The brain as an insulin-sensitive metabolic organ

Interplay of Dietary Fatty Acids and Cholesterol Impacts Brain Mitochondria and Insulin Action

(2020) Mareike Schell et al.   Nutrients

Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial

(2020) Tali Cukierman-Yaffe et al.   LANCET NEUROLOGY

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia

(2020) Suzanne Craft et al.   JAMA Neurology

Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain

(2019) Kristina Wardelmann et al.   Molecular Metabolism

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior

(2019) Marion Soto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin Resistance and Oxidative Stress in the Brain: What’s New?

(2019) Mateusz Maciejczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular effects of dietary fatty acids on brain insulin action and mitochondrial function

(2019) Chantal Chudoba et al.   BIOLOGICAL CHEMISTRY

Rosiglitazone has a neutral effect on the risk of dementia in type 2 diabetes patients

(2019) Chin-Hsiao Tseng   Aging-US

Brain insulin resistance: A treatment target for cognitive impairment and anhedonia in depression

(2019) Julia A. Hamer et al.   EXPERIMENTAL NEUROLOGY

Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

(2019) Tomoko Wakabayashi et al.   Molecular Neurodegeneration

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

(2019) Caroline Fecher et al.   NATURE NEUROSCIENCE

Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance

(2019) Elizabeth M. Rhea et al.   Frontiers in Neuroscience

Antidiabetic medication and risk of dementia in patients with type 2 diabetes: a nested case–control study

(2019) Ida Kim Wium-Andersen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Metformin and risk of Alzheimer’s disease among community-dwelling people with diabetes: a national case-control study

(2019) Janet K Sluggett et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Differential regulation of autophagy during metabolic stress in astrocytes and neurons

(2019) Aditi Kulkarni et al.   Autophagy

Insulin transport into the brain

(2018) Sarah M. Gray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding

(2018) Garron T. Dodd et al.   DIABETES

Insulin regulates astrocyte gliotransmission and modulates behavior

(2018) Weikang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin and leptin excite anorexigenic pro-opiomelanocortin neurones via activation of TRPC5 channels

(2018) J. Qiu et al.   JOURNAL OF NEUROENDOCRINOLOGY

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

(2018) Sreemathi Logan et al.   Molecular Metabolism

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis

(2018) Jared M. Campbell et al.   JOURNAL OF ALZHEIMERS DISEASE

Altered mitochondrial function in insulin-deficient and insulin-resistant states

(2018) Gregory N. Ruegsegger et al.   JOURNAL OF CLINICAL INVESTIGATION

Redox Balance, Antioxidant Defense, and Oxidative Damage in the Hypothalamus and Cerebral Cortex of Rats with High Fat Diet-Induced Insulin Resistance

(2018) Mateusz Maciejczyk et al.   Oxidative Medicine and Cellular Longevity

Insulin regulates POMC neuronal plasticity to control glucose metabolism

(2018) Garron T Dodd et al.   eLife

Links Between Obesity-Induced Brain Insulin Resistance, Brain Mitochondrial Dysfunction, and Dementia

(2018) Jirapas Sripetchwandee et al.   Frontiers in Endocrinology

Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function

(2018) Jordan Rowlands et al.   Frontiers in Endocrinology

Insulin Receptor Isoforms in Physiology and Disease: An Updated View

(2017) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice

(2017) Farhana Naznin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial

(2017) Suzanne Craft et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin action in the brain: Roles in energy and glucose homeostasis

(2017) G. T. Dodd et al.   JOURNAL OF NEUROENDOCRINOLOGY

A molecular census of arcuate hypothalamus and median eminence cell types

(2017) John N Campbell et al.   NATURE NEUROSCIENCE

SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats

(2017) Piangkwan Sa-nguanmoo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action

(2017) Beatrice M. Filippi et al.   Cell Reports

Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation

(2017) J.D. Douglass et al.   Molecular Metabolism

Hepatic Ceramide May Mediate Brain Insulin Resistance and Neurodegeneration in Type 2 Diabetes and Non-alcoholic Steatohepatitis

(2017) Lascelles E. Lyn-Cook et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanisms of Ceramide-Mediated Neurodegeneration

(2017) Ming Tong et al.   JOURNAL OF ALZHEIMERS DISEASE

Pathways for insulin access to the brain: the role of the microvascular endothelial cell

(2016) Rick I. Meijer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Alterations of Mitochondrial Function and Insulin Sensitivity in Human Obesity and Diabetes Mellitus

(2016) Chrysi Koliaki et al.   Annual Review of Nutrition

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

(2016) Cristina García-Cáceres et al.   CELL

Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation

(2016) Candace M. Reno et al.   DIABETES

Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I

(2016) Ana M. Fernandez et al.   DIABETES

Bioenergetics and redox adaptations of astrocytes to neuronal activity

(2016) Juan P. Bolaños   JOURNAL OF NEUROCHEMISTRY

Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling

(2016) A. Kleinridders   JOURNAL OF NEUROENDOCRINOLOGY

Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity

(2015) Claudia A. Grillo et al.   DIABETES

Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance

(2015) Géraldine Gontier et al.   JOURNAL OF NEUROSCIENCE

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

(2015) Tiia Ngandu et al.   LANCET

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

(2015) Giuseppe Verdile et al.   MEDIATORS OF INFLAMMATION

Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans

(2015) Ellen A. Schur et al.   Obesity

Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and AβAccumulation

(2015) Maja Jazvinšćak Jembrek et al.   Oxidative Medicine and Cellular Longevity

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

(2015) Andre Kleinridders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic inflammation and gliosis in obesity

(2015) Mauricio D. Dorfman et al.   Current Opinion in Endocrinology Diabetes and Obesity

Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin

(2015) Rita Slaaby   Scientific Reports

Innate Immune Response in Brain, NF-Kappa B Signaling and Cystatins

(2015) Nataša Kopitar-Jerala   Frontiers in Molecular Neuroscience

Insulin Excites Anorexigenic Proopiomelanocortin Neurons via Activation of Canonical Transient Receptor Potential Channels

(2014) Jian Qiu et al.   Cell Metabolism

Drp1-Mediated Mitochondrial Abnormalities Link to Synaptic Injury in Diabetes Model

(2014) Shengbin Huang et al.   DIABETES

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Sirt1 rescues the obesity induced by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice

(2014) Vina Yanti Susanti et al.   Obesity

Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα

(2014) Eugenia Morselli et al.   Cell Reports

Evidence for altered transport of insulin across the blood–brain barrier in insulin-resistant humans

(2013) Martin Heni et al.   ACTA DIABETOLOGICA

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity

(2013) Marcelo O. Dietrich et al.   CELL

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

(2013) Marc Schneeberger et al.   CELL

Lipid signals and insulin resistance

(2013) Chongben Zhang et al.   Clinical Lipidology

Leptin regulation of Hsp60 impacts hypothalamic insulin signaling

(2013) André Kleinridders et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypothalamic malonyl-CoA and the control of food intake

(2013) Su Gao et al.   PHYSIOLOGY & BEHAVIOR

Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion

(2013) S. G. Rolland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioenergetic role of mitochondrial fusion and fission

(2012) Benedikt Westermann   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Insulin Activates Erk1/2 Signaling in the Dorsal Vagal Complex to Inhibit Glucose Production

(2012) Beatrice M. Filippi et al.   Cell Metabolism

Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

(2012) Suzanne M. de la Monte   Current Alzheimer Research

Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans

(2012) K. Jauch-Chara et al.   DIABETES

Postprandial Administration of Intranasal Insulin Intensifies Satiety and Reduces Intake of Palatable Snacks in Women

(2012) M. Hallschmid et al.   DIABETES

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

(2012) Luis Varela et al.   EMBO REPORTS

AgRP Innervation onto POMC Neurons Increases with Age and Is Accelerated with Chronic High-Fat Feeding in Male Mice

(2012) A. Jamila Newton et al.   ENDOCRINOLOGY

Mitochondrial redox signalling at a glance

(2012) Y. Collins et al.   JOURNAL OF CELL SCIENCE

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study

(2012) Patrick Imfeld et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Regulation of glucose transport by insulin: traffic control of GLUT4

(2012) Dara Leto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism of Oxidative Stress in Neurodegeneration

(2012) Sonia Gandhi et al.   Oxidative Medicine and Cellular Longevity

Effect of Insulin Analogues on Insulin/IGF1 Hybrid Receptors: Increased Activation by Glargine but Not by Its Metabolites M1 and M2

(2012) Cécile Pierre-Eugene et al.   PLoS One

Associations of Fatty Acids in Cerebrospinal Fluid with Peripheral Glucose Concentrations and Energy Metabolism

(2012) Reiner Jumpertz et al.   PLoS One

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

PPARγ Agonist Improves Neuronal Insulin Receptor Function in Hippocampus and Brain Mitochondria Function in Rats with Insulin Resistance Induced by Long Term High-Fat Diets

(2011) Noppamas Pipatpiboon et al.   ENDOCRINOLOGY

Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors

(2011) Manuel Sanchez-Alavez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake

(2010) Kristy Iskandar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Diabetes and Insulin in Regulation of Brain Cholesterol Metabolism

(2010) Ryo Suzuki et al.   Cell Metabolism

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Increased Brain Fatty Acid Uptake in Metabolic Syndrome

(2010) A. Karmi et al.   DIABETES

Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men

(2010) C. Benedict et al.   DIABETES

Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia

(2010) K. A. Diggs-Andrews et al.   DIABETES

Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling

(2010) L. Sciacca et al.   DIABETOLOGIA

Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

(2010) T. L. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin signaling meets mitochondria in metabolism

(2010) Zhiyong Cheng et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Selective neuronal vulnerability to oxidative stress in the brain

(2010) Wang   Frontiers in Aging Neuroscience

CNS-targets in control of energy and glucose homeostasis

(2009) André Kleinridders et al.   CURRENT OPINION IN PHARMACOLOGY

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Thein vivoneuron-to-astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation

(2009) Silvia Mangia et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats

(2009) Eduardo R. Ropelle et al.   JOURNAL OF PHYSIOLOGY-LONDON

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

(2009) Leona Plum et al.   NATURE MEDICINE

Foxo1 integrates insulin signaling with mitochondrial function in the liver

(2009) Zhiyong Cheng et al.   NATURE MEDICINE

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Central insulin action regulates peripheral glucose and fat metabolism in mice

(2008) Linda Koch et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

(2008) Jennifer W. Hill et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Insulin rescues amyloid β-induced impairment of hippocampal long-term potentiation

(2007) Cheng-Che Lee et al.   NEUROBIOLOGY OF AGING