Applications of nanomaterials as vaccine adjuvants

SCIENCE & TECHNOLOGY CONCENTRATES

(2016)   CHEMICAL & ENGINEERING NEWS

Nanoparticle-Delivered Transforming Growth Factor-β siRNA Enhances Vaccination against Advanced Melanoma by Modifying Tumor Microenvironment

(2014) Zhenghong Xu et al.   ACS Nano

Emerging micro- and nanotechnology based synthetic approaches for insulin delivery

(2014) Ran Mo et al.   CHEMICAL SOCIETY REVIEWS

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Engineering the Assemblies of Biomaterial Nanocarriers for Delivery of Multiple Theranostic Agents with Enhanced Antitumor Efficacy

(2013) Hai Wang et al.   ADVANCED MATERIALS

Manipulating the antigen-specific immune response by the hydrophobicity of amphiphilic poly(γ-glutamic acid) nanoparticles

(2013) Fumiaki Shima et al.   BIOMATERIALS

SnapShot: Inflammasomes

(2013) Maninjay K. Atianand et al.   CELL

Can Controversial Nanotechnology Promise Drug Delivery?

(2013) Venkat Ratnam Devadasu et al.   CHEMICAL REVIEWS

Materials based tumor immunotherapy vaccines

(2013) Weiwei Aileen Li et al.   CURRENT OPINION IN IMMUNOLOGY

Cationic polypeptide micelle-based antigen delivery system: A simple and robust adjuvant to improve vaccine efficacy

(2013) Zichao Luo et al.   JOURNAL OF CONTROLLED RELEASE

Immune system targeting by biodegradable nanoparticles for cancer vaccines

(2013) Joana M. Silva et al.   JOURNAL OF CONTROLLED RELEASE

Induction of innate immunity in lungs with virus-like nanoparticles leads to protection against influenza and Streptococcus pneumoniae challenge

(2013) Claudia Mathieu et al.   Nanomedicine-Nanotechnology Biology and Medicine

PLGA nanoparticles loaded with KMP-11 stimulate innate immunity and induce the killing of Leishmania

(2013) Diego M. Santos et al.   Nanomedicine-Nanotechnology Biology and Medicine

Antigen-loaded nanocarriers enhance the migration of stimulated Langerhans cells to draining lymph nodes and induce effective transcutaneous immunization

(2013) Ni Li et al.   Nanomedicine-Nanotechnology Biology and Medicine

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

A Single-Dose PLGA Encapsulated Protective Antigen Domain 4 Nanoformulation Protects Mice against Bacillus anthracis Spore Challenge

(2013) Manish Manish et al.   PLoS One

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

(2013) A. de Titta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dual-Responsive Mesoporous Silica Nanoparticle for Tumor-Triggered Targeting Drug Delivery

(2013) Dong Xiao et al.   Small

The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect

(2013) Samuele Calabro et al.   VACCINE

Particle based vaccine formulations for transcutaneous immunization

(2013) Ankit Mittal et al.   Human Vaccines & Immunotherapeutics

A novel and efficient nicotine vaccine using nano-lipoplex as a delivery vehicle

(2013) Yun Hu et al.   Human Vaccines & Immunotherapeutics

Vaccine delivery using nanoparticles

(2013) Anthony E. Gregory et al.   Frontiers in Cellular and Infection Microbiology

Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate

(2012) Motao Zhu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Receptor-Mediated Delivery of Magnetic Nanoparticles across the Blood–Brain Barrier

(2012) Ruirui Qiao et al.   ACS Nano

Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8+T-cell responses in melanoma patients

(2012) Simone M. Goldinger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

pH-responsive composite microspheres based on magnetic mesoporous silica nanoparticle for drug delivery

(2012) Hao Wen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Targeting tumor antigens to dendritic cells using particulate carriers

(2012) Medha D. Joshi et al.   JOURNAL OF CONTROLLED RELEASE

Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells

(2012) Wendy W.J. Unger et al.   JOURNAL OF CONTROLLED RELEASE

pH and Redox Dual Responsive Nanoparticle for Nuclear Targeted Drug Delivery

(2012) Remant Bahadur K. C. et al.   MOLECULAR PHARMACEUTICS

Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens

(2012) Frank Wegmann et al.   NATURE BIOTECHNOLOGY

Protective Antibody and CD8+ T-Cell Responses to the Plasmodium falciparum Circumsporozoite Protein Induced by a Nanoparticle Vaccine

(2012) Stephen A. Kaba et al.   PLoS One

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

(2012) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Particokinetics of Engineered Nanomaterials for Safe and Effective Therapeutic Applications

(2012) Motao Zhu et al.   Small

Micro/nanoparticle adjuvants for antileishmanial vaccines: Present and future trends

(2012) Ali Badiee et al.   VACCINE

Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris

(2012) Brian Scharf et al.   Nature Communications

Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy

(2012) Hui Yang et al.   Scientific Reports

Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism

(2011) Jaana Palomäki et al.   ACS Nano

Negotiation of Intracellular Membrane Barriers by TAT-Modified Gold Nanoparticles

(2011) Željka Krpetić et al.   ACS Nano

Amino-Functionalized Polystyrene Nanoparticles Activate the NLRP3 Inflammasome in Human Macrophages

(2011) Oleg Lunov et al.   ACS Nano

Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations

(2011) Samar Hamdy et al.   ADVANCED DRUG DELIVERY REVIEWS

Material properties in complement activation

(2011) S. Moein Moghimi et al.   ADVANCED DRUG DELIVERY REVIEWS

Surface Charge Affects Cellular Uptake and Intracellular Trafficking of Chitosan-Based Nanoparticles

(2011) Zhan-Guo Yue et al.   BIOMACROMOLECULES

The use of a gold nanoparticle-based adjuvant to improve the therapeutic efficacy of hNgR-Fc protein immunization in spinal cord-injured rats

(2011) Yong-Tang Wang et al.   BIOMATERIALS

The influence of PEG chain length and targeting moiety on antibody-mediated delivery of nanoparticle vaccines to human dendritic cells

(2011) Luis J. Cruz et al.   BIOMATERIALS

Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery

(2011) Zhiping Zhang et al.   BIOMATERIALS

Nanoparticle immunoagglutination Rayleigh scatter assay to complement microparticle immunoagglutination Mie scatter assay in a microfluidic device

(2011) Brian C. Heinze et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Targeted Drug Delivery Across Blood-Brain-Barrier Using Cell Penetrating Peptides Tagged Nanoparticles

(2011) Meenakshi Malhotra et al.   Current Nanoscience

DC-SIGN mediated antigen-targeting using glycan-modified liposomes: Formulation considerations

(2011) Medha D. Joshi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Induction of Inflammasome-dependent Pyroptosis by Carbon Black Nanoparticles

(2011) Anna C. Reisetter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular organelle-targeted non-viral gene delivery systems

(2011) Young-Wook Won et al.   JOURNAL OF CONTROLLED RELEASE

Kinetics of transport of doxorubicin bound to nanoparticles across the blood–brain barrier

(2011) Stefanie Wohlfart et al.   JOURNAL OF CONTROLLED RELEASE

Altering the immune response with lipid-based nanoparticles

(2011) Dalit Landesman-Milo et al.   JOURNAL OF CONTROLLED RELEASE

Transport of drugs across the blood–brain barrier by nanoparticles

(2011) Stefanie Wohlfart et al.   JOURNAL OF CONTROLLED RELEASE

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Nanoparticles versus the placenta

(2011) Jeffrey A. Keelan   Nature Nanotechnology

A multifunctional core–shell nanoparticle for dendritic cell-based cancer immunotherapy

(2011) Nam-Hyuk Cho et al.   Nature Nanotechnology

Silica and titanium dioxide nanoparticles cause pregnancy complications in mice

(2011) Kohei Yamashita et al.   Nature Nanotechnology

Nano-adjuvant: double TLR stimulation is the key

(2011) Alexandra Flemming   NATURE REVIEWS DRUG DISCOVERY

Activation of Antigen-Specific T Cell-Responses by Mannan-Decorated PLGA Nanoparticles

(2011) Samar Hamdy et al.   PHARMACEUTICAL RESEARCH

Binding of blood proteins to carbon nanotubes reduces cytotoxicity

(2011) C. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis

(2011) Marie Ballester et al.   VACCINE

Distinct Polymer Architecture Mediates Switching of Complement Activation Pathways at the Nanosphere−Serum Interface: Implications for Stealth Nanoparticle Engineering

(2010) Islam Hamad et al.   ACS Nano

Time Evolution of the Nanoparticle Protein Corona

(2010) Eudald Casals et al.   ACS Nano

Intracellular pH-Responsive Mesoporous Silica Nanoparticles for the Controlled Release of Anticancer Chemotherapeutics

(2010) Chia-Hung Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Titanium dioxide induces different levels of IL-1β production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B

(2010) Tomohiro Morishige et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transferrin-conjugated nanoparticles of Poly(lactide)-d-α-Tocopheryl polyethylene glycol succinate diblock copolymer for targeted drug delivery across the blood–brain barrier

(2010) Chee Wee Gan et al.   BIOMATERIALS

Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods

(2010) Yang Qiu et al.   BIOMATERIALS

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Strategies for the intracellular delivery of nanoparticles

(2010) Leo Y. T. Chou et al.   CHEMICAL SOCIETY REVIEWS

Relationship between the size of nanoparticles and their adjuvant activity: Data from a study with an improved experimental design

(2010) Xinran Li et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Potential of polymeric nanoparticles in AIDS treatment and prevention

(2010) Najeh Maissar Khalil et al.   Expert Opinion on Drug Delivery

Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses

(2010) Moses O Oyewumi et al.   Expert Review of Vaccines

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Variable Antibody-dependent Activation of Complement by Functionalized Phospholipid Nanoparticle Surfaces

(2010) Christine T. N. Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro

(2010) Luis J. Cruz et al.   JOURNAL OF CONTROLLED RELEASE

Controlling Ligand Surface Density Optimizes Nanoparticle Binding to ICAM-1

(2010) Amir Fakhari et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Targeting Nanosystems to Human DCs via Fc Receptor as an Effective Strategy to Deliver Antigen for Immunotherapy

(2010) Luis J. Cruz et al.   MOLECULAR PHARMACEUTICS

Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications

(2010) Jinjun Shi et al.   NANO LETTERS

Delivery of a peptide via poly(d,l-lactic-co-glycolic) acid nanoparticles enhances its dendritic cell–stimulatory capacity

(2010) Corbin Clawson et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1  and IL-1 

(2010) A. S. Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyethyleneimine Coating Enhances the Cellular Uptake of Mesoporous Silica Nanoparticles and Allows Safe Delivery of siRNA and DNA Constructs

(2009) Tian Xia et al.   ACS Nano

Application of nanotechnologies for improved immune response against infectious diseases in the developing world

(2009) Michael Look et al.   ADVANCED DRUG DELIVERY REVIEWS

Antigen Delivery with Poly(Propylacrylic Acid) Conjugation Enhances MHC-1 Presentation and T-Cell Activation

(2009) Suzanne Flanary et al.   BIOCONJUGATE CHEMISTRY

Effect of surface charge and agglomerate degree of magnetic iron oxide nanoparticles on KB cellular uptake in vitro

(2009) Yuqing Ge et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Barrier Capacity of Human Placenta for Nanosized Materials

(2009) Peter Wick et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Emulsion-based adjuvants for influenza vaccines

(2009) Frederick R Vogel et al.   Expert Review of Vaccines

Deposition of inhaled nanoparticles in the rat nasal passages: Dose to the olfactory region

(2009) Guilherme J. M. Garcia et al.   INHALATION TOXICOLOGY

Transport across the blood-brain barrier using albumin nanoparticles

(2009) Kinam Park   JOURNAL OF CONTROLLED RELEASE

Strong antibody responses induced by protein antigens conjugated onto the surface of lecithin-based nanoparticles

(2009) Brian R. Sloat et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticles Transferred from Pregnant Mice to Their Offspring Can Damage the Genital and Cranial Nerve Systems

(2009) Ken Takeda et al.   JOURNAL OF HEALTH SCIENCE

Materials engineering for immunomodulation

(2009) Jeffrey A. Hubbell et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Viruses as vaccine vectors for infectious diseases and cancer

(2009) Simon J. Draper et al.   NATURE REVIEWS MICROBIOLOGY

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of humoral and enhanced cellular immune responses by novel core–shell nanosphere- and microsphere-based vaccine formulations following systemic and mucosal administration

(2009) Antonella Caputo et al.   VACCINE

Enhanced Cell Penetration of Acid-Degradable Particles Functionalized with Cell-Penetrating Peptides

(2008) Jessica L. Cohen et al.   BIOCONJUGATE CHEMISTRY

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Delivery of antigen using a novel mannosylated dendrimer potentiates immunogenicityin vitro andin vivo

(2008) Kuo-Ching Sheng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Proton-Sponge Coated Quantum Dots for siRNA Delivery and Intracellular Imaging

(2008) Maksym V. Yezhelyev et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient MHC Class I Presentation by Controlled Intracellular Trafficking of Antigens in Octaarginine-modified Liposomes

(2008) Takashi Nakamura et al.   MOLECULAR THERAPY

Wide Varieties of Cationic Nanoparticles Induce Defects in Supported Lipid Bilayers

(2008) Pascale R. Leroueil et al.   NANO LETTERS

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Nanoparticle-mediated cellular response is size-dependent

(2008) Wen Jiang et al.   Nature Nanotechnology

Quantum Dots for Tracking Dendritic Cells and Priming an Immune Response In Vitro and In Vivo

(2008) Debasish Sen et al.   PLoS One

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetics of gold nanoparticles in the human placenta

(2008) Päivi K. Myllynen et al.   REPRODUCTIVE TOXICOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE