Virus-like particle vaccines: immunology and formulation for clinical translation

Stability of virus-like particles of red-spotted grouper nervous necrosis virus in the aqueous state, and the vaccine potential of lyophilized particles

(2018) Nguyen Thi Lan et al.   BIOLOGICALS

Plant-expressed Hepatitis B core antigen virus-like particles: Characterization and investigation of their stability in simulated and pig gastro-intestinal fluids

(2017) Alberto Berardi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Novel adenovirus encoded virus-like particles displaying the placental malaria associated VAR2CSA antigen

(2017) Anne-Marie C. Andersson et al.   VACCINE

Developments in the formulation and delivery of spray dried vaccines

(2017) Gaurav Kanojia et al.   Human Vaccines & Immunotherapeutics

Virus-like Particle Display of the α-Gal Carbohydrate for Vaccination against Leishmania Infection

(2017) Anna Paula V. Moura et al.   ACS Central Science

Multi-target chimaeric VLP as a therapeutic vaccine in a model of colorectal cancer

(2017) Braeden Donaldson et al.   Journal for ImmunoTherapy of Cancer

Molecular pharming — VLPs made in plants

(2016) Johanna Marsian et al.   CURRENT OPINION IN BIOTECHNOLOGY

Vaccine adjuvants as potential cancer immunotherapeutics

(2016) Burcu Temizoz et al.   INTERNATIONAL IMMUNOLOGY

Viral protein requirements for assembly and release of human parainfluenza virus type 3 virus-like particles

(2016) Megan K. Bracken et al.   JOURNAL OF GENERAL VIROLOGY

Optimized Formulation of a Thermostable Spray-Dried Virus-Like Particle Vaccine against Human Papillomavirus

(2016) Sugandha Saboo et al.   MOLECULAR PHARMACEUTICS

Development of an Interleukin-1β Vaccine in Patients with Type 2 Diabetes

(2016) Claudia Cavelti-Weder et al.   MOLECULAR THERAPY

Intellectual property policies in early-phase research in public–private partnerships

(2016) Hilde Stevens et al.   NATURE BIOTECHNOLOGY

Modular virus-like particles for sublingual vaccination against group A streptococcus

(2016) Arjun Seth et al.   VACCINE

Mucosal Antibodies Induced by Intranasal but Not Intramuscular Immunization Block Norovirus GII.4 Virus-Like Particle Receptor Binding

(2016) Kirsi Tamminen et al.   VIRAL IMMUNOLOGY

Novel miR-122 delivery system based on MS2 virus like particle surface displaying cell-penetrating peptide TAT for hepatocellular carcinoma

(2016) Guojing Wang et al.   Oncotarget

Novel Epstein-Barr virus-like particles incorporating gH/gL-EBNA1 or gB-LMP2 induce high neutralizing antibody titers and EBV-specific T-cell responses in immunized mice

(2016) Elizabeth M. Perez et al.   Oncotarget

Expression and Characterization of Yeast Derived Chikungunya Virus Like Particles (CHIK-VLPs) and Its Evaluation as a Potential Vaccine Candidate

(2016) Shweta Saraswat et al.   PLoS Neglected Tropical Diseases

In Vivo siRNA Delivery Using JC Virus-like Particles Decreases the Expression of RANKL in Rats

(2016) Daniel B Hoffmann et al.   Molecular Therapy-Nucleic Acids

Adjuvant-enhanced CD4 T Cell Responses are Critical to Durable Vaccine Immunity

(2016) Karen A.O. Martins et al.   EBioMedicine

Gene Therapy for Human Lung Adenocarcinoma Using a Suicide Gene Driven by a Lung-Specific Promoter Delivered by JC Virus-Like Particles

(2016) Chun-Nun Chao et al.   PLoS One

Chimeric Bivalent Virus-Like Particle Vaccine for H5N1 HPAI and ND Confers Protection against a Lethal Challenge in Chickens and Allows a Strategy of Differentiating Infected from Vaccinated Animals (DIVA)

(2016) Jin-Yong Noh et al.   PLoS One

TLR7/8 agonists promote NK–DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma

(2015) Zhixia Zhou et al.   CANCER LETTERS

Protective effect of a germline, IL-17-neutralizing antibody in murine models of autoimmune inflammatory disease

(2015) Kiran Dallenbach et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Activation of Toll-like receptor 7 inhibits the proliferation and migration, and induces the apoptosis of pancreatic cancer cells

(2015) BING-BING ZOU et al.   Molecular Medicine Reports

Anti-tumor effect of the alphavirus-based virus-like particle vector expressing prostate-specific antigen in a HLA–DR transgenic mouse model of prostate cancer

(2015) V. Riabov et al.   VACCINE

Preclinical refinements of a broadly protective VLP-based HPV vaccine targeting the minor capsid protein, L2

(2015) Ebenezer Tumban et al.   VACCINE

The large-scale production of an artificial influenza virus-like particle vaccine in silkworm pupae

(2015) Kuniaki Nerome et al.   VACCINE

Vaccine instability in the cold chain: Mechanisms, analysis and formulation strategies

(2014) Ozan S. Kumru et al.   BIOLOGICALS

Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars

(2014) W.F. Tonnis et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Immunotherapy of type-1 allergies with virus-like particles and CpG-motifs

(2014) Ludger Klimek et al.   Expert Review of Clinical Immunology

Influence of parenteral administration routes and additional factors on vaccine safety and immunogenicity: a review of recent literature

(2014) Christian Herzog   Expert Review of Vaccines

Virus-Like Display of a Neo-Self Antigen Reverses B Cell Anergy in a B Cell Receptor Transgenic Mouse Model

(2014) Bryce Chackerian et al.   JOURNAL OF IMMUNOLOGY

Raising Expectations For Subunit Vaccine

(2014) John T. Schiller et al.   JOURNAL OF INFECTIOUS DISEASES

Chimeric GII.4 Norovirus Virus-Like-Particle-Based Vaccines Induce Broadly Blocking Immune Responses

(2014) K. Debbink et al.   JOURNAL OF VIROLOGY

αEnv-decorated phosphatidylserine liposomes trigger phagocytosis of HIV-virus-like particles in macrophages

(2014) Andrea Gramatica et al.   Nanomedicine-Nanotechnology Biology and Medicine

An Engineered Non-Toxic Superantigen Increases Cross Presentation of Hepatitis B Virus Nucleocapsids by Human Dendritic Cells

(2014) Julie D. McIntosh et al.   PLoS One

Mannosylation of Virus-Like Particles Enhances Internalization by Antigen Presenting Cells

(2014) Farah Al-Barwani et al.   PLoS One

Freeze-Drying of Plant Tissue Containing HBV Surface Antigen for the Oral Vaccine against Hepatitis B

(2014) Marcin Czyż et al.   Biomed Research International

Bioengineering virus-like particles as vaccines

(2013) Linda H.L. Lua et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine

(2013) Yap P. Chuan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Long-Term Protective Immunity from an Influenza Virus-Like Particle Vaccine Administered with a Microneedle Patch

(2013) Fu-Shi Quan et al.   Clinical and Vaccine Immunology

Virus-like particles: the future of microbial factories and cell-free systems as platforms for vaccine development

(2013) William A Rodríguez-Limas et al.   CURRENT OPINION IN BIOTECHNOLOGY

Messenger RNA vaccine based on recombinant MS2 virus-like particles against prostate cancer

(2013) Jinming Li et al.   INTERNATIONAL JOURNAL OF CANCER

Evaluation of the stability of enterovirus 71 virus-like particle

(2013) Shih-Yeh Lin et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Development of a Stable Virus-Like Particle Vaccine Formulation against Chikungunya Virus and Investigation of the Effects of Polyanions

(2013) Ryan M. Kramer et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Virus-like particle formulation optimization by miniaturized high-throughput screening

(2013) Johannes Mohr et al.   METHODS

An Enhanced Heterologous Virus-Like Particle for Human Papillomavirus Type 16 Tumour Immunotherapy

(2013) Khairunadwa Jemon et al.   PLoS One

Hepatitis B virus-like particles access major histocompatibility class I and II antigen presentation pathways in primary dendritic cells

(2013) Jessica M. Moffat et al.   VACCINE

A universal virus-like particle-based vaccine for human papillomavirus: Longevity of protection and role of endogenous and exogenous adjuvants

(2013) Ebenezer Tumban et al.   VACCINE

Encapsulation and delivery of plasmid DNA by virus-like nanoparticles engineered from Macrobrachium rosenbergii nodavirus

(2013) Pitchanee Jariyapong et al.   VIRUS RESEARCH

A VLP-based vaccine against interleukin-1α protects mice from atherosclerosis

(2012) Alain C. Tissot et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Influenza vaccines: T-cell responses deserve more attention

(2012) Michael Schotsaert et al.   Expert Review of Vaccines

Innate Immunity Mediates Follicular Transport of Particulate but Not Soluble Protein Antigen

(2012) A. Link et al.   JOURNAL OF IMMUNOLOGY

Antigen Incorporated In Virus-like Particles Is Delivered to Specific Dendritic Cell Subsets That Induce An Effective Antitumor Immune Response In Vivo

(2012) Kunyu Li et al.   JOURNAL OF IMMUNOTHERAPY

Construction and Characterization of Virus-Like Particles: A Review

(2012) Andris Zeltins   MOLECULAR BIOTECHNOLOGY

Norovirus P particle: a subviral nanoparticle for vaccine development against norovirus, rotavirus and influenza virus

(2012) Ming Tan et al.   Nanomedicine

Disassembly and reassembly improves morphology and thermal stability of human papillomavirus type 16 virus-like particles

(2012) Qinjian Zhao et al.   Nanomedicine-Nanotechnology Biology and Medicine

Low-affinity B cells transport viral particles from the lung to the spleen to initiate antibody responses

(2012) J. Bessa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chimeric hepatitis E virus-like particle as a carrier for oral-delivery

(2012) Pitchanee Jariyapong et al.   VACCINE

Stability studies of HIV-1 Pr55gag virus-like particles made in insect cells after storage in various formulation media

(2012) Alisson Lynch et al.   Virology Journal

Cell-Specific Delivery of Diverse Cargos by Bacteriophage MS2 Virus-like Particles

(2011) Carlee E. Ashley et al.   ACS Nano

Human parvovirus B19 virus-like particles: In vitro assembly and stability

(2011) Sandra P. Sánchez-Rodríguez et al.   BIOCHIMIE

GMP issues for recombinant plant-derived pharmaceutical proteins

(2011) Rainer Fischer et al.   BIOTECHNOLOGY ADVANCES

Human JC virus-like particles as a gene delivery vector

(2011) Chi-Fang Chang et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

T-cell-mediated and humoral approaches to universal influenza vaccines

(2011) Maja A Sommerfelt   Expert Review of Vaccines

Cross-presentation of epitopes on virus-like particles via the MHC I receptor recycling pathway

(2011) Stephanie J Win et al.   IMMUNOLOGY AND CELL BIOLOGY

Induction of Virus-Specific Cytotoxic T Lymphocytes as a Basis for the Development of Broadly Protective Influenza Vaccines

(2011) Marine L. B. Hillaire et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Influenza Hemagglutination-Inhibition Antibody Titer as a Correlate of Vaccine-Induced Protection

(2011) Suzanne E. Ohmit et al.   JOURNAL OF INFECTIOUS DISEASES

Germinal center B and follicular helper T cells: siblings, cousins or just good friends?

(2011) Stephen L Nutt et al.   NATURE IMMUNOLOGY

Influenza virus-like particle can accommodate multiple subtypes of hemagglutinin and protect from multiple influenza types and subtypes

(2011) Peter Pushko et al.   VACCINE

Generating enveloped virus-like particles with in vitro assembled cores

(2011) Fan Cheng et al.   VIROLOGY

Prime immunization with rotavirus VLP 2/6 followed by boosting with an adenovirus expressing VP6 induces protective immunization against rotavirus in mice

(2011) Hongli Zhou et al.   Virology Journal

Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway

(2011) Erik de Vries et al.   PLoS Pathogens

The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice

(2010) Fang Ma et al.   Cellular & Molecular Immunology

Multivalent Display and Receptor-Mediated Endocytosis of Transferrin on Virus-Like Particles

(2010) Deboshri Banerjee et al.   CHEMBIOCHEM

Efficient gene transfer using the human JC virus-like particle that inhibits human colon adenocarcinoma growth in a nude mouse model

(2010) L-S Chen et al.   GENE THERAPY

T Cell-dependent and -Independent IgA Responses: Role of TLR Signalling

(2010) Juliana Bessa et al.   IMMUNOLOGICAL INVESTIGATIONS

Memory and Effector CD8 T-cell Responses After Nanoparticle Vaccination of Melanoma Patients

(2010) Daniel E. Speiser et al.   JOURNAL OF IMMUNOTHERAPY

Influenza Virus M2 Ion Channel Protein Is Necessary for Filamentous Virion Formation

(2010) J. S. Rossman et al.   JOURNAL OF VIROLOGY

Carrier induced epitopic suppression of antibody responses induced by virus-like particles is a dynamic phenomenon caused by carrier-specific antibodies

(2010) Andrea Jegerlehner et al.   VACCINE

The Length of Vesicular Stomatitis Virus Particles Dictates a Need for Actin Assembly during Clathrin-Dependent Endocytosis

(2010) David K. Cureton et al.   PLoS Pathogens

A virosomal formulated Her-2/neu multi-peptide vaccine induces Her-2/neu-specific immune responses in patients with metastatic breast cancer: a phase I study

(2009) Ursula Wiedermann et al.   BREAST CANCER RESEARCH AND TREATMENT

Conduits Mediate Transport of Low-Molecular-Weight Antigen to Lymph Node Follicles

(2009) Ramon Roozendaal et al.   IMMUNITY

Alveolar Macrophages and Lung Dendritic Cells Sense RNA and Drive Mucosal IgA Responses

(2009) J. Bessa et al.   JOURNAL OF IMMUNOLOGY

Virus-like Particle (VLP) Lymphatic Trafficking and Immune Response Generation After Immunization by Different Routes

(2009) Rafael Cubas et al.   JOURNAL OF IMMUNOTHERAPY

Transdermal Influenza Immunization with Vaccine-Coated Microneedle Arrays

(2009) Dimitrios G. Koutsonanos et al.   PLoS One

Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge

(2009) Q. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eleven years of Inflexal® V—a virosomal adjuvanted influenza vaccine

(2009) Christian Herzog et al.   VACCINE

Rational Design of a Stable, Freeze-Dried Virus-Like Particle-Based Vaccine Formulation

(2008) R. Lang et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Better Influenza Vaccines for Older People: What Will It Take?

(2008) Janet E. McElhaney et al.   JOURNAL OF INFECTIOUS DISEASES

Physical Stabilization of Norwalk Virus‐Like Particles**The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation.

(2008) Julian Kissmann et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Vaccine against Nicotine for Smoking Cessation: A Randomized Controlled Trial

(2008) Jacques Cornuz et al.   PLoS One

Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus

(2008) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus-like particles from rabbit hemorrhagic disease virus can induce an anti-tumor response

(2008) Matthew Peacey et al.   VACCINE

Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies

(2008) Marina De Filette et al.   VACCINE

Influenza-pseudotyped Gag virus-like particle vaccines provide broad protection against highly pathogenic avian influenza challenge

(2008) Joel R. Haynes et al.   VACCINE

Immunogenicity and safety of measles-mumps-rubella-varicella (MMRV) vaccine followed by one dose of varicella vaccine in children aged 15 months–2 years or 2–6 years primed with measles-mumps-rubella (MMR) vaccine

(2008) Y. Gillet et al.   VACCINE

Efficient induction of mucosal and systemic immune responses by virus-like particles administered intranasally: implications for vaccine design

(2007) Juliana Bessa et al.   EUROPEAN JOURNAL OF IMMUNOLOGY