Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

Accessibility of Different Histone H3-Binding Domains of UHRF1 Is Allosterically Regulated by Phosphatidylinositol 5-Phosphate

(2014) Kathy A. Gelato et al.   MOLECULAR CELL

Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation

(2014) Naoya Hirata et al.   Nature Communications

The Role of Telomeres in Stem Cells and Cancer

(2013) Cagatay Günes et al.   CELL

The molecular basis of ceramide-1-phosphate recognition by C2 domains

(2013) Katherine E. Ward et al.   JOURNAL OF LIPID RESEARCH

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

(2012) Suriyan Ponnusamy et al.   EMBO Molecular Medicine

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

(2012) Sahar A. Saddoughi et al.   EMBO Molecular Medicine

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

The nuclear lamins: flexibility in function

(2012) Brian Burke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of Isoenzyme-Selective Inhibitors of Human Sphingosine Kinases

(2012) Peng Gao et al.   PLoS One

The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast

(2011) Helder C. Ferreira et al.   NATURE CELL BIOLOGY

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence

(2010) Kaori Fujita et al.   NATURE CELL BIOLOGY

A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity

(2010) Mingyi Xie et al.   NUCLEIC ACIDS RESEARCH

Telomerase: An RNP Enzyme Synthesizes DNA

(2010) E. H. Blackburn et al.   Cold Spring Harbor Perspectives in Biology

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Structure of the Tribolium castaneum telomerase catalytic subunit TERT

(2008) Andrew J. Gillis et al.   NATURE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY