Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

Antidepressant effects of insulin in streptozotocin induced diabetic mice: Modulation of brain serotonin system

(2014) Deepali Gupta et al.   PHYSIOLOGY & BEHAVIOR

Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats

(2013) Weiguo Li et al.   BRAIN RESEARCH

Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity

(2013) Marcelo O. Dietrich et al.   CELL

Blunted Refeeding Response and Increased Locomotor Activity in Mice Lacking FoxO1 in Synapsin-Cre-Expressing Neurons

(2013) H. Ren et al.   DIABETES

Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice

(2013) Ling Wang et al.   EXPERIMENTAL NEUROLOGY

Intranasal Insulin Suppresses Systemic but Not Subcutaneous Lipolysis in Healthy Humans

(2013) K. Alexander Iwen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin regulation of Hsp60 impacts hypothalamic insulin signaling

(2013) André Kleinridders et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetes Augments In Vivo Microvascular Blood Flow Dynamics after Stroke

(2013) K. A. Tennant et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Network-Level Structural Abnormalities of Cerebral Cortex in Type 1 Diabetes Mellitus

(2013) In Kyoon Lyoo et al.   PLoS One

Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function

(2013) Ryo Suzuki et al.   PLOS BIOLOGY

Streptozotocin-induced insulin deficiency leads to development of behavioral deficits in rats

(2012) Saida Haider et al.   ACTA NEUROLOGICA BELGICA

Tissue–Specific Insulin Signaling, Metabolic Syndrome, and Cardiovascular Disease

(2012) Christian Rask-Madsen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

(2012) Suzanne M. de la Monte   Current Alzheimer Research

Resting-State Brain Functional Connectivity Is Altered in Type 2 Diabetes

(2012) G. Musen et al.   DIABETES

White Matter Microstructural Integrity in Youth With Type 1 Diabetes

(2012) J. A. V. Antenor-Dorsey et al.   DIABETES

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

FOXO1 in the ventromedial hypothalamus regulates energy balance

(2012) Ki Woo Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Rosiglitazone treatment reversed depression- but not psychosis-like behavior of db/db diabetic mice

(2012) Ajaykumar N Sharma et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease

(2011) Oliver Stöhr et al.   AGE

Insulin increases glutamate transporter GLT1 in cultured astrocytes

(2011) Yi-Fei Ji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypothalamic neurosphere progenitor cells in low birth-weight rat newborns: Neurotrophic effects of leptin and insulin

(2011) Mina Desai et al.   BRAIN RESEARCH

Deficiency of Lipoprotein Lipase in Neurons Modifies the Regulation of Energy Balance and Leads to Obesity

(2011) Hong Wang et al.   Cell Metabolism

Role for Insulin Signaling in Catecholaminergic Neurons in Control of Energy Homeostasis

(2011) A. Christine Könner et al.   Cell Metabolism

Brain Activation During Working Memory Is Altered in Patients With Type 1 Diabetes During Hypoglycemia

(2011) N. R. Bolo et al.   DIABETES

Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors

(2011) Manuel Sanchez-Alavez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

(2011) Marianna Sadagurski et al.   JOURNAL OF CLINICAL INVESTIGATION

Higher levels of heat shock proteins in longer-lived mammals and birds

(2011) Kurtis D. Salway et al.   MECHANISMS OF AGEING AND DEVELOPMENT

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons

(2011) Tim Klöckener et al.   NATURE NEUROSCIENCE

Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity

(2011) Michael J. Stuart et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Direct Interaction of α-Synuclein and AKT Regulates IGF-1 Signaling: Implication of Parkinson Disease

(2011) Ji-Yun Chung et al.   NEUROSIGNALS

Insulin Promotes Glycogen Storage and Cell Proliferation in Primary Human Astrocytes

(2011) Martin Heni et al.   PLoS One

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

(2011) Loredana Stoica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol metabolism in neurons and astrocytes

(2011) Frank W. Pfrieger et al.   PROGRESS IN LIPID RESEARCH

Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases

(2011) Oscar Vadas et al.   Science Signaling

Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease

(2011) Jake G Hoekstra et al.   Alzheimers Research & Therapy

Rescue of Obesity-Induced Infertility in Female Mice due to a Pituitary-Specific Knockout of the Insulin Receptor

(2010) Kathryn J. Brothers et al.   Cell Metabolism

Diabetes and Insulin in Regulation of Brain Cholesterol Metabolism

(2010) Ryo Suzuki et al.   Cell Metabolism

Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men

(2010) C. Benedict et al.   DIABETES

Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia

(2010) K. A. Diggs-Andrews et al.   DIABETES

Neurobehavioral deficits in db/db diabetic mice

(2010) Ajaykumar N. Sharma et al.   PHYSIOLOGY & BEHAVIOR

Hippocampal long-term depression is required for the consolidation of spatial memory

(2010) Y. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer’s disease

(2009) Susanna Freude et al.   FASEB JOURNAL

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RETRACTED: Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy

(2008)   BRAIN

Cognition and diabetes: a lifespan perspective

(2008) Geert Jan Biessels et al.   LANCET NEUROLOGY

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

(2008) Laurent Kappeler et al.   PLOS BIOLOGY