Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function
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Title
Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function
Authors
Keywords
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Journal
Frontiers in Endocrinology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-11-23
DOI
10.3389/fendo.2018.00672
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Note: Only part of the references are listed.- Renal Effects of Incretin-Based Diabetes Therapies: Pre-clinical Predictions and Clinical Trial Outcomes
- (2018) Scott C. Thomson et al. Current Diabetes Reports
- A role for Glucagon-Like Peptide-1 in the regulation of β-cell autophagy
- (2018) Catherine Arden PEPTIDES
- Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic β-cell bioenergetic parameters and metabolism in BRIN-BD11 cells
- (2018) Jordan Rowlands et al. PEPTIDES
- The glucagon-like peptide-1 (GLP-1) analog liraglutide attenuates renal fibrosis
- (2018) Ya-Kun Li et al. PHARMACOLOGICAL RESEARCH
- The Role of Glucagon-Like Peptide 1 (GLP1) in Type 3 Diabetes: GLP-1 Controls Insulin Resistance, Neuroinflammation and Neurogenesis in the Brain
- (2017) Choon Bae et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling
- (2017) Chunhua Dai et al. JOURNAL OF CLINICAL INVESTIGATION
- Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial
- (2017) Dilan Athauda et al. LANCET
- Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats
- (2017) Emanuel Candeias et al. MOLECULAR NEUROBIOLOGY
- GLP-1 and the kidney: from physiology to pharmacology and outcomes in diabetes
- (2017) Marcel H. A. Muskiet et al. Nature Reviews Nephrology
- Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC-δ-dependent neurocircuitry
- (2017) Mengliu Yang et al. Cell Death & Disease
- Liraglutide activates autophagy via GLP-1R to improve functional recovery after spinal cord injury
- (2017) Jian Chen et al. Oncotarget
- GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation
- (2017) Rodrigo Carlessi et al. Scientific Reports
- Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis
- (2017) Shuyang Traub et al. Cell Reports
- The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice
- (2017) Laurie L. Baggio et al. Molecular Metabolism
- Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells
- (2017) Theodora Panagaki et al. Scientific Reports
- Hepatic functions of GLP-1 and its based drugs: current disputes and perspectives
- (2016) Tianru Jin et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK/mTOR pathway
- (2016) Qin He et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy
- (2016) Lydia Lynch et al. Cell Metabolism
- GLP-1 Agonists and Blood Pressure: A Review of the Evidence
- (2016) Aditya Goud et al. CURRENT HYPERTENSION REPORTS
- Acute renal haemodynamic effects of glucagon-like peptide-1 receptor agonist exenatide in healthy overweight men
- (2016) M. H. A. Muskiet et al. DIABETES OBESITY & METABOLISM
- Gastrointestinal actions of glucagon-like peptide-1-based therapies: glycaemic control beyond the pancreas
- (2016) M. M. Smits et al. DIABETES OBESITY & METABOLISM
- GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial
- (2016) Olivia M. Farr et al. DIABETOLOGIA
- The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action
- (2016) Dilan Athauda et al. DRUG DISCOVERY TODAY
- Effect of liraglutide therapy on liver fat content in patients with inadequately controlled type 2 diabetes. The Lira-NAFLD study
- (2016) Jean-Michel Petit et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Decreased Hypothalamic Glucagon-Like Peptide-1 Receptor Expression in Type 2 Diabetes Patients
- (2016) Jennifer S. ten Kulve et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Astrocytes Regulate GLP-1 Receptor-Mediated Effects on Energy Balance
- (2016) D. J. Reiner et al. JOURNAL OF NEUROSCIENCE
- The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism
- (2016) Francesco Andreozzi et al. Journal of Translational Medicine
- Reduced incidence of Parkinson's disease after dipeptidyl peptidase-4 inhibitors-A nationwide case-control study
- (2016) Per Svenningsson et al. MOVEMENT DISORDERS
- Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
- (2016) Steven P. Marso et al. NEW ENGLAND JOURNAL OF MEDICINE
- Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
- (2016) Steven P. Marso et al. NEW ENGLAND JOURNAL OF MEDICINE
- Therapeutic strategies for Alzheimer's disease in clinical trials
- (2016) Justyna Godyń et al. Pharmacological Reports
- GLP-1 is both anxiogenic and antidepressant; divergent effects of acute and chronic GLP-1 on emotionality
- (2016) Rozita H Anderberg et al. PSYCHONEUROENDOCRINOLOGY
- Perspectives in GLP-1 Research: New Targets, New Receptors
- (2016) Giulia Cantini et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Neural effects of gut- and brain-derived glucagon-like peptide-1 and its receptor agonist
- (2016) Kenichi Katsurada et al. Journal of Diabetes Investigation
- Effect of Exendin-4 on Autophagy Clearance in Beta Cell of Rats with Tacrolimus-induced Diabetes Mellitus
- (2016) Sun Woo Lim et al. Scientific Reports
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- (2016) Sarah J. Glastras et al. Scientific Reports
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- (2016) Jenq-Lin Yang et al. Theranostics
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- Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance andβ-Cell Dysfunction
- (2015) Kevin Noel Keane et al. Oxidative Medicine and Cellular Longevity
- Glycogen synthase kinase-3 beta (GSK-3β) signaling: Implications for Parkinson's disease
- (2015) Mojtaba Golpich et al. PHARMACOLOGICAL RESEARCH
- The molecular mechanism of rotenone-induced α-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway
- (2015) Yu-he Yuan et al. TOXICOLOGY LETTERS
- UPR, autophagy, and mitochondria crosstalk underlies the ER stress response
- (2015) Daniela Senft et al. TRENDS IN BIOCHEMICAL SCIENCES
- Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology
- (2015) Beth Levine et al. TRENDS IN CELL BIOLOGY
- Signaling in Muscle Contraction
- (2015) Ivana Y. Kuo et al. Cold Spring Harbor Perspectives in Biology
- Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival
- (2015) J Pfleger et al. Cell Death & Disease
- Motor and Cognitive Advantages Persist 12 Months After Exenatide Exposure in Parkinson’s Disease
- (2015) Iciar Aviles-Olmos et al. Journal of Parkinsons Disease
- Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain
- (2015) Simon C. Cork et al. Molecular Metabolism
- Hypothalamic GLP-1: the control of BAT thermogenesis and browning of white fat
- (2015) Miguel López et al. Adipocyte
- Activation of the GLP-1 Receptors in the Nucleus of the Solitary Tract Reduces Food Reward Behavior and Targets the Mesolimbic System
- (2015) Jennifer E. Richard et al. PLoS One
- GLP-1 receptor agonists have a sustained stimulatory effect on corticosterone release after chronic treatment
- (2014) Maarja Krass et al. ACTA NEUROPSYCHIATRICA
- The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease
- (2014) Christian Hölscher Alzheimers & Dementia
- GLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic reticulum–mitochondria coupling
- (2014) Pablo E. Morales et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Investigating G protein signalling bias at the glucagon-like peptide-1 receptor in yeast
- (2014) C Weston et al. BRITISH JOURNAL OF PHARMACOLOGY
- GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans
- (2014) Sharmila C. Subaran et al. CLINICAL SCIENCE
- GLP-1 Receptor Activation Modulates Appetite- and Reward-Related Brain Areas in Humans
- (2014) L. van Bloemendaal et al. DIABETES
- GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK
- (2014) D. Beiroa et al. DIABETES
- Effect of Exogenous Intravenous Administrations of GLP-1 and/or GIP on Circulating Pro-Atrial Natriuretic Peptide in Subjects With Different Stages of Glucose Tolerance: Figure 1
- (2014) Natalia Rudovich et al. DIABETES CARE
- Liraglutide and the Preservation of Pancreatic β-Cell Function in Early Type 2 Diabetes: The LIBRA Trial
- (2014) Ravi Retnakaran et al. DIABETES CARE
- GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody
- (2014) Charles Pyke et al. ENDOCRINOLOGY
- Characteristics of GLP-1 and exendins action upon glucose transport and metabolism in type 2 diabetic rat skeletal muscle
- (2014) Luis Arnés et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss
- (2014) Anna Secher et al. JOURNAL OF CLINICAL INVESTIGATION
- Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight
- (2014) Laurie L. Baggio et al. JOURNAL OF CLINICAL INVESTIGATION
- Neuronal GLP1R mediates liraglutide’s anorectic but not glucose-lowering effect
- (2014) Stephanie Sisley et al. JOURNAL OF CLINICAL INVESTIGATION
- Exogenous glucagon-like peptide 1 reduces contractions in human colon circular muscle
- (2014) Antonella Amato et al. JOURNAL OF ENDOCRINOLOGY
- Liraglutide enhances glucose transporter 4 translocation via regulation of AMP-activated protein kinase signaling pathways in mouse skeletal muscle cells
- (2014) Zhu Li et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy
- (2014) Vladimir Rogov et al. MOLECULAR CELL
- Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice
- (2014) Rachael Lennox et al. NEUROPHARMACOLOGY
- Chronic Exposure to GLP-1 Increases GLP-1 Synthesis and Release in a Pancreatic Alpha Cell Line (α-TC1): Evidence of a Direct Effect of GLP-1 on Pancreatic Alpha Cells
- (2014) Salvatore Piro et al. PLoS One
- Effects of GLP-1 in the Kidney
- (2014) Jeppe Skov REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
- Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus
- (2014) Trevor J. Biden et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflammation
- (2014) Xing-Chun Wang WORLD JOURNAL OF GASTROENTEROLOGY
- Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion
- (2014) Ghupurjan Gheni et al. Cell Reports
- GLP-1 receptor agonist increases the expression of CTRP3, a novel adipokine, in 3T3-L1 adipocytes through PKA signal pathway
- (2014) X. Li et al. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
- Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection
- (2014) John R. Ussher et al. Molecular Metabolism
- GLP-1 receptor agonists: a review of head-to-head clinical studies
- (2014) Jennifer M. Trujillo et al. Therapeutic Advances in Endocrinology and Metabolism
- Cardioprotective Effects of Exenatide in Patients With ST-Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- (2013) Jong Shin Woo et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation
- (2013) K Pabreja et al. BRITISH JOURNAL OF PHARMACOLOGY
- Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration
- (2013) Y Wang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action
- (2013) Jonathan E. Campbell et al. Cell Metabolism
- Glucagon-like peptide-1 receptor agonist treatment reduces beta cell mass in normoglycaemic mice
- (2013) J. H. Ellenbroek et al. DIABETOLOGIA
- Exendin-4 is effective against metabolic disorders induced by intrauterine and postnatal overnutrition in rodents
- (2013) Hui Chen et al. DIABETOLOGIA
- SIRT1 and SIRT2: emerging targets in neurodegeneration
- (2013) Gizem Donmez et al. EMBO Molecular Medicine
- New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease
- (2013) Miguel Medina et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Intravenous GLP-1 (7-36) Amide for Prevention of Hyperglycemia During Cardiac Surgery: A Randomized, Double-Blind, Placebo-Controlled Study
- (2013) Benjamin A. Kohl et al. JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
- Glucagon-Like Peptide-1 (GLP-1): Effect on Kidney Hemodynamics and Renin-Angiotensin-Aldosterone System in Healthy Men
- (2013) Jeppe Skov et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Exenatide and the treatment of patients with Parkinson’s disease
- (2013) Iciar Aviles-Olmos et al. JOURNAL OF CLINICAL INVESTIGATION
- Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases
- (2013) Christian Hölscher JOURNAL OF ENDOCRINOLOGY
- Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress
- (2013) Mohit K. Sharma et al. JOURNAL OF NEUROCHEMISTRY
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- (2013) Hua Yang et al. JOURNAL OF SURGICAL RESEARCH
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- (2013) D. Katagiri et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
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- (2013) Yen-Ta Chen et al. Journal of Translational Medicine
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- (2013) Hiroki Fujita et al. KIDNEY INTERNATIONAL
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- (2013) Minsuk Kim et al. NATURE MEDICINE
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- (2013) Christopher A. Lamb et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2013) S. Chen et al. NEUROSCIENCE
- Effects of exenatide and liraglutide on heart rate, blood pressure and body weight: systematic review and meta-analysis
- (2013) Louise E Robinson et al. BMJ Open
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- (2013) A. Serrano-Pozo et al. Cold Spring Harbor Perspectives in Medicine
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- (2012) Supriya Swarnkar et al. ARCHIVES OF TOXICOLOGY
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- (2012) Changting Xiao et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
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- (2012) S. Ravassa et al. CARDIOVASCULAR RESEARCH
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- (2012) Mohammad Hossein Noyan-Ashraf et al. CIRCULATION
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- (2012) David C. Rubinsztein et al. CURRENT BIOLOGY
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- (2012) W. Chai et al. DIABETES
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- (2012) S. H. Lockie et al. DIABETES
- GLP-1 receptor agonists: A clinical perspective on cardiovascular effects
- (2012) Dhanwantee Mundil et al. Diabetes & Vascular Disease Research
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- (2012) A. R. Meloni et al. DIABETES OBESITY & METABOLISM
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- (2012) Naim Panjwani et al. ENDOCRINOLOGY
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- (2012) Vadivel Parthsarathy et al. EUROPEAN JOURNAL OF PHARMACOLOGY
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- (2011) N M Whalley et al. JOURNAL OF ENDOCRINOLOGY
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- (2011) A. Hamilton et al. JOURNAL OF NEUROSCIENCE RESEARCH
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- (2011) C. Holmes et al. NEUROLOGY
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- (2011) Bruno Schisano et al. REGULATORY PEPTIDES
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- (2011) Sonya G. Fonseca et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The binary switch between life and death of endoplasmic reticulum-stressed β cells
- (2011) Christine M Oslowski et al. Current Opinion in Endocrinology Diabetes and Obesity
- ER Stress and Its Functional Link to Mitochondria: Role in Cell Survival and Death
- (2011) J. D. Malhotra et al. Cold Spring Harbor Perspectives in Biology
- Roles and Regulation of the Transcription Factor CREB in Pancreatic β -Cells
- (2011) Stephane Dalle et al. Current Molecular Pharmacology
- Glucagon-like peptide 1 receptor stimulation as a means of neuroprotection
- (2010) Alexander Harkavyi et al. BRITISH JOURNAL OF PHARMACOLOGY
- Effects of exogenous glucagon-like peptide-1 on gastric emptying and glucose absorption in the critically ill: Relationship to glycemia*
- (2010) Adam M. Deane et al. CRITICAL CARE MEDICINE
- Glucagon-Like Peptide (GLP)-1(9-36)Amide-Mediated Cytoprotection Is Blocked by Exendin(9-39) Yet Does Not Require the Known GLP-1 Receptor
- (2010) Kiwon Ban et al. ENDOCRINOLOGY
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- (2010) Nitika Arora Gupta et al. HEPATOLOGY
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- (2010) E. Tomas et al. HORMONE AND METABOLIC RESEARCH
- Glucagon-like Peptide-1 Increases β-Cell Glucose Competence and Proliferation by Translational Induction of Insulin-like Growth Factor-1 Receptor Expression
- (2010) Marion Cornu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2010) S. Nath et al. MOLECULAR AND CELLULAR NEUROSCIENCE
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- (2010) Katrin Düvel et al. MOLECULAR CELL
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- (2010) F. Zhang et al. MOLECULAR PHARMACOLOGY
- Liraglutide
- (2010) Daniel J. Drucker et al. NATURE REVIEWS DRUG DISCOVERY
- GSK3 signalling in neural development
- (2010) Eun-Mi Hur et al. NATURE REVIEWS NEUROSCIENCE
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- (2010) Simon Gengler et al. NEUROBIOLOGY OF AGING
- Val8-glucagon-like peptide-1 protects against Aβ1–40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats
- (2010) X.H. Wang et al. NEUROSCIENCE
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- (2010) Hua Li et al. NEUROSCIENCE LETTERS
- Hyperglycemia-induced endoplasmic reticulum stress in endothelial cells
- (2010) Mae Sheikh-Ali et al. NUTRITION
- Retrograde axonal transport: pathways to cell death?
- (2010) Eran Perlson et al. TRENDS IN NEUROSCIENCES
- Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
- (2009) Talib Abbas et al. BEHAVIOURAL BRAIN RESEARCH
- Exendin-4 has an anti-hypertensive effect in salt-sensitive mice model
- (2009) Kunio Hirata et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates
- (2009) Dan Han et al. CELL
- Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB
- (2009) Daniel A. Cunha et al. DIABETES
- Glucagon-Like Peptide-1 Protects -Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop
- (2009) M. Cornu et al. DIABETES
- GLP-1R Agonist Liraglutide Activates Cytoprotective Pathways and Improves Outcomes After Experimental Myocardial Infarction in Mice
- (2009) M. H. Noyan-Ashraf et al. DIABETES
- Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease
- (2009) Paula L. McClean et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- α-Synuclein contributes to GSK-3β-catalyzed Tau phosphorylation in Parkinson’s disease models
- (2009) Tetyana Duka et al. FASEB JOURNAL
- Exendin-4 Promotes Liver Cell Proliferation and Enhances thePDX-1-induced Liver to Pancreas Transdifferentiation Process
- (2009) Vered Aviv et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exenatide Reduces Infarct Size and Improves Cardiac Function in a Porcine Model of Ischemia and Reperfusion Injury
- (2009) Leo Timmers et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- GLP-1 regulates gastroduodenal motility involving cholinergic pathways
- (2009) j. schirra et al. NEUROGASTROENTEROLOGY AND MOTILITY
- DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212
- (2009) Ju Young Kim et al. NEURON
- Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics
- (2009) Emily J. Tsai et al. PHARMACOLOGY & THERAPEUTICS
- Glucagon-Like Peptide-1 Induced Signaling and Insulin Secretion Do Not Drive Fuel and Energy Metabolism in Primary Rodent Pancreatic β-Cells
- (2009) Marie-Line Peyot et al. PLoS One
- Calcium-Dependent Increases in Protein Kinase-A Activity in Mouse Retinal Ganglion Cells Are Mediated by Multiple Adenylate Cyclases
- (2009) Timothy A. Dunn et al. PLoS One
- GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism
- (2009) Y. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP
- (2008) Brian D. Green et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Oxidative stress: the vulnerable β-cell
- (2008) Sigurd Lenzen BIOCHEMICAL SOCIETY TRANSACTIONS
- Cardioprotective and Vasodilatory Actions of Glucagon-Like Peptide 1 Receptor Are Mediated Through Both Glucagon-Like Peptide 1 Receptor–Dependent and –Independent Pathways
- (2008) Kiwon Ban et al. CIRCULATION
- The Type 1 Insulin-Like Growth Factor Receptor Pathway
- (2008) M. M. Chitnis et al. CLINICAL CANCER RESEARCH
- Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake
- (2008) D. A. Sandoval et al. DIABETES
- GLP-1 receptor signaling: effects on pancreatic β-cell proliferation and survival
- (2008) J. Buteau DIABETES & METABOLISM
- Acute Effects of Glucagon-Like Peptide-1 on Hypothalamic Neuropeptide and AMP Activated Kinase Expression in Fasted Rats
- (2008) Sanghee SEO et al. ENDOCRINE JOURNAL
- The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus
- (2008) Décio L. Eizirik et al. ENDOCRINE REVIEWS
- GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid
- (2008) Victor A. Gault et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- The Potential Beneficial Role of Glucagon-like Peptide-1 in Endothelial Dysfunction and Heart Failure Associated with Insulin Resistance
- (2008) T. Nyström HORMONE AND METABOLIC RESEARCH
- Discovery of TBC1D1 as an Insulin-, AICAR-, and Contraction-stimulated Signaling Nexus in Mouse Skeletal Muscle
- (2008) Eric B. Taylor et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease
- (2008) Alexander Harkavyi et al. Journal of Neuroinflammation
- Role of the cAMP sensor Epac as a determinant of KATPchannel ATP sensitivity in human pancreatic β-cells and rat INS-1 cells
- (2008) Guoxin Kang et al. JOURNAL OF PHYSIOLOGY-LONDON
- Mitochondria in the aetiology and pathogenesis of Parkinson's disease
- (2008) Anthony HV Schapira LANCET NEUROLOGY
- Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-β peptide (1–42)
- (2008) Zhenxia Qin et al. NEUROSCIENCE LETTERS
- mTOR—What Does It Do?
- (2008) M.N. Hall TRANSPLANTATION PROCEEDINGS
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