- Home
- Publications
- Publication Search
- Publication Details
Title
Impact of hypoxia on DNA repair and genome integrity
Authors
Keywords
-
Journal
MUTAGENESIS
Volume -, Issue -, Pages -
Publisher
Oxford University Press (OUP)
Online
2019-06-26
DOI
10.1093/mutage/gez019
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Molecular landmarks of tumor hypoxia across cancer types
- (2019) Vinayak Bhandari et al. NATURE GENETICS
- Overall survival and updated progression-free survival outcomes in a randomized phase II study of combination cediranib and olaparib versus olaparib in relapsed platinum-sensitive ovarian cancer
- (2019) J F Liu et al. ANNALS OF ONCOLOGY
- State-of-the-art strategies for targeting the DNA damage response in cancer
- (2018) Patrick G. Pilié et al. Nature Reviews Clinical Oncology
- Combination of triapine, olaparib, and cediranib suppresses progression of BRCA-wild type and PARP inhibitor-resistant epithelial ovarian cancer
- (2018) Z. Ping Lin et al. PLoS One
- 18F-Fluoromisonidazole Kinetic Modeling for Characterization of Tumor Perfusion and Hypoxia in Response to Antiangiogenic Therapy
- (2017) Milan Grkovski et al. JOURNAL OF NUCLEAR MEDICINE
- Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study
- (2017) Michael J Overman et al. LANCET ONCOLOGY
- ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
- (2017) Andrew N. Blackford et al. MOLECULAR CELL
- Non-homologous DNA end joining and alternative pathways to double-strand break repair
- (2017) Howard H. Y. Chang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
- (2017) Parker L. Sulkowski et al. Science Translational Medicine
- Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma
- (2017) Susan E. Scanlon et al. Oncotarget
- Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability
- (2017) Jennifer M.J. Jongen et al. Oncotarget
- The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia
- (2017) Giusy Di Conza et al. Cell Reports
- miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair
- (2016) J. R. Czochor et al. MOLECULAR CANCER RESEARCH
- Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1
- (2016) Katarzyna B. Leszczynska et al. Scientific Reports
- The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy
- (2015) Michael Goldstein et al. Annual Review of Medicine
- Acute vascular response to cediranib treatment in human non-small-cell lung cancer xenografts with different tumour stromal architecture
- (2015) Yanyan Jiang et al. LUNG CANCER
- PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
- (2015) Dung T. Le et al. NEW ENGLAND JOURNAL OF MEDICINE
- Distinct DNA Damage Spectra Induced by Ionizing Radiation in Normoxic and Hypoxic Cells
- (2015) Naoto Shimizu et al. RADIATION RESEARCH
- Monitoring hypoxia and vasculature during bevacizumab treatment in a murine colorectal cancer model
- (2014) L. Heijmen et al. Contrast Media & Molecular Imaging
- The multifaceted von Hippel-Lindau tumour suppressor protein
- (2014) Claire M. Robinson et al. FEBS LETTERS
- PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
- (2014) Muhammad Zaeem Noman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Oxygen control with microfluidics
- (2014) Martin D. Brennan et al. LAB ON A CHIP
- Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised phase 2 study
- (2014) Joyce F Liu et al. LANCET ONCOLOGY
- Hypoxia Provokes Base Excision Repair Changes and a Repair-Deficient, Mutator Phenotype in Colorectal Cancer Cells
- (2014) Norman Chan et al. MOLECULAR CANCER RESEARCH
- Hypoxic Stress Facilitates Acute Activation and Chronic Downregulation of Fanconi Anemia Proteins
- (2014) Susan E. Scanlon et al. MOLECULAR CANCER RESEARCH
- Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation
- (2014) P. Gasparini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cell cycle association and hypoxia regulation of excision repair cross complementation group 1 protein (ERCC1) in tumor cells of head and neck cancer
- (2014) József Dudás et al. TUMOR BIOLOGY
- Hypoxia-inducible hydrogels
- (2014) Kyung Min Park et al. Nature Communications
- Silencing of the DNA Mismatch Repair Gene MLH1 Induced by Hypoxic Stress in a Pathway Dependent on the Histone Demethylase LSD1
- (2014) Yuhong Lu et al. Cell Reports
- Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance
- (2014) Gabriele Multhoff et al. Cancers
- Effects of hypoxia on human cancer cell line chemosensitivity
- (2013) Sara Strese et al. BMC CANCER
- A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells
- (2013) I. B. Barsoum et al. CANCER RESEARCH
- A Phase 1 trial of the poly(ADP-ribose) polymerase inhibitor olaparib (AZD2281) in combination with the anti-angiogenic cediranib (AZD2171) in recurrent epithelial ovarian or triple-negative breast cancer
- (2013) Joyce F. Liu et al. EUROPEAN JOURNAL OF CANCER
- Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication
- (2013) Monica M. Olcina et al. MOLECULAR CELL
- Nucleotide Excision Repair in Eukaryotes
- (2013) O. D. Scharer Cold Spring Harbor Perspectives in Biology
- Translesion DNA Polymerases
- (2013) M. F. Goodman et al. Cold Spring Harbor Perspectives in Biology
- Hypoxia and Human Genome Stability: Downregulation of BRCA2 Expression in Breast Cancer Cell Lines
- (2013) Daniele Fanale et al. Biomed Research International
- p53 Ser15phosphorylation disrupts the p53–RPA70 complex and induces RPA70-mediated DNA repair in hypoxia
- (2012) Esha Madan et al. BIOCHEMICAL JOURNAL
- Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer
- (2012) Veronique M. Neumeister et al. BREAST CANCER RESEARCH AND TREATMENT
- Phase I study to assess the safety and tolerability of olaparib in combination with bevacizumab in patients with advanced solid tumours
- (2012) E Dean et al. BRITISH JOURNAL OF CANCER
- Targeting radiation-resistant hypoxic tumour cells through ATR inhibition
- (2012) I M Pires et al. BRITISH JOURNAL OF CANCER
- HIF1α regulated expression of XPA contributes to cisplatin resistance in lung cancer
- (2012) Yanbin Liu et al. CARCINOGENESIS
- Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability
- (2012) R. Kumareswaran et al. JOURNAL OF CELL SCIENCE
- Hypoxia Modulates A431 Cellular Pathways Association to Tumor Radioresistance and Enhanced Migration Revealed by Comprehensive Proteomic and Functional Studies
- (2012) Yan Ren et al. MOLECULAR & CELLULAR PROTEOMICS
- Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells
- (2011) Imran A. Babar et al. CANCER BIOLOGY & THERAPY
- EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling
- (2011) Chun-Ju Chang et al. CANCER CELL
- A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia
- (2011) F. Bouquet et al. JOURNAL OF CELL SCIENCE
- Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
- (2011) Aude Carreau et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Hypoxia-Induced Epigenetic Regulation and Silencing of the BRCA1 Promoter
- (2011) Y. Lu et al. MOLECULAR AND CELLULAR BIOLOGY
- MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1 Activity during Prolonged Hypoxia
- (2011) U. Bruning et al. MOLECULAR AND CELLULAR BIOLOGY
- Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene
- (2010) F M Buffa et al. BRITISH JOURNAL OF CANCER
- Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment
- (2010) N. Chan et al. CANCER RESEARCH
- mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α
- (2010) Hakan Cam et al. MOLECULAR CELL
- Modulation of mismatch repair and genomic stability by miR-155
- (2010) N. Valeri et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130
- (2010) D. C. Hegan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dual Functions of ASCIZ in the DNA Base Damage Response and Pulmonary Organogenesis
- (2010) Sabine Jurado et al. PLoS Genetics
- MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress
- (2009) M. E. Crosby et al. CANCER RESEARCH
- Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia
- (2009) Shinae Kizaka-Kondoh et al. CANCER SCIENCE
- Hypoxia and Radiation Therapy: Past History, Ongoing Research, and Future Promise
- (2009) Sara Rockwell et al. CURRENT MOLECULAR MEDICINE
- Hypoxia-inducible factor-1α regulates the expression of nucleotide excision repair proteins in keratinocytes
- (2009) Hamid Reza Rezvani et al. NUCLEIC ACIDS RESEARCH
- DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion
- (2008) Hayato Oka et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance
- (2008) N. Chan et al. CANCER RESEARCH
- Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2
- (2008) H Nakamura et al. ONCOGENE
- Hypoxia Causes Downregulation of Mismatch Repair System and Genomic Instability in Stem Cells
- (2008) Francisco Javier Rodríguez-Jiménez et al. STEM CELLS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started