Toll-Like Receptor Pathways in Autoimmune Diseases

Proteomic analysis of plasma identifies the Toll-like receptor agonists S100A8/A9 as a novel possible marker for systemic sclerosis phenotype

(2014) L van Bon et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures

(2014) S. M. Sacre et al.   JOURNAL OF IMMUNOLOGY

Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes

(2014) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Quantitative analysis of the suppressors of cytokine signaling 1 and 3 in peripheral blood leukocytes of patients with multiple sclerosis

(2014) Virginia Sedeño-Monge et al.   JOURNAL OF NEUROIMMUNOLOGY

Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: Ethnic differences and potential new targets for therapeutic drugs

(2014) Beverly D. Lyn-Cook et al.   MOLECULAR IMMUNOLOGY

Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population

(2014) Chin-Man Wang et al.   Scientific Reports

Emerging Role of Endosomal Toll-Like Receptors in Rheumatoid Arthritis

(2014) Ryan Thwaites et al.   Frontiers in Immunology

Tumor Necrosis Factor α Induces Sustained Signaling and a Prolonged and Unremitting Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts

(2013) Angela Lee et al.   ARTHRITIS AND RHEUMATISM

Initial Immunopathogenesis of Multiple Sclerosis: Innate Immune Response

(2013) Norma Y. Hernández-Pedro et al.   Clinical & Developmental Immunology

TLR2 and TLR4 in Autoimmune Diseases: a Comprehensive Review

(2013) Yu Liu et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Therapeutic hope for psoriasis offered by SOCS (suppressor of cytokine signaling) mimetic peptide

(2013) Masato Kubo   EUROPEAN JOURNAL OF IMMUNOLOGY

IFN-β therapy modulates B-cell and monocyte crosstalk via TLR7 in multiple sclerosis patients

(2013) Elena Giacomini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Association study of TLR-9 polymorphisms and systemic lupus erythematosus in Northern Chinese Han population

(2013) Jihui Zhang et al.   GENE

Epstein–Barr Virus Infection Induces Aberrant TLR Activation Pathway and Fibroblast–Myofibroblast Conversion in Scleroderma

(2013) Antonella Farina et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Torque teno virus (TTV) in multiple sclerosis patients with different patterns of disease

(2013) Roberta Mancuso et al.   JOURNAL OF MEDICAL VIROLOGY

Polymorphisms within Toll-like receptors are associated with systemic lupus erythematosus in a cohort of Danish females

(2013) Magdalena Janina Laska et al.   RHEUMATOLOGY

Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors

(2012) Marzena Ciechomska et al.   ANNALS OF THE RHEUMATIC DISEASES

Extracellular GC-rich DNA activates TLR9- and NF-kB-dependent signaling pathways in human adipose-derived mesenchymal stem cells (haMSCs)

(2012) Svetlana Kostjuk et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Altered natural killer cells' response to herpes virus infection in multiple sclerosis involves KIR2DL2 expression

(2012) Roberta Rizzo et al.   JOURNAL OF NEUROIMMUNOLOGY

Association study of IRAK-M and SIGIRR genes with SLE in a large European-descent population

(2012) E Sánchez et al.   LUPUS

Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation

(2012) J. M. Reynolds et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR2 ligation induces the production of IL-23/IL-17 via IL-6, STAT3 and NF-kB pathway in patients with primary Sjogren's syndrome

(2012) Seung-Ki Kwok et al.   ARTHRITIS RESEARCH & THERAPY

Identification of low frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization

(2012) Beate Bohm et al.   ARTHRITIS RESEARCH & THERAPY

Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasis

(2012) S Madonna et al.   Cell Death & Disease

Interferon-beta Inhibits Th17 Cell Differentiation in Patients with Multiple Sclerosis

(2012) Vinod S. Ramgolam et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators

(2011) J. C. A. Broen et al.   ARTHRITIS AND RHEUMATISM

Regulation of remyelination in multiple sclerosis

(2011) Khalid A. Hanafy et al.   FEBS LETTERS

Toll-like receptors in rheumatic diseases: Are we paying a high price for our defense against bugs?

(2011) K.C.M. Santegoets et al.   FEBS LETTERS

A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis

(2011) K Vandenbroeck et al.   GENES AND IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Increased microRNA-146a/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjögren's syndrome

(2011) Erika Zilahi et al.   IMMUNOLOGY LETTERS

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

(2011) A. Kuznik et al.   JOURNAL OF IMMUNOLOGY

Expression of Toll-like Receptors and Their Signaling Pathways in Rheumatoid Synovitis

(2011) YASUNOBU TAMAKI et al.   JOURNAL OF RHEUMATOLOGY

Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells

(2010) Karsten W. Eriksen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis

(2010) Makoto Hirotani et al.   JOURNAL OF NEUROIMMUNOLOGY

Multiplex Screening of 22 Single-Nucleotide Polymorphisms in 7 Toll-like Receptors: An Association Study in Rheumatoid Arthritis

(2010) C. ENEVOLD et al.   JOURNAL OF RHEUMATOLOGY

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis

(2010) Ulrike Hüffmeier et al.   NATURE GENETICS

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Expression of Toll-like receptors 7, 8, and 9 in primary Sjögren's syndrome

(2010) Lingyan Zheng et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

Genetic Variants in Toll-Like Receptors Are Not Associated with Rheumatoid Arthritis Susceptibility or Anti-Tumour Necrosis Factor Treatment Outcome

(2010) Marieke J. H. Coenen et al.   PLoS One

Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

(2010) J. A. Sloane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The investigation of toll-like receptor 3, 9 and 10 gene polymorphisms in Turkish rheumatoid arthritis patients

(2010) Ebru Onalan Etem et al.   RHEUMATOLOGY INTERNATIONAL

Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways

(2009) Kevin M. Dennehy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TLR-3 enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritis

(2009) Kyoung-Woon Kim et al.   IMMUNOLOGY LETTERS

Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype

(2009) George P Christophi et al.   LABORATORY INVESTIGATION

Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer

(2009) L. A. J. O'Neill et al.   PHARMACOLOGICAL REVIEWS

Enhanced interleukin‐10 production by dendritic cells upon stimulation with Toll‐like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion

(2009) A. W. T. van Lieshout et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

SOCS1 and SOCS3 in the control of CNS immunity

(2009) Brandi J. Baker et al.   TRENDS IN IMMUNOLOGY

No evidence of major effects in several toll-like receptor gene polymorphisms in rheumatoid arthritis

(2009) Olivier Jaen et al.   ARTHRITIS RESEARCH & THERAPY

Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA)

(2008) M F Roelofs et al.   ANNALS OF THE RHEUMATIC DISEASES

Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4

(2008) Serena Fineschi et al.   ARTHRITIS AND RHEUMATISM

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis

(2008) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM

The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients

(2008) Jeng-Ting Tsao et al.   CLINICAL AND EXPERIMENTAL MEDICINE

TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus

(2008) John Castiblanco et al.   INFECTION GENETICS AND EVOLUTION

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells

(2008) D Bhaumik et al.   ONCOGENE

Immunological alterations in newly diagnosed primary Sjögren's syndrome characterized by skewed peripheral T‐cell subsets and inflammatory cytokines

(2008) P. Szodoray et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY