Article
Chemistry, Organic
Peng Sun, Junli Ao, Tianjiao Qiao, Shuming Wu, Guangxin Liang
Summary: Efforts towards stereoselective total synthesis of the leucosceptroid family of natural products were reported in this paper, with two synthetic strategies discussed. While the intermolecular addition/ring-closing metathesis cyclization strategy successfully furnished an advanced common intermediate, late-stage transformation encountered difficulties in achieving the desired oxidation of the hydroxyl group. Instead, an interesting tricyclic spiral product was observed.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Bonnie S. Pak, Nantamon Supantanapong, Christopher D. Vanderwal
Summary: The study focused on exploring the cytotoxins lissodimide family, which contains chlorinated compounds, through semisynthesis and analogue-oriented approaches to gain insights into the structure-activity relationships and the novel halogen-pi dispersion interaction involving chlorine atoms.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Lima Rodrigues, Santosh G. Tilve, Mahesh S. Majik
Summary: Thiolane-based bioactive organic compounds, inspired by bioactive natural products, exhibit a variety of astonishing biological activities, making them excellent candidates for drug discovery. This review highlights the development of important thiolane-based therapeutics and aims to inspire chemists and biochemists to take up the challenges in synthesizing and developing thiolane-based drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Avishek Majumder, Nityananda Dutta, Sudatta Dey, Priyanka Sow, Asmita Samadder, Gonela Vijaykumar, Krishnan Rangan, Manindranath Bera
Summary: The three discrete [Zn-6] complexes supported by the carboxylate-based multidentate ligand have been successfully synthesized and characterized. Complex 1 showed potential antidiabetic efficacy, while complexes 2 and 3 exhibited promise as chemopreventive drugs against hepatic carcinoma by maintaining hepatic tissue mass and inhibiting DNA damage in hepatic cells.
INORGANIC CHEMISTRY
(2021)
Article
Green & Sustainable Science & Technology
Rubens Alves Dias, Marilia Rios de Paula, Paloma Maria Silva Rocha Rizol, Jose Alexandre Matelli, Cristiano Rodrigues de Mattos, Jose Antonio Perrella Balestieri
Summary: Fifteen years after the publication of the article on Energy Education in 2004, research has been conducted to identify paths and scientific contributions towards rational energy use in the field of energy education. The analysis highlights the importance of energy education in raising awareness and promoting action in society, emphasizing the need for clear definitions of personal values, attitudes, and behaviors to enhance the effectiveness of educational processes.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Anton R. Egorov, Omar Khubiev, Vasili V. Rubanik, Vasili V. Rubanik Jr, Nikolai N. Lobanov, Serguei V. Savilov, Anatoly A. Kirichuk, Ilya S. Kritchenkov, Alexander G. Tskhovrebov, Andreii S. Kritchenkov
Summary: An ultrasonic approach has been developed for the synthesis of selenium-containing derivatives of chitin and chitosan. The synthetic procedure is simple, efficient, and environmentally friendly. The derivatives show high antibacterial and antifungal activity, surpassing the effect of classic antibiotics. Furthermore, they exhibit promising transfection activity and act as efficient catalysts for alcohol oxidation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Engineering, Electrical & Electronic
Johan Wahlstrom, Isaac Skog
Summary: The study reviews the history of foot-mounted inertial navigation and discusses key issues in designing zero-velocity detectors, providing insights for future research directions.
IEEE SENSORS JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Chen-Hao Wang, Serena DeBeer
Summary: Nitrogenase plays a crucial role in converting atmospheric nitrogen into ammonia, with its catalytic active sites being the focus of chemists for decades. Recent studies have focused on the reactivity and spectroscopic characterization of nitrogenase-related synthetic molecular complexes and biological clusters, contributing to a better understanding of the electronic structure and mechanism of nitrogenases.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Engineering, Environmental
Jad Zalzal, Marianne Hatzopoulou
Summary: This study finds disparities in exposure to traffic-related air pollution among populations with different socioeconomic/ethnic backgrounds. Despite reductions in traffic emissions, these disparities persist and have worsened in some groups.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Metello Innocenti
Summary: The mammalian formin family includes fifteen multi-domain proteins that regulate actin dynamics and microtubules. The small molecule inhibitor of formin homology 2 domains (SMIFH2) has provided a powerful tool to study formins. However, there are still controversies and open questions regarding the substrates and mechanism of action of SMIFH2, but it remains useful in studying formins in health and disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Hongru Ding, Zhihan Chen, Pavana Siddhartha Kollipara, Yaoran Liu, Youngsun Kim, Suichu Huang, Yuebing Zheng
Summary: This study develops an optothermal platform for versatile manipulation of synthetic micro/nanoparticles and live cells using an ultralow-power laser beam and a simple optical setup. Five working modes can be switched through computer programming, and programmable multimodal control of micro/nanoparticles is achieved by incorporating a feedback control system.
Review
Management
Nils Boysen, Philipp Schulze, Armin Scholl
Summary: The assembly line balancing problem is crucial for mass-producers to optimize labor division among workstations. This paper surveys scientific literature on this topic, covering data gathering methods, new problem variants and models, important algorithmic developments, and proposing a research agenda for the future.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Samuel J. Cobb, Santiago Rodriguez-Jimenez, Erwin Reisner
Summary: Electrocatalytic CO2 reduction is a diverse field with different types of catalysts. Enzymes and small molecule catalysts have distinct active sites, while heterogeneous materials have complex and poorly understood active sites. However, as the performance of active sites improves, the gap between these catalysts is closing, enabling the use of different types of catalysts without barriers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biotechnology & Applied Microbiology
Brett J. Kagan, Christopher Gyngell, Tamra Lysaght, Victor M. Cole, Tsutomu Sawai, Julian Savulescu
Summary: This article reviews the key aspects of Synthetic Biological Intelligence (SBI), its potential applications, and the associated ethical concerns. It aims to provide a robust framework for the responsible research and application of SBI technology.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Sioned F. Jones, Himanshu Joshi, Stephen J. Terry, Jonathan R. Burns, Aleksei Aksimentiev, Ulrike S. Eggert, Stefan Howorka
Summary: Equipping DNA with hydrophobic anchors enables targeted interaction with lipid bilayers for various applications. Through experiments and molecular dynamics simulations, the study reveals the complex structure and energetics of hydrophobically tagged DNA within lipid membranes. Fundamental insight gained on DNA-bilayer interactions will guide the rational design of membrane-targeting nanostructures.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Valeria B. Riatto, Mauricio M. Victor, Jaqueline F. Sousa, Carla Menegola
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Medicinal
Matheus A. Meirelles, Carolyne B. Braga, Catia Ornelas, Ronaldo A. Pilli
Article
Chemistry, Multidisciplinary
Franco Della-Felice, Ariel M. Sarotti, Michael J. Krische, Ronaldo A. Pilli
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Materials Science, Biomaterials
Carolyne B. Braga, Larissa A. Kido, Ellen N. Lima, Celina A. Lamas, Valeria H. A. Cagnon, Catia Ornelas, Ronaldo A. Pilli
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Plant Sciences
Thais P. Banzato, Juliana R. Gubiani, Darlon I. Bernardi, Claudio R. Nogueira, Afif F. Monteiro, Fernanda F. Juliano, Severino M. de Alencar, Ronaldo A. Pilli, Carolina A. de Lima, Giovanna B. Longato, Antonio G. Ferreira, Mary Ann Foglio, Joao E. de Carvalho, Debora B. Vendramini-Costa, Roberto G. S. Berlinck
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Chemistry, Organic
Juliana L. L. F. Regueira, Luiz F. Silva Jr, Ronaldo A. Pilli
Article
Chemistry, Multidisciplinary
Julio C. Pastre, Philip R. D. Murray, Duncan L. Browne, Guilherme A. Brancaglion, Renan S. Galaverna, Ronaldo A. Pilli, Steven Ley
Article
Biochemistry & Molecular Biology
Carolyne B. Braga, Ronaldo A. Pilli, Catia Ornelas, Marcus Weck
Summary: This study describes the design and synthesis of multifunctional micelles based on amphiphilic brush block copolymers for imaging and selective drug delivery of natural anticancer compounds. The micelles exhibited excellent drug encapsulation and release properties, high cellular internalization capacity, and significant cytotoxicity against cancer cells. Moreover, the micelles showed high selectivity and preferential cellular uptake in cancer cell lines, demonstrating their potential for efficient drug delivery and image-guided diagnostics using a versatile polymeric nanosystem.
Article
Chemistry, Organic
Giovanni Bernardi Rosso, Bruno Matos Paz, Ronaldo Aloise Pilli
Summary: The proposed structure for the putative Stemona alkaloid named parvistemoamide has been questioned. The study also reports on the intramolecular Friedel-Crafts alkylation of a furan molecule, leading to the synthesis of related compounds.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Matheus A. Meirelles, Ian de Toledo, Samuel Thurow, Gabriela Barreiro, Rafael M. Counago, Ronaldo A. Pilli
Summary: Two routes were developed to synthesize the antimalarial diaminopyrimidine P218 by metalating suitable 2,4-dichloro-5-alkoxypyrimidines at the C-6 position. One route involves late-stage modification of the C-6 position, while the other allows for tail fragment modification of P218. Both routes have successfully synthesized P218 and eight analogues, showing potential for the discovery of new antimalarial drugs.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Natalia Lussari, Ajmir Khan, Ronaldo A. Pilli, Alcindo A. Dos Santos, Luiz F. Silva, Ataualpa A. C. Braga
Summary: The ring expansion reaction promoted by HTIB provides a practical method for the synthesis of seven-membered rings containing fused heterocycles. The computational studies validate the regiochemistry of the reaction and explain the faster reaction rate observed in aqueous methanol.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Yasmin B. T. Fonseca, Nicole M. Almeida, Jamile C. Caldas, Gabriel N. Morais, Isaac M. J. Silva, Valeria B. Riatto, Walter N. L. Santos, Fernando L. B. Moutinho
Summary: This study evaluated the stimulatory effect of a seed coating technology combining the biomass of Dunaliella salina and the bioplastic film of Manihot esculenta on the growth and compound synthesis of Coriandrum sativum plants. The results showed that the coating increased germination percentage and concentration of bioactive compounds, potentially due to the presence of carbohydrates, lipids, and proteins in the microalgae biomass.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Review
Biochemistry & Molecular Biology
Franco Della-Felice, Aloisio de Andrade Bartolomeu, Ronaldo Aloise Pilli
Summary: This article discusses the chemistry of secondary metabolites containing the phosphate ester group, focusing on their structural diversity, biological and pharmacological profiles, and synthetic approaches utilized in the phosphorylation step.
NATURAL PRODUCT REPORTS
(2022)
Article
Chemistry, Analytical
Jonatas de Oliveira S. Silva, Jessica B. S. Lima, Sanny W. M. M. de Carvalho, Mercia V. S. Sant'Anna, Jose C. S. Junior, Ravir R. Farias, Mauricio M. Victor, Eliana Midori Sussuchit
BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
