Bioenergetics and redox adaptations of astrocytes to neuronal activity

Are Astrocytes the Pressure-Reservoirs of Lactate in the Brain?

(2016) Sergey Kasparov   Cell Metabolism

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

(2015) D Jimenez-Blasco et al.   CELL DEATH AND DIFFERENTIATION

Glial Glycolysis Is Essential for Neuronal Survival in Drosophila

(2015) Anne Volkenhoff et al.   Cell Metabolism

Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity

(2015) Wen Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

(2015) T. Sotelo-Hitschfeld et al.   JOURNAL OF NEUROSCIENCE

Brain glycogen in health and disease

(2015) Jordi Duran et al.   MOLECULAR ASPECTS OF MEDICINE

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

mTOR in Brain Physiology and Pathologies

(2015) Joël Bockaert et al.   PHYSIOLOGICAL REVIEWS

NH4+ triggers the release of astrocytic lactate via mitochondrial pyruvate shunting

(2015) Rodrigo Lerchundi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting LDH enzymes with a stiripentol analog to treat epilepsy

(2015) N. Sada et al.   SCIENCE

Do stars govern our actions? Astrocyte involvement in rodent behavior

(2015) João Filipe Oliveira et al.   TRENDS IN NEUROSCIENCES

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

(2015) Paul S. Baxter et al.   Nature Communications

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

(2015) Iben Lundgaard et al.   Nature Communications

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

(2015) Karen F.S. Bell et al.   Nature Communications

Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS

(2015) Bettina Schreiner et al.   Cell Reports

Uncertainties in pentose-phosphate pathway flux assessment underestimate its contribution to neuronal glucose consumption: relevance for neurodegeneration and aging

(2015) Anne-Karine Bouzier-Sore et al.   Frontiers in Aging Neuroscience

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory

(2015) Monika Tadi et al.   PLoS One

Non-preferential fuelling of the Na+/K+-ATPase pump

(2014) Ignacio Fernández-Moncada et al.   BIOCHEMICAL JOURNAL

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes

(2014) R. F. Deighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuron-glia networks: integral gear of brain function

(2014) Gertrudis Perea et al.   Frontiers in Cellular Neuroscience

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

(2013) Diana Zala et al.   CELL

Glycolysis and Oxidative Phosphorylation in Neurons and Astrocytes during Network Activity in Hippocampal Slices

(2013) Anton I Ivanov et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuronal activity regulates astrocytic Nrf2 signaling

(2013) A. Habas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic signaling by lactate in the brain

(2013) L. Felipe Barros   TRENDS IN NEUROSCIENCES

APC/C-Cdh1 coordinates neurogenesis and cortical size during development

(2013) Maria Delgado-Esteban et al.   Nature Communications

Novel Model of Neuronal Bioenergetics: Postsynaptic Utilization of Glucose but not Lactate Correlates Positively with Ca2+ Signalling in Cultured Mouse Glutamatergic Neurons

(2012) Lasse K. Bak et al.   ASN Neuro

Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration

(2012) P Rodriguez-Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Acute feedback control of astrocytic glycolysis by lactate

(2012) T. Sotelo-Hitschfeld et al.   GLIA

Endothelial Cell-Derived Nitric Oxide Enhances Aerobic Glycolysis in Astrocytes via HIF-1 -Mediated Target Gene Activation

(2012) B. Brix et al.   JOURNAL OF NEUROSCIENCE

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes

(2011) Oleg Palygin et al.   BRITISH JOURNAL OF PHARMACOLOGY

3D view to tumor suppression: lkb1, polarity and the arrest of oncogenic c-myc

(2011) Johanna I. Partanen et al.   CELL CYCLE

Bioenergetic dysfunction in Huntington's disease human cybrids

(2011) I. Luisa Ferreira et al.   EXPERIMENTAL NEUROLOGY

Sweet Sixteen for ANLS

(2011) Luc Pellerin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Fast and Reversible Stimulation of Astrocytic Glycolysis by K+ and a Delayed and Persistent Effect of Glutamate

(2011) C. X. Bittner et al.   JOURNAL OF NEUROSCIENCE

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

(2011) D Nguyen et al.   Cell Death & Disease

Oxidative Stress and Energy Crises in Neuronal Dysfunction

(2010) David G. Nicholls   Annals of the New York Academy of Sciences

Vitamin E, Ascorbate, Glutathione, Glutathicne Disulfide, and Enzymes of Glutathione Metabolism in Cultures of Chick Astrocytes and Neurons: Evidence that Astrocytes Play an Important Role in Antioxidative Processes in the Brain

(2010) Tapas K. Makar et al.   JOURNAL OF NEUROCHEMISTRY

Characterisation of the Expression of NMDA Receptors in Human Astrocytes

(2010) Ming-Chak Lee et al.   PLoS One

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

(2010) K. F. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway

(2010) R. E. Haskew-Layton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+levels

(2009) Lasse K. Bak et al.   JOURNAL OF NEUROCHEMISTRY

Simultaneous single neuron recording of O2consumption, [Ca2+]iand mitochondrial membrane potential in glutamate toxicity

(2009) Marc Gleichmann et al.   JOURNAL OF NEUROCHEMISTRY

Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

(2009) Sung W. Choi et al.   JOURNAL OF NEUROCHEMISTRY

AMPK in the brain: its roles in energy balance and neuroprotection

(2009) Gabriele V. Ronnett et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of Cdh1-APC Function in Axon Growth by Cdh1 Phosphorylation

(2009) M. A. Huynh et al.   JOURNAL OF NEUROSCIENCE

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Molecular Motors and Synaptic Assembly

(2009) Qian Cai et al.   NEUROSCIENTIST

Glycolysis: a bioenergetic or a survival pathway?

(2009) Juan P. Bolaños et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of APC/C Activators in Mitosis and Meiosis

(2008) Jillian A. Pesin et al.   Annual Review of Cell and Developmental Biology

Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity

(2008) Carolina Maestre et al.   EMBO JOURNAL

The Anaphase Promoting Complex Induces Substrate Degradation during Neuronal Differentiation

(2008) Dympna Harmey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: A review

(2008) M. M. C. Wamelink et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Genomic stability and tumour suppression by the APC/C cofactor Cdh1

(2008) Irene García-Higuera et al.   NATURE CELL BIOLOGY

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c

(2008) Allyson E. Vaughn et al.   NATURE CELL BIOLOGY

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

(2008) Sofia Papadia et al.   NATURE NEUROSCIENCE

Mitochondrial fragmentation in neurodegeneration

(2008) Andrew B. Knott et al.   NATURE REVIEWS NEUROSCIENCE

Role of retinal glial cells in neurotransmitter uptake and metabolism

(2008) Andreas Bringmann et al.   NEUROCHEMISTRY INTERNATIONAL

AMPK: a metabolic gauge regulating whole-body energy homeostasis

(2008) Ricardo Lage et al.   TRENDS IN MOLECULAR MEDICINE

Na+-Ca2+cosignaling in the stimulation of the glucose transporter GLUT1 in cultured astrocytes

(2007) Omar H. Porras et al.   GLIA