Hypoxia-Driven Effects in Cancer: Characterization, Mechanisms, and Therapeutic Implications

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

(2021) Nicole E. Scharping et al.   NATURE IMMUNOLOGY

Genome-wide CRISPR-Cas9 knockout library screening identified PTPMT1 in cardiolipin synthesis is crucial to survival in hypoxia in liver cancer

(2021) Macus Hao-Ran Bao et al.   Cell Reports

Cancer Stemness Meets Immunity: From Mechanism to Therapy

(2021) Peiwen Chen et al.   Cell Reports

Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer

(2021) Catríona M. Dowling et al.   Science Advances

Mechanism and current progress of Poly ADP-ribose polymerase (PARP) inhibitors in the treatment of ovarian cancer

(2020) Feiyue Zheng et al.   BIOMEDICINE & PHARMACOTHERAPY

HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis

(2020) Yanling Niu et al.   CANCER RESEARCH

Annual report to the nation on the status of cancer, part I: National cancer statistics

(2020) S. Jane Henley et al.   CANCER

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia

(2020) Sylwia Bartoszewska et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

YC-1 potentiates the antitumor activity of gefitinib by inhibiting HIF-1α and promoting the endocytic trafficking and degradation of EGFR in gefitinib-resistant non-small-cell lung cancer cells

(2020) Hui Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

HSP47 promotes metastasis of breast cancer by interacting with myosin IIA via the unfolded protein response transducer IRE1α

(2020) Akihiro Yoneda et al.   ONCOGENE

USP37 promotes deubiquitination of HIF2α in kidney cancer

(2020) Kai Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer

(2020) Ozge Saatci et al.   Nature Communications

Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer

(2020) Chengheng Liao et al.   Cancer Discovery

CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment

(2020) Yue Jin et al.   Frontiers in Oncology

A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence

(2020) Tianjun Zhou et al.   ACS Nano

Oxygenation and A2AR blockade to eliminate hypoxia/HIF-1α-adenosinergic immunosuppressive axis and improve cancer immunotherapy

(2020) Katarina Halpin-Veszeleiova et al.   CURRENT OPINION IN PHARMACOLOGY

Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity

(2020) Emma U. Hammarlund et al.   SCIENCE

IOX1 Suppresses Wnt Target Gene Transcription and Colorectal Cancer Tumorigenesis through Inhibition of KDM3 Histone Demethylases

(2020) Rosalie G. Hoyle et al.   MOLECULAR CANCER THERAPEUTICS

A metastasis map of human cancer cell lines

(2020) Xin Jin et al.   NATURE

HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells

(2019) Eloy Moreno Roig et al.   Cells

HIF Inhibitors: Status of Current Clinical Development

(2019) Jaleh Fallah et al.   Current Oncology Reports

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

(2019) Abhishek A. Chakraborty et al.   SCIENCE

Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer

(2019) Wei-Lun Hwang et al.   Journal of Hematology & Oncology

UTX Mutations in Human Cancer

(2019) Lu Wang et al.   CANCER CELL

Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy

(2019) Yuka Miyake et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

(2019) Yue Huang et al.   CANCER CELL

The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc

(2019) Han Dong et al.   NATURE IMMUNOLOGY

Cancer stemness, intratumoral heterogeneity, and immune response across cancers

(2019) Alex Miranda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting hypoxia-induced carbonic anhydrase IX enhances immune checkpoint blockade locally and systemically

(2019) Shawn C Chafe et al.   Cancer Immunology Research

Low CD8+ T Cell Infiltration and High PD-L1 Expression Are Associated with Level of CD44+/CD133+ Cancer Stem Cells and Predict an Unfavorable Prognosis in Pancreatic Cancer

(2019) Ya-Chin Hou et al.   Cancers

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

(2019) Yi-Ling Hsieh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy

(2019) Iris Uribesalgo et al.   EMBO Molecular Medicine

The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism

(2019) Soojeong Chang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma

(2019) Rui Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Impact of hypoxia on DNA repair and genome integrity

(2019) Alanna R Kaplan et al.   MUTAGENESIS

Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment

(2019) Elena Butturini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of hypoxia signalling: new implications for nephrology

(2019) Johannes Schödel et al.   Nature Reviews Nephrology

HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor in Clear Cell Renal Cell Carcinoma Patients

(2019) Kevin D Courtney et al.   CLINICAL CANCER RESEARCH

Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis

(2019) Inês Godet et al.   Nature Communications

Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer

(2019) Lawrence Fong et al.   Cancer Discovery

Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers

(2019) Emily N. Arner et al.   Frontiers in Oncology

Expression of HIF-1α is related to a poor prognosis and tamoxifen resistance in contralateral breast cancer

(2019) Annika Jögi et al.   PLoS One

TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss

(2019) Lianxin Hu et al.   Cancer Discovery

Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3

(2018) Richa Nigam et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

(2018) Thomas M. Ashton et al.   CLINICAL CANCER RESEARCH

A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer

(2018) Jing Dong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Diagnostic and Prognostic Biomarkers in ovarian cancer and the potential roles of cancer stem cells – An updated review

(2018) Thingreila Muinao et al.   EXPERIMENTAL CELL RESEARCH

Intermittent hypoxia induces a metastatic phenotype in breast cancer

(2018) Anna Chen et al.   ONCOGENE

Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins

(2018) Kalpana Deepa Priya Dorayappan et al.   ONCOGENE

Long Noncoding RNA in Cancer: Wiring Signaling Circuitry

(2018) Chunru Lin et al.   TRENDS IN CELL BIOLOGY

Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling

(2018) Maria Peiris-Pagès et al.   Oncotarget

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

(2018) Lan Thi Hanh Phi et al.   Stem Cells International

Up-regulation of miR-210 induced by a hypoxic microenvironment promotes breast cancer stem cells metastasis, proliferation, and self-renewal by targeting E-cadherin

(2018) Tingting Tang et al.   FASEB JOURNAL

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

(2018) Kunihiko Hinohara et al.   CANCER CELL

Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment

(2018) Kaitlin Graham et al.   International Journal of Nanomedicine

Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell

(2018) Yibing Si et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy

(2018) Priyamvada Jayaprakash et al.   JOURNAL OF CLINICAL INVESTIGATION

KDM5B Promotes Drug Resistance by Regulating Melanoma Propagating Cell Subpopulations

(2018) Xiaoni Liu et al.   MOLECULAR CANCER THERAPEUTICS

Independent Prognostic Value of Hypoxia-inducible Factor 1-alpha Expression in Small Cell Lung Cancer

(2017) Chang-Sheng Lin et al.   International Journal of Medical Sciences

Clinical Advances of Hypoxia-Activated Prodrugs in Combination With Radiation Therapy

(2017) Ishna N. Mistry et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Long noncoding RNA HAS2-AS1 mediates hypoxia-induced invasiveness of oral squamous cell carcinoma

(2017) Guiquan Zhu et al.   MOLECULAR CARCINOGENESIS

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

(2017) Georg Fluegen et al.   NATURE CELL BIOLOGY

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Expression of Hypoxia-Associated Protein HIF-1α in Follicular Thyroid Cancer is Associated with Distant Metastasis

(2017) Aumayr Klaus et al.   PATHOLOGY & ONCOLOGY RESEARCH

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

(2017) Jing-Wen Shih et al.   Nature Communications

Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

(2017) Yu-Xiong Feng et al.   Nature Communications

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway

(2017) Ying Pang et al.   Oncotarget

The extracellular vesicles secreted by lung cancer cells in radiation therapy promote endothelial cell angiogenesis by transferring miR-23a

(2017) Yongfa Zheng et al.   PeerJ

CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer

(2017) Jieyao Li et al.   OncoImmunology

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

(2016) Kimberly J. Briggs et al.   CELL

Breast cancer stem cell: the roles and therapeutic implications

(2016) Fang Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric Carcinoma

(2016) Phu Hung Nguyen et al.   CLINICAL CANCER RESEARCH

A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer

(2016) Stephen M Hatfield et al.   CURRENT OPINION IN PHARMACOLOGY

Hypoxic reprograming of H3K27me3 and H3K4me3 at the INK4A locus

(2016) Soojeong Chang et al.   FEBS LETTERS

Ultrasound Triggered Tumor Oxygenation with Oxygen-Shuttle Nanoperfluorocarbon to Overcome Hypoxia-Associated Resistance in Cancer Therapies

(2016) Xuejiao Song et al.   NANO LETTERS

Glycolysis and the pentose phosphate pathway are differentially associated with the dichotomous regulation of glioblastoma cell migration versus proliferation

(2016) Annegret Kathagen-Buhmann et al.   NEURO-ONCOLOGY

Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway

(2016) G R Sareddy et al.   ONCOGENE

A Phase II Trial of a Histone Deacetylase Inhibitor Panobinostat in Patients With Low-Grade Neuroendocrine Tumors

(2016) Ning Jin et al.   ONCOLOGIST

2-Methoxyestradiol inhibits the proliferation and migration and reduces the radioresistance of nasopharyngeal carcinoma CNE-2 stem cells via NF-κB/HIF-1 signaling pathway inactivation and EMT reversal

(2016) Shun-Long Wu et al.   ONCOLOGY REPORTS

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of multidrug resistance 1/P-glycoprotein on the hypoxia-induced multidrug resistance of human laryngeal cancer cells

(2016) Dawei Li et al.   Oncology Letters

Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia

(2015) Muhammad Zaeem Noman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

(2015) Helai P. Mohammad et al.   CANCER CELL

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine

(2015) T. Bishop et al.   CIRCULATION RESEARCH

EglN2 associates with the NRF1‐PGC1α complex and controls mitochondrial function in breast cancer

(2015) Jing Zhang et al.   EMBO JOURNAL

PHD1 regulates p53-mediated colorectal cancer chemoresistance

(2015) S. Deschoemaeker et al.   EMBO Molecular Medicine

Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality

(2015) A. McIntyre et al.   EMBO Molecular Medicine

UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1

(2015) H.-J. Choi et al.   EMBO REPORTS

IOX1, a JMJD2A inhibitor, suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II by regulating the expression of cell cycle-related proteins

(2015) QI HU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Four-Week Studies of Oral Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia

(2015) L. Holdstock et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Upregulation of extracellular matrix metalloproteinase inducer promotes hypoxia-induced epithelial-mesenchymal transition in esophageal cancer

(2015) XIAOPENG WU et al.   Molecular Medicine Reports

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Hyperoside induces apoptosis and inhibits growth in pancreatic cancer via Bcl-2 family and NF-κB signaling pathway both in vitro and in vivo

(2015) Yilong Li et al.   TUMOR BIOLOGY

Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation

(2015) Isabel R. Schlaepfer et al.   Oncotarget

Long Non Coding RNA MALAT1 Promotes Tumor Growth and Metastasis by inducing Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma

(2015) Xuan Zhou et al.   Scientific Reports

Elevated endoplasmic reticulum stress reinforced immunosuppression in the tumor microenvironment via myeloid-derived suppressor cells

(2015) Bo-Ra Lee et al.   Oncotarget

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

(2014) Joseph C. Walsh et al.   ANTIOXIDANTS & REDOX SIGNALING

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1

(2014) T. Umezu et al.   BLOOD

Epithelial-mesenchymal transition (EMT) markers have prognostic impact in multiple primary oral squamous cell carcinoma

(2014) Sabrina Daniela da Silva et al.   CLINICAL & EXPERIMENTAL METASTASIS

DNA double-strand break repair pathway choice and cancer

(2014) Tomas Aparicio et al.   DNA REPAIR

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells

(2014) XIAO-JIAN HAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia Promotes Dissemination and Colonization in New Bone Marrow Niches in Waldenström Macroglobulinemia

(2014) Barbara Muz et al.   MOLECULAR CANCER RESEARCH

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

(2014) Holger K. Eltzschig et al.   NATURE REVIEWS DRUG DISCOVERY

Effects of the HIF-1α and NF-κB loop on epithelial-mesenchymal transition and chemoresistance induced by hypoxia in pancreatic cancer cells

(2014) ZHUO-XIN CHENG et al.   ONCOLOGY REPORTS

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

(2014) T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation

(2014) P. Gasparini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

(2014) Debangshu Samanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of different hypoxia models on metastatic potential of SGC-7901 gastric cancer cells

(2014) Zhi-Feng Miao et al.   TUMOR BIOLOGY

Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells

(2013) Annegret Kathagen et al.   ACTA NEUROPATHOLOGICA

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Wnt/β-catenin signaling enhances hypoxia-induced epithelial–mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling

(2013) Qi Zhang et al.   CARCINOGENESIS

Oxygen-independent Regulation of HIF-1: Novel Involvement of PI3K/ AKT/mTOR Pathway in Cancer

(2013) Faton Agani et al.   CURRENT CANCER DRUG TARGETS

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Clinical and pathological impact ofVHL, PBRM1, BAP1, SETD2, KDM6A, andJARID1cin clear cell renal cell carcinoma

(2013) Lucy Gossage et al.   GENES CHROMOSOMES & CANCER

HIF1α and HIF2α independently activate SRC to promote melanoma metastases

(2013) Sara C. Hanna et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules

(2013) Anand Ramteke et al.   MOLECULAR CARCINOGENESIS

PERK/eIF2  signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

(2013) K. M. Rouschop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

(2013) J. Baginska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers

(2013) Justin K. Smit et al.   RADIOTHERAPY AND ONCOLOGY

Modulators of HIF1α and NFkB in Cancer Treatment: Is it a Rational Approach for Controlling Malignant Progression?

(2013) Marco Tafani et al.   Frontiers in Pharmacology

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

(2012) A. K. Azab et al.   BLOOD

TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells

(2012) Lionel Flamant et al.   BMC CANCER

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

From stem cells to cancer stem cells: HIF takes the stage

(2012) Kyoung Eun Lee et al.   CURRENT OPINION IN CELL BIOLOGY

Clinical and Pathologic Impact of Select Chromatin-modulating Tumor Suppressors in Clear Cell Renal Cell Carcinoma

(2012) A. Ari Hakimi et al.   EUROPEAN UROLOGY

Histone Deacetylases Activate Hepatocyte Growth Factor Signaling by Repressing MicroRNA-449 in Hepatocellular Carcinoma Cells

(2012) Reena Buurman et al.   GASTROENTEROLOGY

Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

(2012) Federica Maione et al.   JOURNAL OF CLINICAL INVESTIGATION

Combination therapy for hepatocellular carcinoma: Additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib

(2012) Anja Lachenmayer et al.   JOURNAL OF HEPATOLOGY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial dynamics regulates migration and invasion of breast cancer cells

(2012) J Zhao et al.   ONCOGENE

Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

(2012) L. Schito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

(2012) S. J. Conley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brief Report: Intravital Imaging of Cancer Stem Cell Plasticity in Mammary Tumors

(2012) Anoek Zomer et al.   STEM CELLS

Acute versus chronic hypoxia in tumors

(2012) C. Bayer et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression

(2011) M. Z. Noman et al.   CANCER RESEARCH

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer

(2011) J. D. Sun et al.   CLINICAL CANCER RESEARCH

Intestinal Hypoxia-inducible Factor-2α (HIF-2α) Is Critical for Efficient Erythropoiesis

(2011) Erik R. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

(2011) H Zhang et al.   ONCOGENE

Nuclear Factor-κB–Dependent Epithelial to Mesenchymal Transition Induced by HIF-1α Activation in Pancreatic Cancer Cells under Hypoxic Conditions

(2011) Zhuo-Xin Cheng et al.   PLoS One

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

(2011) C. C.-L. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

(2010) P. P. Kapitsinou et al.   BLOOD

Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability

(2010) I. M. Pires et al.   CANCER RESEARCH

Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment

(2010) N. Chan et al.   CANCER RESEARCH

Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stem-like characteristics in a hypoxic environment

(2010) M Takeuchi et al.   CELL DEATH AND DIFFERENTIATION

Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination

(2010) Einar K. Rofstad et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

(2010) Hakan Cam et al.   MOLECULAR CELL

Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity

(2010) Hsieh   ONCOLOGY REPORTS

Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells

(2009) Chie Kudo-Saito et al.   CANCER CELL

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

(2009) William Y. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

(2009) Nawneet K. Kurrey et al.   STEM CELLS

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY