Article
Immunology
Stilla Bauernfeind, Sebastian Einhauser, Leonid Tydykov, Anna-Lena Mader, Bernd Salzberger, Florian Hitzenbichler, Arno Mohr, Ralph Burkhardt, Ralf Wagner, David Peterhoff
Summary: In a previous study, a significant association was found between reactogenicity and SARS-CoV-2 antibody titers and neutralization capacity in males after basic vaccination with BNT162b2, and this association persisted after booster vaccination. However, after booster vaccination, the association between reactogenicity and antibody response was no longer evident, especially in females.
Article
Immunology
Victoria G. Hall, Victor H. Ferreira, Heidi Wood, Matthew Ierullo, Beata Majchrzak-Kita, Kathy Manguiat, Alyssia Robinson, Vathany Kulasingam, Atul Humar, Deepali Kumar
Summary: Delayed dosing intervals can enhance immune response to COVID-19 vaccination, including virus neutralization against wild-type and variant viruses. This finding has significant implications for the global implementation of vaccines.
Article
Multidisciplinary Sciences
Fabrice Carrat, Paola Mariela Saba Villarroel, Nathanael Lapidus, Toscane Fourie, Helene Blanche, Celine Dorival, Jerome Nicol, Jean-Francois Deleuze, Olivier Robineau
Summary: This study found significant differences in the antibody response against SARS-CoV-2 in the general population depending on previous infection and vaccination, with factors such as age, gender, and vaccination time playing a role.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
Ana-Luisa Stefanski, Hector Rincon-Arevalo, Eva Schrezenmeier, Kirsten Karberg, Franziska Szelinski, Jacob Ritter, Bernd Jahrsdoerfer, Hubert Schrezenmeier, Carolin Ludwig, Arne Sattler, Katja Kotsch, Yidan Chen, Anne Claussnitzer, Hildrun Haibel, Fabian Proft, Gabriela Guerra, Pawel Durek, Frederik Heinrich, Marta Ferreira-Gomes, Gerd R. Burmester, Andreas Radbruch, Mir-Farzin Mashreghi, Andreia C. Lino, Thomas Doerner
Summary: Patients with autoimmune inflammatory rheumatic diseases receiving rituximab (RTX) therapy require a minimum of 10 B cells per microliter in the peripheral circulation to mount an appropriate immune response to SARS-CoV-2 vaccination. Functionally relevant B cell depletion results in impaired interferon-gamma secretion by spike-specific CD4 T cells.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Fisheries
Yingli Gao, Lu Qiang, Liyuan Zhang, Ruiming Tan, Xingqiang Wang, Yongxiang Yu
Summary: This study investigated the mucosal and humoral immune responses of javelin goby to immersion vaccination with Vibrio vulnificus bacterin. The results showed that serum antibody titers increased gradually after vaccination, while mucosal antibody titers in the gill, skin, and intestine showed a faster response. Antigen uptake was significantly enhanced in mucosa-associated tissues compared to other organs. The histological results indicated an increase in mucous cell numbers in mucosa-associated tissues, with a shift in mucin components. These findings provide valuable information on mucosal immunity in fish and highlight the advantage of immersion vaccines in eliciting a high level of local immune response.
AQUACULTURE INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Simon Ronicke, Bilgin Osmanodja, Klemens Budde, Annika Jens, Charlotte Hammett, Nadine Koch, Bianca Zukunft, Friederike Bachmann, Mira Choi, Ulrike Weber, Bettina Eberspaecher, Joerg Hofmann, Fritz Grunow, Michael Mikhailov, Fabian Halleck, Eva Schrezenmeier
Summary: The immunogenicity of SARS-CoV-2 vaccines in kidney transplant recipients is limited, and repeated vaccinations show a decrease in antibody levels over time with high interindividual variability. Different assays may produce divergent results, suggesting the need for repeated sampling and shorter vaccination intervals in these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Zhaozhen Liu, Can Pang, Yuchuan Deng, Caiping Guo, Jia Li, Yanping Li, Ruolei Xin, Xiyao Li, Conghui Xu, Chun Huang, Hongyan Lu, Jie Li
Summary: This study investigated the immunogenicity of the quadrivalent inactivated influenza vaccine in HIV-infected and uninfected individuals, and found that HIV-infected individuals had weaker immune responses, especially those with CD4+ T cell counts below 350 cells/mm3.
Article
Biochemistry & Molecular Biology
Shruthishree D. Padiyappa, Hemavathi Avalappa, Madhusudana Somegowda, Shankarappa Sridhara, Yeldur P. Venkatesh, Bettadatunga T. Prabhakar, Siddanakoppalu N. Pramod, Mona S. Almujaydil, Shadi Shokralla, Ashraf M. M. Abdelbacki, Hosam O. Elansary, Ahmed M. El-Sabrout, Eman A. Mahmoud
Summary: This study investigated the immunogenicity and adjuvanticity of garlic agglutinins (ASA) and found that they can modulate immune cells and affect the immune response to food antigens. The results suggest that ASA has the potential to be used as an oral and mucosal adjuvant for delivering weak antigens.
Article
Geriatrics & Gerontology
T. -Y. Lin, S. -C Hung
Summary: This study found that frailty is associated with impaired humoral responses following COVID-19 vaccination among hemodialysis patients. Frail patients had progressively lower levels of antibodies and a lower likelihood of antibody seroconversion after vaccination.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Immunology
Jakub Wronski, Bozena Jaszczyk, Leszek Roszkowski, Anna Felis-Giemza, Krzysztof Bonek, Anna Kornatka, Magdalena Plebanczyk, Tomasz Burakowski, Barbara Lisowska, Brygida Kwiatkowska, Wlodzimierz Maslinski, Malgorzata Wislowska, Magdalena Massalska, Marzena Ciechomska, Ewa Kuca-Warnawin
Summary: Patients with inflammatory arthritis show lower humoral and cellular responses after receiving the COVID-19 booster vaccine compared to healthy controls. Immunomodulatory drugs may impact the immune response post booster vaccination.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Alexis Cuffel, Sarah Maylin, Helene Le Buanec, Constance Delaugerre, Marine Minier, David Bergerat, Marine Merandet, Charles Cassius, Regis Peffault de Latour, Jerome Le Goff, Gerard Socie, Sophie Caillat-Zucman, Marie Robin, Alienor Xhaard
Summary: In this study, alloHSCT recipients who received two BNT162b2 doses were prospectively studied. All patients seroconverted, and there were no significant differences in anti-S IgG levels and neutralizing antibodies percentages between the two groups. Some low serological responders had detectable CD4 + T cell proliferative responses.
Article
Multidisciplinary Sciences
Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Miwa Sasai, Chin Yang Chang, Jiayu A. Tai, Tomoyuki Nishikawa, Kunihiko Yamashita, Naoki Sakaguchi, Shota Yoshida, Satoshi Baba, Munehisa Shimamura, Sachiko Okamoto, Yasunori Amaishi, Hideto Chono, Junichi Mineno, Hiromi Rakugi, Ryuichi Morishita, Masahiro Yamamoto, Hironori Nakagami
Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic. New technologies, including mRNA vaccines, have been used to develop vaccines to prevent the spread of the virus. Researchers have modified a DNA vaccine to enhance its antigenicity and further updated it to target the Delta variant. The study found that intradermal injection using a pyro-drive jet injector induced higher levels of neutralizing antibodies and effectively protected mice from Delta variant infection.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Ruben Rose, Franziska Neumann, Olaf Grobe, Thomas Lorentz, Helmut Fickenscher, Andi Krumbholz
Summary: This study compared the humoral immune response after heterologous vaccination with a SARS-CoV-2 vector vaccine and mRNA vaccine, and the antibody response after homologous vaccination schemes. The study found that heterologous vaccination resulted in a strong antibody response comparable to that of a homologous BNT162b2 vaccination scheme, indicating the development of a robust humoral immunity. However, for the delta variant, a reduction in neutralizing efficacy was observed in some participants.
Review
Biochemistry & Molecular Biology
Jeong-Ju Yoo, Dong Keon Yon, Seung Won Lee, Jae Il Shin, Beom Kyung Kim
Summary: After SARS-CoV-2 vaccination, OLT recipients had a 70% humoral immune response rate, lower than healthy controls but favorable compared to other solid organ transplant recipients. Factors such as male sex, old age, chronic kidney disease, obesity, and high immunosuppressant doses increased the risk of unresponsiveness in OLT patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Myeong Hee Kim, So Young Kang, Woo In Lee, Min Young Lee
Summary: We evaluated the immunogenicity of ChAdOx1 nCoV-19 vaccination by measuring SARS-CoV-2 IgG levels and studying the influence of factors such as gender, age, and adverse reactions. The study involved 1028 serum samples from 452 healthcare workers. SARS-CoV-2 IgG levels were measured using the SARS-CoV-2 IgG II Quant assay. Participants provided information on the intensity and duration of adverse reactions. The seropositive rates after the first and second doses were 95.5% and 100%, respectively. Median antibody levels showed a 4.2-fold increase after the second dose and a 3.5-fold decrease five months later.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Chemistry, Physical
Gabriela Navarro-Tovar, Denisse Rocha-Garcia, Alejandra Wong-Arce, Gabriela Palestino, Sergio Rosales-Mendoza
Article
Polymer Science
Denisse Rocha-Garcia, M. de Lourdes Betancourt-Mendiola, Alejandra Wong-Arce, Sergio Rosales-Mendoza, Jaime Reyes-Hernandez, Omar Gonzalez-Ortega, Gabriela Palestino
EUROPEAN POLYMER JOURNAL
(2018)
Article
Fisheries
M. Tello-Olea, S. Rosales-Mendoza, A. Campa-Cordova, G. Palestino, A. Luna-Gonzalez, M. Reyes-Becerril, E. Velazquez, L. Hernandez-Adame, C. Angulo
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Pharmacology & Pharmacy
Rosalba Patino-Herrera, Jose Francisco Louvier-Hernandez, Eleazar M. Escamilla-Silva, Julie Chaumel, Alma Gabriela Palestino Escobedo, Elias Perez
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Chemistry, Physical
Cesar del Angel-Olarte, Luis Hernandez-Adame, Antonio Mendez-Blas, Gabriela Palestino
JOURNAL OF ALLOYS AND COMPOUNDS
(2019)
Article
Engineering, Environmental
Gabriela S. Garcia-Briones, Raul Ocampo-Perez, Cesar F. A. Gomez-Duran, Teresa Neri-Gomez, Gabriela Palestino
CHEMICAL ENGINEERING JOURNAL
(2019)
Article
Biochemistry & Molecular Biology
Luis Hernandez-Adame, Carlos Angulo, Karen Delgado, Marion Schiavone, Mathieu Castex, Gabriela Palestino, Lourdes Betancourt-Mendiola, Martha Reyes-Becerril
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Polymer Science
Miguel Olvera-Sosa, Antonio Guerra-Contrera, Cesar F. A. Gomez-Duran, Raul Gonzalez-Garcia, Gabriela Palestino
JOURNAL OF APPLIED POLYMER SCIENCE
(2020)
Article
Engineering, Environmental
Benita Ortega-Berlanga, Luis Hernandez-Adame, Cesar del Angel-Olarte, Fernanda Aguilar, Sergio Rosales-Mendoza, Gabriela Palestino
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Polymer Science
Antonio Guerra-Contreras, Abygail Camacho-Ramirez, Miguel Olvera-Sosa, Raul Gonzalez-Garcia, Gabriela Palestino
Summary: The paper presents an alternative method for rust removal on metallic surfaces using poly(acrylic acid) and poly(acrylic acid-co-itaconic acid), which proves to be effective and environmentally friendly. Experimental results indicate that the molecular weight of the polymers, and thus the rust removal effectiveness, can be controlled by adjusting the molar ratio of the initiator and monomers.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Miguel Olvera-Sosa, Sergio Rosales-Mendoza, Gabriela S. Garcia-Briones, Maria De Lourdes Betancourt-Mendiola, Omar Gonzalez-Ortega, Gabriela Palestino
Summary: The innovative synthesis of a bio-based poly(acrylic acid) and Schizochytrium sp. resulted in new hybrid biopolymers with thermal and mechanical properties dependent on microalgae biomass type and concentration. The copolymers showed different behaviors based on the source of microalgae used in the synthesis.
MATERIALS TODAY COMMUNICATIONS
(2021)
Review
Crystallography
Benita Ortega-Berlanga, Lourdes Betancourt-Mendiola, Cesar del Angel-Olarte, Luis Hernandez-Adame, Sergio Rosales-Mendoza, Gabriela Palestino
Summary: In the past decade, there has been an increase in publications focusing on the novel physical and chemical aspects of gadolinium-based oxide and oxysulfide particles, particularly in the biomedical field. These materials show promising optical properties for developing new probes and bioimaging techniques, with interesting optical behavior influenced by various factors. The review summarizes the latest research on evaluating the optical properties of these particles and their potential applications in MRI contrast agents and drug delivery vehicles, while also discussing administration routes, biodistribution, cytotoxicity, and future perspectives in the field.
Article
Pharmacology & Pharmacy
Ileana Garcia-Silva, Miguel Olvera-Sosa, Benita Ortega-Berlanga, Victor Ruiz-Rodriguez, Gabriela Palestino, Sergio Rosales-Mendoza
Summary: In this study, hybrid polyacrylic acid and Schizochytrium sp. microalgae (PAA/Schizo) microgels were synthesized using the cell wall fraction as crosslinker. The physicochemical characterization showed that the microgels were stable, negatively charged, and not toxic to cells. The microgels demonstrated efficient loading of bovine serum albumin (BSA) and showed potential as antigen delivery vehicles for immunotherapy development.
Article
Dentistry, Oral Surgery & Medicine
Jose R. Gutierrez-Camacho, Luis Alejandro Aguilera-Galaviz, G. Sanchez-Balderas, Gabriela Palestino, Norma Veronica Zavala-Alonso, Cesar Gaitan-Fonseca
Summary: This study evaluated enamel surface hydrophobic modification as a method to prevent demineralization. The results showed that 1% and 4% octadeyltrichlorosilane provided protection to the tooth enamel surface, preventing demineralization in acidic medium. This method is feasible for clinical practice.
ODOVTOS INTERNATIONAL JOURNAL OF DENTAL SCIENCES
(2022)
Article
Chemistry, Analytical
Candida Anahy Cisneros-Covarrubias, Gabriela Palestino, Cesar F. A. Gomez-Duran, Sergio Rosales-Mendoza, Maria de Lourdes Betancourt-Mendiola
Summary: An optimized microwave-assisted method for chemical functionalization of porous silicon particles was proposed in this study, showing improved efficiency and reduced reaction time. The impact of microwave irradiation on surface coverage was found to be dependent on various factors, including the surface chemistry of PSip and reaction conditions.
ANALYTICAL METHODS
(2021)