Applications of Yamaguchi Method to Esterification and Macrolactonization in Total Synthesis of Bioactive Natural Products

Total synthesis of (3R, 4S)-4-hydroxylasiodiplodin

(2020) G. Nagendra Reddy et al.   SYNTHETIC COMMUNICATIONS

Diterpenoids: Natural Distribution, Semisynthesis at Room Temperature and Pharmacological Aspects‐A Decade Update

(2020) Sasadhar Majhi   ChemistrySelect

Chemical derivatization of natural products: Semisynthesis and pharmacological aspects- A decade update

(2020) Sasadhar Majhi et al.   TETRAHEDRON

Total Synthesis of 1-Hydroxytaxinine

(2019) Yusuke Imamura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advance in biological activities of natural guaiane-type sesquiterpenes

(2019) Gang-Hua Ma et al.   MEDICINAL CHEMISTRY RESEARCH

Total synthesis of the proposed structure of xylarolide

(2019) Sudhakar Reddy Mopuri et al.   TETRAHEDRON LETTERS

First Total Synthesis of Jomthonic Acid A

(2019) Mohan Dumpala et al.   SYNLETT

A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti-Trypanosomal Macrolides

(2019) Matthew J. Anketell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evolution and Diversity of Assembly-Line Polyketide Synthases

(2019) Aleksandra Nivina et al.   CHEMICAL REVIEWS

Total Synthesis of (−)-Enigmazole A

(2018) Keisuke Sakurai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Belizentrin Methyl Ester: Report on a Likely Conquest

(2018) Felix Anderl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis and Biological Evaluation of the Glycosylated Macrocyclic Antibiotic Mangrolide A

(2018) Hiromu Hattori et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill.

(2018) Vishal Sharma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Divergent Strategy in Natural Product Total Synthesis

(2018) Lei Li et al.   CHEMICAL REVIEWS

Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery

(2018) Iwao Ojima et al.   JOURNAL OF NATURAL PRODUCTS

Chagas disease

(2018) José A Pérez-Molina et al.   LANCET

Synthesis of Fucosylated Chondroitin Sulfate Nonasaccharide as a Novel Anticoagulant Targeting Intrinsic Factor Xase Complex

(2018) Xiao Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization of the Jomthonic Acids Biosynthesis Pathway and Isolation of Novel Analogues in Streptomyces caniferus GUA-06-05-006A

(2018) Raúl García-Salcedo et al.   Marine Drugs

First Stereoselective Total Synthesis of Anti-Inflammatory Metabolite­ Penicillinolide A

(2018) Palakodety Krishna et al.   SYNTHESIS-STUTTGART

Human African trypanosomiasis

(2017) Philippe Büscher et al.   LANCET

Strategies to diversify natural products for drug discovery

(2017) Gang Li et al.   MEDICINAL RESEARCH REVIEWS

Anti-Inflammatory Effects, SAR, and Action Mechanism of Monoterpenoids from Radix Paeoniae Alba on LPS-Stimulated RAW 264.7 Cells

(2017) Xiaoxu Bi et al.   MOLECULES

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

(2017) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

Current drug therapy and pharmaceutical challenges for Chagas disease

(2016) José Bermudez et al.   ACTA TROPICA

An analysis of FDA-approved drugs: natural products and their derivatives

(2016) Eric Patridge et al.   DRUG DISCOVERY TODAY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Counting on natural products for drug design

(2016) Tiago Rodrigues et al.   Nature Chemistry

Total Synthesis of Sacrolide A by Following a Nozaki-Hiyama-Kishi Macrocyclization Strategy

(2016) Bighnanshu K. Jena et al.   Asian Journal of Organic Chemistry

Total Synthesis of Mycalolides A and B through Olefin Metathesis

(2015) Masaki Kita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

10-Step Asymmetric Total Synthesis and Stereochemical Elucidation of (+)-Dragmacidin D

(2015) Jeffrey J. Jackson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tigliane Diterpenoids from the Euphorbiaceae and Thymelaeaceae Families

(2015) Hong-Bing Wang et al.   CHEMICAL REVIEWS

A Stereoselective Total Synthesis of Xyolide, a Natural Bioactive Nonenolide

(2015) Lingaiah Maram et al.   HELVETICA CHIMICA ACTA

Total Synthesis of (−)-Enigmazole A

(2015) Yanran Ai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products

(2015) Michail Tsakos et al.   NATURAL PRODUCT REPORTS

Chagas’ Disease

(2015) Caryn Bern   NEW ENGLAND JOURNAL OF MEDICINE

Actinoallolides A–E, New Anti-trypanosomal Macrolides, Produced by an Endophytic Actinomycete, Actinoallomurus fulvus MK10-036

(2015) Yuki Inahashi et al.   ORGANIC LETTERS

Total Synthesis of the Protected Aglycon of Fidaxomicin (Tiacumicin B, Lipiarmycin A3)

(2014) Hideki Miyatake-Ondozabal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of the Tiacumicin B (Lipiarmycin A3/Fidaxomicin) Aglycone

(2014) Florian Glaus et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sacrolide A, a new antimicrobial and cytotoxic oxylipin macrolide from the edible cyanobacteriumAphanothece sacrum

(2014) Naoya Oku et al.   Beilstein Journal of Organic Chemistry

Identification of the n-1 fatty acid as an antibacterial constituent from the edible freshwater cyanobacteriumNostoc verrucosum

(2014) Naoya Oku et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Belizentrin, a Highly Bioactive Macrocycle from the Dinoflagellate Prorocentrum belizeanum

(2014) Humberto J. Domínguez et al.   ORGANIC LETTERS

Modified Yamaguchi Reagent: Convenient and Efficient Esterification

(2014) Yoshinori Okuno et al.   SYNTHETIC COMMUNICATIONS

Total Syntheses of Amphidinolides T1, T3, and T4

(2013) J. Stephen Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Amphidinolide F

(2013) Gaëlle Valot et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural products - modifying metabolite pathways in plants

(2013) Agata Staniek et al.   Biotechnology Journal

Total Syntheses and Biological Reassessment of Lactimidomycin, Isomigrastatin and Congener Glutarimide Antibiotics

(2013) Kévin Micoine et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis and Biological Evaluation of Grassypeptolide A

(2013) Hui Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cover Picture: (Chem. Eur. J. 1/2014)

(2013)   CHEMISTRY-A EUROPEAN JOURNAL

Stereoselective Total Synthesis of Multiplolide A and of a Diastereoisomer

(2013) Bandi Chennakesava Reddy et al.   HELVETICA CHIMICA ACTA

Okadaic Acid: More than a Diarrheic Toxin

(2013) Vanessa Valdiglesias et al.   Marine Drugs

Xyolide, a bioactive nonenolide from an Amazonian endophytic fungus, Xylaria feejeensis

(2013) Ezra G. Baraban et al.   TETRAHEDRON LETTERS

Total Syntheses of Amphidinolides B, G, and H

(2012) Akihiro Hara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Rhizopodin

(2012) Michael Dieckmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of RNA-Polymerase Inhibitor Ripostatin B and 15-Deoxyripostatin A

(2012) Wufeng Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Update 1 of: Macrolactonizations in the Total Synthesis of Natural Products

(2012) A. Parenty et al.   CHEMICAL REVIEWS

Nonanolides of Natural Origin: Structure, Synthesis, and Biological Activity

(2012) P. Sun et al.   CURRENT MEDICINAL CHEMISTRY

Macrocycles in new drug discovery

(2012) Jamie Mallinson et al.   Future Medicinal Chemistry

Jomthonic Acid A, a Modified Amino Acid from a Soil-Derived Streptomyces

(2012) Yasuhiro Igarashi et al.   JOURNAL OF NATURAL PRODUCTS

From natural product to marketed drug: the tiacumicin odyssey

(2012) William Erb et al.   NATURAL PRODUCT REPORTS

Total Synthesis of Bryostatin 1: A Short Route

(2011) Soraya Manaviazar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis and Biological Evaluation of (−)-Englerin A and B: Synthesis of Analogues with Improved Activity Profile

(2011) Lea Radtke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cytotoxic lasiodiplodin derivatives from the fungus Syncephalastrum racemosum

(2011) Mongkol Buayairaksa et al.   ARCHIVES OF PHARMACAL RESEARCH

Direct amide formation from unactivated carboxylic acids and amines

(2011) C. Liana Allen et al.   CHEMICAL COMMUNICATIONS

Natural Taxanes: Developments Since 1828

(2011) Yu-Fang Wang et al.   CHEMICAL REVIEWS

Peptide Coupling Reagents, More than a Letter Soup

(2011) Ayman El-Faham et al.   CHEMICAL REVIEWS

Chemodiversity in Freshwater and Terrestrial Cyanobacteria – A Source for Drug Discovery

(2011) George E. Chlipala et al.   CURRENT DRUG TARGETS

From Total Synthesis to Diverted Total Synthesis: Case Studies in the Amphidinolide Series

(2011) Alois Fürstner   ISRAEL JOURNAL OF CHEMISTRY

Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery

(2011) Eric Marsault et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Dragmacidin D via Direct C–H Couplings

(2011) Debashis Mandal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rethinking amide bond synthesis

(2011) Vijaya R. Pattabiraman et al.   NATURE

Iododesilylation of TIPS-, TBDPS-, and TBS-Substituted Alkenes in Connection with the Synthesis of Amphidinolides B/D

(2011) Mireia Sidera et al.   ORGANIC LETTERS

New Approaches to the Total Synthesis of the Bryostatin Antitumor Macrolides

(2010) Karl J. Hale et al.   Chemistry-An Asian Journal

Amphidinolide C3, a New Cytotoxic 25-Membered Macrolide from Marine Dinoflagellate Amphidinium sp

(2010) Jun'ichi Kobayashi et al.   HETEROCYCLES

Nucleophilic Acyl Substitution via Aromatic Cation Activation of Carboxylic Acids: Rapid Generation of Acid Chlorides under Mild Conditions

(2010) David J. Hardee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isolation, Structural Elucidation, and Absolute Stereochemistry of Enigmazole A, a Cytotoxic Phosphomacrolide from the Papua New Guinea Marine SpongeCinachyrella enigmatica

(2010) Naoya Oku et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of Tiacumicin B Biosynthetic Gene Cluster Affording Diversified Tiacumicin Analogues and Revealing a Tailoring Dihalogenase

(2010) Yi Xiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinase targets in renal-cell carcinomas: reassessing the old and discovering the new

(2010) Kyle A Furge et al.   LANCET ONCOLOGY

Synthesis and Biological Activity of Novel L-Amino Acid Based Analgesic Compounds

(2010) Junzhu Pan et al.   Letters in Drug Design & Discovery

Myxobacterial secondary metabolites: bioactivities and modes-of-action

(2010) Kira J. Weissman et al.   NATURAL PRODUCT REPORTS

The tetracycline resistome

(2009) Maulik Thaker et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Impact of Natural Products on Developing New Anti-Cancer Agents†

(2009) Gordon M. Cragg et al.   CHEMICAL REVIEWS

The A–Z of bacterial translation inhibitors

(2009) Daniel N. Wilson   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The natural history of antibiotics

(2009) Jon Clardy et al.   CURRENT BIOLOGY

Amphidinolides and Its Related Macrolides from Marine Dinoflagellates

(2009) Jun'ichi Kobayashi   JOURNAL OF ANTIBIOTICS

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

The Absolute Configuration of Rhizopodin and Its Inhibition of Actin Polymerization by Dimerization

(2008) Gregor Hagelueken et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Configurational assignment of rhizopodin, an actin-binding macrolide from the myxobacterium Myxococcus stipitatus

(2008) Nicole Horstmann et al.   CHEMICAL COMMUNICATIONS

Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis

(2008) M. Kurabachew et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY

Englerin A, a Selective Inhibitor of Renal Cancer Cell Growth, fromPhyllanthus engleri

(2008) Ranjala Ratnayake et al.   ORGANIC LETTERS

Fifteen years of biological and synthetic studies of decarestrictine family

(2007) Valéria Belli Riatto et al.   TETRAHEDRON