Innate Immune Response in Brain, NF-Kappa B Signaling and Cystatins

Cystatin D Locates in the Nucleus at Sites of Active Transcription and Modulates Gene and Protein Expression

(2015) Gemma Ferrer-Mayorga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The pathogenic role of the inflammasome in neurodegenerative diseases

(2015) Leslie C. Freeman et al.   JOURNAL OF NEUROCHEMISTRY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

(2015) Audrey Gustin et al.   PLoS One

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Decreased IL-10 expression in stefin B-deficient macrophages is regulated by the MAP kinase and STAT-3 signaling pathways

(2014) Katarina Maher et al.   FEBS LETTERS

Abnormal microglial activation in theCstb−/−mouse, a model for progressive myoclonus epilepsy, EPM1

(2014) Olesya Okuneva et al.   GLIA

A Role for Stefin B (Cystatin B) in Inflammation and Endotoxemia

(2014) Katarina Maher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Critical Role for Human Caspase-4 in Endotoxin Sensitivity

(2014) Y. Kajiwara et al.   JOURNAL OF IMMUNOLOGY

Cystatin F Regulates Proteinase Activity in IL-2-activated Natural Killer Cells

(2014) Katarina Maher et al.   PROTEIN AND PEPTIDE LETTERS

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

The Role of Cysteine Proteinases and their Inhibitors in the Host-Pathogen Cross Talk

(2013) Natasa Kopitar-Jerala   CURRENT PROTEIN & PEPTIDE SCIENCE

Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status

(2013) Joshua Jabaut et al.   FREE RADICAL BIOLOGY AND MEDICINE

Human astrocytes express a novel NLRP2 inflammasome

(2013) Julia Minkiewicz et al.   GLIA

NF-κB: Emerging roles in hippocampal development and function

(2013) Sean J. Crampton et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms

(2013) Petr Broz et al.   PLoS Pathogens

Cystatins in Immune System

(2013) Špela Magister et al.   Journal of Cancer

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Inflammatory Mediators Alter the Astrocyte Transcriptome and Calcium Signaling Elicited by Multiple G-Protein-Coupled Receptors

(2012) M. E. Hamby et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Increased expression of stefin B in the nucleus of T98G astrocytoma cells delays caspase activation

(2012) Tao Sun et al.   Frontiers in Molecular Neuroscience

Cystatin C in Alzheimer's disease

(2012) Gurjinder Kaur et al.   Frontiers in Molecular Neuroscience

NF-κB in immunobiology

(2011) Matthew S Hayden et al.   CELL RESEARCH

Toll-like receptors

(2011) Eva Marie Y. Moresco et al.   CURRENT BIOLOGY

Early Microglial Activation Precedes Neuronal Loss in the Brain of theCstb−/−Mouse Model of Progressive Myoclonus Epilepsy, EPM1

(2011) Saara Tegelberg et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Non-canonical NF-κB signaling pathway

(2010) Shao-Cong Sun   CELL RESEARCH

Nonconventional Initiation Complex Assembly by STAT and NF-κB Transcription Factors Regulates Nitric Oxide Synthase Expression

(2010) Matthias Farlik et al.   IMMUNITY

Stefin B Interacts with Histones and Cathepsin L in the Nucleus

(2010) Slavko Čeru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin 18 in the CNS

(2010) Silvia Alboni et al.   Journal of Neuroinflammation

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Macrophage responses to interferon-γ are dependent on cystatin C levels

(2009) Katarina H. Frendéus et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

(2009) Silvia ρlvarez-Díaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Glycosylation Directs Targeting and Activation of Cystatin F from Intracellular and Extracellular Sources

(2009) Jeff D Colbert et al.   TRAFFIC

Selectivity of the NF- B Response

(2009) R. Sen et al.   Cold Spring Harbor Perspectives in Biology

NF- B as a Critical Link Between Inflammation and Cancer

(2009) M. Karin   Cold Spring Harbor Perspectives in Biology

Virus Infection Induces NF-κB-Dependent Interchromosomal Associations Mediating Monoallelic IFN-β Gene Expression

(2008) Effie Apostolou et al.   CELL

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis

(2008) Garth Hamilton et al.   EMBO JOURNAL

Cystatins: Biochemical and structural properties, and medical relevance

(2008) ">Vito Turk   Frontiers in Bioscience-Landmark

An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation

(2008) Carol Ho Yan Fong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Molecular background of EPM1—Unverricht–Lundborg disease

(2007) Tarja Joensuu et al.   EPILEPSIA