Article
Microbiology
Babar Khan, Yu Li, Wei Wei, Guiyou Liu, Cheng Xiao, Bo He, Chen Zhang, Nasir Ahmed Rajput, Yonghao Ye, Wei Yan
Summary: Chemical investigation of the plant-derived endophytic fungus Diaporthe unshiuensis YSP3 led to the isolation of four new compounds, including two new xanthones, one new alternariol methyl ether derivative, and one alpha-pyrone derivative, along with eight known compounds. The structures of new compounds were determined through spectroscopic data and single-crystal X-ray diffraction analysis. All new compounds were evaluated for their antimicrobial and cytotoxic activities. Compound 1 exhibited cytotoxic activity against HeLa and MCF-7 cells, while compound 3 demonstrated antibacterial effect on Bacillus subtilis.
Article
Microbiology
Shikai Zhang, Qing Xu, Changbo Ji, Xiaoyu Han, Yang Zhou, Chao Liang, Linran Ma, Weijian Sun, Yanling Li, Zhengyou Yang, Fengchun Zhao, Yuan Tian
Summary: This study investigates the effects of small molecule-induced secondary metabolites of the endophytic fungus Diaporthe sp. AC1 on antibacterial activity and tumor cytotoxicity. The results show that the compound induced by 1-MT exhibits optimal antibacterial activity and tumor cytotoxicity, while other compounds show varying levels of biological activity.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Yan Chen, Ge Zou, Wencong Yang, Yingying Zhao, Qi Tan, Lin Chen, Jinmei Wang, Changyang Ma, Wenyi Kang, Zhigang She
Summary: New compounds were isolated from the endophytic fungus, with two showing potent anti-inflammatory activities. The structures were determined through extensive analysis, and the absolute configurations were established by ECD calculations and specific rotation comparison.
Article
Forestry
Jessica Esmeralda Vega-Ceja, Rosa Maria Jimenez-Amezcua, Jose Anzaldo-Hernandez, Jose Antonio Silva-Guzman, Jose Guillermo Torres-Rendon, Maria Guadalupe Lomeli-Ramirez, Salvador Garcia-Enriquez
Summary: This study investigates the toxic effect of Datura stramonium extracts on fungi, finding that different extraction solvents have varied impacts on fungal growth.
Article
Biochemistry & Molecular Biology
Kumar Vishven Naveen, SeonJu Park, Kandasamy Saravanakumar, Anbazhagan Sathiyaseelan, Myeong-Hyeon Wang
Summary: The present study evaluated the mycochemical abundance, cytotoxic and hemolytic activities of ethyl acetate extract (EAE) from endophytic Penicillium camponotum (PC) and Penicillium fuscoglaucum (PF). The EAE-PF showed higher yield with total phenols (26.59 +/- 1.52 mg of GAE/g DW) and flavonoids (3.12 +/- 1.83 mg of QE/g DW). It exhibited inhibitory effects on the proliferation of breast cancer cells (BT-474 and MDA-MB-231) with IC50 values of 0.112 and 0.120 mg/mL, respectively, while showing no toxicity to normal cells. The EAE-PF also demonstrated low hemolytic activity in erythrocytes. Metabolic profiling identified several mycochemicals in EAE-PF, and molecular docking analysis suggested their interactions with cancer-related proteins.
PROCESS BIOCHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Dekui Zhang, Weijian Sun, Wenjie Xu, Changbo Ji, Yang Zhou, Jingyi Sun, Yutong Tian, Yanling Li, Fengchun Zhao, Yuan Tian
Summary: Five endophytic fungi belonging to Aspergillus and Alternaria genera were isolated from Lagopsis supina. The antimicrobial activity of their fermented extracts against Staphylococcus and Fusarium graminearum was tested, with Aspergillus ochraceus XZC-1 showing the best activity. Four compounds were discovered, two of which displayed antifungal and antibacterial activity and selective cytotoxicity against cancer cell lines. This study suggests that endophytic fungi from L. supina have the potential to produce bioactive molecules for drug or agricultural antibiotic development.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huiting Lin, Yan Liang, Kumaravel Kaliaperumal, Qin Xiong, Shuo Duan, Yueming Jiang, Jun Zhang
Summary: The endophytic fungus HT-79 isolated from a healthy navel orange tree showed significant inhibition against Xanthomonas citri subsp. citri. The active compound, linoleic acid, exhibited strong antibacterial activity against the citrus canker disease-causing bacterium by disrupting the cell membrane and inducing the overproduction of reactive oxygen species (ROS).
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mengyi Deng, Yangli Pu, Zhenling Wan, Jinbo Xu, Shuai Huang, Jiang Xie, Xianli Zhou
Summary: A chemical investigation of the EtOAc extract of the endophytic fungus Penicillium herquei led to the isolation of nine undescribed oxidized ergosterols, penicisterols A-I (1-9), along with ten known analogs (10-19). Their structures and absolute configurations were elucidated by a combination of spectroscopic data analysis and computational methods, and their cytotoxic activity against five cancer cell lines was evaluated. Compounds 2 and 3 showed moderate cytotoxic activity against 4T1, A549, and HeLa cells.
Article
Chemistry, Multidisciplinary
Silvana Alfei, Barbara Marengo, Giulia Elda Valenti, Cinzia Domenicotti
Summary: The study found that two polystyrene-based copolymers (P5, P7) have good anti-tumor effects on neuroblastoma cells, reducing cell viability and showing a significant correlation between cytotoxicity and reactive oxygen species (ROS) generation.
Article
Plant Sciences
Xu Pang, Guo-Wei Cai, Meng-Yan Wang, Xiu-Fei Chen, Wen-Ni He, Wu-Li Zhao, Tao Zhang, Li-Yan Yu
Summary: Twenty-two metabolites were isolated from Penicillium sp. CPCC 401423 cultured on rice and their structures were identified. Among them, nine compounds were identified as new. These compounds were tested for their cytotoxic activity against pancreatic carcinoma cells.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Infectious Diseases
Farkhod Eshboev, Marina Karakozova, Jaloliddin Abdurakhmanov, Khayrulla Bobakulov, Khayotjon Dolimov, Akhror Abdurashidov, Asadali Baymirzaev, Artyom Makhnyov, Ekaterina Terenteva, Sobirdjan Sasmakov, Galina Piyakina, Dilfuza Egamberdieva, Pavel A. Nazarov, Shakhnoz Azimova
Summary: According to the World Health Organization, drug-resistant infections could cause up to 10 million deaths annually by 2050, highlighting the urgent need to find new antibiotics. Natural compounds from endophytic fungi, such as Chaetomium elatum, isolated from Hyssopus officinalis, show potential as new-generation antibiotics. Penicillic acid, isolated for the first time from C. elatum, exhibited strong antibacterial activities against Bacillus subtilis and Staphylococcus aureus, as well as antibiofilm effects. These findings contribute to the search for effective antibiotics to combat drug resistance.
Article
Biochemistry & Molecular Biology
Jhuly W. F. Lacerda, Katia A. Siqueira, Leonardo G. Vasconcelos, Barbara S. Bellete, Evandro L. Dall'Oglio, Paulo T. Sousa Junior, Tomer M. Faraggi, Lucas C. C. Vieira, Marcos A. Soares, Olivia M. Sampaio
Summary: This study investigates the impact of endophytic fungi Diaporthe phaseolorum and Trichoderma spirale on the metabolic profiles of Combretum lanceolatum plant, revealing significant changes in the biosynthesis of primary metabolites.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Chemistry, Medicinal
Geting Ye, Cuiying Huang, Jialin Li, Tao Chen, Jing Tang, Wenbin Liu, Yuhua Long
Summary: In this study, six new DIKETOPIPERAZINE alkaloids were isolated from the fungus Aspergillus sp. 16-5c, along with ten known alkaloids. Bioassay results revealed significant alpha-glucosidase inhibitory activity in compounds 1 and 9, moderate activity in compounds 3, 10, 11, and 15, while no compounds showed PTP1B enzyme inhibition activity.
Article
Microbiology
Paulo Castro, Rodolfo Parada, Carlos Corrial, Leonora Mendoza, Milena Cotoras
Summary: Two endophytic fungi, Epicoccum sp. and Pleosporales sp., were isolated from Chilean foothills and their extracts showed antifungal activity against Botrytis cinerea, suggesting their potential as alternatives to synthetic fungicides.
Article
Infectious Diseases
Flaminia Mazzone, Viktor E. Simons, Lasse van Geelen, Marian Frank, Attila Mandi, Tibor Kurtan, Klaus Pfeffer, Rainer Kalscheuer
Summary: Toxoplasma gondii is a pathogen that can infect various warm-blooded animals, including humans, causing toxoplasmosis. Current treatments for toxoplasmosis have severe side effects and are not effective in eradicating chronic infection. Therefore, there is an urgent need to develop novel anti-toxoplasma drugs with low toxicity. In this study, eight natural products were isolated from the crude extract of the endophytic fungus Paraboeremia selaginellae obtained from the leaves of the plant Philodendron monstera. Six of these natural products showed antitoxoplasma activity with low or no cytotoxicity in human cell lines. These findings suggest that biphenyl ethers, bioxanthracenes, and 5S,6S-phomalactone from P. selaginellae are potential candidates for novel anti-toxoplasma drugs.
Article
Biochemistry & Molecular Biology
Nisha Sharma, Himanshu Sankrityayan, Ajinath Kale, Anil Bhanudas Gaikwad
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Review
Cardiac & Cardiovascular Systems
Himanshu Sankrityayan, Ajinath Kale, Nisha Sharma, Hans-Joachim Anders, Anil Bhanudas Gaikwad
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2020)
Review
Biochemistry & Molecular Biology
Nisha Sharma, Anannya Sircar, Hans-Joachim Anders, Anil Bhanudas Gaikwad
Summary: Liver and kidney play vital roles in maintaining homeostasis and their injuries can affect each other. Excessive fructose intake, insulin resistance, inflammatory cytokines production, activation of the renin-angiotensin system, and redox imbalance are involved in the interaction between liver and kidney. AKI and NAFLD have impacts on liver and kidney functions through various biochemical and molecular pathways.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Nisha Sharma, Anil Bhanudas Gaikwad
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Review
Medicine, Research & Experimental
Niharika Shiva, Nisha Sharma, Yogesh A. Kulkarni, Shrikant R. Mulay, Anil Bhanudas Gaikwad
Article
Biotechnology & Applied Microbiology
G. Singh, J. Singh, V. Singamaneni, S. Singh, P. Gupta, M. Katoch
Summary: This study isolated a novel dipeptide, serine-glycine-betaine, from the endophyte Macrophomina phaseolina associated with Brugmansia aurea L., which exhibited activity against human cancer cells by inducing apoptosis. Genomic analysis revealed the potential biosynthesis pathway of serine-glycine-betaine. The findings suggest dipeptides like serine-glycine-betaine and tyrosine-betaine may be specific to fungal genera and could be used for diagnostic purposes.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Manoj Kushwaha, Arem Qayum, Shreyans K. Jain, Jasvinder Singh, Amit Kumar Srivastava, Shubham Srivastava, Nisha Sharma, Vidushi Abrol, Ruchi Malik, Shashank K. Singh, Ram A. Vishwakarma, Sundeep Jaglan
Summary: Seven cytochalasins were isolated from a fungal extract, with 19,20-epoxycytochalasin C showing higher cytotoxic potential compared to its oxidized metabolite. Mass spectrometry analysis revealed the oxidation of 19,20-epoxycytochalasin C to a less cytotoxic metabolite, indicating a potential target for cancer treatment.
Article
Biochemistry & Molecular Biology
Deepak Chowrasia, Asif Jafri, Iqbal Azad, Juhi Rais, Nisha Sharma, Fahad Khan, Ajay Kumar, Sudhir Kumar, Md Arshad
Summary: In this study, synthesized curcumin analogues were tested for their anticancer activity against human ovarian and lung adenocarcinoma cells, showing potential interaction with VEGFR2 and non-toxic properties, with some compounds exhibiting good anti-proliferative activity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Engineering, Electrical & Electronic
Ravi Sharma, Vibha Chopra, Nisha Sharma, Abhijeet R. Kadam, S. J. Dhoble, Birendra Singh
Summary: The tissue equivalent Li2B4O7: Cu material showed a linear TL response curve after exposure to 50 MeV Li3+ ion beam, making it a potential candidate for dosimetry of lithium ions.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Venugopal Singamaneni, Bashir Lone, Jasvinder Singh, Pankaj Kumar, Sumeet Gairola, Shashank Singh, Prasoon Gupta
Summary: The study identified two new labdane diterpenes from Roscoea purpurea, which showed significant cytotoxic activity against lung cancer cells. This is the first report of isolation of these compounds in R. purpurea, indicating potential for further research in this area.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Vidushi Abrol, Manoj Kushwaha, Divya Arora, Sharada Mallubhotla, Sundeep Jaglan
Summary: Diethyl sulfate (DES)-based chemical mutagenesis was used to diversify secondary metabolites in different fungal strains. A mutant strain of Penicillium oxalicum was isolated and found to produce 10 bioactive molecules. Compounds like tuckolide, methylpenicinoline, and penipanoid A showed potent antibacterial activity, while N-[2-(4-hydroxyphenyl)ethenyl]formamide and tuckolide demonstrated strong antioxidant properties. DES-based mutagenesis was proven to be an effective strategy in diversifying fungal secondary metabolites.
Article
Biotechnology & Applied Microbiology
Vidushi Abrol, Manoj Kushwaha, Sharada Mallubhotla, Sundeep Jaglan
Summary: Diethyl sulphate-based mutagenesis was used to obtain mutant strain MT2-3538 with 2.1 fold higher cyclosporine A production. Further optimization of media combination led to a 16-fold increase in cyclosporine yield for MT2-3538, showing potential for commercial applications.
Article
Biochemistry & Molecular Biology
Anju Thapa, Ravinder Kaushik, Smriti Arora, Sundeep Jaglan, Varun Jaswal, Virendra Kumar Yadav, Manjeet Singh, Aarti Bains, Prince Chawla, Azhar Khan, Melinda Fogarasi, Szabolcs Fogarasi
Summary: Yersiniosis, a zoonotic disease caused by Yersinia enterocolitica, is prevalent in Europe and known for its high antibiotic resistance. This study evaluated the antimicrobial activity of an extract from Picrorhiza kurroa against Yersinia enterocolitica. The extract showed effective antimicrobial activity and potential bioactive compounds were identified. Picroside-1 exhibited higher antimicrobial potential and lysed Yersinia enterocolitica cells. Docking analysis revealed its interaction with the dihydrofolate reductase protein, suggesting it as a possible drug candidate for Yersinia enterocolitica.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Nisha Sharma, Bikram Singh, Aruna Bhatia, Raghbir Chand Gupta, Mohammad Saleem Wani
Summary: The study examined different cytotypes of Boerhavia diffusa for pharmacological properties and found that the diploid cytotype exhibited higher activity in terms of anti-diabetic and anti-bacterial effects, as compared to tetraploid and octaploid cytotypes.
ADVANCES IN TRADITIONAL MEDICINE
(2021)
Article
Environmental Sciences
Nisha Sharma, Anil Bhanudas Gaikwad
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2020)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
