Article
Biochemistry & Molecular Biology
Max-Hinderk Schuler, Alyssa M. English, Tianyao Xiao, Thane J. Campbell, Janet M. Shaw, Adam L. Hughes
Summary: Amino acids are crucial for cellular function, but elevated levels can lead to cellular toxicity. The mitochondrial-derived compartment (MDC) has been identified as a protective mechanism against amino acid stress, promoting amino acid catabolism and maintaining homeostasis through nutrient transporter remodeling.
Article
Multidisciplinary Sciences
Tanisha Singh, Yuanyuan Jiao, Lisa M. Ferrando, Svitlana Yablonska, Fang Li, Emily C. Horoszko, David Lacomis, Robert M. Friedlander, Diane L. Carlisle
Summary: This study revealed a unified mitochondrial dysfunction phenotype in motor neurons of sALS and fALS patients, suggesting that treatments aimed at rescuing mitochondrial function may be beneficial for both types of ALS patients.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Anyuan He, John M. Dean, Irfan J. Lodhi
Summary: Peroxisomes play a crucial role in cellular responses to stress by regulating metabolic adaptation and environmental cues. They are dynamic organelles that can modulate proliferation, morphology, and movement within cells, and engage in crosstalk with other organelles.
TRENDS IN CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
F. X. Reymond Sutandy, Ines Goessner, Georg Tascher, Christian Muench
Summary: This study demonstrates that cytosol-mitochondrial reactive oxygen species (mtROS) and accumulation of mitochondrial protein precursors in the cytosol (c-mtProt) play a critical role in initiating the mitochondrial unfolded protein response (UPRmt). The findings reveal a link between mitochondrial and cytosolic proteostasis and provide molecular insight into UPRmt signaling in human cells.
Review
Biochemistry & Molecular Biology
Alessandro Luciani, Matthew C. S. Denley, Larissa P. Govers, Vincenzo Sorrentino, D. Sean Froese
Summary: Mitochondria, as the powerhouse of the cell, play a crucial role in sustaining energy metabolism and homeostasis, especially in terminally differentiated cells. Dysregulation of the mitochondrial network can lead to a wide range of hereditary and acquired diseases, highlighting the importance of understanding and potentially reversing the pathophysiology of these disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Caroline E. Dewar, Silke Oeljeklaus, Jan Mani, Wignand W. D. Muehlhaeuser, Corinne von Kaenel, Johannes Zimmermann, Torsten Ochsenreiter, Bettina Warscheid, Andre Schneider
Summary: Mitochondrial quality control mechanism in Trypanosoma brucei is characterized by the ablation of ATOM69, which triggers a unique pathway resulting in the degradation of non-imported mitochondrial proteins. This process involves the recruitment of an unknown protein, an E3 ubiquitin ligase, and a ubiquitin-like protein (TbUbL1) and the release of TbUbL1 from the nucleus to the cytosol.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Terytty Yang Li, Qi Wang, Arwen W. Gao, Xiaoxu Li, Yu Sun, Adrienne Mottis, Minho Shong, Johan Auwerx
Summary: Lysosomal acidification through v-ATPase is crucial for the transcriptional activation of the mitochondrial unfolded protein response (UPRmt). The activation of lysosomes by v-ATPase stimulates mTORC1, which then phosphorylates the transcription factor ATF4, leading to the activation of the UPRmt and mitochondrial function resilience.
Article
Cell Biology
Timo Loeser, Aljoscha Joppe, Andrea Hamann, Heinz D. Osiewacz
Summary: Research shows that the inner mitochondrial membrane undergoes morphological changes and functional impairments during aging in the fungal aging model, with a reorganization of mitochondrial phospholipids identified through lipidomic analysis. The i-AAA protease PaIAP plays a crucial role in regulating phospholipid metabolism, affecting mitochondrial function and lifespan under different growth conditions.
Article
Microbiology
Omar M. Barrientos, Elizabeth Langley, Yolanda Gonzalez, Carlos Cabello, Martha Torres, Silvia Guzman-Beltran
Summary: The physiological state of human macrophages may affect the metabolism and persistence of Mycobacterium tuberculosis. The production of ROS in macrophages induces oxidative stress in bacteria and enhances gene expression, potentially contributing to the long-term survival of the bacteria within the host.
Article
Cell Biology
Xiaowen Ma, Sharon Manley, Hui Qian, Yuan Li, Chen Zhang, Kevin Li, Benjamin Ding, Fengli Guo, Allen Chen, Xing Zhang, Meilian Liu, Meihua Hao, Benjamin Kugler, E. Matthew Morris, John Thyfault, Ling Yang, Hiromi Sesaki, Hong-Min Ni, Heidi McBride, Wen-Xing Ding
Summary: During hepatocyte dedifferentiation, a newly discovered intracellular organelle called the mitochondria-lysosome-related organelle (MLRO) plays a crucial role in regulating mitochondrial homeostasis. The MLRO is formed through the fusion of mitochondria-derived vesicles (MDVs) with lysosomes and is involved in mitochondrial protein degradation and hepatocyte dedifferentiation. This organelle, resembling damaged lysosomes, can be cleared by overexpression of the transcription factor EB (TFEB). The MLRO acts as an alternative mechanism for mitochondrial quality control during cell dedifferentiation, independent of canonical autophagy/mitophagy.
Article
Biochemistry & Molecular Biology
Chang-Chun Song, Kostas Pantopoulos, Guang-Hui Chen, Chong-Chao Zhong, Tao Zhao, Dian-Guang Zhang, Zhi Luo
Summary: In this study, it was found that a high-iron diet increased intestinal iron content and promoted lipid deposition. This phenomenon was mediated by the HIF1α-PPARγ pathway, involving oxidative stress and mitochondrial dysfunction.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiangfeng Niu, Ethan Stancliffe, Susan J. Gelman, Lingjue Wang, Michaela Schwaiger-Haber, Joe L. Rowles, Leah P. Shriver, Gary J. Patti
Summary: In this study, an approach to resolve the fluxes of NADPH in the cytosol and mitochondria was introduced using deuterium tracing. It was found that challenges in the cytosol affected NADPH fluxes in the cytosol, while challenges in the mitochondria affected NADPH fluxes in the mitochondria. This work highlights the value of using proline labeling as a reporter system for studying compartmentalized metabolism and reveals independent regulation of NADPH homeostasis in the cytosol and mitochondria, without evidence for NADPH shuttle activity.
NATURE CHEMICAL BIOLOGY
(2023)
Review
Oncology
Xiaogang Zheng, Xiaodong Jin, Fei Ye, Xiongxiong Liu, Boyi Yu, Zheng Li, Ting Zhao, Weiqiang Chen, Xinguo Liu, Cuixia Di, Qiang Li
Summary: Ferroptosis is a regulated cell death mode triggered by iron-dependent toxic membrane lipid peroxidation. It has attracted extensive attention due to its association with various diseases. The potential applications of ferroptosis in radiotherapy and immunotherapy have been elucidated, providing new strategies for clinical tumor treatment.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yun Qiu, Ya-Ning Shi, Neng Zhu, Shuo Zhang, Chan-Juan Zhang, Jia Gu, Peng He, Ai-Guo Dai, Li Qin
Summary: Pyroptosis is a pro-inflammatory cell death caused by Gasdermin (GSMD) family-mediated membrane pore formation and cell lysis. It leads to the release of inflammatory factors and inflammation in multiple tissues, impacting various metabolic disorders. Lipid metabolism plays a significant role in pyroptosis, as bioactive lipid molecules act as triggers and regulators of pyroptosis. Understanding the relationship between lipid molecules, such as cholesterol and fatty acids, and pyroptosis during metabolic processes can provide insights into disease pathogenesis and aid in developing effective strategies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Editorial Material
Endocrinology & Metabolism
Mohamed A. Eldeeb, Andrea Soumbasis, Edward A. Fon
Summary: Given their polyvalent roles, mitochondria face the challenge of continuous exposure to stressors, such as mitochondrial import defects, which result in dysfunction. Recent research has discovered a quality control pathway, dependent on a presequence translocase-associated import motor (PAM) complex, in which misfolded proteins reduce mitochondrial protein import and subsequently trigger mitophagy without loss of mitochondrial membrane potential.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Feng Hong, Bei Liu, Bill X. Wu, Jordan Morreall, Brady Roth, Christopher Davies, Shaoli Sun, J. Alan Diehl, Zihai Li
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Salih Gencer, Natalia Oleinik, Jisun Kim, Shanmugam Panneer Selvam, Ryan De Palma, Mohammed Dany, Rose Nganga, Raquela J. Thomas, Can E. Senkal, Philip H. Howe, Besim Ogretmen
Article
Biochemistry & Molecular Biology
Feng Hong, Bei Liu, Bill X. Wu, Jordan Morreall, Brady Roth, Christopher Davies, Shaoli Sun, J. Alan Diehl, Zihai Li
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Salih Gencer, Natalia Oleinik, Jisun Kim, Shanmugam Panneer Selvam, Ryan De Palma, Mohammed Dany, Rose Nganga, Raquela J. Thomas, Can E. Senkal, Philip H. Howe, Besim Ogretmen
Article
Biochemical Research Methods
Katherine Coburn, Zephan Melville, Ehson Aligholizadeh, Braden M. Roth, Kristen M. Varney, France Carrier, Edwin Pozharski, David J. Weber
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Shanmugam Panneer Selvam, Braden M. Roth, Rose Nganga, Jisun Kim, Marion A. Cooley, Kristi Helke, Charles D. Smith, Besim Ogretmen
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
G. Logan Draughn, Morgan E. Milton, Erik A. Feldmann, Benjamin G. Bobay, Braden M. Roth, Andrew L. Olson, Richele J. Thompson, Luis A. Actis, Christopher Davies, John Cavanagh
JOURNAL OF MOLECULAR BIOLOGY
(2018)
Article
Biophysics
Brandon F. Young, Braden M. Roth, Christopher Davies
BIOMOLECULAR NMR ASSIGNMENTS
(2019)
Article
Biochemistry & Molecular Biology
Ryan M. De Palma, Stuart R. Parnham, Yitong Lo, Joshua J. Oaks, Yuri K. Peterson, Zdzislaw M. Szulc, Braden M. Roth, Yongna Xing, Besim Ogretmen
Article
Biophysics
Braden M. Roth, Kristen M. Varney, Hui Yang, David J. Weber, Alan E. Tomkinson
BIOMOLECULAR NMR ASSIGNMENTS
(2019)
Article
Biophysics
Braden M. Roth, Ryan M. DePalma, Mary E. Cook, Kristen M. Varney, David J. Weber, Besim Ogretmen
Summary: SET is a multifunctional protein that plays a role in regulating various cellular processes, with its overexpression or post-translational modification in certain cancers correlated with poor clinical outcomes. Inhibition of the interaction between SET and PP2A may present a promising approach for tumor suppression.
BIOMOLECULAR NMR ASSIGNMENTS
(2021)
Article
Oncology
Paramita Chakraborty, Rasesh Y. Parikh, Seungho Choi, Danh Tran, Monika Gooz, Zachariah T. Hedley, Do-Sung Kim, Dariusz Pytel, Inhong Kang, Satish N. Nadig, Gyda C. Beeson, Lauren Ball, Meenal Mehrotra, Hongjun Wang, Stefano Berto, Viswanathan Palanisamy, Hong Li, Shilpak Chatterjee, Paulo C. Rodriguez, Eduardo N. Maldonado, J. Alan Diehl, Vamsi K. Gangaraju, Shikhar Mehrotra