Sphingolipids and their metabolism in physiology and disease

Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein

(2017) Natalia Santos Ferreira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition

(2017) Alexei Gorelik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PNPLA1 Deficiency in Mice and Humans Leads to a Defect in the Synthesis of Omega-O-Acylceramides

(2017) Susanne Grond et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

(2017) Louise van der Weyden et al.   NATURE

Structural insights into adiponectin receptors suggest ceramidase activity

(2017) Ieva Vasiliauskaité-Brooks et al.   NATURE

Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation

(2017) Yitao Wang et al.   Scientific Reports

ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain

(2017) Birol Cabukusta et al.   Scientific Reports

Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 CohortHighlights

(2016) Aki S. Havulinna et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

(2016) Sonia Hernández-Tiedra et al.   Autophagy

Inhibition of ceramide de novo synthesis as a postischemic strategy to reduce myocardial reperfusion injury

(2016) M. R. Reforgiato et al.   BASIC RESEARCH IN CARDIOLOGY

Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543

(2016) TongFa Ju et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ

(2016) Jinbiao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A 19-Gene expression signature as a predictor of survival in colorectal cancer

(2016) Nurul Ainin Abdul Aziz et al.   BMC Medical Genomics

Ceramide synthases in biomedical research

(2016) Francesca Cingolani et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Role of neutral ceramidase in colon cancer

(2016) Mónica García-Barros et al.   FASEB JOURNAL

Sphingolipids as targets for treatment of fungal infections

(2016) Rodrigo Rollin-Pinheiro et al.   Future Medicinal Chemistry

Sphingosine kinases are not required for inflammatory responses in macrophages.

(2016) Yuquan Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation

(2016) Yoshimitsu Taguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

(2016) Takayuki Sassa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis

(2016) Amrita Jain et al.   JOURNAL OF CELL SCIENCE

ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation

(2016) Christopher J. Clarke et al.   JOURNAL OF LIPID RESEARCH

Deficiency of the alkaline ceramidase ACER3 manifests in early childhood by progressive leukodystrophy

(2016) Simon Edvardson et al.   JOURNAL OF MEDICAL GENETICS

Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis

(2016) Zi-Jian Xiong et al.   JOURNAL OF MOLECULAR BIOLOGY

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure

(2016) Kifayathullah Liakath-Ali et al.   JOURNAL OF PATHOLOGY

Smpd3Expression in both Chondrocytes and Osteoblasts Is Required for Normal Endochondral Bone Development

(2016) Jingjing Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphatase PP2A is requisite for the function of regulatory T cells

(2016) Sokratis A Apostolidis et al.   NATURE IMMUNOLOGY

Increased Plasma Levels of Select Deoxy-ceramide and Ceramide Species are Associated with Increased Odds of Diabetic Neuropathy in Type 1 Diabetes: A Pilot Study

(2016) Samar M. Hammad et al.   NEUROMOLECULAR MEDICINE

Ozanimod Induction and Maintenance Treatment for Ulcerative Colitis

(2016) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

T cell-intrinsic S1PR1 regulates endogenous effector T-cell egress dynamics from lymph nodes during infection

(2016) Alexandre P. Benechet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex

(2016) Kyungho Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency

(2016) Stefka D. Spassieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingomyelin is sorted at thetransGolgi network into a distinct class of secretory vesicle

(2016) Yongqiang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The enigma of ceramide synthase regulation in mammalian cells

(2016) Marthe-Susanna Wegner et al.   PROGRESS IN LIPID RESEARCH

Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism

(2016) Vitor Teixeira et al.   PROGRESS IN LIPID RESEARCH

Plasma ceramide, a real-time predictive marker of pulmonary and hepatic metastases response to stereotactic body radiation therapy combined with irinotecan

(2016) Nolwenn Dubois et al.   RADIOTHERAPY AND ONCOLOGY

Human acid sphingomyelinase structures provide insight to molecular basis of Niemann–Pick disease

(2016) Yan-Feng Zhou et al.   Nature Communications

Crystal structure of mammalian acid sphingomyelinase

(2016) Alexei Gorelik et al.   Nature Communications

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells

(2016) Melissa McNaughton et al.   Oncotarget

Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans

(2016) Irina Soltau et al.   PLoS One

Tumor suppressive functions of ceramide: evidence and mechanisms

(2015) Sehamuddin Galadari et al.   APOPTOSIS

Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study

(2015) Jin M. Cheng et al.   ATHEROSCLEROSIS

Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization

(2015) Vinodh Rajagopalan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ceramide induced mitophagy and tumor suppression

(2015) Mohammed Dany et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The molecular medicine of acid ceramidase

(2015) Michael Frohbergh et al.   BIOLOGICAL CHEMISTRY

Tackling the biophysical properties of sphingolipids to decipher their biological roles

(2015) Ana C. Carreira et al.   BIOLOGICAL CHEMISTRY

Insulin treatment increases myocardial ceramide accumulation and disrupts cardiometabolic function

(2015) Aimee E. Hodson et al.   Cardiovascular Diabetology

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

(2015) Jonathan Y. Xia et al.   Cell Metabolism

Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer

(2015) L. Zhang et al.   CLINICAL CANCER RESEARCH

Regulation of hematogenous tumor metastasis by acid sphingomyelinase

(2015) A. Carpinteiro et al.   EMBO Molecular Medicine

Intracellular sphingosine kinase 2–derived sphingosine-1-phosphate mediates epidermal growth factor–induced ezrin-radixin-moesin phosphorylation and cancer cell invasion

(2015) Mohamad M. Adada et al.   FASEB JOURNAL

HSAN1 mutations in serine palmitoyltransferase reveal a close structure–function–phenotype relationship

(2015) Heiko Bode et al.   HUMAN MOLECULAR GENETICS

The Crystal Structure of an Integral Membrane Fatty Acid α-Hydroxylase

(2015) Guangyu Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acid Ceramidase in Melanoma

(2015) Natalia Realini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dihydroceramides: From Bit Players to Lead Actors

(2015) Monowarul Mobin Siddique et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 Deacetylates Ceramide Synthases

(2015) Sergei A. Novgorodov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transbilayer distribution of lipids at nano scale

(2015) M. Murate et al.   JOURNAL OF CELL SCIENCE

Ceramide Synthase 4 Regulates Stem Cell Homeostasis and Hair Follicle Cycling

(2015) Franziska Peters et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sphingolipids in High Fat Diet and Obesity-Related Diseases

(2015) Songhwa Choi et al.   MEDIATORS OF INFLAMMATION

HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation

(2015) Victoria A. Blaho et al.   NATURE

Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration

(2015) Lihong Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphogenesis checkpoint kinase Swe1 is the executor of lipolysis-dependent cell-cycle progression

(2015) Neha Chauhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

(2015) Anneleen Daemen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase

(2015) Michael V. Airola et al.   STRUCTURE

Ceramides – Lipotoxic Inducers of Metabolic Disorders

(2015) Bhagirath Chaurasia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest

(2015) A A Shamseddine et al.   Cell Death & Disease

Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis

(2015) M Taniguchi et al.   Cell Death & Disease

Sphingosine 1-phosphate signaling pathway in inner ear biology. New therapeutic strategies for hearing loss?

(2015) Ricardo Romero-Guevara et al.   Frontiers in Aging Neuroscience

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

Ceramide as a Mediator of Non-Alcoholic Fatty Liver Disease and Associated Atherosclerosis

(2015) Takhar Kasumov et al.   PLoS One

Drugging Sphingosine Kinases

(2014) Webster L. Santos et al.   ACS Chemical Biology

Ceramide-Activated Phosphatase Mediates Fatty Acid–Induced Endothelial VEGF Resistance and Impaired Angiogenesis

(2014) Vishal C. Mehra et al.   AMERICAN JOURNAL OF PATHOLOGY

Ceramide center stage in progressive myoclonus epilepsies

(2014) Rose-Mary Boustany   ANNALS OF NEUROLOGY

Impairment of ceramide synthesis causes a novel progressive myoclonus epilepsy

(2014) Nicola Vanni et al.   ANNALS OF NEUROLOGY

Regulation of alkaline ceramidase activity by the c-Src-mediated pathway

(2014) Hirotsune Sasaki et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology

(2014) Takayuki Sassa et al.   Biomolecules & Therapeutics

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

Dual Functions of theTrans-2-Enoyl-CoA Reductase TER in the Sphingosine 1-Phosphate Metabolic Pathway and in Fatty Acid Elongation

(2014) Takeshi Wakashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Neutral Sphingomyelinase Pathway Regulates Packaging of the Prion Protein into Exosomes

(2014) Belinda B. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential Roles of Neutral Ceramidase and Sphingosine in Mitochondrial Dysfunction Due to Traumatic Brain Injury

(2014) Sergei A. Novgorodov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingomyelin Synthase 2, but Not Sphingomyelin Synthase 1, Is Involved in HIV-1 Envelope-mediated Membrane Fusion

(2014) Yasuhiro Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone Morphogenic Protein (BMP) Signaling Up-regulates Neutral Sphingomyelinase 2 to Suppress Chondrocyte Maturation via the Akt Protein Signaling Pathway as a Negative Feedback Mechanism

(2014) Hironori Kakoi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoregulation of the Ceramide Transport Protein CERT at Serine 315 in the Interaction with VAMP-associated Protein (VAP) for Inter-organelle Trafficking of Ceramide in Mammalian Cells

(2014) Keigo Kumagai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human genetic disorders of sphingolipid biosynthesis

(2014) Leonardo Astudillo et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer

(2014) Nicole Sänger et al.   Molecular Oncology

Coupling between endocytosis and sphingosine kinase 1 recruitment

(2014) Hongying Shen et al.   NATURE CELL BIOLOGY

Glycerophospholipid and Sphingolipid Species and Mortality: The Ludwigshafen Risk and Cardiovascular Health (LURIC) Study

(2014) Alexander Sigruener et al.   PLoS One

Acid Sphingomyelinase Serum Activity Predicts Mortality in Intensive Care Unit Patients after Systemic Inflammation: A Prospective Cohort Study

(2014) Matthias Kott et al.   PLoS One

Bcl2L13 is a ceramide synthase inhibitor in glioblastoma

(2014) S. A. Jensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss

(2014) Jing Chen et al.   PLoS Genetics

Inhibition of CeramideDe NovoSynthesis with Myriocin Affects Lipid Metabolism in the Liver of Rats with Streptozotocin-Induced Type 1 Diabetes

(2014) Krzysztof Kurek et al.   Biomed Research International

Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy

(2014) Masayuki Nagahashi et al.   Biomed Research International

TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids

(2014) Alexander Muir et al.   eLife

Sphingosine Kinase 1 Promotes Malignant Progression in Colon Cancer and Independently Predicts Survival of Patients With Colon Cancer by Competing Risk Approach in South Asian Population

(2014) Sheryl S L Tan et al.   Clinical and Translational Gastroenterology

Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy

(2014) Mai-Britt Mosbech et al.   Annals of Clinical and Translational Neurology

Imaging local sphingomyelin-rich domains in the plasma membrane using specific probes and advanced microscopy

(2013) Mitsuhiro Abe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingolipids and lifespan regulation

(2013) Xinhe Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingolipids and lysosomal pathologies

(2013) Heike Schulze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Acid sphingomyelinase determines melanoma progression and metastatic behaviour via the microphtalmia-associated transcription factor signalling pathway

(2013) L Bizzozero et al.   CELL DEATH AND DIFFERENTIATION

The yeast sphingolipid signaling landscape

(2013) David J. Montefusco et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Topological and Functional Characterization of the ssSPTs, Small Activating Subunits of Serine Palmitoyltransferase

(2013) Jeffrey M. Harmon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of C18:1-Phytoceramide as the Candidate Lipid Mediator for Hydroxyurea Resistance in Yeast

(2013) Nabil Matmati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramides and Glucosylceramides Are Independent Antagonists of Insulin Signaling

(2013) Jose A. Chavez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chemical Basis of Serine Palmitoyltransferase Inhibition by Myriocin

(2013) John M. Wadsworth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

(2013) Dhirendra K. Simanshu et al.   NATURE

Increased Oxidative Stress Impairs Adipose Tissue Function in Sphingomyelin Synthase 1 Null Mice

(2013) Masato Yano et al.   PLoS One

Sphingosine Kinase Activity Is Not Required for Tumor Cell Viability

(2013) Karen Rex et al.   PLoS One

Functional Loss of Two Ceramide Synthases Elicits Autophagy-Dependent Lifespan Extension in C. elegans

(2013) Mai-Britt Mosbech et al.   PLoS One

Molecular Basis of Sphingosine Kinase 1 Substrate Recognition and Catalysis

(2013) Zhulun Wang et al.   STRUCTURE

Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity

(2013) Natalia Realini et al.   Scientific Reports

Ceramides predict verbal memory performance in coronary artery disease patients undertaking exercise: a prospective cohort pilot study

(2013) Mahwesh Saleem et al.   BMC Geriatrics

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

(2012) Mark E. Schnute et al.   BIOCHEMICAL JOURNAL

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Role of down-regulated neutral ceramidase during all-trans retinoic acid-induced neuronal differentiation in SH-SY5Y neuroblastoma cells

(2012) Kouji Tanaka et al.   JOURNAL OF BIOCHEMISTRY

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Phosphatase 1α Mediates Ceramide-induced ERM Protein Dephosphorylation

(2012) Daniel Canals et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways

(2012) Yidi Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain

(2012) F.-Xabier Contreras et al.   NATURE

Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants

(2012) Cosima Rhein et al.   PLoS One

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Loss of ceramide synthase 3 causes lethal skin barrier disruption

(2011) Richard Jennemann et al.   HUMAN MOLECULAR GENETICS

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase

(2011) Russell W. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutral Sphingomyelinase 2 Activity and Protein Stability Are Modulated by Phosphorylation of Five Conserved Serines

(2011) Simone Filosto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Dihydroceramide Desaturase as a Directin VitroTarget for Fenretinide

(2011) Mehrdad Rahmaniyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid phosphate phosphatase 3 enables efficient thymic egress

(2011) Béatrice Bréart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity

(2011) Z. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Defining a role for sphingosine kinase 1 in p53-dependent tumors

(2011) L A Heffernan-Stroud et al.   ONCOGENE

Enhanced Selectivity for Sulfatide by Engineered Human Glycolipid Transfer Protein

(2011) Valeria R. Samygina et al.   STRUCTURE

HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging

(2010) S. Michal Jazwinski et al.   AGING CELL

Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase

(2010) Alexander A. Chumanevich et al.   CARCINOGENESIS

Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro

(2010) Viviana Anelli et al.   FASEB JOURNAL

The BCL-2 Protein BAK Is Required for Long-chain Ceramide Generation during Apoptosis

(2010) Leah J. Siskind et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Sphingolipid Mediator Ceramide in Obesity and Renal Injury in Mice Fed a High-Fat Diet

(2010) K. M. Boini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Endothelial Membrane Remodeling Is Obligate for Anti-Angiogenic Radiosensitization during Tumor Radiosurgery

(2010) Jean-Philip Truman et al.   PLoS One

Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation

(2009) Bill X. Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Fatty acid 2-Hydroxylation in mammalian sphingolipid biology

(2009) Hiroko Hama   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The SPTLC3 Subunit of Serine Palmitoyltransferase Generates Short Chain Sphingoid Bases

(2009) Thorsten Hornemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of the CERT START Domain with Inhibitors Provide Insights into the Mechanism of Ceramide Transfer

(2009) Norio Kudo et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

The vascular S1P gradient—Cellular sources and biological significance

(2008) T HLA   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Role for sphingosine kinase 1 in colon carcinogenesis

(2008) Toshihiko Kawamori et al.   FASEB JOURNAL

Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer

(2008) Ayman EM Mahdy et al.   MOLECULAR THERAPY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE