccine formulations

(2012) Gabriel I. Parra et al.   VACCINE

Safety and immunogenicity of a Sf9 insect cell-derived respiratory syncytial virus fusion protein nanoparticle vaccine

(2012) Gregory M. Glenn et al.   VACCINE

Hepatitis E vaccine development

(2012) Ting Wu et al.   Human Vaccines & Immunotherapeutics

Norovirus Vaccine against Experimental Human Norwalk Virus Illness

(2011) Robert L. Atmar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Norovirus VLPs and rotavirus VP6 protein as combined vaccine for childhood gastroenteritis

(2011) Vesna Blazevic et al.   VACCINE

Molecular and structural characterization of the L1 virus-like particles that are used as vaccine antigens inCervarix™, the AS04-adjuvanted HPV-16 and -18 cervical cancer vaccine

(2010) Michel Deschuyteneer et al.   Human vaccines & immunotherapeutics

Immunogenicity, large scale safety and lot consistency of an intradermal influenza vaccine in adults aged 18–60 years: Randomized, controlled, Phase III trial

(2010) Robert Arnou et al.   Human vaccines & immunotherapeutics

Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial

(2010) Feng-Cai Zhu et al.   LANCET

Viral nanoparticles as platforms for next-generation therapeutics and imaging devices

(2010) Nicole F. Steinmetz   Nanomedicine-Nanotechnology Biology and Medicine

Influenza virus-like particle vaccines

(2009) Joel R Haynes   Expert Review of Vaccines

Buckyballs Meet Viral Nanoparticles: Candidates for Biomedicine

(2009) Nicole F. Steinmetz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biological Gene Delivery Vehicles: Beyond Viral Vectors

(2009) Yiqi Seow et al.   MOLECULAR THERAPY

Adenovirus Dodecahedron, as a Drug Delivery Vector

(2009) Monika Zochowska et al.   PLoS One

Safety and immunogenicity of a new hepatitis B vaccine for the protection of patients with renal insufficiency including pre-haemodialysis and haemodialysis patients

(2008) Jiri Beran   EXPERT OPINION ON BIOLOGICAL THERAPY

Epaxal®: a virosomal vaccine to prevent hepatitis A infection

(2008) Patrick A Bovier   Expert Review of Vaccines

Rationale and design of a community-based double-blind randomized clinical trial of an HPV 16 and 18 vaccine in Guanacaste, Costa Rica

(2008) Rolando Herrero et al.   VACCINE

Host-range and pathogenicity of hepatitis B viruses

(2007) Hans-Jürgen Netter et al.   Future Virology