Links Between Obesity-Induced Brain Insulin Resistance, Brain Mitochondrial Dysfunction, and Dementia

Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4

(2018) J. Pearson-Leary et al.   BEHAVIOURAL BRAIN RESEARCH

FGF21 and DPP-4 inhibitor equally prevents cognitive decline in obese rats

(2018) Piangkwan Sa-nguanmoo et al.   BIOMEDICINE & PHARMACOTHERAPY

Hippocampal insulin resistance links maternal obesity with impaired neuronal plasticity in adult offspring

(2018) Lisa Schmitz et al.   PSYCHONEUROENDOCRINOLOGY

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

(2017) Sophia M. Raefsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ginsenoside Re Ameliorates Brain Insulin Resistance and Cognitive Dysfunction in High Fat Diet-Induced C57BL/6 Mice

(2017) Jong Min Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Intranasal insulin treatment restores cognitive deficits and insulin signaling impairment induced by repeated methamphetamine exposure

(2017) Elmira Beirami et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

(2017) Seung Hyun Baek et al.   JOURNAL OF NEUROSCIENCE

FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice

(2017) Qingzhi Wang et al.   MOLECULAR NEUROBIOLOGY

SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats

(2017) Piangkwan Sa-nguanmoo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action

(2017) Beatrice M. Filippi et al.   Cell Reports

Mechanisms of Ceramide-Mediated Neurodegeneration

(2017) Ming Tong et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Amyloid-β Levels are Associated with the Extent of Mitochondrial Dysfunction in Different Brain Regions and the Degree of Cognitive Impairment in Alzheimer's Transgenic Mice

(2017) Natasa Dragicevic et al.   JOURNAL OF ALZHEIMERS DISEASE

Alterations of Mitochondrial Function and Insulin Sensitivity in Human Obesity and Diabetes Mellitus

(2016) Chrysi Koliaki et al.   Annual Review of Nutrition

ZiBu PiYin recipe prevents diabetes-associated cognitive decline in rats: possible involvement of ameliorating mitochondrial dysfunction, insulin resistance pathway and histopathological changes

(2016) Zheng Sun et al.   BMC Complementary and Alternative Medicine

Early effects of a high-caloric diet and physical exercise on brain volumetry and behavior: a combined MRI and histology study in mice

(2016) Markus Sack et al.   Brain Imaging and Behavior

Glucagon-like peptide 1 improves insulin resistance in vitro through anti-inflammation of macrophages

(2016) C. Guo et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Energy restriction combined with dipeptidyl peptidase-4 inhibitor exerts neuroprotection in obese male rats

(2016) Hiranya Pintana et al.   BRITISH JOURNAL OF NUTRITION

Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I

(2016) Ana M. Fernandez et al.   DIABETES

Potential effects of current drug therapies on cognitive impairment in patients with type 2 diabetes

(2016) Caterina Palleria et al.   FRONTIERS IN NEUROENDOCRINOLOGY

FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats

(2016) Piangkwan Sa-nguanmoo et al.   HORMONES AND BEHAVIOR

Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons

(2016) Yunhua Peng et al.   JOURNAL OF NEUROCHEMISTRY

Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway

(2016) FangFang et al.   METABOLIC BRAIN DISEASE

Testosterone deprivation has neither additive nor synergistic effects with obesity on the cognitive impairment in orchiectomized and/or obese male rats

(2016) Hiranya Pintana et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Human 'brite/beige' adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice

(2016) So Yun Min et al.   NATURE MEDICINE

Effects of cafeteria diet and high fat diet intake on anxiety, learning and memory in adult male rats

(2016) Renata Tavares Beschizza Pini et al.   NUTRITIONAL NEUROSCIENCE

Biology of Beige Adipocyte and Possible Therapy for Type 2 Diabetes and Obesity

(2016) Fernando Lizcano et al.   International Journal of Endocrinology

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

(2016) Mohd Waseem Akhtar et al.   Nature Communications

Vagus Nerve Stimulation Exerts the Neuroprotective Effects in Obese-Insulin Resistant Rats, Leading to the Improvement of Cognitive Function

(2016) Titikorn Chunchai et al.   Scientific Reports

Saturated lipids decrease mitofusin 2 leading to endoplasmic reticulum stress activation and insulin resistance in hypothalamic cells

(2015) Brenda Diaz et al.   BRAIN RESEARCH

Naringin Improves Neuronal Insulin Signaling, Brain Mitochondrial Function, and Cognitive Function in High-Fat Diet-Induced Obese Mice

(2015) Dongmei Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Increased Oxidative Stress and Mitochondrial Dysfunction in Zucker Diabetic Rat Liver and Brain

(2015) Haider Raza et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Insulin Resistance as Common Molecular Denominator Linking Obesity to Alzheimer’s Disease

(2015) Domenico Nuzzo et al.   Current Alzheimer Research

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline

(2015) V. A. Gault et al.   DIABETES OBESITY & METABOLISM

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice

(2015) Nicholas Douris et al.   ENDOCRINOLOGY

New targets to treat obesity and the metabolic syndrome

(2015) Kathleen A. Martin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Obesity accelerates cognitive decline by aggravating mitochondrial dysfunction, insulin resistance and synaptic dysfunction under estrogen-deprived conditions

(2015) Wasana Pratchayasakul et al.   HORMONES AND BEHAVIOR

Insulin receptor A and Sirtuin 1 synergistically improve learning and spatial memory following chronic salidroside treatment during hypoxia

(2015) Kalpana Barhwal et al.   JOURNAL OF NEUROCHEMISTRY

Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

(2015) William A. Banks et al.   Journal of Neuroinflammation

Effects of palatable cafeteria diet on cognitive and noncognitive behaviors and brain neurotrophins’ levels in mice

(2015) Daniela D. Leffa et al.   METABOLIC BRAIN DISEASE

Incretin-based therapies for obesity treatment

(2015) Aline Haas de Mello et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Fibroblast growth factor 21 protects mouse brain against d-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation

(2015) Yinhang Yu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity

(2015) Zhigang Liu et al.   PLoS One

Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice

(2015) Linkang Zhou et al.   Nature Communications

Garlic extract attenuates brain mitochondrial dysfunction and cognitive deficit in obese-insulin resistant rats

(2014) Hiranya Pintana et al.   Applied Physiology Nutrition and Metabolism

DPP-4 Inhibitor and PPARγ Agonist Restore the Loss of CA1 Dendritic Spines in Obese Insulin-resistant Rats

(2014) Jirapas Sripetchwandee et al.   ARCHIVES OF MEDICAL RESEARCH

Extended exposure to a palatable cafeteria diet alters gene expression in brain regions implicated in reward, and withdrawal from this diet alters gene expression in brain regions associated with stress

(2014) Sarah I. Martire et al.   BEHAVIOURAL BRAIN RESEARCH

FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss

(2014) Bryn M. Owen et al.   Cell Metabolism

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

Insulin Regulates Brain Function, but How Does It Get There?

(2014) S. M. Gray et al.   DIABETES

GABAergic Neurogliaform Cells Represent Local Sources of Insulin in the Cerebral Cortex

(2014) G. Molnar et al.   JOURNAL OF NEUROSCIENCE

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

Brain glucose transporters: Implications for neurologic disease

(2014) E. E. Benarroch   NEUROLOGY

Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice

(2014) Rachael Lennox et al.   NEUROPHARMACOLOGY

Oxidative Stress and Metabolic Pathologies: From an Adipocentric Point of View

(2014) Soazig Le Lay et al.   Oxidative Medicine and Cellular Longevity

Lixisenatide improves recognition memory and exerts neuroprotective actions in high-fat fed mice

(2014) Rachael Lennox et al.   PEPTIDES

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide

(2014) Krzysztof Łabuzek et al.   Pharmacological Reports

Cinnamon Extract Improves Insulin Sensitivity in the Brain and Lowers Liver Fat in Mouse Models of Obesity

(2014) Tina Sartorius et al.   PLoS One

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Obesity: Pathophysiology and Intervention

(2014) Yi Zhang et al.   Nutrients

Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1

(2014) Johanna Mäkelä et al.   SpringerPlus

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

(2014) Enrique Blázquez et al.   Frontiers in Endocrinology

Short exposure to a diet rich in both fat and sugar or sugar alone impairs place, but not object recognition memory in rats

(2013) Jessica E. Beilharz et al.   BRAIN BEHAVIOR AND IMMUNITY

The PPARγ agonist pioglitazone crosses the blood–brain barrier and reduces tumor growth in a human xenograft model

(2013) Christian Grommes et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice

(2013) Zhuofeng Lin et al.   Cell Metabolism

Fibroblast Growth Factor 21 Improves Insulin Resistance and Ameliorates Renal Injury indb/dbMice

(2013) H. W. Kim et al.   ENDOCRINOLOGY

FGF21 suppresses hepatic glucose production through the activation of atypical protein kinase Cι/λ

(2013) Ling-Jie Kong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bax induces cytochrome c release by multiple mechanisms in mitochondria from MCF7 cells

(2013) Nancy P. Gómez-Crisóstomo et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms

(2013) Shaodong Guo   JOURNAL OF ENDOCRINOLOGY

DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats

(2013) Hiranya Pintana et al.   JOURNAL OF ENDOCRINOLOGY

Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment

(2013) Y. Hara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview of Epidemiology and Contribution of Obesity to Cardiovascular Disease

(2013) Marjorie Bastien et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Computational classification of mitochondrial shapes reflects stress and redox state

(2013) T Ahmad et al.   Cell Death & Disease

Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration

(2012) Fei Yin et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Control of Cellular Life, Stress, and Death

(2012) Lorenzo Galluzzi et al.   CIRCULATION RESEARCH

Ceramide and Insulin Resistance: How Should the Issue Be Approached?

(2012) J. Gorski   DIABETES

DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption

(2012) Noppamas Pipatpiboon et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice

(2012) W D Porter et al.   INTERNATIONAL JOURNAL OF OBESITY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibroblast growth factor-21 serum concentrations are associated with metabolic and hepatic markers in humans

(2012) Susan Kralisch et al.   JOURNAL OF ENDOCRINOLOGY

Alcohol, insulin resistance and the liver-brain axis

(2012) Suzanne de la Monte et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats

(2012) Hiranya Pintana et al.   LIFE SCIENCES

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Actions of incretin metabolites on locomotor activity, cognitive function and in vivo hippocampal synaptic plasticity in high fat fed mice

(2012) David Porter et al.   PEPTIDES

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

(2011) Charlotte J. Green et al.   BIOCHEMICAL JOURNAL

NFκB-mediated metabolic inflammation in peripheral tissues versus central nervous system

(2011) Dongsheng Cai   CELL CYCLE

Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress

(2011) X Liu et al.   CELL DEATH AND DIFFERENTIATION

Insulin-producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT1A receptor

(2011) Jiangnan Luo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb

(2011) Tomoko Kuwabara et al.   EMBO Molecular Medicine

PPARγ Agonist Improves Neuronal Insulin Receptor Function in Hippocampus and Brain Mitochondria Function in Rats with Insulin Resistance Induced by Long Term High-Fat Diets

(2011) Noppamas Pipatpiboon et al.   ENDOCRINOLOGY

Effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders

(2011) Wasana Pratchayasakul et al.   LIFE SCIENCES

Effects of high-fat diet on insulin receptor function in rat hippocampus and the level of neuronal corticosterone

(2011) Wasana Pratchayasakul et al.   LIFE SCIENCES

Obesity, insulin resistance and free fatty acids

(2011) Guenther Boden   Current Opinion in Endocrinology Diabetes and Obesity

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids

(2010) Sun Ju Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impairing the Mitochondrial Fission and Fusion Balance: A New Mechanism of Neurodegeneration

(2010) Andrew B. Knott et al.   Annals of the New York Academy of Sciences

Mitochondria and Neuroplasticity

(2010) Aiwu Cheng et al.   ASN Neuro

Mitochondrial dynamics in cell death and neurodegeneration

(2010) Dong-Hyung Cho et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

(2010) D. W. Porter et al.   DIABETES OBESITY & METABOLISM

Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

(2010) V A Gault et al.   INTERNATIONAL JOURNAL OF OBESITY

Insulin signaling meets mitochondria in metabolism

(2010) Zhiyong Cheng et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

(2009) Jing Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Obesity-induced Insulin Resistance and Hyperglycemia

(2009) J A. Jeevendra Martyn et al.   ANESTHESIOLOGY

Activation of NF-κB by Palmitate in Endothelial Cells

(2009) Ezekiel Maloney et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Contribution of Impaired Myocardial Insulin Signaling to Mitochondrial Dysfunction and Oxidative Stress in the Heart

(2009) Sihem Boudina et al.   CIRCULATION

Obesity, Inflammation, and Insulin Resistance – A Mini-Review

(2009) Maximilian Zeyda et al.   GERONTOLOGY

Prolonged Exposure to Insulin Suppresses Mitochondrial Production in Primary Hepatocytes

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo electrophysiological effects of insulin in the rat brain

(2009) Peter Kovacs et al.   NEUROPEPTIDES

Insulin Signaling Regulates Mitochondrial Function in Pancreatic β-Cells

(2009) Siming Liu et al.   PLoS One

Palatable cafeteria diet ameliorates anxiety and depression-like symptoms following an adverse early environment

(2009) Jayanthi Maniam et al.   PSYCHONEUROENDOCRINOLOGY

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of ceramide-induced neuronal death: Cell metabolism meets neurodegeneration

(2008) Gonzalo Arboleda et al.   BRAIN RESEARCH REVIEWS

Role of Mitochondrial Dysfunction in Insulin Resistance

(2008) Jeong-a Kim et al.   CIRCULATION RESEARCH

Rosiglitazone attenuates the cognitive deficits induced by high fat diet feeding in rats

(2008) Asif R. Pathan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON

The Role of Incretins in Glucose Homeostasis and Diabetes Treatment

(2008) W. Kim et al.   PHARMACOLOGICAL REVIEWS

Synaptic plasticity, memory and the hippocampus: a neural network approach to causality

(2007) Guilherme Neves et al.   NATURE REVIEWS NEUROSCIENCE