Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury

(2014) Pinelopi P. Kapitsinou et al.   JOURNAL OF CLINICAL INVESTIGATION

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

Neutrophil Intercellular Communication in Acute Lung Injury. Emerging Roles of Microparticles and Gap Junctions

(2013) Viola Dengler et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Perioperative Organ Injury

(2013) Karsten Bartels et al.   ANESTHESIOLOGY

CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury

(2013) Heidi Ehrentraut et al.   FASEB JOURNAL

Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury

(2013) Tobias Eckle et al.   FASEB JOURNAL

Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice

(2013) Xiang Xue et al.   GASTROENTEROLOGY

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Fundamental role for HIF-1α in constitutive expression of human β defensin-1

(2013) C J Kelly et al.   Mucosal Immunology

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

AstraZeneca bets on FibroGen's anaemia drug

(2013) Monica Hoyos Flight   NATURE REVIEWS DRUG DISCOVERY

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Hypoxia Modulates Infection of Epithelial Cells by Pseudomonas aeruginosa

(2013) Bettina Schaible et al.   PLoS One

Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart

(2013) Z. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of IL-1 -induced NF- B by hydroxylases links key hypoxic and inflammatory signaling pathways

(2013) C. C. Scholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis

(2013) L. E. Glover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia and inflammation are two sides of the same coin

(2013) K. Bartels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuating myocardial ischemia by targeting A2B adenosine receptors

(2013) Holger K. Eltzschig et al.   TRENDS IN MOLECULAR MEDICINE

HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium

(2013) Tobias Eckle et al.   PLOS BIOLOGY

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success

(2012) Cristina Branco-Price et al.   CANCER CELL

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors

(2012) Yan Xia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Acute Respiratory Distress Syndrome

(2012)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Central Role for Endothelial Human Deneddylase-1/SENP8 in Fine-Tuning the Vascular Inflammatory Response

(2012) S. F. Ehrentraut et al.   JOURNAL OF IMMUNOLOGY

Paneth Cell-Mediated Multiorgan Dysfunction after Acute Kidney Injury

(2012) S. W. Park et al.   JOURNAL OF IMMUNOLOGY

A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection

(2012) Cheryl Y. M. Okumura et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

(2012) Tobias Eckle et al.   NATURE MEDICINE

Purinergic Signaling during Inflammation

(2012) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adora2b Adenosine Receptor Engagement Enhances Regulatory T Cell Abundance during Endotoxin-Induced Pulmonary Inflammation

(2012) Heidi Ehrentraut et al.   PLoS One

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Hypoxic Preconditioning Protects From Warm Liver Ischemia-Reperfusion Injury Through the Adenosine A2B Receptor

(2012) Alexander Choukèr et al.   TRANSPLANTATION

New Anemia Therapies: Translating Novel Strategies From Bench to Bedside

(2011) Iain C. Macdougall   AMERICAN JOURNAL OF KIDNEY DISEASES

Cardiopulmonary Bypass–associated Acute Kidney Injury

(2011) Avinash B. Kumar et al.   ANESTHESIOLOGY

Adenosine and Hypoxia-Inducible Factor Signaling in Intestinal Injury and Recovery

(2011) Sean P. Colgan et al.   Annual Review of Physiology

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Effect of Hypoxia-Inducible Factor-1α Gene Therapy on Walking Performance in Patients With Intermittent Claudication

(2011) Mark A. Creager et al.   CIRCULATION

Cancer Therapeutic Agents Targeting Hypoxia-Inducible Factor-1

(2011) R. Wang et al.   CURRENT MEDICINAL CHEMISTRY

Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis

(2011) Carol M Aherne et al.   GUT

Vasodilator Phosphostimulated Protein (VASP) Protects Endothelial Barrier Function During Hypoxia

(2011) Marthe A. Schmit et al.   INFLAMMATION

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia-Inducible Factor-1α–Dependent Protection from Intestinal Ischemia/Reperfusion Injury Involves Ecto-5′-Nucleotidase (CD73) and the A2B Adenosine Receptor

(2011) Melanie L. Hart et al.   JOURNAL OF IMMUNOLOGY

Neddylation-Induced Conformational Control Regulates Cullin RING Ligase Activity In Vivo

(2011) Boon Kim Boh et al.   JOURNAL OF MOLECULAR BIOLOGY

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

(2011) Bjoern O. Schroeder et al.   NATURE

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

(2011) Margaret S. Herridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Hydroxylase Inhibitor Dimethyloxallyl Glycine Attenuates Endotoxic Shock Via Alternative Activation of Macrophages and IL-10 Production by B1 Cells

(2011) Emily Hams et al.   SHOCK

The resurgence of A2B adenosine receptor signaling

(2010) Carol M. Aherne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation

(2010) A.-K. Riegel et al.   BLOOD

Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

(2010) Murtaza M. Tambuwala et al.   GASTROENTEROLOGY

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

Hypoxia-inducible factor-1α regulates β cell function in mouse and human islets

(2010) Kim Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

The Antimicrobial Peptide DEFB1 Is Associated with Caries

(2010) A. Ozturk et al.   JOURNAL OF DENTAL RESEARCH

SP1-Dependent Induction of CD39 Facilitates Hepatic Ischemic Preconditioning

(2010) M. L. Hart et al.   JOURNAL OF IMMUNOLOGY

Signaling through the A2B Adenosine Receptor Dampens Endotoxin-Induced Acute Lung Injury

(2010) U. Schingnitz et al.   JOURNAL OF IMMUNOLOGY

Metabolic Shifts in Immunity and Inflammation

(2010) D. J. Kominsky et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

(2010) W. M. Bernhardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial

(2010) Hans Erik Bøtker et al.   LANCET

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans

(2010) Cormac T. Taylor et al.   PHYSIOLOGY

Activation of Hypoxia Inducible Factor 1 Is a General Phenomenon in Infections with Human Pathogens

(2010) Nadine Werth et al.   PLoS One

Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon

(2010) L. Peyrin-Biroulet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Evidence for High-Altitude Adaptation in Tibet

(2010) T. S. Simonson et al.   SCIENCE

Adenosine: An Old Drug Newly Discovered

(2009) Holger K. Eltzschig   ANESTHESIOLOGY

MicroRNA Control in the Immune System: Basic Principles

(2009) Changchun Xiao et al.   CELL

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Crohn’s Disease: an Immune Deficiency State

(2009) Daniel J. B. Marks et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Regulation of Angiogenesis by Oxygen and Metabolism

(2009) Peter Fraisl et al.   DEVELOPMENTAL CELL

Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation

(2009) Holger K Eltzschig et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury

(2009) Martin Schneider et al.   GASTROENTEROLOGY

A 3′ UTR transition within DEFB1 is associated with chronic and aggressive periodontitis

(2009) A S Schaefer et al.   GENES AND IMMUNITY

Contribution of Adenosine A2B Receptors to Inflammatory Parameters of Experimental Colitis

(2009) J.-S. Frick et al.   JOURNAL OF IMMUNOLOGY

Translation of remote ischaemic preconditioning into clinical practice

(2009) Rajesh K Kharbanda et al.   LANCET

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

(2009) Peter Fraisl et al.   NATURE REVIEWS DRUG DISCOVERY

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Arterial Blood Gases and Oxygen Content in Climbers on Mount Everest

(2009) Michael P.W. Grocott et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Role of Extracellular Adenosine in Acute Lung Injury

(2009) Tobias Eckle et al.   PHYSIOLOGY

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

(2009) Gregg L. Semenza   PHYSIOLOGY

Adenosine A2A receptor is a unique angiogenic target of HIF-2  in pulmonary endothelial cells

(2009) A. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic effect of HIF-1  gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia

(2009) S. Rey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of dutasteride on the expression of hypoxia-inducible factor-1α, vascular endothelial growth factor and microvessel density in rat and human prostate tissue

(2009) Ja Hyeon Ku et al.   SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY

HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak

(2008) J. C. Morote-Garcia et al.   BLOOD

Central role of Sp1-regulated CD39 in hypoxia/ischemia protection

(2008) H. K. Eltzschig et al.   BLOOD

Camptothecins: A SAR/QSAR Study

(2008) Rajeshwar P. Verma et al.   CHEMICAL REVIEWS

Hypoxia-Inducible Factor-1 Is Central to Cardioprotection

(2008) Tobias Eckle et al.   CIRCULATION

Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α

(2008) Jeremy Ben-Shoshan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

W1376 Tumor Necrosis Factor Alpha and Interferon Gamma Induce Apoptosis in Enteric Glia: Protective Role of Brain-Derived Neurotrophic Factor

(2008) Christoph Hartmann et al.   GASTROENTEROLOGY

Extracellular Adenosine Production by Ecto-5′-Nucleotidase Protects During Murine Hepatic Ischemic Preconditioning

(2008) Melanie L. Hart et al.   GASTROENTEROLOGY

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade

(2008) Yatrik M. Shah et al.   GASTROENTEROLOGY

Hypoxia-Inducible Factor–Dependent Repression of Equilibrative Nucleoside Transporter 2 Attenuates Mucosal Inflammation During Intestinal Hypoxia

(2008) Julio C. Morote–Garcia et al.   GASTROENTEROLOGY

PX-478, an inhibitor of hypoxia-inducible factor-1α, enhances radiosensitivity of prostate carcinoma cells

(2008) Sanjeewani T. Palayoor et al.   INTERNATIONAL JOURNAL OF CANCER

Critical Role of HIF-1α in Keratinocyte Defense against Bacterial Infection

(2008) Carole Peyssonnaux et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interdependent roles for hypoxia inducible factor and nuclear factor-κB in hypoxic inflammation

(2008) Cormac T. Taylor   JOURNAL OF PHYSIOLOGY-LONDON

Inhibition of Hypoxia Inducible Factor Hydroxylases Protects Against Renal Ischemia-Reperfusion Injury

(2008) P. Hill et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1  and -2 

(2008) M. Puppo et al.   MOLECULAR CANCER THERAPEUTICS

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS

A Gain-of-Function Mutation in theHIF2AGene in Familial Erythrocytosis

(2008) Melanie J. Percy et al.   NEW ENGLAND JOURNAL OF MEDICINE

ATP Release from Vascular Endothelia Occurs Across Cx43 Hemichannels and Is Attenuated during Hypoxia

(2008) Marion Faigle et al.   PLoS One

Oxygen-Independent Stabilization of Hypoxia Inducible Factor (HIF)-1 during RSV Infection

(2008) Helene A. Haeberle et al.   PLoS One

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease

(2008) Ágnes Katalin Kocsis et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia

(2008) Almut Grenz et al.   PLOS MEDICINE

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY