Article
Neurosciences
Xiaohan Yang, Yuan Xu, Wenting Gao, Li Wang, Xinnan Zhao, Gang Liu, Kai Fan, Shuang Liu, Huimin Hao, Siyan Qu, Renhou Dong, Xiaokai Ma, Jianmei Ma
Summary: Research suggests that insulin resistance (IR) may be one of the underlying mechanisms linking type 2 diabetes (T2D) and Alzheimer's disease (AD). Hyperinsulinemia, characteristic of IR, could impact microglia, leading to neuroinflammation and cognitive impairments.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Antonella Tramutola, Simona Lanzillotta, Giuseppe Aceto, Sara Pagnotta, Gabriele Ruffolo, Pierangelo Cifelli, Federico Marini, Cristian Ripoli, Eleonora Palma, Claudio Grassi, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone
Summary: Down syndrome (DS) is associated with Alzheimer's disease (AD) and brain insulin resistance. The KYCCSRK peptide has shown potential for improving insulin signaling in DS and reducing AD-like neuropathology in mice.
Review
Neurosciences
Suelen Santos Alves, Rui Milton Patricio da Silva-Junior, Gabriel Servilha-Menezes, Jan Homolak, Melita Salkovic-Petrisic, Norberto Garcia-Cairasco
Summary: Alzheimer's disease is a severe public health problem and current medical approaches are limited to symptomatic interventions, with a high failure rate in clinical trials. While most studies have focused on the amyloid cascade hypothesis, it is clear that AD is a multifactorial disorder.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Endocrinology & Metabolism
Tanya S. McDonald, Titaya Lerskiatiphanich, Trent M. Woodruff, Pamela A. McCombe, John D. Lee
Summary: Neurodegeneration refers to the progressive loss of neurons in disorders like Alzheimer's, Huntington's, and Parkinson's disease. Energy metabolism disturbances and alterations are common features in the onset and progression of these diseases. Understanding these metabolic changes could lead to improved treatment options for neurodegenerative disorders.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Nutrition & Dietetics
Richard J. Johnson, Dean R. Tolan, Dale Bredesen, Maria Nagel, Laura G. Sanchez-Lozada, Mehdi Fini, Scott Burtis, Miguel A. Lanaspa, David Perlmutter
Summary: Fructose metabolism activates a survival mechanism that helps preserve glucose supply for the brain in times of scarcity, but prolonged engagement of this mechanism may contribute to the development of Alzheimer's disease. Diets high in sugar, high glycemic carbohydrates, and salt can activate this pathway. Further studies are needed to understand the role of fructose metabolism and its metabolite, uric acid, in Alzheimer's disease, and dietary and pharmacologic trials should be conducted to explore potential benefits in the prevention, management, or treatment of this disease.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Oksana Fihurka, Yanhong Wang, Yuzhu Hong, Xiaoyang Lin, Ning Shen, Haiqiang Yang, Breanna Brown, Marcus Mommer, Tarek Zieneldien, Yitong Li, Janice Kim, Minghua Li, Jianfeng Cai, Qingyu Zhou, Chuanhai Cao
Summary: This study evaluated the therapeutic properties of a novel nanoformulation containing melatonin, insulin, and THC for the treatment of Alzheimer's disease. The results showed that this nanoformulation significantly improved spatial learning memory and decreased tau phosphorylation and mitochondrial dysfunction. Therefore, this multi-targeting nanoformulation could be a safe and effective therapeutic for Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Sheryl T. Carr, Erin R. Saito, Chase M. Walton, Jeremy Y. Saito, Cameron M. Hanegan, Cali E. Warren, Annie M. Trumbull, Benjamin T. Bikman
Summary: This study found that hyperinsulinemia leads to ceramide accumulation and mitochondrial impairments in the brain, which may be involved in the development and progression of Alzheimer's disease (AD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Inci Kazkayasi, Gokcen Telli, Emirhan Nemutlu, Serdar Uma
Summary: This study found that intranasal metformin treatment can improve learning and memory functions in ICV-STZ-induced AD mice, by increasing insulin sensitivity.
Article
Cell Biology
Hemant Srivastava, Alexander Tate Lasher, Akash Nagarajan, Liou Y. Sun
Summary: Alzheimer's disease (AD) is a prevalent form of dementia that is characterized by cognitive decline with age. Treatment options for AD are limited, making it a significant public health concern. Recent research has shown that metabolic dysfunction and insulin therapy may play a role in the development of AD. In this study, the TgF344-AD rat model was used to examine the relationship between body composition, insulin sensitivity, glucose tolerance, and behavioral assessments of learning, memory, and anxiety. The results showed that female TgF344-AD rats exhibited impaired glucose clearance and reduced insulin sensitivity, while male rats showed no differences or improved glucose clearance. Male rats also displayed impairments in learning and memory, while female rats showed impairments only at a later age. Additionally, female rats displayed increased anxiety at a younger age, but no differences were detected in males. These findings suggest that metabolic impairments occur before or simultaneously with cognitive decline and anxiety, in a sexually dimorphic manner, in the TgF344-AD rat model.
Article
Behavioral Sciences
Suelen Santos Alves, Gabriel Servilha-Menezes, Leticia Rossi, Rui Milton Patricio da Silva Junior, Norberto Garcia-Cairasco
Summary: Since glucose reuptake by neurons is mostly independent of insulin, it has been a question whether insulin has any roles in the brain. The identification of insulin receptors in the central nervous system has fueled investigations of insulin functions in the brain. It is known that insulin can influence glucose reuptake by neurons, especially during high energy-demand activities. The high density of insulin receptors in the hippocampus suggests important roles of insulin related to memory. In this context, disturbed insulin signaling in experimental animal models of Alzheimer's disease (AD) is reviewed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Immunology
Yun Li, Xiaohuan Xia, Yi Wang, Jialin C. Zheng
Summary: This review summarizes the latest progress on the relationship between mitochondrial dysfunction and microglial activation in AD, highlighting the importance of studying this relationship and potential therapeutic strategies.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Ankit Verma, Anna Shteinfer-Kuzmine, Nikita Kamenetsky, Srinivas Pittala, Avijit Paul, Edna Nahon Crystal, Alberto Ouro, Vered Chalifa-Caspi, Swaroop Kumar Pandey, Alon Monsengo, Noga Vardi, Shira Knafo, Varda Shoshan-Barmatz
Summary: Alzheimer's disease (AD) is associated with mitochondrial dysfunctions, and VDAC1 plays a key role in controlling metabolism and calcium homeostasis. This study used a newly developed inhibitor, VBIT-4, to target VDAC1 and prevent mitochondrial dysfunction and cell death.
TRANSLATIONAL NEURODEGENERATION
(2022)
Article
Gastroenterology & Hepatology
Mary P. Moore, Rory P. Cunningham, Grace M. Meers, Sarah A. Johnson, Andrew A. Wheeler, Rama R. Ganga, Nicole M. Spencer, James B. Pitt, Alberto Diaz-Arias, Ahmed I. A. Swi, Ghassan M. Hammoud, Jamal A. Ibdah, Elizabeth J. Parks, R. Scott Rector
Summary: Compromised hepatic FAO and mitochondrial turnover are intimately linked to increasing NAFLD severity in patients with obesity.
Review
Endocrinology & Metabolism
Meng Mei, Maochang Liu, Yan Mei, Jing Zhao, Yang Li
Summary: This article reviews the role and mechanism of sphingolipids in brain insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: There is an association between type 2 diabetes mellitus and Alzheimer's disease, as both can increase the risk of developing Alzheimer's disease. Insulin resistance inhibits neuronal insulin receptors, impairing amyloid beta clearance and leading to the development of Alzheimer's disease.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kenji Fukui, Heather A. Ferris, C. Ronald Kahn
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Editorial Material
Endocrinology & Metabolism
Heather A. Ferris, C. Ronald Kahn
Article
Multidisciplinary Sciences
Heather A. Ferris, Rachel J. Perry, Gabriela V. Moreira, Gerald I. Shulman, Jay D. Horton, C. Ronald Kahn
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Editorial Material
Pediatrics
Heather A. Ferris, Elvira Isganaitis, Florence Brown
Article
Medicine, Research & Experimental
Weikang Cai, Chang Xue, Masaji Sakaguchi, Masahiro Konishi, Alireza Shirazian, Heather A. Ferris, Mengyao E. Li, Ruichao Yu, Andre Kleinridders, Emmanuel N. Pothos, C. Ronald Kahn
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Endocrinology & Metabolism
Andre Kleinridders, Heather A. Ferris, Michelle L. Reyzer, Michaela Rath, Marion Soto, M. Lisa Manier, Jeffrey Spraggins, Zhihong Yang, Robert C. Stanton, Richard M. Caprioli, C. Ronald Kahn
MOLECULAR METABOLISM
(2018)
Article
Endocrinology & Metabolism
Andre Kleinridders, Heather A. Ferris, Weikang Cai, C. Ronald Kahn
Editorial Material
Health Care Sciences & Services
Keith M. Swetz, Daniel D. Matlock, Heather Ferris, Susan Hunt
JOURNAL OF PALLIATIVE MEDICINE
(2013)
Editorial Material
Endocrinology & Metabolism
Andre Kleinridders, Heather A. Ferris, Sulay Tovar
FRONTIERS IN ENDOCRINOLOGY
(2018)
Review
Chemistry, Medicinal
Joshua A. Kulas, Thaddeus K. Weigel, Heather A. Ferris
DRUG DEVELOPMENT RESEARCH
(2020)
Article
Multidisciplinary Sciences
Hao Wang, Joshua A. Kulas, Chao Wang, David M. Holtzman, Heather A. Ferris, Scott B. Hansen
Summary: The study shows that apoE uses astrocyte-derived cholesterol to traffic neuronal APP in and out of lipid clusters, generating A beta peptide. Deletion of astrocyte cholesterol synthesis reduces amyloid and tau burden in a mouse model of AD, indicating that cholesterol is kept low in neurons and astrocytes regulate A beta accumulation through cholesterol signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Aminata P. Coulibaly, Pinar Pezuk, Paul Varghese, William Gartman, Danielle Triebwasser, Joshua A. Kulas, Lei Liu, Mariam Syed, Petr Tvrdik, Heather Ferris, J. Javier Provencio
Summary: The study findings suggest that MPO plays a role as a mediator of neuronal dysfunction in SAH by influencing neurons and glial cells. The results indicate that the activity of innate immune cells in the meninges modulates the activity and function of the underlying brain tissue in SAH.
Article
Multidisciplinary Sciences
Lisa A. Post, Joshua A. Kulas, Joshua L. Milstein, Sarah V. L. Sebastian, Seyyedmohsen Hosseini-Barkooie, Max E. Stevenson, George S. Bloom, Heather A. Ferris
Summary: A study found that a protein called Inceptor is present in the brain and is associated with insulin and IGF1 signaling, with higher levels in the cortex of female brains. However, knocking down Inceptor in neuron cultures, as well as high-fat diet in mice and Alzheimer's disease in mouse and human tissue, did not show significant changes in insulin receptor signaling and Inceptor levels.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Tao Huang, Seyyedmohsen Hosseinibarkooie, Adam L. Borne, Mitchell E. Granade, Jeffrey W. Brulet, Thurl E. Harris, Heather A. Ferris, Ku-Lung Hsu
Summary: The sulfonyl-triazoles (SuTEx) chemistry is a new type of electrophile that can react covalently with proteins, useful for chemical proteomics and protein ligand discovery. Functionalized SuTEx probes have been utilized to map protein interaction networks and discover binding sites in live cells, leading to the identification of important probe-modified sites within the protein kinase C-alpha C2 domain.
Article
Endocrinology & Metabolism
Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Summary: Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. Cytokine macrophage migration inhibitory factor (MIF) plays a role in regulating adipose HSL and adipocyte hypertrophy. Both intracellular and extracellular MIF have opposing effects on HSL, but extracellular action predominates to downregulate HSL and exacerbate obesity development during high-fat diet (HFD).
MOLECULAR METABOLISM
(2024)
Article
Endocrinology & Metabolism
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu
Summary: This study aimed to explore the role of GPSM1 in POMC neurons and the underlying mechanisms in metabolic homeostasis. Through various molecular, biochemical, immunofluorescent, immunohistochemical analyses, and cell culture studies, the study revealed the pathophysiological role of GPSM1 in POMC neurons and its regulation of POMC neuron activity.
MOLECULAR METABOLISM
(2024)