Targeting Pattern Recognition Receptors (PRR) for Vaccine Adjuvantation: From Synthetic PRR Agonists to the Potential of Defective Interfering Particles of Viruses

Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer

(2017) Shikhar Mehrotra et al.   Journal of Hematology & Oncology

Natural STING Agonist as an “Ideal” Adjuvant for Cutaneous Vaccination

(2016) Ji Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Triggering Intracellular Receptors for Vaccine Adjuvantation

(2016) Alice Gutjahr et al.   TRENDS IN IMMUNOLOGY

Abstract A044: Immunological effects of a novel RNA-based adjuvant in liver cancer patients

(2016) Luisa Circelli et al.   Cancer Immunology Research

Adjuvants: Classification,Modus Operandi, and Licensing

(2016) Juliana de Souza Apostólico et al.   Journal of Immunology Research

Vaccination in patients with primary immune deficiency, secondary immune deficiency and autoimmunity with immune regulatory abnormalities

(2015) Martha M Eibl et al.   Immunotherapy

A novel RNA-based adjuvant combines strong immunostimulatory capacities with a favorable safety profile

(2015) Regina Heidenreich et al.   INTERNATIONAL JOURNAL OF CANCER

PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine

(2015) Ting-Hin Ho et al.   JOURNAL OF VIROLOGY

Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant

(2015) Vladimir Beljanski et al.   JOURNAL OF VIROLOGY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Poly(I:C) as cancer vaccine adjuvant: Knocking on the door of medical breakthroughs

(2015) Rachid Ammi et al.   PHARMACOLOGY & THERAPEUTICS

Cloned Defective Interfering Influenza RNA and a Possible Pan-Specific Treatment of Respiratory Virus Diseases

(2015) Nigel Dimmock et al.   Viruses-Basel

Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I

(2015) Jie Xu et al.   mBio

Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans

(2015) Yan Sun et al.   PLoS Pathogens

Contribution of Toll-like receptors to the control of hepatitis B virus infection by initiating antiviral innate responses and promoting specific adaptive immune responses

(2014) Zhiyong Ma et al.   Cellular & Molecular Immunology

Immunogenicity of Intradermal Trivalent Influenza Vaccine With Topical Imiquimod: A Double Blind Randomized Controlled Trial

(2014) Ivan F. N. Hung et al.   CLINICAL INFECTIOUS DISEASES

MDA5 Participates in the Detection of Paramyxovirus Infection and Is Essential for the Early Activation of Dendritic Cells in Response to Sendai Virus Defective Interfering Particles

(2014) J. S. Yount et al.   JOURNAL OF IMMUNOLOGY

Defective Interfering Influenza Virus RNAs: Time To Reevaluate Their Clinical Potential as Broad-Spectrum Antivirals?

(2014) N. J. Dimmock et al.   JOURNAL OF VIROLOGY

Mechanisms of RIG-I-Like Receptor Activation and Manipulation by Viral Pathogens

(2014) M. U. Gack   JOURNAL OF VIROLOGY

Combinations of various CpG motifs cloned into plasmid backbone modulate and enhance protective immunity of viral replicon DNA anthrax vaccines

(2014) Yun-Zhou Yu et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Evaluation of the immune response to RTS,S/AS01 and RTS,S/AS02 adjuvanted vaccines

(2014) Geert Leroux-Roels et al.   Human Vaccines & Immunotherapeutics

TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens

(2014) Ryan McClure et al.   Frontiers in Immunology

TLR Agonists as Modulators of the Innate Immune Response and Their Potential as Agents Against Infectious Disease

(2014) Edin J. Mifsud et al.   Frontiers in Immunology

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

Deep Sequencing Analysis of Defective Genomes of Parainfluenza Virus 5 and Their Role in Interferon Induction

(2013) M. J. Killip et al.   JOURNAL OF VIROLOGY

Sequence Analysis of In Vivo Defective Interfering-Like RNA of Influenza A H1N1 Pandemic Virus

(2013) K. Saira et al.   JOURNAL OF VIROLOGY

Highly immunostimulatory RNA derived from a Sendai virus defective viral genome

(2013) Xiomara Mercado-López et al.   VACCINE

H5N1 vaccines in humans

(2013) Mariana Baz et al.   VIRUS RESEARCH

Pollinex Quattro: An innovative four injections immunotherapy In allergic rhinitis

(2013) Martin Rosewich et al.   Human Vaccines & Immunotherapeutics

Defective Viral Genomes Arising In Vivo Provide Critical Danger Signals for the Triggering of Lung Antiviral Immunity

(2013) Karla Tapia et al.   PLoS Pathogens

Mechanisms of Action of Adjuvants

(2013) Sunita Awate et al.   Frontiers in Immunology

A Sendai Virus-Derived RNA Agonist of RIG-I as a Virus Vaccine Adjuvant

(2012) L. Martínez-Gil et al.   JOURNAL OF VIROLOGY

Development of VAX128, a recombinant hemagglutinin (HA) influenza-flagellin fusion vaccine with improved safety and immune response

(2012) David N. Taylor et al.   VACCINE

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins

(2011) Taro Kawai et al.   EMBO Molecular Medicine

Regulation of effector and memory T-cell functions by type I interferon

(2011) Jonathan P. Huber et al.   IMMUNOLOGY

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

(2011) Marina Caskey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defective interfering influenza A virus protects in vivo against disease caused by a heterologous influenza B virus

(2011) P. D. Scott et al.   JOURNAL OF GENERAL VIROLOGY

Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis

(2011) M. J. Killip et al.   JOURNAL OF GENERAL VIROLOGY

Targeting of Toll-like receptors: a decade of progress in combating infectious diseases

(2011) Mona Hedayat et al.   LANCET INFECTIOUS DISEASES

Defective Interfering Viral Particles in Acute Dengue Infections

(2011) Dongsheng Li et al.   PLoS One

A novel broad-spectrum treatment for respiratory virus infections: Influenza-based defective interfering virus provides protection against pneumovirus infection in vivo

(2011) Andrew J. Easton et al.   VACCINE

Safety and immunogenicity of a recombinant M2e–flagellin influenza vaccine (STF2.4xM2e) in healthy adults

(2011) Christine B. Turley et al.   VACCINE

Failure to activate the IFN-β promoter by a paramyxovirus lacking an interferon antagonist

(2011) M.J. Killip et al.   VIROLOGY

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

Induction of CD8+ T-Cell Responses Against Novel Glioma–Associated Antigen Peptides and Clinical Activity by Vaccinations With α-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma

(2010) Hideho Okada et al.   JOURNAL OF CLINICAL ONCOLOGY

Global, regional, and national causes of child mortality in 2008: a systematic analysis

(2010) Robert E Black et al.   LANCET

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

(2010) A. Baum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Key concepts in immunology

(2010) Muriel Moser et al.   VACCINE

Heterocellular induction of interferon by negative-sense RNA viruses

(2010) S. Chen et al.   VIROLOGY

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Dendritic cells require a systemic type I interferon response to mature and induce CD4+Th1 immunity with poly IC as adjuvant

(2009) M. Paula Longhi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

Randomized, Double‐Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria‐Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

(2009) Kent E. Kester et al.   JOURNAL OF INFECTIOUS DISEASES

Defective interfering viruses and their potential as antiviral agents

(2009) A. C. Marriott et al.   REVIEWS IN MEDICAL VIROLOGY

Defective Interfering RNAs: Foes of Viruses and Friends of Virologists

(2009) Kunj Pathak et al.   Viruses-Basel

Synthetic Double-Stranded RNAs Are Adjuvants for the Induction of T Helper 1 and Humoral Immune Responses to Human Papillomavirus in Rhesus Macaques

(2009) Christiane Stahl-Hennig et al.   PLoS Pathogens

Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant

(2008) C. R. Casella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human Papillomavirus Types 16 and 18 Vaccine (Recombinant, AS04 Adjuvanted, Adsorbed) [Cervarix???]

(2008) Susan J Keam et al.   DRUGS

A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: a North American Brain Tumor Consortium (NABTC01-05)

(2008) Nicholas Butowski et al.   JOURNAL OF NEURO-ONCOLOGY

Toll-like receptor 9 (TLR9) agonists in the treatment of cancer

(2008) A M Krieg   ONCOGENE

The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine

(2008) C. Trumpfheller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

(2007) R. E. Randall et al.   JOURNAL OF GENERAL VIROLOGY