Characterization of the Jomthonic Acids Biosynthesis Pathway and Isolation of Novel Analogues in Streptomyces caniferus GUA-06-05-006A

Neothioviridamide, a Polythioamide Compound Produced by Heterologous Expression of a Streptomyces sp. Cryptic RiPP Biosynthetic Gene Cluster

(2018) Teppei Kawahara et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis and Evaluation of Antibacterial Activity of Bottromycins

(2018) Takeshi Yamada et al.   JOURNAL OF ORGANIC CHEMISTRY

Genomics-Driven Natural Product Discovery in Actinomycetes

(2018) Guoqing Niu   TRENDS IN BIOTECHNOLOGY

Activation and mechanism of a cryptic oviedomycin gene cluster via the disruption of a global regulatory gene,adpA, inStreptomyces ansochromogenes

(2017) Jingjing Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-ribosomal peptide synthetases: Identifying the cryptic gene clusters and decoding the natural product

(2017) Mangal Singh et al.   JOURNAL OF BIOSCIENCES

Bacterial Production of a Pederin Analogue by a Free-Living Marine Alphaproteobacterium

(2017) Carmen Schleissner et al.   JOURNAL OF NATURAL PRODUCTS

Marine microorganisms as a promising and sustainable source of bioactive molecules

(2017) G. Romano et al.   MARINE ENVIRONMENTAL RESEARCH

antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification

(2017) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams

(2017) Subhasish Saha et al.   Chemical Science

Caboxamycin biosynthesis pathway and identification of novel benzoxazoles produced by cross-talk in Streptomyces sp. NTK 937

(2017) Armando A. Losada et al.   Microbial Biotechnology

Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling

(2017) Christopher D. Kassotis et al.   Scientific Reports

Marine Sponges as a Drug Treasure

(2016) Komal Anjum et al.   Biomolecules & Therapeutics

Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects

(2016) Kozo Ochi   JOURNAL OF ANTIBIOTICS

Natural product discovery: past, present, and future

(2016) Leonard Katz et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Discovery Strategies of Bioactive Compounds Synthesized by Nonribosomal Peptide Synthetases and Type-I Polyketide Synthases Derived from Marine Microbiomes

(2016) Grigoris Amoutzias et al.   Marine Drugs

Next Generation Sequencing of Actinobacteria for the Discovery of Novel Natural Products

(2016) Juan Gomez-Escribano et al.   Marine Drugs

Comparative Genomics of Syntrophic Branched-Chain Fatty Acid Degrading Bacteria

(2016) Takashi Narihiro et al.   MICROBES AND ENVIRONMENTS

Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative

(2016) Raúl García Salcedo et al.   Microbial Cell Factories

Pharmacological Potential of Phylogenetically Diverse Actinobacteria Isolated from Deep-Sea Coral Ecosystems of the Submarine Avilés Canyon in the Cantabrian Sea

(2016) Aida Sarmiento-Vizcaíno et al.   MICROBIAL ECOLOGY

An Ocean of Discovery: Biodiversity Beyond the Census of Marine Life

(2016) Paul Snelgrove   PLANTA MEDICA

Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining

(2016) Michael A. Skinnider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Products and the Gene Cluster Revolution

(2016) Paul R. Jensen   TRENDS IN MICROBIOLOGY

A catalogue of 136 microbial draft genomes from Red Sea metagenomes

(2016) Mohamed F. Haroon et al.   Scientific Data

Elicitation of secondary metabolism in actinomycetes

(2015) Usama Ramadan Abdelmohsen et al.   BIOTECHNOLOGY ADVANCES

Genome Mining ofStreptomycessp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway

(2015) Carolina Cano-Prieto et al.   CHEMBIOCHEM

PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A

(2015) Marta Pérez et al.   JOURNAL OF ANTIBIOTICS

Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes

(2015) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms

(2015) F. Reen et al.   Marine Drugs

Minimum Information about a Biosynthetic Gene cluster

(2015) Marnix H Medema et al.   Nature Chemical Biology

Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)

(2015) Michael A. Skinnider et al.   NUCLEIC ACIDS RESEARCH

Marine Microbial Metagenomics: From Individual to the Environment

(2014) Ching-Hung Tseng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Jomthonic acids B and C, two new modified amino acids from Streptomyces sp

(2014) Linkai Yu et al.   JOURNAL OF ANTIBIOTICS

Total Synthesis and Stereochemistry Revision of Mannopeptimycin Aglycone

(2014) Shinichiro Fuse et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Complex regulation of secondary metabolism controlling pathogenicity in the phytopathogenic fungusAlternaria alternata

(2014) Shinya Takaoka et al.   NEW PHYTOLOGIST

MBGD update 2015: microbial genome database for flexible ortholog analysis utilizing a diverse set of genomic data

(2014) Ikuo Uchiyama et al.   NUCLEIC ACIDS RESEARCH

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

(2014) Kazuya Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation and identification of five clusters for secondary metabolites inStreptomyces albus J1074

(2014) Carlos Olano et al.   Microbial Biotechnology

Challenges and triumphs to genomics-based natural product discovery

(2013) Paul R. Jensen et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster

(2013) Yunzi Luo et al.   Nature Communications

The biodiscovery potential of marine bacteria: an investigation of phylogeny and function

(2013) Martin Mühling et al.   Microbial Biotechnology

Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis

(2012) Chong Wai Liew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Jomthonic Acid A, a Modified Amino Acid from a Soil-Derived Streptomyces

(2012) Yasuhiro Igarashi et al.   JOURNAL OF NATURAL PRODUCTS

Importance of the MbtH-like protein TioT for production and activation of the thiocoraline adenylation domain of TioK

(2012) Olga E. Zolova et al.   MedChemComm

Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin in Streptomyces lydicus: Tailoring Modification of 3-Methyl-Aspartate

(2011) D. H. Horna et al.   JOURNAL OF BACTERIOLOGY

Marine compounds and their antiviral activities

(2010) Jarred Yasuhara-Bell et al.   ANTIVIRAL RESEARCH

MbtH-Like Proteins as Integral Components of Bacterial Nonribosomal Peptide Synthetases

(2010) Elizabeth A. Felnagle et al.   BIOCHEMISTRY

The expanding role of marine microbes in pharmaceutical development

(2010) Amanda L Waters et al.   CURRENT OPINION IN BIOTECHNOLOGY

Marine genomics: at the interface of marine microbial ecology and biodiscovery

(2010) Karla B. Heidelberg et al.   Microbial Biotechnology

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

(2010) Juan Pablo Gomez-Escribano et al.   Microbial Biotechnology

In vitro Characterization of Enzymes Involved in the Synthesis of Nonproteinogenic Residue (2S,3S)-β-Methylphenylalanine in Glycopeptide Antibiotic Mannopeptimycin

(2009) Yu-Ting Huang et al.   CHEMBIOCHEM

Advances in the Understanding and Use of the Genomic Base of Microbial Secondary Metabolite Biosynthesis for the Discovery of New Natural Products⊥

(2009) James B. McAlpine   JOURNAL OF NATURAL PRODUCTS

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

Metagenomic approaches to natural products from free-living and symbiotic organisms

(2009) Sean F. Brady et al.   NATURAL PRODUCT REPORTS

Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem

(2009) Carmen Cuevas et al.   NATURAL PRODUCT REPORTS

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Ziconotide: an update and review

(2008) Jason A Williams et al.   EXPERT OPINION ON PHARMACOTHERAPY

Mining microbial genomes for new natural products and biosynthetic pathways

(2008) G. L. Challis   MICROBIOLOGY-SGM

Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages

(2008) T. L. Simmons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase

(2007) Hrvoje Petković et al.   ORGANIC & BIOMOLECULAR CHEMISTRY